{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:52:03Z","timestamp":1793904723831,"version":"4.8.0"},"reference-count":341,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["342124"],"award-info":[{"award-number":["342124"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014438","name":"Business Finland","doi-asserted-by":"publisher","award":["8957 \/31\/2022"],"award-info":[{"award-number":["8957 \/31\/2022"]}],"id":[{"id":"10.13039\/501100014438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["VI.Vidi.233.193"],"award-info":[{"award-number":["VI.Vidi.233.193"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF25OC0103238"],"award-info":[{"award-number":["NNF25OC0103238"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF25OC0100601"],"award-info":[{"award-number":["NNF25OC0100601"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF24SA0100980"],"award-info":[{"award-number":["NNF24SA0100980"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF20CC0035580"],"award-info":[{"award-number":["NNF20CC0035580"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolic Engineering"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ymben.2026.05.003","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:33:01Z","timestamp":1779147181000},"page":"102479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The state of metabolic engineering in the versatile bacterial cell factory Cupriavidus necator H16"],"prefix":"10.1016","volume":"97","author":[{"given":"Neha","family":"Bansal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tytti","family":"J\u00e4ms\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Arango","family":"Saavedra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Donati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Orsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico J.","family":"Claassens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymben.2026.05.003_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jbiotec.2018.03.007","article-title":"Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16","volume":"274","author":"Aboulnaga","year":"2018","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib2","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1021\/acssynbio.8b00342","article-title":"Less is more: toward a genome-reduced bacillus cell factory for \u201cDifficult Proteins\u201d","volume":"8","author":"Aguilar Su\u00e1rez","year":"2019","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2024.109239","article-title":"Fermentation strategies for PHB production in a novel membrane bioreactor: Investigating batch and fed-batch operations","volume":"204","author":"Akkoyunlu","year":"2024","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.ymben.2026.05.003_bib4","doi-asserted-by":"crossref","first-page":"9667","DOI":"10.1039\/D0CC03229H","article-title":"H2 as a fuel for flavin- and H2O2-dependent biocatalytic reactions","volume":"56","author":"Al-Shameri","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ymben.2026.05.003_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00878-18","article-title":"Functional genetic elements for controlling gene expression in Cupriavidus necator H16","volume":"84","author":"Alagesan","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11306-017-1302-z","article-title":"13C-assisted metabolic flux analysis to investigate heterotrophic and mixotrophic metabolism in Cupriavidus necator H16","volume":"14","author":"Alagesan","year":"2018","journal-title":"Metabolomics"},{"key":"10.1016\/j.ymben.2026.05.003_bib7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/bs.mie.2025.01.017","article-title":"Cupriavidus necator as a model organism for CO2-based biotechnology","volume":"714","author":"Alhafiz","year":"2025","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ymben.2026.05.003_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.tibtech.2022.06.010","article-title":"Dehazing redox homeostasis to foster purple bacteria biotechnology","volume":"41","author":"Alloul","year":"2023","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.watres.2018.12.025","article-title":"Volatile fatty acids impacting phototrophic growth kinetics of purple bacteria: paving the way for protein production on fermented wastewater","volume":"152","author":"Alloul","year":"2019","journal-title":"Water Res."},{"key":"10.1016\/j.ymben.2026.05.003_bib10","doi-asserted-by":"crossref","DOI":"10.1128\/aem.02007-22","article-title":"Minimizing the lag phase of Cupriavidus necator growth under autotrophic, heterotrophic, and mixotrophic conditions","volume":"89","author":"Amer","year":"2023","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10295-015-1585-x","article-title":"Methods and advances in metabolic flux analysis: a mini-review","volume":"42","author":"Antoniewicz","year":"2015","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib12","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s13068-019-1489-5","article-title":"The genetic basis of 3-hydroxypropanoate metabolism in Cupriavidus necator H16","volume":"12","author":"Arenas-L\u00f3pez","year":"2019","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.ymben.2026.05.003_bib13","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1021\/acssynbio.4c00757","article-title":"CnRed: efficient, marker-free genome engineering of Cupriavidus necator H16 by adapted Lambda red Recombineering","volume":"14","author":"Arhar","year":"2025","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12934-023-02280-2","article-title":"CO2-based production of phytase from highly stable expression plasmids in Cupriavidus necator H16","volume":"23","author":"Arhar","year":"2024","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib15","doi-asserted-by":"crossref","first-page":"7497","DOI":"10.1007\/s00253-017-8470-7","article-title":"Polyhydroxyalkanoate production from sucrose by Cupriavidus necator strains harboring csc genes from Escherichia coli W","volume":"101","author":"Arikawa","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib16","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s12934-016-0583-7","article-title":"Evaluation of gene expression cassettes and production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) with a fine modulated monomer composition by using it in Cupriavidus necator","volume":"15","author":"Arikawa","year":"2016","journal-title":"Microb. Cell Fact."},{"issue":"11","key":"10.1016\/j.ymben.2026.05.003_bib17","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1002\/cssc.201900327","article-title":"Hydrogen\u2010Driven Cofactor Regeneration for Stereoselective Whole\u2010Cell C=C Bond Reduction in Cupriavidus necator","volume":"12","author":"Assil\u2010Companioni","year":"2019","journal-title":"ChemSusChem"},{"key":"10.1016\/j.ymben.2026.05.003_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00705-20","article-title":"Applying statistical design of experiments to understanding the effect of growth medium components on Cupriavidus necator H16 growth","volume":"86","author":"Azubuike","year":"2020","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib19","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nbt.2021.07.003","article-title":"pCAT vectors overcome inefficient electroporation of Cupriavidus necator H16","volume":"65","author":"Azubuike","year":"2021","journal-title":"N. Biotech."},{"key":"10.1016\/j.ymben.2026.05.003_bib20","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.pep.2004.09.001","article-title":"High level recombinant protein expression in Ralstonia eutropha using T7 RNA polymerase based amplification","volume":"38","author":"Barnard","year":"2004","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.ymben.2026.05.003_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bej.2024.109617","article-title":"Individual process steps optimization of Cupriavidus necator-catalyzed production of \u03b1-humulene","volume":"215","author":"Becker","year":"2025","journal-title":"Biochem. Eng. J."