{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:02:32Z","timestamp":1792252952195,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017695","name":"Health Commission of Hunan Province","doi-asserted-by":"publisher","award":["20254642"],"award-info":[{"award-number":["20254642"]}],"id":[{"id":"10.13039\/100017695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025JJ80472"],"award-info":[{"award-number":["2025JJ80472"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.yjmcc.2026.05.007","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T15:16:07Z","timestamp":1778771767000},"page":"16-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Silencing PACS2 attenuates cardiac hypertrophy by inhibiting ferroptosis via activating SIRT1"],"prefix":"10.1016","volume":"217","author":[{"given":"Zhijie","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinzhuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.yjmcc.2026.05.007_bb0005","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1161\/HYPERTENSIONAHA.123.21710","article-title":"Precision hypertension","volume":"81","author":"Dzau","year":"2024","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.yjmcc.2026.05.007_bb0010","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.3390\/ijms26125610","article-title":"Cardiac damage in hypertension: from molecular mechanisms to novel therapeutic approaches","volume":"26","author":"Gallo","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.yjmcc.2026.05.007_bb0015","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.3390\/ijms26094022","article-title":"Morphometric and molecular interplay in hypertension-induced cardiac Remodeling with an emphasis on the potential therapeutic implications","volume":"26","author":"Gaydarski","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0020","article-title":"Extracellular vesicular microRNAs and cardiac hypertrophy","volume":"15","author":"Hu","year":"2024","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"9","key":"10.1016\/j.yjmcc.2026.05.007_bb0025","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.yjmcc.2026.05.007_bb0030","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00109-023-02318-3","article-title":"TRIM-containing 44 aggravates cardiac hypertrophy via TLR4\/NOX4-induced ferroptosis","volume":"101","author":"Wu","year":"2023","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110974","article-title":"PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK\/P53 signaling pathway","volume":"113","author":"Lv","year":"2024","journal-title":"Cell. Signal."},{"issue":"10","key":"10.1016\/j.yjmcc.2026.05.007_bb0040","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41419-023-06175-3","article-title":"PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy","volume":"14","author":"Yang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.05.007_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106328","article-title":"Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijcard.2022.12.003","article-title":"Ferulic acid attenuates high glucose-induced MAM alterations via PACS2\/IP3R2\/FUNDC1\/VDAC1 pathway activating proapoptotic proteins and ameliorates cardiomyopathy in diabetic rats","volume":"372","author":"Salin Raj","year":"2023","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.05.007_bb0055","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/rna.28300","article-title":"miR-499 protects cardiomyocytes from H 2O 2-induced apoptosis via its effects on Pdcd4 and Pacs2","volume":"11","author":"Wang","year":"2014","journal-title":"RNA Biol."},{"issue":"17","key":"10.1016\/j.yjmcc.2026.05.007_bb0060","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5695723","article-title":"The Nrf-2\/HO-1 signaling axis: a ray of hope in cardiovascular diseases","volume":"2020","author":"Zhang","year":"2020","journal-title":"Cardiol. Res. Pract."},{"issue":"6","key":"10.1016\/j.yjmcc.2026.05.007_bb0070","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3390\/cells12060936","article-title":"The role of oxidative stress in vitiligo: an update on its pathogenesis and therapeutic implications","volume":"12","author":"Chang","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.yjmcc.2026.05.007_bb0080","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1007\/s10753-025-02334-0","article-title":"C7ORF41 alleviates ferroptosis via the Keap1\/Nrf2\/HO-1 axis in endotoxin-associated acute kidney injury","volume":"48","author":"Yu","year":"2025","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.05.007_bb0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-022-02400-6","article-title":"Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1\/Nrf2\/HO-1\/Gpx4 pathway","volume":"19","author":"Dang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114591","article-title":"Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1\/Nrf2 pathway","volume":"162","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103563","article-title":"PDE4D inhibition ameliorates cardiac hypertrophy and heart failure by activating mitophagy","volume":"81","author":"Fu","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0100","doi-asserted-by":"crossref","DOI":"10.1177\/09603271251361892","article-title":"Robinin attenuates cardiac hypertrophy in pulmonary heart disease by modulating SIRT1\/NF-\u03baB signaling and inhibiting oxidative stress and the NLRP3 inflammasome","volume":"44","author":"Wang","year":"2025","journal-title":"Hum. Exp. Toxicol."},{"issue":"5","key":"10.1016\/j.yjmcc.2026.05.007_bb0105","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.celrep.2014.07.049","article-title":"The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest","volume":"8","author":"Atkins","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.lfs.2017.03.006","article-title":"MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor","volume":"175","author":"Bao","year":"2017","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.yjmcc.2026.05.007_bb0115","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/s41374-018-0091-y","article-title":"Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis","volume":"99","author":"Li","year":"2019","journal-title":"Lab. Investig."