{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:11:47Z","timestamp":1782256307889,"version":"3.54.5"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Metabolic Engineering"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.ymben.2011.01.002","type":"journal-article","created":{"date-parts":[[2011,2,2]],"date-time":"2011-02-02T09:52:46Z","timestamp":1296640366000},"page":"336-344","source":"Crossref","is-referenced-by-count":37,"title":["Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties"],"prefix":"10.1016","volume":"13","author":[{"given":"Jine","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huarong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymben.2011.01.002_bib1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1021\/np0705763","article-title":"Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity","volume":"71","author":"Baig","year":"2008","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.ymben.2011.01.002_bib2","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/nbt1265","article-title":"Molecular engineering approaches to peptide, polyketide and other antibiotics","volume":"24","author":"Baltz","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymben.2011.01.002_bib3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1128\/AAC.23.6.926","article-title":"Polyoxin D inhibits growth of zoopathogenic fungi","volume":"23","author":"Becker","year":"1983","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ymben.2011.01.002_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7164\/antibiotics.38.9","article-title":"Metabolic products of microorganisms. 228. New nikkomycins produced by mutants of Streptomyces tendae","volume":"38","author":"Bormann","year":"1985","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ymben.2011.01.002_bib5","doi-asserted-by":"crossref","first-page":"582","DOI":"10.7164\/antibiotics.52.582","article-title":"Novel nikkomycins Lx and Lz produced by genetically engineered Streptomyces tendae Tu901","volume":"52","author":"Bormann","year":"1999","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ymben.2011.01.002_bib6","doi-asserted-by":"crossref","first-page":"913","DOI":"10.7164\/antibiotics.42.913","article-title":"Isolation of Streptomyces tendae mutants with an altered nikkomycin spectrum","volume":"42","author":"Bormann","year":"1989","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ymben.2011.01.002_bib7","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1128\/jb.178.4.1216-1218.1996","article-title":"Cloning and heterologous expression of the entire set of structural genes for nikkomycin synthesis from Streptomyces tendae Tu901 in Streptomyces lividans","volume":"178","author":"Bormann","year":"1996","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2011.01.002_bib8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.chembiol.2008.08.009","article-title":"Improved antifungal polyene macrolides via engineering of the nystatin biosynthetic genes in Streptomyces noursei","volume":"15","author":"Brautaset","year":"2008","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ymben.2011.01.002_bib9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF00409207","article-title":"Metabolic products of microorganisms. 181. Chitin synthase from fungi, a test model for substances with insecticidal properties","volume":"121","author":"Brillinger","year":"1979","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ymben.2011.01.002_bib10","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1128\/AAC.01007-06","article-title":"Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm","volume":"51","author":"Brun","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ymben.2011.01.002_bib11","first-page":"102","article-title":"Molecular characterization of co-transcribed genes from Streptomyces tendae Tu901 involved in the biosynthesis of the peptidyl moiety of the peptidyl nucleoside antibiotic nikkomycin","volume":"262","author":"Bruntner","year":"1999","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.ymben.2011.01.002_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1074-5521(02)00090-X","article-title":"Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics","volume":"9","author":"Chen","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ymben.2011.01.002_bib13","doi-asserted-by":"crossref","first-page":"10627","DOI":"10.1074\/jbc.M807534200","article-title":"Characterization of the polyoxin biosynthetic gene cluster from Streptomyces cacaoi and engineered production of polyoxin H","volume":"284","author":"Chen","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymben.2011.01.002_bib14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s002840010141","article-title":"Cloning, sequencing, and function of sanF: a gene involved in nikkomycin biosynthesis of Streptomyces ansochromogenes","volume":"41","author":"Chen","year":"2000","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.ymben.2011.01.002_bib15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/cbic.200300583","article-title":"The blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization","volume":"4","author":"Cone","year":"2003","journal-title":"Chembiochem"},{"key":"10.1016\/j.ymben.2011.01.002_bib16","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1099\/00221287-137-8-1805","article-title":"Structure-activity