{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T09:28:30Z","timestamp":1793525310667,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008121","name":"Ministry of Defense","doi-asserted-by":"publisher","award":["TA"],"award-info":[{"award-number":["TA"]}],"id":[{"id":"10.13039\/501100008121","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["TA 18H02815"],"award-info":[{"award-number":["TA 18H02815"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["YN 20K08482"],"award-info":[{"award-number":["YN 20K08482"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.yjmcc.2026.07.014","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:23:33Z","timestamp":1785281013000},"page":"97-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cell-specific ERK2 signaling in vascular smooth muscle cells drives vascular dysfunction and systolic heart failure"],"prefix":"10.1016","volume":"218","author":[{"given":"Kazuki","family":"Kagami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nagatomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Toya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Yumita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumu","family":"Osaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Yukino-Iwashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Taruoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Ishinoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayami","family":"Naito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Pag\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Pouyss\u00e9gur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.yjmcc.2026.07.014_bb0005","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/cvr\/cvz006","article-title":"Ponatinib-induced cardiotoxicity: delineating the signalling mechanisms and potential rescue strategies","volume":"115","author":"Singh","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2026.07.014_bb0010","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.yjmcc.2014.04.009","article-title":"Elucidating ERK2 function in the heart","volume":"72","author":"Del Re","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2026.07.014_bb0015","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/CIRCRESAHA.110.231514","article-title":"Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth","volume":"108","author":"Kehat","year":"2011","journal-title":"Circ. Res."},{"issue":"16","key":"10.1016\/j.yjmcc.2026.07.014_bb0020","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1161\/01.CIR.0000127126.73759.23","article-title":"MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo","volume":"109","author":"Lips","year":"2004","journal-title":"Circulation"},{"issue":"35","key":"10.1016\/j.yjmcc.2026.07.014_bb0025","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","article-title":"Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo","volume":"104","author":"Purcell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.yjmcc.2026.07.014_bb0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/HYPERTENSIONAHA.112.196543","article-title":"Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy","volume":"61","author":"Schreier","year":"2013","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.yjmcc.2026.07.014_bb0035","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/cvr\/cvab149","article-title":"Epidermal growth factor receptor-dependent maintenance of cardiac contractility","volume":"118","author":"Guo","year":"2022","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.07.014_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00395-022-00909-8","article-title":"Coronary blood flow in heart failure: cause, consequence and bystander","volume":"117","author":"Heusch","year":"2022","journal-title":"Basic Res. Cardiol."},{"issue":"5443","key":"10.1016\/j.yjmcc.2026.07.014_bb0045","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.286.5443.1374","article-title":"Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice","volume":"286","author":"Pag\u00e8s","year":"1999","journal-title":"Science"},{"issue":"33","key":"10.1016\/j.yjmcc.2026.07.014_bb0050","doi-asserted-by":"crossref","first-page":"11953","DOI":"10.1523\/JNEUROSCI.2349-11.2011","article-title":"ERK2 contributes to the control of social behaviors in mice","volume":"31","author":"Satoh","year":"2011","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.yjmcc.2026.07.014_bb0055","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000215985.18538.c4","article-title":"Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability","volume":"98","author":"Oka","year":"2006","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2026.07.014_bb0060","doi-asserted-by":"crossref","first-page":"E592","DOI":"10.1152\/ajpendo.00277.2013","article-title":"Effects of insulin resistance on skeletal muscle growth and exercise capacity in type 2 diabetic mouse models","volume":"306","author":"Ostler","year":"2014","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yjmcc.2026.07.014_bb0065","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13104-016-1900-2","article-title":"AdapterRemoval v2: rapid adapter trimming, identification, and read merging","volume":"9","author":"Schubert","year":"2016","journal-title":"BMC. Res. Notes"},{"issue":"4","key":"10.1016\/j.yjmcc.2026.07.014_bb0070","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.07.014_bb0075","article-title":"decoupleR: ensemble of computational methods to infer biological activities from omics data","volume":"2","author":"Badia","year":"2022","journal-title":"Bioinform. Adv."