},{"key":"10.1016\/j.ymben.2026.05.003_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113463","article-title":"Emergent approaches to efficient and sustainable polyhydroxyalkanoate production","volume":"26","author":"Bedade","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.ymben.2026.05.003_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.nbt.2015.06.002","article-title":"Improvement of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) production by dual feeding with levulinic acid and sodium propionate in Cupriavidus necator","volume":"33","author":"Berezina","year":"2016","journal-title":"N. Biotech."},{"key":"10.1016\/j.ymben.2026.05.003_bib24","article-title":"Food production from air: gas precision fermentation with hydrogen-oxidising bacteria","author":"Bernal-Cabas","year":"2025","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib25","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.biochi.2012.03.021","article-title":"Isopentenyl diphosphate isomerase: a checkpoint to isoprenoid biosynthesis","volume":"94","author":"Berthelot","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.ymben.2026.05.003_bib26","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1128\/aem.56.10.3133-3138.1990","article-title":"Biosynthesis of poly-beta-hydroxyalkanoates from pentoses by Pseudomonas pseudoflava","volume":"56","author":"Bertrand","year":"1990","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.133407","article-title":"Aerobic autotrophic isopropanol production under low H2 atmosphere in Hollow Fiber Membrane Bioreactor","volume":"440","author":"Bisceglie","year":"2026","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101218","article-title":"A sustainable chemicals manufacturing paradigm using CO2 and renewable H2","volume":"23","author":"Bommareddy","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.ymben.2026.05.003_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/j.1574-6968.1990.tb04951.x","article-title":"Genetics of CO2 fixation in the chemoautotroph","author":"Bowien","year":"1990","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.ymben.2026.05.003_bib30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s00203-002-0441-3","article-title":"Genetics and control of CO(2) assimilation in the chemoautotroph Ralstonia eutropha","volume":"178","author":"Bowien","year":"2002","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev.mi.35.100181.002201","article-title":"Physiology and biochemistry of aerobic hydrogen-oxidizing bacteria","volume":"35","author":"Bowien","year":"1981","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jbiotec.2023.02.011","article-title":"Comparison of plasmid stabilization systems during heterologous isopropanol production in fed-batch bioreactor","volume":"366","author":"Boy","year":"2023","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib33","doi-asserted-by":"crossref","first-page":"5454","DOI":"10.1128\/JB.00493-10","article-title":"Elucidation of beta-oxidation pathways in Ralstonia eutropha H16 by examination of global gene expression","volume":"192","author":"Brigham","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib34","series-title":"Advanced Biofuels and Bioproducts","first-page":"1065","article-title":"Engineering Ralstonia eutropha for production of isobutanol from CO2, H2, and O2","author":"Brigham","year":"2013"},{"key":"10.1016\/j.ymben.2026.05.003_bib35","doi-asserted-by":"crossref","first-page":"8033","DOI":"10.1128\/AEM.01693-12","article-title":"Whole-genome microarray and gene deletion studies reveal regulation of the polyhydroxyalkanoate production cycle by the stringent response in Ralstonia eutropha H16","volume":"78","author":"Brigham","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"issue":"24","key":"10.1016\/j.ymben.2026.05.003_bib36","doi-asserted-by":"crossref","first-page":"11885","DOI":"10.1039\/D4GC04228J","article-title":"Upcycling atmospheric CO2 to polyhydroxyalkanoates via sequential chemo-biocatalytic processes","volume":"26","author":"Bruch","year":"2024","journal-title":"Green Chem."},{"key":"10.1016\/j.ymben.2026.05.003_bib37","series-title":"Active Learning Guides Automated Discovery of DNA Delivery via Electroporation for Non-model Microbes","author":"Brumwell","year":"2025"},{"key":"10.1016\/j.ymben.2026.05.003_bib38","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1128\/JB.00207-10","article-title":"Roles of multiple acetoacetyl coenzyme A reductases in polyhydroxybutyrate biosynthesis in Ralstonia eutropha H16","volume":"192","author":"Budde","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib39","first-page":"181","article-title":"[NiFe]-hydrogenases of Ralstonia eutropha H16: modular enzymes for oxygen-tolerant biological hydrogen oxidation","volume":"10","author":"Burgdorf","year":"2005","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib40","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/am.17.1.176-178.1969","article-title":"Protein quality of the bacterium hydrogenomonas eutropha","volume":"17","author":"Calloway","year":"1969","journal-title":"Appl. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib41","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ymben.2022.10.016","article-title":"Improving growth of Cupriavidus necator H16 on formate using adaptive laboratory evolution-informed engineering","volume":"75","author":"Calvey","year":"2023","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib42","article-title":"Hydrogen-fueled CO2 reduction using oxygen-tolerant oxidoreductases","volume":"10","author":"Cha","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib43","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1111\/j.1365-2672.2009.04158.x","article-title":"Conversion of volatile fatty acids into polyhydroxyalkanoate by Ralstonia eutropha","volume":"106","author":"Chakraborty","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib44","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.1468","article-title":"Production of fatty acids in Ralstonia eutropha H16 by engineering \u03b2-oxidation and carbon storage","volume":"3","author":"Chen","year":"2015","journal-title":"PeerJ"},{"key":"10.1016\/j.ymben.2026.05.003_bib45","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1021\/acscatal.8b00226","article-title":"Enzyme-assisted microbial electrosynthesis of Poly(3-hydroxybutyrate) via CO2 bioreduction by engineered Ralstonia eutropha","volume":"8","author":"Chen","year":"2018","journal-title":"ACS Catal."},{"key":"10.1016\/j.ymben.2026.05.003_bib46","series-title":"MICROORGANISMS FOR BIOSYNTHESIS OF LIMONENE ON GASEOUS SUBSTRATES","author":"Christer","year":"2015"},{"key":"10.1016\/j.ymben.2026.05.003_bib47","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ymben.2020.08.004","article-title":"Replacing the calvin cycle with the reductive glycine pathway in Cupriavidus necator","volume":"62","author":"Claassens","year":"2020","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib48","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41929-019-0272-0","article-title":"Making quantitative sense of electromicrobial production","volume":"2","author":"Claassens","year":"2019","journal-title":"Nat. Catal."},{"issue":"36","key":"10.1016\/j.ymben.2026.05.003_bib49","doi-asserted-by":"crossref","first-page":"22452","DOI":"10.1073\/pnas.2012288117","article-title":"Phosphoglycolate salvage in a chemolithoautotroph using the Calvin cycle","volume":"117","author":"Claassens","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ymben.2026.05.003_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ymben.2023.06.015","article-title":"Engineering the biological conversion of formate into crotonate in Cupriavidus necator","volume":"79","author":"Collas","year":"2023","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib51","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.copbio.2019.10.002","article-title":"Renewable methanol and formate as microbial feedstocks","volume":"62","author":"Cotton","year":"2020","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib52","first-page":"38","article-title":"Genomic view of energy metabolism in Ralstonia eutropha H16","volume":"16","author":"Cramm","year":"2009","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib53","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/acs.accounts.3c00098","article-title":"Turning carbon dioxide into sustainable food and chemicals: how electrosynthesized acetate is paving the way for fermentation innovation","volume":"56","author":"Crandall","year":"2023","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ymben.2026.05.003_bib54","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.1128\/JB.00228-08","article-title":"Formate as the main branch point for methylotrophic metabolism in Methylobacterium extorquens AM1","volume":"190","author":"Crowther","year":"2008","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib55","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ymben.2016.05.002","article-title":"Metabolic engineering of Cupriavidus necator for heterotrophic and autotrophic alka(e)ne production","volume":"37","author":"Cr\u00e9pin","year":"2016","journal-title":"Metab. Eng."