{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:54:32Z","timestamp":1791266072054,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.yjmcc.2026.04.005","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T22:18:18Z","timestamp":1776637098000},"page":"36-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["OSK-mediated partial reprogramming induces cardiomyocyte dedifferentiation, overcomes cytokinesis barriers, and promotes post-MI endogenous cardiac regeneration"],"prefix":"10.1016","volume":"215","author":[{"given":"Yaobin","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.yjmcc.2026.04.005_bb0005","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update: a report from the american heart association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.yjmcc.2026.04.005_bb0010","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2026.04.005_bb0015","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1161\/CIRCULATIONAHA.121.057019","article-title":"Genetic proliferation tracing reveals a rapid cell cycle withdrawal in preadolescent cardiomyocytes","volume":"145","author":"Pu","year":"2022","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.yjmcc.2026.04.005_bb0020","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/j.jacc.2006.02.002","article-title":"Regeneration gaps: observations on stem cells and cardiac repair","volume":"47","author":"Murry","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0025","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/j.2040-4603.2016.tb00669.x","article-title":"Pathophysiology of heart failure","volume":"6","author":"Tanai","year":"2015","journal-title":"Compr. Physiol."},{"issue":"6020","key":"10.1016\/j.yjmcc.2026.04.005_bb0030","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.yjmcc.2026.04.005_bb0035","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCRESAHA.119.315408","article-title":"Polyploidy in cardiomyocytes","volume":"126","author":"Derks","year":"2020","journal-title":"Circ. Res."},{"issue":"7432","key":"10.1016\/j.yjmcc.2026.04.005_bb0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature11682","article-title":"Mammalian heart renewal by pre-existing cardiomyocytes","volume":"493","author":"Senyo","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.yjmcc.2026.04.005_bb0045","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.017839","article-title":"Changes in cardiomyocyte cell cycle and hypertrophic growth during fetal to adult in mammals","volume":"10","author":"Bishop","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2026.04.005_bb0050","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.yjmcc.2020.11.016","article-title":"What we know about cardiomyocyte dedifferentiation","volume":"152","author":"Zhu","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2026.04.005_bb0055","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.50163","article-title":"Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart","volume":"8","author":"Honkoop","year":"2019","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0060","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.devcel.2020.02.019","article-title":"Dynamic transcriptional responses to injury of regenerative and non-regenerative cardiomyocytes revealed by single-nucleus RNA sequencing","volume":"53","author":"Cui","year":"2020","journal-title":"Dev. Cell"},{"issue":"7288","key":"10.1016\/j.yjmcc.2026.04.005_bb0065","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","article-title":"Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes","volume":"464","author":"Kikuchi","year":"2010","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-30468-4","article-title":"Activation of Nkx2.5 transcriptional program is required for adult myocardial repair","volume":"13","author":"de Sena-Tom\u00e1s","year":"2022","journal-title":"Nat. Commun."},{"issue":"6538","key":"10.1016\/j.yjmcc.2026.04.005_bb0075","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1126\/science.abe2762","article-title":"Kr\u00fcppel-like factor 1 is a core cardiomyogenic trigger in zebrafish","volume":"372","author":"Ogawa","year":"2021","journal-title":"Science"},{"issue":"6562","key":"10.1016\/j.yjmcc.2026.04.005_bb0080","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1126\/science.abg5159","article-title":"Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice","volume":"373","author":"Chen","year":"2021","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12943-020-01291-6","article-title":"Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc","volume":"20","author":"Madden","year":"2021","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.yjmcc.2026.04.005_bb0090","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.celrep.2018.03.057","article-title":"MYC releases early reprogrammed human cells from proliferation pause via retinoblastoma protein inhibition","volume":"23","author":"Rand","year":"2018","journal-title":"Cell Rep."},{"issue":"7836","key":"10.1016\/j.yjmcc.2026.04.005_bb0095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0100","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1161\/CIRCRESAHA.123.322620","article-title":"Spatial multiplexed protein profiling of cardiac ischemia-reperfusion injury","volume":"133","author":"Yao","year":"2023","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.yjmcc.2026.04.005_bb0105","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s43587-023-00527-6","article-title":"The information theory of aging","volume":"3","author":"Lu","year":"2023","journal-title":"Nat. Aging"},{"key":"10.1016\/j.yjmcc.2026.04.005_bb0110","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yjmcc.2022.04.007","article-title":"Methods of mouse cardiomyocyte isolation from postnatal heart","volume":"168","author":"Feng","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2026.04.005_bb0115","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/CIRCRESAHA.117.308428","article-title":"Multimodal regulation of cardiac myocyte proliferation","volume":"121","author":"Yuan","year":"2017","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0120","doi-asserted-by":"crossref","DOI":"10.1186\/s13619-025-00257-7","article-title":"Rewiring cell identity and metabolism to drive cardiomyocyte proliferation","volume":"14","author":"Zheng","year":"2025","journal-title":"Cell Regen."