},{"key":"10.1016\/j.yjmcc.2026.07.014_bb0080","article-title":"Isolation of mouse peritoneal cavity cells","volume":"35","author":"Ray","year":"2010","journal-title":"J. Vis. Exp."},{"issue":"12","key":"10.1016\/j.yjmcc.2026.07.014_bb0085","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1038\/leu.2017.112","article-title":"Myeloproliferative leukemia protein activation directly induces fibrocyte differentiation to cause myelofibrosis","volume":"31","author":"Maekawa","year":"2017","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.yjmcc.2026.07.014_bb0090","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000361","article-title":"Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction","volume":"2","author":"Kujiraoka","year":"2013","journal-title":"J. Am. Heart Assoc."},{"issue":"5","key":"10.1016\/j.yjmcc.2026.07.014_bb0095","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1083\/jcb.132.5.849","article-title":"Expression of the SM22alpha promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cells","volume":"132","author":"Li","year":"1996","journal-title":"J. Cell Biol."},{"issue":"49","key":"10.1016\/j.yjmcc.2026.07.014_bb0100","doi-asserted-by":"crossref","first-page":"17132","DOI":"10.1073\/pnas.0406041101","article-title":"Restricted inactivation of serum response factor to the cardiovascular system","volume":"101","author":"Miano","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.yjmcc.2026.07.014_bb0105","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1046\/j.1365-2443.2003.00680.x","article-title":"Essential role for ERK2 mitogen-activated protein kinase in placental development","volume":"8","author":"Hatano","year":"2003","journal-title":"Genes Cells"},{"key":"10.1016\/j.yjmcc.2026.07.014_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fcell.2016.00053","article-title":"ERK1 and ERK2 map kinases: specific roles or functional redundancy?","volume":"4","author":"Busca","year":"2016","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.yjmcc.2026.07.014_bb0115","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yjmcc.2014.03.002","article-title":"Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction","volume":"72","author":"Ulm","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2026.07.014_bb0120","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/ehf2.12497","article-title":"Assessing the role of extracellular signal-regulated kinases 1 and 2 in volume overload-induced cardiac remodelling","volume":"6","author":"Jochmann","year":"2019","journal-title":"ESC Heart Fail."},{"issue":"23","key":"10.1016\/j.yjmcc.2026.07.014_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.122.027538","article-title":"Endothelial extracellular signal-regulated kinase\/thromboxane A2\/Prostanoid receptor pathway aggravates endothelial dysfunction and insulin resistance in a mouse model of metabolic syndrome","volume":"11","author":"Sato","year":"2022","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.yjmcc.2026.07.014_bb0130","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/CIRCRESAHA.115.308238","article-title":"DUSP8 regulates cardiac ventricular remodeling by altering ERK1\/2 signaling","volume":"119","author":"Liu","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.07.014_bb0135","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaccao.2019.08.012","article-title":"Increase in blood pressure associated with tyrosine kinase inhibitors targeting vascular endothelial growth factor","volume":"1","author":"Waliany","year":"2019","journal-title":"JACC CardioOncol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.07.014_bb0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/ATVBAHA.120.314694","article-title":"Arterial thrombotic complications of tyrosine kinase inhibitors","volume":"41","author":"Wu","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.07.014_bb0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/CIRCULATIONAHA.108.776831","article-title":"Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics","volume":"118","author":"Chen","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.07.014_bb0150","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12012-012-9183-x","article-title":"The dual-targeted HER1\/HER2 tyrosine kinase inhibitor lapatinib strongly potentiates the cardiac myocyte-damaging effects of doxorubicin","volume":"13","author":"Hasinoff","year":"2013","journal-title":"Cardiovasc. Toxicol."