{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:35:44Z","timestamp":1788233744944,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2021J01218"],"award-info":[{"award-number":["2021J01218"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.yjmcc.2025.10.006","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:02:12Z","timestamp":1761058932000},"page":"104-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Beneficial effects of aryl hydrocarbon receptor activation on post-infarction myocardial metabolism, inflammation and fibrosis: implications from multi-omics"],"prefix":"10.1016","volume":"209","author":[{"given":"Yong","family":"Chu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxiu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dajun","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2025.10.006_bb0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/ehf2.13144","article-title":"Heart failure after myocardial infarction: incidence and predictors","volume":"8","author":"Jen\u010da","year":"2021","journal-title":"ESC Heart Failure"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103968","article-title":"New diagnostic and therapeutic strategies for myocardial infarction via nanomaterials","volume":"78","author":"Shi","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0015","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1016\/j.jacc.2016.09.972","article-title":"The emerging role of metabolomics in the diagnosis and prognosis of cardiovascular disease","volume":"68","author":"Ussher","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0020","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0025","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s00109-022-02269-1","article-title":"Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy","volume":"100","author":"Chen","year":"2022","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0030","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1111\/jcmm.15180","article-title":"Cardiac metabolism as a driver and therapeutic target of myocardial infarction","volume":"24","author":"Zuurbier","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0035","doi-asserted-by":"crossref","first-page":"1533105","DOI":"10.3389\/fcvm.2025.1533105","article-title":"Regenerative therapies for myocardial infarction: exploring the critical role of energy metabolism in achieving cardiac repair","volume":"12","author":"Ren","year":"2025","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0040","first-page":"23","article-title":"Immune and inflammatory networks in myocardial infarction: current research and its potential implications for the clinic","author":"Anzai","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0045","first-page":"c1304","article-title":"Macrophages in myocardial infarction","volume":"323","author":"Kubota","year":"2022","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12933-022-01506-8","article-title":"Infarct size, inflammatory burden, and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: a multicenter international registry","volume":"21","author":"Paolisso","year":"2022","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154293","article-title":"Huoxin pill prevents excessive inflammation and cardiac dysfunction following myocardial infarction by inhibiting adverse Wnt\/\u03b2-catenin signaling activation","volume":"104","author":"He","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0060","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1093\/cvr\/cvab269","article-title":"EDIL3 deficiency ameliorates adverse cardiac remodelling by neutrophil extracellular traps (NET)-mediated macrophage polarization","volume":"118","author":"Wei","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027228","article-title":"Global characteristics and dynamics of single immune cells after myocardial infarction","volume":"11","author":"Zhuang","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0070","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ejhf.696","article-title":"Myocardial fibrosis: biomedical research from bench to bedside","volume":"19","author":"Gy\u00f6ngy\u00f6si","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0075","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1172\/JCI94753","article-title":"Fibroblast-specific TGF-\u03b2-Smad2\/3 signaling underlies cardiac fibrosis","volume":"127","author":"Khalil","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0080","first-page":"22","article-title":"Exercise training alleviates cardiac fibrosis through increasing fibroblast growth factor 21 and regulating TGF-\u03b21-Smad2\/3-MMP2\/9 signaling in mice with myocardial infarction","author":"Ma","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0085","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s13105-020-00778-6","article-title":"Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-\u03b2\/Smad signaling in myocardial infarction model of rats","volume":"77","author":"Mehdipoor","year":"2021","journal-title":"J. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0090","first-page":"19","article-title":"The role of the aryl hydrocarbon receptor (AHR) in immune and inflammatory diseases","author":"Neavin","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0095","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/kfs204","article-title":"Role of the ah receptor in homeostatic control of fatty acid synthesis in the liver","volume":"129","author":"Tanos","year":"2012","journal-title":"Toxicol Sci Off J Soc Toxicol"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2004.12.003","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: a microarray study","volume":"207","author":"Fletcher","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0105","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020502","article-title":"Activation of aryl hydrocarbon receptor by ITE improves cardiac function in mice after myocardial infarction","volume":"10","author":"Seong","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105180","article-title":"The aryl hydrocarbon receptor: an environmental effector in the pathogenesis of fibrosis","volume":"160","author":"Shi","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0115","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1007\/s00204-019-02446-1","article-title":"Ablation