{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:10:32Z","timestamp":1790885432749,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008870","name":"Shanghai Agriculture and Rural Affairs Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23Y1190020"],"award-info":[{"award-number":["23Y1190020"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["20244Y0139"],"award-info":[{"award-number":["20244Y0139"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.yjmcc.2025.10.005","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T09:47:34Z","timestamp":1761299254000},"page":"119-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Targeting gut microbiotasu-derived butyrate for Ferroptosis inhibition in Sepsis-induced myocardial dysfunction"],"prefix":"10.1016","volume":"209","author":[{"given":"Jianfei","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2025.10.005_bb0005","unstructured":"L. Evans, A. Rhodes, W. Alhazzani, M. Antonelli, C.M. Coopersmith, C. French, et al., Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021, Intensive Care Med. 47 (11) (2021) 1181\u20131247."},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0010","doi-asserted-by":"crossref","unstructured":"Y. Lin, Y. Xu, Z. Zhang, Sepsis-Induced Myocardial Dysfunction (SIMD): the Pathophysiological Mechanisms and Therapeutic Strategies Targeting Mitochondria, Inflammation 43 (4) (2020) 1184\u20131200.","DOI":"10.1007\/s10753-020-01233-w"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0015","doi-asserted-by":"crossref","unstructured":"E.J. Choi, H. Nam, C.R. Chung, J.H. Yang, G.Y. Suh, S. Park, et al., Korean Sepsis Alliance (KSA) investigators, Impact of Elevated Troponin Level at the Time of Sepsis Recognition on the Clinical Outcomes: A Propensity Score-Matched Cohort Study, J. Am. Heart Assoc. 14(9)(2025):e038651.","DOI":"10.1161\/JAHA.124.038651"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0020","doi-asserted-by":"crossref","unstructured":"X. Jiang, B.R. Stockwell, M. Conrad, Ferroptosis: mechanisms, biology and role in disease, Nat. Rev. Mol. Cell. Biol. 22 (4) (2021) 266\u2013282.","DOI":"10.1038\/s41580-020-00324-8"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0025","doi-asserted-by":"crossref","unstructured":"X. Li, H. Sun, L. Zhang, H. Liang, B. Zhang, J. Yang, et al., GDF15 attenuates sepsis-induced myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the SOCS1\/GPX4 signaling pathway, Eur. J. Pharmacol. 982 (2024) 176894.","DOI":"10.1016\/j.ejphar.2024.176894"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0030","doi-asserted-by":"crossref","unstructured":"N. Li, W. Wang, H. Zhou, Q. Wu, M. Duan, C. Liu, et al., Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury, Free Radic. Biol. Med. 160 (2020) 303\u2013318.","DOI":"10.1016\/j.freeradbiomed.2020.08.009"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0035","doi-asserted-by":"crossref","unstructured":"S.Y. Sheng, J.M. Li, X.Y. Hu, Y. Wang, Regulated cell death pathways in cardiomyopathy, Acta. Pharmacol. Sin. 44 (8) (2023) 1521\u20131535.","DOI":"10.1038\/s41401-023-01068-9"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0040","doi-asserted-by":"crossref","unstructured":"Y. Zeng, G. Cao, L. Lin, Y. Zhang, X. Lou, X. Ma, et al., Resveratrol Attenuates Sepsis-Induced Cardiomyopathy in Rats through Anti-Ferroptosis via the Sirt1\/Nrf2 Pathway, J. Invest. Surg. 36 (1) (2023) 2157521.","DOI":"10.1080\/08941939.2022.2157521"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0045","doi-asserted-by":"crossref","unstructured":"M.W. Adelman, M.H. Woodworth, C. Langelier, L.M. Busch, J.A. Kempker, C.S. Kraft, et al., The gut microbiome's role in the development, maintenance, and outcomes of sepsis, Crit. Care 24 (1) (2020) 278.","DOI":"10.1186\/s13054-020-02989-1"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0050","doi-asserted-by":"crossref","unstructured":"X. Lin, C. Lin, X. Li, F. Yao, X. Guo, M. Wang, et al., Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection, J. Microbiol. 62(12) (2024) 1113\u20131124.","DOI":"10.1007\/s12275-024-00190-5"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0055","doi-asserted-by":"crossref","unstructured":"K. Shimizu, T. Yamada, H. Ogura, T. Mohri, T. Kiguchi, S. Fujimi, et al., Synbiotics modulate gut microbiota and reduce enteritis and ventilator-associated pneumonia in patients with sepsis: a randomized controlled trial, Crit. Care 22 (1) (2018) 239.","DOI":"10.1186\/s13054-018-2167-x"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0060","doi-asserted-by":"crossref","unstructured":"E.S. Chambers, T. Preston, G. Frost, D.J. Morrison, Role of Gut Microbiota-Generated Short-Chain Fatty Acids in Metabolic and Cardiovascular Health, Curr. Nutr. Rep. 7 (4) (2018) 198\u2013470.","DOI":"10.1007\/s13668-018-0248-8"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0065","doi-asserted-by":"crossref","unstructured":"E. Nabizadeh, J. Sadeghi, M.A. Rezaee, H. Hamishehkar, A. Hasani, H.S. Kafil, et al., The profile of key gut microbiota members and short-chain fatty acids in patients with sepsis, Heliyon 9(7) (2023) e17880.","DOI":"10.1016\/j.heliyon.2023.e17880"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0070","doi-asserted-by":"crossref","unstructured":"L. Zhang, J. Du, N. Yano, H.Wang, Y.T. Zhao, P.M. Dubielecka, et al., Sodium Butyrate Protects -Against High Fat Diet-Induced Cardiac Dysfunction and Metabolic Disorders in Type II Diabetic Mice, J. Cell Biochem. 