{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:17:28Z","timestamp":1788952648870,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20241854"],"award-info":[{"award-number":["BK20241854"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270327"],"award-info":[{"award-number":["82270327"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070309"],"award-info":[{"award-number":["82070309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370384"],"award-info":[{"award-number":["82370384"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.yjmcc.2026.08.007","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T23:21:00Z","timestamp":1787095260000},"page":"32-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TMEM175 deficiency impairs autophagic degradation and alleviates mitochondrial oxidative damage in cardiomyocytes through AMPK activation"],"prefix":"10.1016","volume":"219","author":[{"given":"Qingliu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fucheng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengzhou","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.yjmcc.2026.08.007_bb0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41580-019-0185-4","article-title":"Lysosomes as dynamic regulators of cell and organismal homeostasis","volume":"21","author":"Ballabio","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.yjmcc.2026.08.007_bb0010","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1152\/physrev.00025.2023","article-title":"The ion channels of endomembranes","volume":"104","author":"Hu","year":"2024","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.08.007_bb0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1089\/bioe.2025.0010","article-title":"Lysosomal ion channels and transporters: recent findings, therapeutic potential, and technical approaches","volume":"7","author":"Kondratskyi","year":"2025","journal-title":"Bioelectricity"},{"issue":"5","key":"10.1016\/j.yjmcc.2026.08.007_bb0020","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.cell.2015.08.002","article-title":"TMEM175 is an organelle K+ channel regulating lysosomal function","volume":"162","author":"Cang","year":"2015","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.yjmcc.2026.08.007_bb0025","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.cell.2022.05.021","article-title":"Parkinson\u2019s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes","volume":"185","author":"Hu","year":"2022","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.yjmcc.2026.08.007_bb0030","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1111\/febs.16814","article-title":"Characterization of the role of TMEM175 in an in vitro lysosomal H+ fluxes model","volume":"290","author":"Yang","year":"2023","journal-title":"FEBS J."},{"issue":"9","key":"10.1016\/j.yjmcc.2026.08.007_bb0035","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1073\/pnas.1616332114","article-title":"TMEM175 deficiency impairs lysosomal and mitochondrial function and increases alpha-synuclein aggregation","volume":"114","author":"Jinn","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.yjmcc.2026.08.007_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.70008","article-title":"Unraveling pH regulation of TMEM175, an endolysosomal cation channel with a role in Parkinson\u2019s disease","volume":"240","author":"Schulze","year":"2025","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"10.1016\/j.yjmcc.2026.08.007_bb0045","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1002\/jcp.31096","article-title":"TMEM175 downregulation participates in impairment of the autophagy related lysosomal dynamics following neonatal hypoxic-ischemic brain injury","volume":"238","author":"Zhang","year":"2023","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.08.007_bb0050","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1186\/s12967-024-05228-1","article-title":"Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT\/TMEM175 pathway","volume":"22","author":"Liu","year":"2024","journal-title":"J. Transl. Med."},{"issue":"11","key":"10.1016\/j.yjmcc.2026.08.007_bb0055","article-title":"TMEM175 plays a crucial role in osteoblast differentiation by regulating lysosomal function and autophagy","volume":"47","author":"Lee","year":"2024","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.yjmcc.2026.08.007_bb0060","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s10020-024-00858-z","article-title":"Modulation of anti-cardiac fibrosis immune responses by changing M2 macrophages into M1 macrophages","volume":"30","author":"Chen","year":"2024","journal-title":"Mol. Med."},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2026.08.007_bb0065","article-title":"Beyond acid-base dyshomeostasis: dynamic instability of neuronal lysosomal pH as a pathogenic mechanism and therapeutic target in neurological diseases","volume":"250","author":"Tang","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2021.12.006","article-title":"The role of autophagy in death of cardiomyocytes","volume":"165","author":"Ikeda","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0075","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.freeradbiomed.2025.05.419","article-title":"The peptide from C-phycocyanin alleviates myocardial ischemia-reperfusion injury by suppressing ferroptosis via upregulating UCHL3","volume":"237","author":"Li","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0080","doi-asserted-by":"crossref","unstructured":"A.Jr. Hinton, S.M. Claypool, K. Neikirk, N. Senoo, C.H. Wanjalla, A. Kirabo, et al. Mitochondrial structure and function in human heart failure. Circ. Res. 135 (2) (2024) 372\u2013396.","DOI":"10.1161\/CIRCRESAHA.124.323800"},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103424","article-title":"Schaftoside improves HFpEF through regulation the autophagy-lysosome pathway by allosterically targeting CaMKII-delta","volume":"78","author":"Zhang","year":"2024","journal-title":"Redox Biol."