},{"issue":"7288","key":"10.1016\/j.yjmcc.2026.04.005_bb0125","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.yjmcc.2026.04.005_bb0130","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/CIRCULATIONAHA.116.024307","article-title":"Dedifferentiation, proliferation, and redifferentiation of adult mammalian cardiomyocytes after ischemic injury","volume":"136","author":"Wang","year":"2017","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/CIRCULATIONAHA.123.066004","article-title":"YAP overcomes mechanical barriers to induce mitotic rounding and adult cardiomyocyte division","volume":"151","author":"Morikawa","year":"2025","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.yjmcc.2026.04.005_bb0140","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.stem.2022.03.009","article-title":"A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration","volume":"29","author":"Du","year":"2022","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.yjmcc.2026.04.005_bb0145","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.apsb.2024.01.021","article-title":"Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration","volume":"14","author":"Fu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.yjmcc.2026.04.005_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yjmcc.2020.07.004","article-title":"Cardiomyocyte cell cycling, maturation, and growth by multinucleation in postnatal swine","volume":"146","author":"Velayutham","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"23","key":"10.1016\/j.yjmcc.2026.04.005_bb0155","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1089\/scd.2019.0193","article-title":"Residual diploidy in polyploid tissues: a cellular state with enhanced proliferative capacity for tissue regeneration?","volume":"28","author":"Patterson","year":"2019","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0160","article-title":"Cell proliferation fate mapping reveals regional cardiomyocyte cell-cycle activity in subendocardial muscle of left ventricle","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.yjmcc.2026.04.005_bb0165","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s43587-022-00183-2","article-title":"In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice","volume":"2","author":"Browder","year":"2022","journal-title":"Nat. Aging"},{"issue":"3","key":"10.1016\/j.yjmcc.2026.04.005_bb0170","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13578","article-title":"Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming","volume":"21","author":"Chondronasiou","year":"2022","journal-title":"Aging Cell"},{"issue":"4","key":"10.1016\/j.yjmcc.2026.04.005_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110730","article-title":"In vivo partial cellular reprogramming enhances liver plasticity and regeneration","volume":"39","author":"Hishida","year":"2022","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.yjmcc.2026.04.005_bb0180","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.stemcr.2020.09.010","article-title":"In vivo reprogramming ameliorates aging features in dentate gyrus cells and improves memory in mice","volume":"15","author":"Rodr\u00edguez-Matell\u00e1n","year":"2020","journal-title":"Stem Cell Rep."},{"issue":"7","key":"10.1016\/j.yjmcc.2026.04.005_bb0185","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In vivo amelioration of age-associated hallmarks by partial reprogramming","volume":"167","author":"Ocampo","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0190","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ymthe.2018.10.014","article-title":"Non-viral, tumor-free induction of transient cell reprogramming in mouse skeletal muscle to enhance tissue regeneration","volume":"27","author":"de L\u00e1zaro","year":"2019","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.04.005_bb0195","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1038\/s41467-020-15174-3","article-title":"Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells","volume":"11","author":"Sarkar","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.yjmcc.2026.04.005_bb0200","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s44161-024-00428-w","article-title":"YAP induces a neonatal-like pro-renewal niche in the adult heart","volume":"3","author":"Li","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2026.04.005_bb0205","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/164_2016_56","article-title":"Wnt signaling in cardiac remodeling and heart failure","volume":"243","author":"Stylianidis","year":"2017","journal-title":"Handb. Exp. Pharmacol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282826000568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282826000568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:37:23Z","timestamp":1783021043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282826000568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":41,"alternative-id":["S0022282826000568"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.04.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OSK-mediated partial reprogramming induces cardiomyocyte dedifferentiation, overcomes cytokinesis barriers, and promotes post-MI endogenous cardiac regeneration","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}