118 (8) (2017) 2395\u20132408.","DOI":"10.1002\/jcb.25902"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0075","doi-asserted-by":"crossref","unstructured":"X. Lou, J. Xue, R. Shao, Y. Yang, D. Ning, C. Mo, et al., Fecal microbiota transplantation and short-chain fatty acids reduce sepsis mortality by remodeling antibiotic-induced gut microbiota disturbances, Front. Immunol. 13 (2022) 1063543.","DOI":"10.3389\/fimmu.2022.1063543"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0080","doi-asserted-by":"crossref","unstructured":"M.R. Amorim, A.A. de Jesus, N.N. Santos-Junior, M.J.A Rocha, J.E. Nogueira, M.E. Batalh\u00e3o et al., Autonomic Disbalance During Systemic Inflammation is Associated with Oxidative Stress Changes in Sepsis Survivor Rats, Inflammation 45 (3) (2022) 1239\u20131253.","DOI":"10.1007\/s10753-021-01617-6"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0085","doi-asserted-by":"crossref","unstructured":"T. Jia, S. Wang, C. Luo, Z. Wang, G. Liu, Z. Shang, et al., Levosimendan Ameliorates Post-resuscitation Acute Intestinal Microcirculation Dysfunction Partly Independent of its Effects on Systemic Circulation: A Pilot Study on Cardiac Arrest in a Rat Model, Shock 56 (4) (2021) 639\u2013646.","DOI":"10.1097\/SHK.0000000000001771"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0090","doi-asserted-by":"crossref","unstructured":"H. Zhang, J. Xu, Q. Wu, H. Fang, X. Shao, X. Ouyang, et al., Gut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid, J. Inflamm. Res. 15 (2022) 2103\u20132119.","DOI":"10.2147\/JIR.S350566"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0095","doi-asserted-by":"crossref","unstructured":"D. Chen, X. Liang, L. Zhang, J. Zhang, L. Gao, D. Yan, et al., E3 Ubiquitin Ligase FBXO32 Promotes LPS-Induced Cardiac Injury by Regulating ANXA1\/PI3K\/AKT Signaling, Inflammation. Epub ahead of print. (2025).","DOI":"10.21203\/rs.3.rs-4874434\/v1"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0100","doi-asserted-by":"crossref","unstructured":"J. Liu, W. Fu, X. Wang, Z. Liang, F. Meng, The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury, Front. Cardiovasc. Med. 12 ( 2025) 557119.","DOI":"10.3389\/fcvm.2025.1557119"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0105","doi-asserted-by":"crossref","unstructured":"Y. Jiao, Q. Zhang, J. Zhang, Y. Zha, J. Wang, Y. Li, et al., Platelet-rich plasma ameliorates lipopolysaccharide-induced cardiac injury by inflammation and ferroptosis regulation, Front. Pharmacol. 13 (2022) 1026641.","DOI":"10.3389\/fphar.2022.1026641"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0110","doi-asserted-by":"crossref","unstructured":"C. Kong, X. Ni, Y. Wang, A. Zhang, Y. Zhang, F. Lin, et al., ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking, Cell Death Discov. 8 (1) (2022) 187.","DOI":"10.1038\/s41420-022-00957-y"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0115","doi-asserted-by":"crossref","unstructured":"H. Chen, Y. Qian, C. Jiang, L. Tang, J. Yu, L. Zhang, et al., Butyrate ameliorated ferroptosis in ulcerative colitis through modulating Nrf2\/GPX4 signal pathway and improving intestinal barrier, Biochim. Biophys. Acta. Mol. Basis. Dis. 1870 (2) (2024) 166984.","DOI":"10.1016\/j.bbadis.2023.166984"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0120","doi-asserted-by":"crossref","unstructured":"C.J. Yang, H.C. Chang, P.C. Sung, M.C. Ge, H.Y. Tang, M.L. Cheng, et al., Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury, Cell Rep. 43 (1) (2024) 113591.","DOI":"10.1016\/j.celrep.2023.113591"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0125","doi-asserted-by":"crossref","unstructured":"G. Wang, S. Qin, L. Chen, H. Geng, Y. Zheng, C. Xia, et al., Butyrate dictates ferroptosis sensitivity through FFAR2-mTOR signaling, Cell Death Dis. 14 (4) (2023) 292.","DOI":"10.1038\/s41419-023-05778-0"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0130","doi-asserted-by":"crossref","unstructured":"F. Wang, Z. Jin, K. Shen, T. Weng, Z. Chen, J. Feng, et al., Butyrate pretreatment attenuates heart depression in a mice model of endotoxin-induced sepsis