},{"issue":"10","key":"10.1016\/j.ymben.2026.05.003_bib56","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1002\/bit.26805","article-title":"Alka(e)ne synthesis in Cupriavidus necator boosted by the expression of endogenous and heterologous ferredoxin\u2013ferredoxin reductase systems","volume":"115","author":"Cr\u00e9pin","year":"2018","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib58","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1099\/mic.0.000131","volume":"161","author":"Dangel","year":"2015","journal-title":"Microbiology (Reading, Engl)"},{"key":"10.1016\/j.ymben.2026.05.003_bib59","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1073\/pnas.120163297","article-title":"One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products","volume":"97","author":"Datsenko","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ymben.2026.05.003_bib60","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1099\/00207713-19-4-375","article-title":"Proposal to reject the genus hydrogenomonas: taxonomic implications","volume":"19","author":"Davis","year":"1969","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib61","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s00253-005-0217-1","article-title":"Comparative study of promoters for the production of polyhydroxyalkanoates in recombinant strains of Wautersia eutropha","volume":"71","author":"Delamarre","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib62","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.tibtech.2025.02.006","article-title":"Streamlined and efficient genome editing in Cupriavidus necator H16 using an optimised SIBR-cas system","volume":"43","author":"Della Valle","year":"2025","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.ese.2023.100261","article-title":"Microbial electrosynthesis of acetate from CO2 in three-chamber cells with gas diffusion biocathode under moderate saline conditions","volume":"16","author":"Dess\u00ec","year":"2023","journal-title":"Environ. Sci. Ecotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.130266","article-title":"Gas fermentation combined with water electrolysis for production of polyhydroxyalkanoate copolymer from carbon dioxide by engineered Ralstonia eutropha","volume":"394","author":"Di Stadio","year":"2024","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib65","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s12934-024-02583-y","article-title":"A novel engineered strain of methylorubrum extorquens for methylotrophic production of glycolic acid","volume":"23","author":"Dietz","year":"2024","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2025.128222","article-title":"Fructose metabolism in Entner-Doudoroff pathway-deficient Cupriavidus necator H16 depends on the Calvin shunt","volume":"298","author":"Ding","year":"2025","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.ymben.2026.05.003_bib67","doi-asserted-by":"crossref","DOI":"10.1002\/cssc.202301721","article-title":"Coupling of CO2 electrolysis with parallel and semi-automated biopolymer synthesis - ex-cell and without downstream processing","volume":"17","author":"Dinges","year":"2024","journal-title":"ChemSusChem"},{"key":"10.1016\/j.ymben.2026.05.003_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.copbio.2025.103306","article-title":"Optimizing Cupriavidus necator H16 as a host for aerobic C1 conversion","volume":"93","author":"Donati","year":"2025","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib69","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41564-025-01941-9","article-title":"One-carbon fixation via the synthetic reductive glycine pathway exceeds yield of the Calvin cycle","volume":"10","author":"Dronsella","year":"2025","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.mimet.2021.106323","article-title":"The pMTL70000 modular, plasmid vector series for strain engineering in Cupriavidus necator H16","volume":"189","author":"Ehsaan","year":"2021","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.ymben.2026.05.003_bib71","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.copbio.2017.07.017","article-title":"A short history of RubisCO: the rise and fall (?) of Nature's predominant CO2 fixing enzyme","volume":"49","author":"Erb","year":"2018","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib72","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.nbt.2025.02.009","article-title":"Utilization of lactose and whey permeate for the sustainable production of polyhydroxyalkanoates by Hydrogenophaga pseudoflava DSM1034","volume":"87","author":"Favaro","year":"2025","journal-title":"N. Biotech."},{"key":"10.1016\/j.ymben.2026.05.003_bib73","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ymben.2025.01.001","article-title":"CIFR (Clone-Integrate-Flip-out-Repeat): a toolset for iterative genome and pathway engineering of Gram-negative bacteria","volume":"88","author":"Federici","year":"2025","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib74","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ymben.2025.04.009","article-title":"Harnessing CO2 fixation and reducing power recycling for enhanced polyhydroxyalkanoates industrial bioproduction","volume":"91","author":"Feng","year":"2025","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib75","series-title":"Trajectories for the evolution of bacterial CO 2 -concentrating mechanisms","author":"Flamholz","year":"2022"},{"key":"10.1016\/j.ymben.2026.05.003_bib76","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/bit.260060406","article-title":"A continuous culture apparatus for the microbial utilization of hydrogen produced by electrolysis of water in closed\u2010cycle space systems","volume":"6","author":"Foster","year":"1964","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib77","first-page":"124","article-title":"The genome organization of Ralstonia eutropha strain H16 and related species of the Burkholderiaceae","volume":"16","author":"Fricke","year":"2009","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib78","doi-asserted-by":"crossref","first-page":"4719","DOI":"10.1128\/jb.175.15.4719-4728.1993","article-title":"Physiological and biochemical characterization of the soluble formate dehydrogenase, a molybdoenzyme from Alcaligenes eutrophus","volume":"175","author":"Friedebold","year":"1993","journal-title":"J. Bacteriol."},{"issue":"1","key":"10.1016\/j.ymben.2026.05.003_bib79","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1099\/00221287-115-1-185","article-title":"Formate and Oxalate Metabolism in Alcaligenes eutrophus","volume":"115","author":"FRIEDRICH","year":"1979","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib80","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11306-013-0567-0","article-title":"Metabolite profiles of polyhydroxyalkanoate-producing Ralstonia eutropha H16","volume":"10","author":"Fukui","year":"2014","journal-title":"Metabolomics"},{"key":"10.1016\/j.ymben.2026.05.003_bib81","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1007\/s00253-011-3100-2","article-title":"Evaluation of promoters for gene expression in polyhydroxyalkanoate-producing Cupriavidus necator H16","volume":"89","author":"Fukui","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib82","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.biortech.2017.06.139","article-title":"Valorization of waste glycerol for the production of poly (3-hydroxybutyrate) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer by Cupriavidus necator and extraction in a sustainable manner","volume":"243","author":"Gahlawat","year":"2017","journal-title":"Bioresour. Technol."