},{"issue":"9","key":"10.1016\/j.yjmcc.2026.08.007_bb0090","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1042\/BCJ20160780","article-title":"The lysosome: a crucial hub for AMPK and mTORC1 signalling","volume":"474","author":"Carroll","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155239","article-title":"TBC1D15-Drp1 interaction-mediated mitochondrial homeostasis confers cardioprotection against myocardial ischemia\/reperfusion injury","volume":"134","author":"Sun","year":"2022","journal-title":"Metabolism"},{"issue":"16\u201318","key":"10.1016\/j.yjmcc.2026.08.007_bb0100","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1089\/ars.2020.8253","article-title":"NDP52 protects against myocardial infarction-provoked cardiac anomalies through promoting autophagosome-lysosome fusion via recruiting TBK1 and RAB7","volume":"36","author":"Sun","year":"2022","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.yjmcc.2026.08.007_bb0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2024.10.012","article-title":"Nondigestible stachyose binds membranous HSP90\u03b2 on small intestinal epithelium to regulate the exosomal miRNAs: a new function and mechanism","volume":"37","author":"Li","year":"2025","journal-title":"Cell Metab."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0110","series-title":"Ion and molecule transport in lysosomes","first-page":"1","article-title":"Endosomal and lysosomal electrophysiology","author":"Zhang","year":"2020"},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155872","article-title":"Baicalin induces cell death of non-small cell lung cancer cells via MCOLN3-mediated lysosomal dysfunction and autophagy blockage","volume":"133","author":"Dong","year":"2024","journal-title":"Phytomedicine"},{"issue":"24","key":"10.1016\/j.yjmcc.2026.08.007_bb0120","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.7150\/thno.46883","article-title":"TBC1D15\/RAB7-regulated mitochondria-lysosome interaction confers cardioprotection against acute myocardial infarction-induced cardiac injury","volume":"10","author":"Yu","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110924","article-title":"7,8,3\u2032-Trihydroxyflavone prevents doxorubicin-induced cardiotoxicity and mitochondrial dysfunction via activating Akt signaling pathway in H9c2 cells","volume":"112","author":"Zhao","year":"2023","journal-title":"Cell. Signal."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0130","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2019.09.033","article-title":"Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing","volume":"145","author":"Wang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.freeradbiomed.2023.02.006","article-title":"BDNF mimetic 7,8-dihydroxyflavone rescues rotenone-induced cytotoxicity in cardiomyocytes by ameliorating mitochondrial dysfunction","volume":"198","author":"Hang","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.116951","article-title":"BDNF mimetics recover palmitic acid-induced injury in cardiomyocytes by ameliorating Akt-dependent mitochondrial impairments","volume":"486","author":"Zhang","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0145","article-title":"Renal glomerular mitochondria function in salt-sensitive hypertension","volume":"10","author":"Domondon","year":"2019","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2026.08.007_bb0150","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00395-019-0721-6","article-title":"The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3","volume":"114","author":"Zhao","year":"2019","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.08.007_bb0155","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202403104","article-title":"Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress","volume":"224","author":"Feng","year":"2025","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103511","article-title":"The UCP2\/PINK1\/LC3b-mediated mitophagy is involved in the protection of NRG1 against myocardial ischemia\/reperfusion injury","volume":"80","author":"Li","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.yjmcc.2019.02.006","article-title":"The cardiomyocyte \u201credox rheostat\u201d: redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death","volume":"129","author":"Meijles","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"12","key":"10.1016\/j.yjmcc.2026.08.007_bb0170","doi-asserted-by":"crossref","DOI":"10.1096\/fba.2025-00201","article-title":"RBM25 regulates p38 MAPK pathway activation via exon 16 skipping of MAP4K4 in a rat model of post-infarction heart failure","volume":"7","author":"Li","year":"2025","journal-title":"FASEB. Bioadv."