{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:00:43Z","timestamp":1787162443734,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2015ZDTD044"],"award-info":[{"award-number":["2015ZDTD044"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000383"],"award-info":[{"award-number":["82000383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460076"],"award-info":[{"award-number":["82460076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070395"],"award-info":[{"award-number":["82070395"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.yjmcc.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T08:31:17Z","timestamp":1763627477000},"page":"98-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Soluble epoxide hydrolase deficiency rescues heart failure with preserved ejection fraction by targeting cytochrome P450 2E1"],"prefix":"10.1016","volume":"210","author":[{"given":"Min","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.yjmcc.2025.11.005_bb0005","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jacc.2007.04.064","article-title":"Hospitals, characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF registry","volume":"50","author":"Fonarow","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0010","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jacc.2005.09.022","article-title":"Investigators, clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: a report from the acute decompensated heart failure National Registry (ADHERE) database","volume":"47","author":"Yancy","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","article-title":"Get with the guidelines scientific advisory, Investigators, trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes","volume":"126","author":"Steinberg","year":"2012","journal-title":"Circulation"},{"issue":"37","key":"10.1016\/j.yjmcc.2025.11.005_bb0020","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1093\/eurheartj\/ehad389","article-title":"Mechanisms of benefits of sodium-glucose cotransporter 2 inhibitors in heart failure with preserved ejection fraction","volume":"44","author":"Pandey","year":"2023","journal-title":"Eur. Heart J."},{"issue":"8 Pt 1","key":"10.1016\/j.yjmcc.2025.11.005_bb0025","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jchf.2023.05.010","article-title":"Design and baseline characteristics of STEP-HFpEF program evaluating Semaglutide in patients with obesity HFpEF phenotype","volume":"11","author":"Kosiborod","year":"2023","journal-title":"JACC Heart Fail."},{"issue":"23","key":"10.1016\/j.yjmcc.2025.11.005_bb0030","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/CIRCULATIONAHA.110.011031","article-title":"Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction","volume":"124","author":"Zile","year":"2011","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.yjmcc.2025.11.005_bb0035","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"12","key":"10.1016\/j.yjmcc.2025.11.005_bb0040","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1161\/CIRCRESAHA.119.314898","article-title":"Nuclear miR-320 mediates diabetes-induced cardiac dysfunction by activating transcription of fatty acid metabolic genes to cause lipotoxicity in the heart","volume":"125","author":"Li","year":"2019","journal-title":"Circ. Res."},{"issue":"7752","key":"10.1016\/j.yjmcc.2025.11.005_bb0045","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0163-7827(03)00049-3","article-title":"Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function","volume":"43","author":"Spector","year":"2004","journal-title":"Prog. Lipid Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2025.11.005_bb0055","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1177\/002215540405200403","article-title":"Distribution of soluble epoxide hydrolase and of cytochrome P450 2C8, 2C9, and 2J2 in human tissues","volume":"52","author":"Enayetallah","year":"2004","journal-title":"J. Histochem. Cytochem."},{"issue":"5431","key":"10.1016\/j.yjmcc.2025.11.005_bb0060","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.285.5431.1276","article-title":"Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids","volume":"285","author":"Node","year":"1999","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.yjmcc.2025.11.005_bb0065","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/HJH.0b013e32831aedfa","article-title":"Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats","volume":"27","author":"Revermann","year":"2009","journal-title":"J. Hypertens."