},{"issue":"1","key":"10.1016\/j.ymben.2026.05.003_bib83","doi-asserted-by":"crossref","DOI":"10.1186\/2191-0855-4-2","article-title":"Insights into bacterial CO2 metabolism revealed by the characterization of four carbonic anhydrases in Ralstonia eutropha H16","volume":"4","author":"Gai","year":"2014","journal-title":"AMB Express"},{"issue":"36","key":"10.1016\/j.ymben.2026.05.003_bib84","doi-asserted-by":"crossref","first-page":"13486","DOI":"10.1021\/acssuschemeng.4c03561","article-title":"Stable Platform for Mevalonate Bioproduction from CO2","volume":"12","author":"Garavaglia","year":"2024","journal-title":"ACS Sustain. Chem. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib85","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.nbt.2019.11.005","article-title":"Isopropanol production from carbon dioxide in Cupriavidus necator in a pressurized bioreactor","volume":"56","author":"Garrigues","year":"2020","journal-title":"New Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib86","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ymben.2021.06.010","article-title":"Engineering Cupriavidus necator H16 for the autotrophic production of (R)-1,3-butanediol","volume":"67","author":"Gascoyne","year":"2021","journal-title":"Metab. Eng."},{"issue":"11","key":"10.1016\/j.ymben.2026.05.003_bib87","doi-asserted-by":"crossref","first-page":"6194","DOI":"10.1128\/jb.172.11.6194-6203.1990","article-title":"Partitioning of broad-host-range plasmid RP4 is a complex system involving site-specific recombination","volume":"172","author":"Gerlitz","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib88","doi-asserted-by":"crossref","first-page":"6654","DOI":"10.1128\/JB.184.23.6654-6664.2002","article-title":"Differential expression of the CO2 fixation operons of Rhodobacter sphaeroides by the Prr\/Reg two-component system during chemoautotrophic growth","volume":"184","author":"Gibson","year":"2002","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib89","article-title":"Cupriavidus necator as flexible platform organism for trehalose production","author":"Gizewski","year":"2025","journal-title":"Res. Sq"},{"key":"10.1016\/j.ymben.2026.05.003_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225737","article-title":"Adaptive laboratory evolution of Cupriavidus necator H16 for carbon Co-Utilization with glycerol","volume":"20","author":"Gonz\u00e1lez-Villanueva","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymben.2026.05.003_bib91","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1759-8753-3-3","article-title":"Insertion site preference of Mu, Tn5, and Tn7 transposons","volume":"3","author":"Green","year":"2012","journal-title":"Mobile DNA"},{"key":"10.1016\/j.ymben.2026.05.003_bib92","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymben.2019.07.006","article-title":"Exploiting Hydrogenophaga pseudoflava for aerobic syngas-based production of chemicals","volume":"55","author":"Grenz","year":"2019","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib93","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1007\/s00253-014-5591-0","article-title":"Isopropanol production with engineered Cupriavidus necator as bioproduction platform","volume":"98","author":"Grousseau","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib94","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biortech.2013.08.120","article-title":"Impact of sustaining a controlled residual growth on polyhydroxybutyrate yield and production kinetics in Cupriavidus necator","volume":"148","author":"Grousseau","year":"2013","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib95","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jbiotec.2014.06.030","article-title":"Versatile and stable vectors for efficient gene expression in Ralstonia eutropha H16","volume":"186","author":"Gruber","year":"2014","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib96","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jbiotec.2016.04.026","article-title":"Design of inducible expression vectors for improved protein production in Ralstonia eutropha H16 derived host strains","volume":"235","author":"Gruber","year":"2016","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib97","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/1751-7915.12149","article-title":"Kinetic and stoichiometric characterization of organoautotrophic growth of Ralstonia eutropha on formic acid in fed-batch and continuous cultures","volume":"8","author":"Grunwald","year":"2015","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-93720-9","article-title":"Untargeted metabolomics analysis of Ralstonia eutropha during plant oil cultivations reveals the presence of a fucose salvage pathway","volume":"11","author":"Gutschmann","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymben.2026.05.003_bib99","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/s41467-020-14941-6","article-title":"A genome-wide approach for identification and characterisation of metabolite-inducible systems","volume":"11","author":"Hanko","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymben.2026.05.003_bib100","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ymben.2022.02.003","article-title":"Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production","volume":"72","author":"Hanko","year":"2022","journal-title":"Metab. Eng."},{"issue":"15","key":"10.1016\/j.ymben.2026.05.003_bib101","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.3390\/polym17152104","article-title":"Metabolic Engineering Strategies for Enhanced Polyhydroxyalkanoate (PHA) Production in Cupriavidus necator","volume":"17","author":"Hectors","year":"2025","journal-title":"Polymers"},{"key":"10.1016\/j.ymben.2026.05.003_bib102","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1432-1033.1996.0674p.x","article-title":"Alcaligenes eutrophus possesses a second pyruvate dehydrogenase (E1)","volume":"237","author":"Hein","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.ymben.2026.05.003_bib103","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/1751-7915.12873","article-title":"Studies on the aerobic utilization of synthesis gas (syngas) by wild type and recombinant strains of Ralstonia eutropha H16","volume":"11","author":"Heinrich","year":"2018","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2023.120892","article-title":"Production of poly(3-hydroxybutyrate)\/poly(lactic acid) from industrial wastewater by wild-type Cupriavidus necator H16","volume":"249","author":"Hern\u00e1ndez-Herreros","year":"2024","journal-title":"Water Res."},{"key":"10.1016\/j.ymben.2026.05.003_bib105","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ijhydene.2025.03.198","article-title":"Effect of pH and salinity on photofermentative hydrogen and poly-hydroxybutyric acid production via Rhodobacter capsulatus YO3","volume":"118","author":"Ho\u015fafc\u0131","year":"2025","journal-title":"Int. J. Hydrogen Energy"},{"key":"10.1016\/j.ymben.2026.05.003_bib106","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ymben.2024.10.011","article-title":"Adaptive laboratory evolution and metabolic engineering of Cupriavidus necator for improved catabolism of volatile fatty acids","volume":"86","author":"Holmes","year":"2024","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib107","doi-asserted-by":"crossref","DOI":"10.1128\/aem.00515-25","article-title":"Insights into genetic determinants of volatile fatty acid catabolism in Cupriavidus necator H16","volume":"91","author":"Holmes","year":"2025","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib108","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1021\/acs.orglett.5b01154","article-title":"Asymmetric biocatalytic amination of ketones at the expense of NH3 and molecular hydrogen","volume":"17","author":"Holzer","year":"2015","journal-title":"Org. Lett."