relationships of the nikkomycins","volume":"137","author":"Decker","year":"1991","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.ymben.2011.01.002_bib17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.7164\/antibiotics.37.80","article-title":"New nikkomycins by mutasynthesis and directed fermentation","volume":"37","author":"Delzer","year":"1984","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ymben.2011.01.002_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1128\/JB.104.1.189-196.1970","article-title":"Mechanism of action of the antifugal agent polyoxin D","volume":"104","author":"Endo","year":"1970","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2011.01.002_bib19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jbiotec.2005.12.001","article-title":"Combinatorial biosynthesis\u2014potential and problems","volume":"124","author":"Floss","year":"2006","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2011.01.002_bib20","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1021\/bi00633a013","article-title":"Biosynthesis of the polyoxins, nucleoside peptide antibiotics: biosynthetic pathway for 5-O-carbamoyl-2-amino-2-deoxy-l-xylonic acid (carbamoylpolyoxamic acid)","volume":"16","author":"Funayama","year":"1977","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymben.2011.01.002_bib21","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1469-0691.2004.00996.x","article-title":"In-vitro activity of nikkomycin Z alone and in combination with polyenes, triazoles or echinocandins against Aspergillus fumigatus","volume":"10","author":"Ganesan","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.ymben.2011.01.002_bib22","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1073\/pnas.0337542100","article-title":"PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin","volume":"100","author":"Gust","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymben.2011.01.002_bib23","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2174\/156802608784221505","article-title":"Combinatorial biosynthesis, metabolic engineering and mutasynthesis for the generation of new aminocoumarin antibiotics","volume":"8","author":"Heide","year":"2008","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.ymben.2011.01.002_bib24","doi-asserted-by":"crossref","first-page":"260","DOI":"10.7164\/antibiotics.27.260","article-title":"Studies on the mode of action of polyoxins. VI. Effect of polyoxin B on chitin synthesis in polyoxin-sensitive and resistant strains of Alternaria kikuchiana","volume":"27","author":"Hori","year":"1974","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ymben.2011.01.002_bib25","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1021\/ja01054a045","article-title":"Studies on polyoxins, antifungal antibiotics. 13. The structure of polyoxins","volume":"91","author":"Isono","year":"1969","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ymben.2011.01.002_bib26","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0040-4039(01)98906-3","article-title":"The structures of polyoxins A and B","volume":"9","author":"Isono","year":"1968","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.ymben.2011.01.002_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1054-3589(08)60071-X","article-title":"Use of azoles for systemic antifungal therapy","volume":"39","author":"Kauffman","year":"1997","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.ymben.2011.01.002_bib28","series-title":"Practical Streptomyces Genetics","author":"Kieser","year":"2000"},{"key":"10.1016\/j.ymben.2011.01.002_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/yea.837","article-title":"Inhibitory effect of nikkomycin Z on chitin synthases in Candida albicans","volume":"19","author":"Kim","year":"2002","journal-title":"Yeast"},{"key":"10.1016\/j.ymben.2011.01.002_bib30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1021\/jm00105a026","article-title":"Synthesis and biological evaluation of dipeptidyl and tripeptidyl polyoxin and nikkomycin analogues as anticandidal prodrugs","volume":"34","author":"Krainer","year":"1991","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.ymben.2011.01.002_bib31","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1046\/j.1432-1327.2000.01162.x","article-title":"Molecular characterization of two genes from Streptomyces tendae Tu901 required for the formation of the 4-formyl-4-imidazolin-2-one-containing nucleoside moiety of the peptidyl nucleoside antibiotic nikkomycin","volume":"267","author":"Lauer","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ymben.2011.01.002_bib32","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s004380000352","article-title":"Molecular characterization of co-transcribed genes from Streptomyces tendae Tu901 involved in the biosynthesis of the peptidyl moiety and assembly of the peptidyl nucleoside antibiotic nikkomycin","volume":"264","author":"Lauer","year":"2001","journal-title":"Mol. Gen. Genet."