via anti-inflammation and anti-oxidation, Am. J. Emerg. Med. 35 (3) (2017) 402\u2013409.","DOI":"10.1016\/j.ajem.2016.11.022"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0135","doi-asserted-by":"crossref","unstructured":"L.T. Zhang, Y.M. Yao, J.Q. Lu, X.J. Yan, Y. Yu, Z.Y. Sheng, Sodium butyrate prevents lethality of severe sepsis in rats, Shock, 27 (6) (2007) 672\u2013677.","DOI":"10.1097\/SHK.0b013e31802e3f4c"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0140","doi-asserted-by":"crossref","unstructured":"A. von Knethen, B. Br\u00fcne, Histone Deacetylation Inhibitors as Therapy Concept in Sepsis, Int. J. Mol. Sci. 20(2) (2019) 346.","DOI":"10.3390\/ijms20020346"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0145","doi-asserted-by":"crossref","unstructured":"Q. Zhang, C. Lu, W. Fan, J. Zhang, Y. Yin, Application background and mechanism of short-chain fatty acids in sepsis-associated encephalopathy. Front. Cell Infect. Microbiol. 13 (2023) 1137161.","DOI":"10.3389\/fcimb.2023.1137161"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0150","doi-asserted-by":"crossref","unstructured":"X. Shi, X. Lv, D. Xiao, Gossypol improves myocardial dysfunction caused by sepsis by regulating histone acetylation, Clin. Transl. Sci. 16 (2023) 2189\u20132197.","DOI":"10.1111\/cts.13618"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0155","doi-asserted-by":"crossref","unstructured":"O. Rroji, A. Kumar, S.S. Karuppagounder, R.R. Ratan, Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases, Neurobiol. Dis. 147 (2021) 105145.","DOI":"10.1016\/j.nbd.2020.105145"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0160","doi-asserted-by":"crossref","unstructured":"I.V. Gregoretti, Y.M. Lee, H.V. Goodson, Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis, J. Mol. Biol. 338 (1) (2004) 17\u201331.","DOI":"10.1016\/j.jmb.2004.02.006"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0165","doi-asserted-by":"crossref","unstructured":"H. Zhu, L. Shan, P.W. Schiller, A. Mai, T. Peng, Histone deacetylase-3 activation promotes tumor necrosis factor-alpha (TNF-alpha) expression in cardiomyocytes during lipopolysaccharide stimulation, J. Biol. Chem. 285 (13) (2010) 9429\u20139436.","DOI":"10.1074\/jbc.M109.071274"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0170","doi-asserted-by":"crossref","unstructured":"Y. Li, T. Zhao, B. Liu, I. Halaweish, R. Mazitschek, X. Duan, et al., Inhibition of histone deacetylase 6 improves long-term survival in a lethal septic model, J. Trauma Acute Care Surg, 78 (2) (2015) 378\u2013385.","DOI":"10.1097\/TA.0000000000000510"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0175","doi-asserted-by":"crossref","unstructured":"M.R. Shakespear, D.M. Hohenhaus, G.M. Kelly, N.A. Kamal, P. Gupta, L. I. Labzin, et al., Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages, J. Biol. Chem. 288 (35) (2013) 25362\u201325374.","DOI":"10.1074\/jbc.M113.496281"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0180","doi-asserted-by":"crossref","unstructured":"L. Yang, C. Wu, Y. Cui, S. Dong, Knockdown of histone deacetylase 9 attenuates sepsis-induced myocardial injury and inflammatory response, Exp. Anim. 72 (3) (2023) 356\u2013366.","DOI":"10.1538\/expanim.22-0072"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0185","doi-asserted-by":"crossref","unstructured":"L. Zhang, S. Jin, C. Wang, R. Jiang, J. Wan, Histone deacetylase inhibitors attenuate acute lung injury during cecal ligation and puncture-induced polymicrobial sepsis, World J. Surg, 34 (7) (2010) 1676\u20131683.","DOI":"10.1007\/s00268-010-0493-5"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0190","doi-asserted-by":"crossref","unstructured":"J.R. Davie, Inhibition of histone deacetylase activity by butyrate, J. Nutr. 133 (7 Suppl) (2003) 2485S\u20132493S.","DOI":"10.1093\/jn\/133.7.2485S"},{"key":"10.1016\/j.yjmcc.2025.10.005_bb0195","doi-asserted-by":"crossref","unstructured":"B. Kartal, F.N. Denizler-Ebiri, M. G\u00fcven, F. Ta\u015fp\u0131nar, H. Canp\u0131nar, S. \u00c7etin, et al., Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach, Med. Oncol. 41 (5) (2024) 97.","DOI":"10.1007\/s12032-024-02340-6"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282500183X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282500183X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:00:15Z","timestamp":1778706015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228282500183X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":39,"alternative-id":["S002228282500183X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.10.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting gut microbiotasu-derived butyrate for Ferroptosis inhibition in Sepsis-induced myocardial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}