},{"key":"10.1016\/j.ymben.2026.05.003_bib109","doi-asserted-by":"crossref","DOI":"10.5812\/tms-129317","article-title":"Optimization of the alpha-amylase production from microbial source: a systematic review of experimental studies","volume":"2","author":"Hormoznejad","year":"2022","journal-title":"Trends in Med Sci"},{"key":"10.1016\/j.ymben.2026.05.003_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.124866","article-title":"Production of acetoin from renewable resources under heterotrophic and mixotrophic conditions","volume":"329","author":"H\u00e4rrer","year":"2021","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.124866","article-title":"Production of acetoin from renewable resources under heterotrophic and mixotrophic conditions","volume":"329","author":"H\u00e4rrer","year":"2021","journal-title":"Bioresour. Technol."},{"issue":"1","key":"10.1016\/j.ymben.2026.05.003_bib112","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-020-01812-9","article-title":"A novel gene expression system for Ralstonia eutropha based on the T7 promoter","volume":"20","author":"Hu","year":"2020","journal-title":"BMC Microbiol."},{"issue":"6","key":"10.1016\/j.ymben.2026.05.003_bib113","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1021\/acs.est.9b06755","article-title":"Microbial Protein out of Thin Air: Fixation of Nitrogen Gas by an Autotrophic Hydrogen-Oxidizing Bacterial Enrichment","volume":"54","author":"Hu","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib114","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.procbio.2014.12.004","article-title":"Development of a feeding strategy for high cell and PHA density fed-batch fermentation of Ralstonia eutropha H16 from organic acids and their salts","volume":"50","author":"Huschner","year":"2015","journal-title":"Process Biochem."},{"key":"10.1016\/j.ymben.2026.05.003_bib115","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s11814-016-0333-x","article-title":"Comparison of metabolite profiling of Ralstonia eutropha H16 phaBCA mutants grown on different carbon sources","volume":"34","author":"Im","year":"2017","journal-title":"Kor. J. Chem. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib116","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jbiosc.2013.07.016","article-title":"Modification of \u03b2-oxidation pathway in Ralstonia eutropha for production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from soybean oil","volume":"117","author":"Insomphun","year":"2014","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib117","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1205822","article-title":"Precise manipulation of chromosomes in vivo enables genome-wide codon replacement","volume":"333","author":"Isaacs","year":"2011","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.ymben.2026.05.003_bib118","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0922-338X(90)90041-T","article-title":"Batch culture of Alcaligenes eutrophus ATCC 17697T using recycled gas closed circuit culture system","volume":"69","author":"Ishizaki","year":"1990","journal-title":"J. Ferment. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib119","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0922-338X(91)90277-N","article-title":"Production of poly-\u03b2-hydroxybutyric acid from carbon dioxide by Alcaligenes eutrophus ATCC 17697T","volume":"71","author":"Ishizaki","year":"1991","journal-title":"J. Ferment. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib120","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jbiotec.2025.08.007","article-title":"Characterization of single cell protein produced by Cupriavidus necator grown on various nitrogen and carbon sources","volume":"408","author":"Ismail","year":"2025","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib121","doi-asserted-by":"crossref","DOI":"10.1128\/aem.00748-24","article-title":"The energy metabolism of Cupriavidus necator in different trophic conditions","volume":"90","author":"Jahn","year":"2024","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib122","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.69019","article-title":"Protein allocation and utilization in the versatile chemolithoautotroph Cupriavidus necator","volume":"10","author":"Jahn","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.ymben.2026.05.003_bib123","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ymben.2022.08.005","article-title":"Thermodynamic limitations of PHB production from formate and fructose in Cupriavidus necator","volume":"73","author":"Janasch","year":"2022","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib124","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3390\/fermentation8030125","article-title":"Establishing mixotrophic growth of Cupriavidus necator H16 on CO2 and volatile fatty acids","volume":"8","author":"Jawed","year":"2022","journal-title":"Fermentation"},{"key":"10.1016\/j.ymben.2026.05.003_bib125","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.70201","article-title":"Comparative genomic assessment of the Cupriavidus necator species for one-carbon based biomanufacturing","volume":"18","author":"Jespersen","year":"2025","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib126","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ymben.2025.04.001","article-title":"Enhancing oil feedstock utilization for high-yield low-carbon polyhydroxyalkanoates industrial bioproduction","volume":"91","author":"Jiang","year":"2025","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib127","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s12934-024-02615-7","article-title":"H2-driven xylitol production in Cupriavidus necator H16","volume":"23","author":"J\u00e4ms\u00e4","year":"2024","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib128","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13568-023-01577-0","article-title":"Inactivation of poly(3-hydroxybutyrate) (PHB) biosynthesis in \u201cKnallgas\u201d bacterium Xanthobacter sp. SoF1","volume":"13","author":"J\u00e4ms\u00e4","year":"2023","journal-title":"AMB Express"},{"key":"10.1016\/j.ymben.2026.05.003_bib129","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1021\/acssynbio.8b00136","article-title":"An engineered constitutive promoter set with broad activity range for Cupriavidus necator H16","volume":"7","author":"Johnson","year":"2018","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib130","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib131","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jbiotec.2024.10.001","article-title":"Recycling potential of Cupriavidus necator for life support in space: production of SCPs from volatile fatty acid and urea mixture","volume":"396","author":"Joris","year":"2024","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib132","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12934-015-0226-4","article-title":"An analysis of the changes in soluble hydrogenase and global gene expression in Cupriavidus necator (Ralstonia eutropha) H16 grown in heterotrophic diauxic batch culture","volume":"14","author":"Jugder","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib133","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2269","article-title":"Construction and use of a Cupriavidus necator H16 soluble hydrogenase promoter (PSH) fusion to gfp (green fluorescent protein)","volume":"4","author":"Jugder","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.ymben.2026.05.003_bib134","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0141-3910(03)00227-1","article-title":"High yield production of polyhydroxyalkanoates from soybean oil by Ralstonia eutropha and its recombinant strain","volume":"83","author":"Kahar","year":"2004","journal-title":"Polym. Degrad. Stabil."