of aryl hydrocarbon receptor promotes angiotensin II-induced cardiac fibrosis through enhanced c-Jun\/HIF-1\u03b1 signaling","volume":"93","author":"Ichihara","year":"2019","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0120","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1002\/ehf2.14532","article-title":"Activation of AHR by ITE improves cardiac remodelling and function in rats after myocardial infarction","volume":"10","author":"Lin","year":"2023","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0125","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1161\/01.CIR.0000016721.84535.00","article-title":"Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat","volume":"105","author":"Sia","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0130","article-title":"ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0135","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0140","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.freeradbiomed.2021.03.014","article-title":"Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation","volume":"167","author":"Wei","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/978-1-4939-3139-2_16","article-title":"The Aryl hydrocarbon receptor in immunity: tools and potential","volume":"1371","author":"Esser","year":"2016","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0150","first-page":"21","article-title":"Aryl hydrocarbon receptor connects inflammation to breast Cancer","author":"Guarnieri","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0155","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1158\/1541-7786.MCR-08-0042","article-title":"Cross-talk between aryl hydrocarbon receptor and mitogen-activated protein kinase signaling pathway in liver cancer through c-raf transcriptional regulation","volume":"6","author":"Borlak","year":"2008","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0160","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1111\/jcmm.15384","article-title":"Targeting mitochondrial fusion and fission proteins for cardioprotection","volume":"24","author":"Hernandez-Resendiz","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0165","first-page":"14","article-title":"Mitochondrial dysfunction in cardiac disease: the fort fell","author":"Paraskevaidis","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0170","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/cvr\/cvaa343","article-title":"Hydralazine protects the heart against acute ischaemia\/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission","volume":"118","author":"Kalkhoran","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ctm2.13","article-title":"NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases","volume":"10","author":"Wang","year":"2020","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0180","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1002\/jcp.30285","article-title":"The NLRP3 inflammasome: multiple activation pathways and its role in primary cells during ventricular remodeling","volume":"236","author":"Yan","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0185","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1159\/000493042","article-title":"MicroRNA-495 ameliorates cardiac microvascular endothelial cell injury and inflammatory reaction by suppressing the NLRP3 Inflammasome signaling pathway","volume":"49","author":"Zhou","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0190","article-title":"Phloretin ameliorates heart function after myocardial infarction via NLRP3\/Caspase-1\/IL-1\u03b2 signaling","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0195","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/cvr\/cvaa324","article-title":"Cardiac fibrosis","volume":"117","author":"Frangogiannis","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31504","article-title":"Novel therapeutic strategies targeting fibroblasts to improve heart disease","volume":"240","author":"Li","year":"2025","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0205","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.matbio.2018.01.013","article-title":"Extracellular matrix remodeling and cardiac fibrosis","volume":"68-69","author":"Li","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0210","first-page":"10","article-title":"A review of the molecular mechanisms underlying cardiac fibrosis and atrial fibrillation","author":"Sygitowicz","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0215","first-page":"17","article-title":"Hitting the target! Challenges and opportunities for TGF-\u03b2 inhibition for the treatment of cardiac fibrosis","author":"Vistnes","year":"2024","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0220","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1161\/RES.0000000000000097","article-title":"Assessing cardiac metabolism: a scientific statement from the American Heart Association","volume":"118","author":"Taegtmeyer","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0225","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/cvr\/cvz060","article-title":"Pivotal role of membrane substrate transporters on the metabolic alterations in the pressure-overloaded heart","volume":"115","author":"Geraets","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2025.10.006_bb0230","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1093\/nar\/gkac360","article-title":"Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling","volume":"50","author":"Watzky","year":"2022","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825001841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825001841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:24:23Z","timestamp":1773293063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282825001841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":46,"alternative-id":["S0022282825001841"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.10.006","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Beneficial effects of aryl hydrocarbon receptor activation on post-infarction myocardial metabolism, inflammation and fibrosis: implications from multi-omics","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}