},{"key":"10.1016\/j.ymben.2011.01.002_bib33","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/cbic.200800008","article-title":"The mildiomycin biosynthesis: initial steps for sequential generation of 5-hydroxymethylcytidine 5\u2032-monophosphate and 5-hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119","volume":"9","author":"Li","year":"2008","journal-title":"Chembiochem"},{"key":"10.1016\/j.ymben.2011.01.002_bib34","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1099\/mic.0.028639-0","article-title":"polR, a pathway-specific transcriptional regulatory gene, positively controls polyoxin biosynthesis in Streptomyces cacaoi subsp. asoensis","volume":"55","author":"Li","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.ymben.2011.01.002_bib35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2958.2009.06968.x","article-title":"PolY, a transcriptional regulator with ATPase activity, directly activates transcription of polR in polyoxin biosynthesis in Streptomyces cacaoi","volume":"75","author":"Li","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ymben.2011.01.002_bib36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1475-2859-8-61","article-title":"Selectively improving nikkomycin Z production by blocking the imidazolone biosynthetic pathway of nikkomycin X and uracil feeding in Streptomyces ansochromogenes","volume":"8","author":"Liao","year":"2009","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2011.01.002_bib37","first-page":"397","article-title":"sanN encoding a dehydrogenase is essential for nikkomycin biosynthesis in Streptomyces ansochromogenes","volume":"18","author":"Ling","year":"2008","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2011.01.002_bib38","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1111\/j.1365-2958.2005.04512.x","article-title":"A pathway-specific transcriptional regulatory gene for nikkomycin biosynthesis in Streptomyces ansochromogenes that also influences colony development","volume":"55","author":"Liu","year":"2005","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ymben.2011.01.002_bib39","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.chembiol.2005.12.012","article-title":"Genetic engineering in Streptomyces roseosporus to produce hybrid lipopeptide antibiotics","volume":"13","author":"Miao","year":"2006","journal-title":"Chem. Biol."},{"key":"10.1016\/j.ymben.2011.01.002_bib40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ymben.2005.12.002","article-title":"SanJ, an ATP-dependent picolinate-CoA ligase, catalyzed the conversion of picolinate to picolinate-CoA during nikkomycin biosynthesis in Streptomyces ansochromogenes","volume":"8","author":"Niu","year":"2006","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2011.01.002_bib41","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1128\/AAC.01609-08","article-title":"Pharmacokinetics of nikkomycin Z after single rising oral doses","volume":"53","author":"Nix","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.ymben.2011.01.002_bib42","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ymben.2008.07.001","article-title":"Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering","volume":"10","author":"Olano","year":"2008","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2011.01.002_bib43","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1021\/jo900244m","article-title":"Application of the Ugi reaction for the one-pot synthesis of uracil polyoxin C analogues","volume":"74","author":"Plant","year":"2009","journal-title":"J. Org. Chem."},{"key":"10.1016\/j.ymben.2011.01.002_bib44","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1039\/b905068j","article-title":"Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles","author":"Sanchez","year":"2009","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.ymben.2011.01.002_bib45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1367-5931(00)00185-X","article-title":"Combinatorial biosynthesis of polyketides and nonribosomal peptides","volume":"5","author":"Staunton","year":"2001","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.ymben.2011.01.002_bib46","first-page":"131","article-title":"A new antibiotic, polyoxin A","volume":"18","author":"Suzuki","year":"1965","journal-title":"J. Antibiot."},{"key":"10.1016\/j.ymben.2011.01.002_bib47","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1271\/bbb1961.45.1901","article-title":"Polyoxin N, a new member of the polyoxin family","volume":"45","author":"Uramoto","year":"1981","journal-title":"Agric. Biol. Chem."},{"key":"10.1016\/j.ymben.2011.01.002_bib48","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1517\/14656566.6.10.1657","article-title":"Echinocandins: role in antifungal therapy","volume":"6","author":"Zaas","year":"2005","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.ymben.2011.01.002_bib49","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1021\/jm701269v","article-title":"Combinatorial biosynthesis of natural products","volume":"51","author":"Zhang","year":"2008","journal-title":"J. Med. Chem."}],"container-title":["Metabolic Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096717611000036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096717611000036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T06:10:56Z","timestamp":1592287856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096717611000036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S1096717611000036"],"URL":"https:\/\/doi.org\/10.1016\/j.ymben.2011.01.002","relation":{},"ISSN":["1096-7176"],"issn-type":[{"value":"1096-7176","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}