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0070","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1038\/s41598-018-23504-1","article-title":"Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia","volume":"8","author":"Tu","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.yjmcc.2025.11.005_bb0075","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41419-020-2594-x","article-title":"Inhibition of soluble epoxide hydrolase attenuates renal tubular mitochondrial dysfunction and ER stress by restoring autophagic flux in diabetic nephropathy","volume":"11","author":"Jiang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.yjmcc.2025.11.005_bb0080","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1073\/pnas.261710799","article-title":"Inhibitors of soluble epoxide hydrolase attenuate vascular smooth muscle cell proliferation","volume":"99","author":"Davis","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0085","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/abbi.1995.1059","article-title":"Metabolism of epoxyeicosatrienoic acids by cytosolic epoxide hydrolase: substrate structural determinants of asymmetric catalysis","volume":"316","author":"Zeldin","year":"1995","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.11.005_bb0090","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3892\/ijmm.2014.1844","article-title":"A potential therapeutic effect of CYP2C8 overexpression on anti-TNF-alpha activity","volume":"34","author":"Liu","year":"2014","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.yjmcc.2025.11.005_bb0095","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/acel.12507","article-title":"CYP2J2 and its metabolites (epoxyeicosatrienoic acids) attenuate cardiac hypertrophy by activating AMPKalpha2 and enhancing nuclear translocation of Akt1","volume":"15","author":"Wang","year":"2016","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.yjmcc.2025.11.005_bb0100","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1210\/en.2012-2166","article-title":"Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice","volume":"154","author":"Ma","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.yjmcc.2025.11.005_bb0105","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.freeradbiomed.2018.02.009","article-title":"CYP2J2-derived EETs attenuated ethanol-induced myocardial dysfunction through inducing autophagy and reducing apoptosis","volume":"117","author":"Zhou","year":"2018","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.yjmcc.2025.11.005_bb0110","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.addr.2011.03.006","article-title":"The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases","volume":"63","author":"Xu","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0115","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s43657-022-00069-8","article-title":"Increased soluble epoxide hydrolase activity positively correlates with mortality in heart failure patients with preserved ejection fraction: evidence from metabolomics","volume":"3","author":"Peng","year":"2023","journal-title":"Phenomics"},{"issue":"3","key":"10.1016\/j.yjmcc.2025.11.005_bb0120","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/cvr\/cvu254","article-title":"miR-21-3p regulates cardiac hypertrophic response by targeting histone deacetylase-8","volume":"105","author":"Yan","year":"2015","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0125","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000438607","article-title":"MicroRNA-320a regulates the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting HOXA10","volume":"38","author":"Huang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"issue":"9","key":"10.1016\/j.yjmcc.2025.11.005_bb0130","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1161\/CIRCULATIONAHA.114.012285","article-title":"Upregulation of MG53 induces diabetic cardiomyopathy through transcriptional activation of peroxisome proliferation-activated receptor alpha","volume":"131","author":"Liu","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2025.11.005_bb0135","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1677\/JOE-07-0619","article-title":"IGF-II\/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide\/BNP expression via Galphaq interaction and protein kinase C-alpha\/CaMKII activation in H9c2 cardiomyoblast cells","volume":"197","author":"Chu","year":"2008","journal-title":"J. Endocrinol."},{"issue":"5","key":"10.1016\/j.yjmcc.2025.11.005_bb0140","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/HYPERTENSIONAHA.121.17548","article-title":"Inhibition of soluble epoxide hydrolase attenuates Bosutinib-induced blood pressure elevation","volume":"78","author":"Cui","year":"2021","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.yjmcc.2025.11.005_bb0145","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1161\/CIRCULATIONAHA.120.050498","article-title":"Myocardial gene expression signatures in human heart failure with preserved ejection fraction","volume":"143","author":"Hahn","year":"2021","journal-title":"Circulation"},{"issue":"27","key":"10.1016\/j.yjmcc.2025.11.005_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202200546","article-title":"Succinylation inhibits the enzymatic hydrolysis of the extracellular matrix protein fibrillin 1 and promotes gastric cancer progression","volume":"vol. 9","author":"Wang","year":"2022","journal-title":"Adv. Sci."