},{"issue":"7","key":"10.1016\/j.yjmcc.2026.05.007_bb0120","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3390\/md23070287","article-title":"Rosmarinic acid protects against acetaminophen-induced hepatotoxicity by suppressing ferroptosis and oxidative stress through Nrf2\/HO-1 activation in mice","volume":"23","author":"Wu","year":"2025","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.05.007_bb0125","article-title":"The impact of decreased SIRT1 levels on pediatric primary hypertension and left ventricular hypertrophy: a case-control study","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0130","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"issue":"21","key":"10.1016\/j.yjmcc.2026.05.007_bb0135","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3390\/cells11213336","article-title":"Angiotensin II-induced signal transduction mechanisms for cardiac hypertrophy","volume":"11","author":"Bhullar","year":"2022","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.yjmcc.2026.05.007_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.100997","article-title":"miR-135b: an emerging player in cardio-cerebrovascular diseases","volume":"14","author":"Shao","year":"2024","journal-title":"J. Pharm. Anal."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.05.007_bb0145","doi-asserted-by":"crossref","first-page":"4989","DOI":"10.1007\/s12013-025-01819-x","article-title":"PCBP2 promotes NRG4 mRNA stability to diminish angiotensin II-induced hypertrophy, NLRP3 inflammasome activation, and oxidative stress of AC16 cardiomyocytes","volume":"83","author":"Zhang","year":"2025","journal-title":"Cell Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.05.007_bb0150","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0155","doi-asserted-by":"crossref","first-page":"117193","DOI":"10.1016\/j.bcp.2025.117193","article-title":"Tetramethylpyrazine ameliorates sepsis-induced liver injury via inhibiting ferroptosis","volume":"241","author":"Wang","year":"2025","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.05.007_bb0160","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12933-024-02514-6","article-title":"PACS2\/CPT1A\/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy","volume":"23","author":"Xiang","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122650","article-title":"Ferroptosis: an important mechanism of disease mediated by the gut-liver-brain axis","volume":"347","author":"Yu","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0170","series-title":"The Mechanisms of Ferroptosis Under Hypoxia","first-page":"3329","volume":"vol. 43(7)","author":"Gao","year":"2023"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.05.007_bb0175","article-title":"The sirtuin family in health and disease","volume":"7","author":"Wu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8","key":"10.1016\/j.yjmcc.2026.05.007_bb0180","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3390\/biom12081079","article-title":"Progress in nonalcoholic fatty liver disease: SIRT family regulates mitochondrial biogenesis","volume":"12","author":"Zeng","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2024.176709","article-title":"Artesunate attenuates isoprenaline induced cardiac hypertrophy in rats via SIRT1 inhibiting NF-\u03baB activation","volume":"977","author":"Golatkar","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.943321","article-title":"Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism","volume":"13","author":"Cui","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.yjmcc.2026.05.007_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.779177","article-title":"SIRT1: a potential therapeutic target in autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.05.007_bb0200","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/gt.2010.105","article-title":"Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution","volume":"18","author":"Prasad","year":"2011","journal-title":"Gene Ther."},{"issue":"2","key":"10.1016\/j.yjmcc.2026.05.007_bb0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00395-020-0779-1","article-title":"Triad3A attenuates pathological cardiac hypertrophy involving the augmentation of ubiquitination-mediated degradation of TLR4 and TLR9","volume":"115","author":"Lu","year":"2020","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2026.05.007_bb0210","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/s41374-021-00678-3","article-title":"LncRNA TINCR improves cardiac hypertrophy by regulating the miR-211-3p-VEGFB-SDF-1\u03b1-CXCR4 pathway","volume":"102","author":"Tu","year":"2022","journal-title":"Lab. Investig."},{"issue":"10","key":"10.1016\/j.yjmcc.2026.05.007_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-021-04185-7","article-title":"FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer","volume":"12","author":"Yao","year":"2021","journal-title":"Cell Death Dis."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282600074X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282600074X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T13:01:18Z","timestamp":1784984478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228282600074X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":43,"alternative-id":["S002228282600074X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.05.007","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silencing PACS2 attenuates cardiac hypertrophy by inhibiting ferroptosis via activating SIRT1","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}