},{"key":"10.1016\/j.ymben.2026.05.003_bib135","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1007\/s13369-018-3118-1","article-title":"The use of palm oil-based waste cooking oil to enhance the production of polyhydroxybutyrate [P(3HB)] by Cupriavidus necator H16 strain","volume":"43","author":"Kamilah","year":"2018","journal-title":"Arabian J. Sci. Eng."},{"issue":"47","key":"10.1016\/j.ymben.2026.05.003_bib136","doi-asserted-by":"crossref","first-page":"15049","DOI":"10.1039\/D5GC03751D","article-title":"Hydrogen-driven, ATP-dependent biocatalytic reduction of carboxylic acids under non-explosive conditions","volume":"27","author":"Karava","year":"2025","journal-title":"Green Chem."},{"key":"10.1016\/j.ymben.2026.05.003_bib137","first-page":"1085","article-title":"The BioCyc collection of microbial genomes and metabolic pathways. Brief","volume":"20","author":"Karp","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ymben.2026.05.003_bib138","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1021\/acssynbio.3c00104","article-title":"Systematic part transfer by extending a modular toolkit to diverse bacteria","volume":"12","author":"Keating","year":"2023","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib139","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.733753","article-title":"From Biogas and Hydrogen to Microbial Protein Through Co-Cultivation of Methane and Hydrogen Oxidizing Bacteria","volume":"9","author":"Kerckhof","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib140","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tibtech.2020.09.004","article-title":"From acetate to bio-based products: underexploited potential for industrial biotechnology","volume":"39","author":"Kiefer","year":"2021","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib141","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12934-022-01962-7","article-title":"Engineering Cupriavidus necator H16 for enhanced lithoautotrophic poly(3-hydroxybutyrate) production from CO2","volume":"21","author":"Kim","year":"2022","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib142","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2025.1595440","article-title":"A promoter library for tuning gene expression in Cupriavidus necator under autotrophic conditions","volume":"13","author":"Kitagawa","year":"2025","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib143","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1128\/JB.182.10.2716-2724.2000","article-title":"The H(2) sensor of Ralstonia eutropha is a member of the subclass of regulatory [NiFe] hydrogenases","volume":"182","author":"Kleihues","year":"2000","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib144","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/jat.4621","article-title":"In vitro genotoxicological evaluation of protein-rich powder derived from Xanthobacter sp. SoF1","volume":"44","author":"Klinzing","year":"2024","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ymben.2026.05.003_bib145","doi-asserted-by":"crossref","DOI":"10.1264\/jsme2.ME24007","article-title":"The discovery of membrane vesicle biogenesis in the polyhydroxybutyrate-non-producing mutant strain of Cupriavidus necator H16","volume":"39","author":"Koh","year":"2024","journal-title":"Microb. Environ."},{"key":"10.1016\/j.ymben.2026.05.003_bib146","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1021\/pr101289v","article-title":"Analyses of soluble and membrane proteomes of Ralstonia eutropha H16 reveal major changes in the protein complement in adaptation to lithoautotrophy","volume":"10","author":"Kohlmann","year":"2011","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.ymben.2026.05.003_bib147","article-title":"Rhodo-box: a synthetic biology toolbox to facilitate metabolic engineering of Rhodobacter sphaeroides","author":"Kostanj\u0161ek","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.ymben.2026.05.003_bib148","article-title":"Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 11: suitability of taxonomic units notified to EFSA until September 2019","volume":"18","author":"Koutsoumanis","year":"2020","journal-title":"EFSA J."},{"key":"10.1016\/j.ymben.2026.05.003_bib149","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1002\/anie.201711302","article-title":"CO2 to terpenes: Autotrophic and electroautotrophic \u03b1-Humulene production with Cupriavidus necator","volume":"57","author":"Krieg","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ymben.2026.05.003_bib150","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1099\/00221287-130-8-1987","article-title":"Mixotrophic capabilities of Alcaligenes eutrophus","volume":"130","author":"K\u00e4rst","year":"1984","journal-title":"Microbiology (Reading, Engl)"},{"issue":"5","key":"10.1016\/j.ymben.2026.05.003_bib151","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/bioengineering9050204","article-title":"Lab-Scale Cultivation of Cupriavidus necator on Explosive Gas Mixtures: Carbon Dioxide Fixation into Polyhydroxybutyrate","volume":"9","author":"Lambauer","year":"2022","journal-title":"Bioengineering"},{"key":"10.1016\/j.ymben.2026.05.003_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcou.2024.102800","article-title":"Production of polyhydroxybutyrate from industrial flue gas by microbial electrosynthesis","volume":"83","author":"Langsdorf","year":"2024","journal-title":"J. CO2 Util."},{"key":"10.1016\/j.ymben.2026.05.003_bib153","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.copbio.2015.10.007","article-title":"Developing fermentative terpenoid production for commercial usage","volume":"37","author":"Leavell","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib154","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s12257-016-0197-2","article-title":"Microbial production of ethanol from acetate by engineered Ralstonia eutropha","volume":"21","author":"Lee","year":"2016","journal-title":"Biotechnol. Bioproc. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib155","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.4014\/jmb.1909.09002","article-title":"Production of bio-based isoprene by the mevalonate pathway cassette in Ralstonia eutropha","volume":"29","author":"Lee","year":"2019","journal-title":"J. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib156","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2015025118","article-title":"Photovoltaic-driven microbial protein production can use land and sunlight more efficiently than conventional crops","volume":"118","author":"Leger","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ymben.2026.05.003_bib157","first-page":"255","article-title":"The hydrogen-sensing apparatus in Ralstonia eutropha","volume":"4","author":"Lenz","year":"2002","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib158","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/bs.mie.2018.10.008","article-title":"O2-tolerant [NiFe]-hydrogenases of Ralstonia eutropha H16: physiology, molecular biology, purification, and biochemical analysis","volume":"613","author":"Lenz","year":"2018","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ymben.2026.05.003_bib159","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.95.21.12474","article-title":"A novel multicomponent regulatory system mediates H2 sensing in Alcaligenes eutrophus","volume":"95","author":"Lenz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ymben.2026.05.003_bib160","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12934-025-02840-8","article-title":"Characterizing the growth of PHA-producing microorganisms on short-chain carboxylic acids","volume":"24","author":"Leonhardt","year":"2025","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib161","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.1217643","article-title":"Integrated electromicrobial conversion of CO2 to higher alcohols","volume":"335","author":"Li","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ymben.2026.05.003_bib162","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s12934-020-01494-y","article-title":"Engineering the calvin-benson-bassham cycle and hydrogen utilization pathway of Ralstonia eutropha for improved autotrophic growth and polyhydroxybutyrate