},{"issue":"2","key":"10.1016\/j.yjmcc.2025.11.005_bb0155","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1158\/0008-5472.CAN-17-1912","article-title":"SHMT2 Desuccinylation by SIRT5 drives cancer cell proliferation","volume":"78","author":"Yang","year":"2018","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0160","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41467-021-21931-9","article-title":"Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction","volume":"12","author":"Schiattarella","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2025.11.005_bb0165","article-title":"Glimepiride use is associated with reduced cardiovascular mortality in patients with type 2 diabetes and chronic heart failure: a prospective cohort study","author":"He","year":"2022","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.11.005_bb0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2023.10.009","article-title":"Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids","volume":"185","author":"Zhao","year":"2023","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12933-020-01208-z","article-title":"Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF","volume":"20","author":"Bode","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"issue":"11","key":"10.1016\/j.yjmcc.2025.11.005_bb0180","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.tips.2016.08.001","article-title":"Epoxyeicosatrienoic acid as therapy for diabetic and ischemic cardiomyopathy","volume":"37","author":"Romashko","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"9","key":"10.1016\/j.yjmcc.2025.11.005_bb0185","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1161\/CIRCRESAHA.123.322619","article-title":"Epoxyeicosatrienoic acids prevent cardiac dysfunction in viral myocarditis via interferon type I signaling","volume":"133","author":"Zhou","year":"2023","journal-title":"Circ. Res."},{"issue":"24","key":"10.1016\/j.yjmcc.2025.11.005_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202300571","article-title":"A biomimetic nanoparticle exerting protection against acute liver failure by suppressing CYP2E1 activity and scavenging excessive ROS","volume":"12","author":"Yao","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"9","key":"10.1016\/j.yjmcc.2025.11.005_bb0195","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00592-023-02110-2","article-title":"Cyp2e1 knockdown attenuates high glucose-induced apoptosis and oxidative stress of cardiomyocytes by activating PI3K\/Akt signaling","volume":"60","author":"Wang","year":"2023","journal-title":"Acta Diabetol."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0200","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009871","article-title":"New molecular mechanism underlying Myc-mediated cytochrome P450 2E1 upregulation in apoptosis and energy metabolism in the myocardium","volume":"8","author":"Guan","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0205","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12933-016-0424-3","article-title":"Transcriptomic alterations in the heart of non-obese type 2 diabetic Goto-Kakizaki rats","volume":"15","author":"S\u00e1rk\u00f6zy","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.11.005_bb0210","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/0006-291X(87)91525-7","article-title":"The induction of a specific form of cytochrome P-450 (P-450j) by fasting","volume":"142","author":"Hong","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.11.005_bb0215","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0026-895X(25)10989-9","article-title":"Induction of cytochrome P450IIE1 in the obese overfed rat","volume":"39","author":"Raucy","year":"1991","journal-title":"Mol. Pharmacol."},{"issue":"7","key":"10.1016\/j.yjmcc.2025.11.005_bb0220","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1093\/jn\/121.7.959","article-title":"Regulation of hepatic microsomal cytochrome P450IIE1 level by dietary lipids and carbohydrates in rats","volume":"121","author":"Yoo","year":"1991","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.11.005_bb0225","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/01.HYP.0000150782.28485.91","article-title":"Decreased levels of cytochrome P450 2E1-derived eicosanoids sensitize renal arteries to constrictor agonists in spontaneously hypertensive rats","volume":"45","author":"Zhang","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2025.11.005_bb0230","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.yjmcc.2017.07.006","article-title":"Soluble epoxide hydrolase activation by S-nitrosation contributes to cardiac ischemia-reperfusion injury","volume":"110","author":"Ding","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.11.005_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103424","article-title":"Schaftoside improves HFpEF through regulation the autophagy-lysosome pathway by allosterically targeting CaMKII-\u03b4","volume":"78","author":"Zhang","year":"2024","journal-title":"Redox Biol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825002032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825002032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T12:45:12Z","timestamp":1780749912000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282825002032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":47,"alternative-id":["S0022282825002032"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.11.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soluble epoxide hydrolase deficiency rescues heart failure with preserved ejection fraction by targeting cytochrome P450 2E1","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}