},{"issue":"11","key":"10.1016\/j.yjmcc.2026.07.014_bb0155","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1056\/NEJMoa022457","article-title":"Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia","volume":"348","author":"O\u2019Brien","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"27","key":"10.1016\/j.yjmcc.2026.07.014_bb0160","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1056\/NEJM200412303512724","article-title":"Somatic mutations of EGFR in colorectal cancers and glioblastomas","volume":"351","author":"Barber","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.yjmcc.2026.07.014_bb0165","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1038\/nrd4281","article-title":"Targeting RAS-ERK signalling in cancer: promises and challenges","volume":"13","author":"Samatar","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"issue":"12","key":"10.1016\/j.yjmcc.2026.07.014_bb0170","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1161\/CIRCRESAHA.111.255695","article-title":"A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity","volume":"109","author":"Cheng","year":"2011","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.yjmcc.2026.07.014_bb0175","doi-asserted-by":"crossref","first-page":"e376","DOI":"10.1016\/S2352-3026(15)00127-1","article-title":"Ponatinib as first-line treatment for patients with chronic myeloid leukaemia in chronic phase: a phase 2 study","volume":"2","author":"Jain","year":"2015","journal-title":"Lancet Haematol"},{"issue":"3","key":"10.1016\/j.yjmcc.2026.07.014_bb0180","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1152\/physrev.00024.2010","article-title":"Myocardial AKT: the omnipresent nexus","volume":"91","author":"Sussman","year":"2011","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.07.014_bb0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.yjmcc.2004.11.005","article-title":"Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt","volume":"38","author":"Matsui","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"19","key":"10.1016\/j.yjmcc.2026.07.014_bb0190","doi-asserted-by":"crossref","first-page":"12333","DOI":"10.1073\/pnas.172376399","article-title":"Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice","volume":"99","author":"Condorelli","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.07.014_bb0195","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jsps.2020.03.002","article-title":"Liraglutide attenuates gefitinib-induced cardiotoxicity and promotes cardioprotection through the regulation of MAPK\/NF-kappaB signaling pathways","volume":"28","author":"AlAsmari","year":"2020","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.yjmcc.2026.07.014_bb0200","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fphar.2015.00102","article-title":"The case for inhibiting p38 mitogen-activated protein kinase in heart failure","volume":"6","author":"Arabacilar","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yjmcc.2026.07.014_bb0205","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.3389\/fimmu.2018.03029","article-title":"Recent developments on the crosstalk between STAT3 and inflammation in heart function and disease","volume":"9","author":"Kurdi","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.yjmcc.2026.07.014_bb0210","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1080\/10428194.2016.1239258","article-title":"Ponatinib reduces viability, migration, and functionality of human endothelial cells","volume":"58","author":"Gover-Proaktor","year":"2017","journal-title":"Leuk. Lymphoma"},{"issue":"2","key":"10.1016\/j.yjmcc.2026.07.014_bb0215","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1161\/CIRCRESAHA.115.306532","article-title":"RhoA\/rho-kinase in the cardiovascular system","volume":"118","author":"Shimokawa","year":"2016","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.07.014_bb0220","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.92352","article-title":"Development of MK-8353, an orally administered ERK1\/2 inhibitor, in patients with advanced solid tumors","volume":"3","author":"Moschos","year":"2018","journal-title":"JCI Insight"},{"issue":"6","key":"10.1016\/j.yjmcc.2026.07.014_bb0225","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1007\/s00280-018-3564-1","article-title":"Effect of ulixertinib, a novel ERK1\/2 inhibitor, on the QT\/QTc interval in patients with advanced solid tumor malignancies","volume":"81","author":"Mendzelevski","year":"2018","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"6","key":"10.1016\/j.yjmcc.2026.07.014_bb0230","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1158\/1078-0432.CCR-19-2574","article-title":"A first-in-human phase I study to evaluate the ERK1\/2 inhibitor GDC-0994 in patients with advanced solid tumors","volume":"26","author":"Varga","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2026.07.014_bb0235","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1634\/theoncologist.2020-0292","article-title":"A phase Ib study to evaluate the MEK inhibitor Cobimetinib in combination with the ERK1\/2 inhibitor GDC-0994 in patients with advanced solid tumors","volume":"25","author":"Weekes","year":"2020","journal-title":"Oncologist"},{"issue":"5","key":"10.1016\/j.yjmcc.2026.07.014_bb0240","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1161\/HYPERTENSIONAHA.118.11554","article-title":"Physiological Diagnostic Criteria for Vascular Failure","volume":"72","author":"Tanaka","year":"2018","journal-title":"Hypertension"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282826001185?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282826001185?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T09:02:27Z","timestamp":1793523747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282826001185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":48,"alternative-id":["S0022282826001185"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.07.014","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cell-specific ERK2 signaling in vascular smooth muscle cells drives vascular dysfunction and systolic heart failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}