production","volume":"19","author":"Li","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib163","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s10295-019-02156-8","article-title":"Development of an autotrophic fermentation technique for the production of fatty acids using an engineered Ralstonia eutropha cell factory","volume":"46","author":"Li","year":"2019","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib164","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1021\/sb4001189","article-title":"A synthetic anhydrotetracycline-controllable gene expression system in Ralstonia eutropha H16","volume":"4","author":"Li","year":"2015","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib165","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1002\/bit.29043","article-title":"Rewiring Cupriavidus necator for enhanced polyhydroxybutyrate production via genetic toolkits and feeding strategy","volume":"122","author":"Lin","year":"2025","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib166","doi-asserted-by":"crossref","DOI":"10.1128\/MRA.00814-19","article-title":"Complete genome sequence of Cupriavidus necator H16 (DSM 428)","volume":"8","author":"Little","year":"2019","journal-title":"Microbiol. Resour. Announc."},{"key":"10.1016\/j.ymben.2026.05.003_bib167","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1126\/science.aaf5039","article-title":"Water splitting-biosynthetic system with CO2 reduction efficiencies exceeding photosynthesis","volume":"352","author":"Liu","year":"2016","journal-title":"Science"},{"issue":"25","key":"10.1016\/j.ymben.2026.05.003_bib168","doi-asserted-by":"crossref","first-page":"6450","DOI":"10.1073\/pnas.1706371114","article-title":"Ambient nitrogen reduction cycle using a hybrid inorganic\u2013biological system","volume":"114","author":"Liu","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ymben.2026.05.003_bib169","article-title":"A fermentation process for the production of poly(3-hydroxybutyrate) using waste cooking oil or waste fish oil as inexpensive carbon substrate","volume":"33","author":"Loan","year":"2022","journal-title":"Biotechnol. Rep."},{"key":"10.1016\/j.ymben.2026.05.003_bib170","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s10295-014-1439-y","article-title":"Study of metabolic network of Cupriavidus necator DSM 545 growing on glycerol by applying elementary flux modes and yield space analysis","volume":"41","author":"Lopar","year":"2014","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib171","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/s41587-025-02632-w","article-title":"Electro-microbial production techno-economic viability and environmental implications","volume":"43","author":"Lovat","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib172","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00253-012-4320-9","article-title":"Studies on the production of branched-chain alcohols in engineered Ralstonia eutropha","volume":"96","author":"Lu","year":"2012","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib173","first-page":"1267","article-title":"Engineering of an L-arabinose metabolic pathway in Ralstonia eutropha W50","volume":"53","author":"Lu","year":"2013","journal-title":"Weishengwu Xuebao"},{"key":"10.1016\/j.ymben.2026.05.003_bib174","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41929-023-01079-z","article-title":"Construction and modular implementation of the THETA cycle for synthetic CO2 fixation","volume":"6","author":"Luo","year":"2023","journal-title":"Nat. Catal."},{"key":"10.1016\/j.ymben.2026.05.003_bib175","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12934-020-01345-w","article-title":"CRISPR\/Cas9-deaminase enables robust base editing in Rhodobacter sphaeroides 2.4.1","volume":"19","author":"Luo","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib176","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.124169","article-title":"Trehalose production by Cupriavidus necator from CO2 and hydrogen gas","volume":"319","author":"L\u00f6we","year":"2021","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib177","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009729","article-title":"The complete multipartite genome sequence of Cupriavidus necator JMP134, a versatile pollutant degrader","volume":"5","author":"Lykidis","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.ymben.2026.05.003_bib178","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1080\/07388551.2023.2208285","article-title":"Bacterial genome reduction for optimal chassis of synthetic biology: a review","volume":"44","author":"Ma","year":"2024","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib179","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/MMBR.63.1.21-53.1999","article-title":"Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic","volume":"63","author":"Madison","year":"1999","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ymben.2026.05.003_bib180","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ymben.2017.05.007","article-title":"Over expression of GroESL in Cupriavidus necator for heterotrophic and autotrophic isopropanol production","volume":"42","author":"Marc","year":"2017","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib181","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijbiomac.2014.04.016","article-title":"Recovery of amorphous polyhydroxybutyrate granules from Cupriavidus necator cells grown on used cooking oil","volume":"71","author":"Martino","year":"2014","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymben.2026.05.003_bib182","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/s41589-018-0168-3","article-title":"Escherichia coli \u201cMarionette\u201d strains with 12 highly optimized small-molecule sensors","volume":"15","author":"Meyer","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib183","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1002\/bit.27788","article-title":"Gram-scale production of the sesquiterpene \u03b1-humulene with Cupriavidus necator","volume":"118","author":"Milker","year":"2021","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib184","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12934-021-01562-x","article-title":"First time \u03b2-farnesene production by the versatile bacterium Cupriavidus necator","volume":"20","author":"Milker","year":"2021","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib185","doi-asserted-by":"crossref","DOI":"10.1093\/jimb\/kuae008","article-title":"Expanding the synthetic biology toolbox of Cupriavidus necator for establishing fatty acid production","volume":"51","author":"Mishra","year":"2024","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib186","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1128\/AEM.00973-13","article-title":"Engineering of Ralstonia eutropha H16 for autotrophic and heterotrophic production of methyl ketones","volume":"79","author":"M\u00fcller","year":"2013","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib187","doi-asserted-by":"crossref","DOI":"10.1128\/aem.02560-24","article-title":"Adaptively evolved Methylorubrum extorquens with enhanced formate tolerance and its application in 3-hydroxypropionic acid production","volume":"91","author":"Mo","year":"2025","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib188","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/jat.4432","article-title":"Toxicological evaluation of protein powder derived from Cupriavidus necator","volume":"43","author":"Modica","year":"2023","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.ymben.2026.05.003_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2023.108264","article-title":"Cupriavidus necator as a platform for polyhydroxyalkanoate production: an overview of strains, metabolism, and modeling approaches","volume":"69","author":"Morlino","year":"2023","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ymben.2026.05.003_bib190","doi-asserted-by":"crossref","DOI":"10.1093\/jimb\/kuae052","article-title":"Purple non-sulfur bacteria for biotechnological