},{"issue":"33","key":"10.1016\/j.yjmcc.2026.08.007_bb0175","doi-asserted-by":"crossref","first-page":"23230","DOI":"10.1021\/jacs.4c05623","article-title":"Discovery of selective inhibitors for the lysosomal parkinson's disease channel TMEM175","volume":"146","author":"Oh","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.08.007_bb0180","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s12276-024-01206-1","article-title":"Transmembrane proteins with unknown function (TMEMs) as ion channels: electrophysiological properties, structure, and pathophysiological roles","volume":"56","author":"Kang","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"12","key":"10.1016\/j.yjmcc.2026.08.007_bb0185","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/j.molcel.2026.05.004","article-title":"Mitochondria-lysosome coupling contributes to lysosome acidification and aging","volume":"86","author":"Liu","year":"2026","journal-title":"Mol. Cell"},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2026.08.007_bb0190","article-title":"Dimethyl fumarate ameliorates high-fat\/high-cholesterol diet-induced renal lipotoxicity in association with increased TFEB nuclear translocation, improved lysosomal acidification, and enhanced autophagy-lysosome function","volume":"251","author":"Zhang","year":"2026","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.yjmcc.2026.08.007_bb0195","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-026-00559-z","article-title":"Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease","volume":"15","author":"Sheshadri","year":"2026","journal-title":"Transl. Neurodegener."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.08.007_bb0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/08958378.2025.2507251","article-title":"TMEM175 activity in BK-deficient macrophages maintains lysosomal function and mediates silica-induced inflammatory response in macrophages","volume":"37","author":"Kendall","year":"2025","journal-title":"Inhal. Toxicol."},{"issue":"21","key":"10.1016\/j.yjmcc.2026.08.007_bb0205","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1016\/j.neuron.2025.07.029","article-title":"Structural insights into the activation of TMEM175 by small molecule","volume":"113","author":"Zhu","year":"2025","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.yjmcc.2026.08.007_bb0210","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.4049\/jimmunol.2300406","article-title":"The lysosomal calcium channel TRPML1 maintains mitochondrial fitness in NK cells through interorganelle cross-talk","volume":"211","author":"Clement","year":"2023","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.yjmcc.2026.08.007_bb0215","first-page":"637","article-title":"Lysosomal membrane protein Sidt2 knockout induces apoptosis of human hepatocytes in vitro independent of the autophagy-lysosomal pathway","volume":"43","author":"Xu","year":"2023","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"41","key":"10.1016\/j.yjmcc.2026.08.007_bb0220","doi-asserted-by":"crossref","first-page":"16804","DOI":"10.1074\/jbc.R117.789271","article-title":"Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions","volume":"292","author":"Wong","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0225","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.freeradbiomed.2020.02.029","article-title":"Mitochondrial superoxide\/hydrogen peroxide: an emerging therapeutic target for metabolic diseases","volume":"152","author":"Yan","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0230","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2022.12.082","article-title":"Doxorubicin induces cardiomyocyte death owing to the accumulation of dysfunctional mitochondria by inhibiting the autophagy fusion process","volume":"195","author":"Toda","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.116750","article-title":"Cordycepin alleviates metabolic dysfunction-associated liver disease by restoring mitochondrial homeostasis and reducing oxidative stress via parkin-mediated mitophagy","volume":"232","author":"Tian","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yjmcc.2026.08.007_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114613","article-title":"Berberine improves cardiac insufficiency through AMPK\/PGC-1alpha signaling-mediated mitochondrial homeostasis and apoptosis in HFpEF mice","volume":"155","author":"Hu","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.yjmcc.2026.08.007_bb0245","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1038\/s41401-026-01749-1","article-title":"TMEM175 rescues post-infarct cardiac dysfunction via mTORC1-lysosomal axis modulation","volume":"47","author":"Chen","year":"2026","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282826001252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282826001252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:50:56Z","timestamp":1788951056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282826001252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":49,"alternative-id":["S0022282826001252"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.08.007","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TMEM175 deficiency impairs autophagic degradation and alleviates mitochondrial oxidative damage in cardiomyocytes through AMPK activation","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2026.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}