applications","volume":"52","author":"Morrison","year":"2024","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib191","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12934-019-1255-1","article-title":"Efficient Cas9-based genome editing of Rhodobacter sphaeroides for metabolic engineering","volume":"18","author":"Mougiakos","year":"2019","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib192","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1021\/acssynbio.4c00869","article-title":"Synthetic genetic elements enable rapid characterization of inorganic carbon uptake systems in Cupriavidus necator H16","volume":"14","author":"Nakamura","year":"2025","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib193","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ymben.2020.09.002","article-title":"Valorization of CO2 through lithoautotrophic production of sustainable chemicals in Cupriavidus necator","volume":"62","author":"Nangle","year":"2020","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib194","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2025.133531","article-title":"Metabolic engineering of Ralstonia eutropha for enhanced poly(3-hydroxybutyrate) production from crude glycerol","volume":"441","author":"Ng","year":"2026","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiotec.2025.08.013","article-title":"Performance of a pilot scale pressurized deep-jet gas bioreactor for SCP production with Cupriavidus necator H16","volume":"408","author":"Novak","year":"2025","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib196","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1186\/1471-2164-14-745","article-title":"RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria","volume":"14","author":"Novichkov","year":"2013","journal-title":"BMC Genom."},{"key":"10.1016\/j.ymben.2026.05.003_bib197","article-title":"Improved fermentation strategies in a bioreactor for enhancing poly(3-hydroxybutyrate) (PHB) production by wild type Cupriavidus necator from fructose","volume":"7","author":"Nygaard","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.ymben.2026.05.003_bib198","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00253-014-6240-3","article-title":"Methylobacterium extorquens: methylotrophy and biotechnological applications","volume":"99","author":"Ochsner","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib199","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2859-12-2","article-title":"Hydrogen-driven asymmetric reduction of hydroxyacetone to (R)-1,2-propanediol by Ralstonia eutropha transformant expressing alcohol dehydrogenase from Kluyveromyces lactis","volume":"12","author":"Oda","year":"2013","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib200","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jbiotec.2025.07.020","article-title":"Development of a DNA endonuclease I-SceI-based scarless genome editing system for Cupriavidus necator","volume":"406","author":"Oh","year":"2025","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib201","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1046\/j.1365-2958.1999.01613.x","article-title":"Dual control by regulatory gene fdsR of the fds operon encoding the NAD+-linked formate dehydrogenase of Ralstonia eutropha","volume":"34","author":"Oh","year":"1999","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib202","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jbiosc.2011.09.014","article-title":"Identification of mutation points in Cupriavidus necator NCIMB 11599 and genetic reconstitution of glucose-utilization ability in wild strain H16 for polyhydroxyalkanoate production","volume":"113","author":"Orita","year":"2012","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib203","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/bit.27593","article-title":"The transition of Rhodobacter sphaeroides into a microbial cell factory","volume":"118","author":"Orsi","year":"2021","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib204","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10295-019-02201-6","article-title":"Characterization of heterotrophic growth and sesquiterpene production by Rhodobacter sphaeroides on a defined medium","volume":"46","author":"Orsi","year":"2019","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib205","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nbt.1614","article-title":"What is flux balance analysis?","volume":"28","author":"Orth","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib206","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13068-021-02063-0","article-title":"Synthetic biology toolkit for engineering cupriviadus necator H16 as a platform for CO2 valorization","volume":"14","author":"Pan","year":"2021","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.ymben.2026.05.003_bib207","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1049\/enb.2020.0005","article-title":"Hydrogen oxidising bacteria for production of single\u2010cell protein and other food and feed ingredients","volume":"4","author":"Pander","year":"2020","journal-title":"Eng. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib208","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.tibtech.2021.01.001","article-title":"Metabolic engineering of Cupriavidus necator H16 for sustainable biofuels from CO2","volume":"39","author":"Panich","year":"2021","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib209","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2024.131214","article-title":"Functional plasticity of HCO3- uptake and CO2 fixation in Cupriavidus necator H16","volume":"410","author":"Panich","year":"2024","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib210","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s002030050609","article-title":"Aerobic chemolithoautotrophic growth and RubisCO function in Rhodobacter capsulatus and a spontaneous gain of function mutant of Rhodobacter sphaeroides","volume":"170","author":"Paoli","year":"1998","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib211","first-page":"193","article-title":"Development of a gene knockout system for Ralstonia eutropha H16 based on the broad-host-range vector expressing a mobile group II intron","volume":"309","author":"Park","year":"2010","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.ymben.2026.05.003_bib212","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1752-0509-5-101","article-title":"Genome-scale reconstruction and in silico analysis of the Ralstonia eutropha H16 for polyhydroxyalkanoate synthesis, lithoautotrophic growth, and 2-methyl citric acid production","volume":"5","author":"Park","year":"2011","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib213","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130360","article-title":"Tailored polyhydroxyalkanoate production from renewable non-fatty acid carbon sources using engineered Cupriavidus necator H16","volume":"263","author":"Park","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymben.2026.05.003_bib214","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ymben.2013.08.002","article-title":"Metabolic engineering of Ralstonia eutropha for the biosynthesis of 2-hydroxyacid-containing polyhydroxyalkanoates","volume":"20","author":"Park","year":"2013","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010106","article-title":"A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications","volume":"18","author":"Pearcy","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib216","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cell.2016.05.003","article-title":"A comprehensive, CRISPR-based functional analysis of essential genes in bacteria","volume":"165","author":"Peters","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ymben.2026.05.003_bib217","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/nbt1244","article-title":"Genome sequence of the bioplastic-producing \u201cKnallgas\u201d bacterium Ralstonia eutropha H16","volume":"24","author":"Pohlmann","year":"2006","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib218","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12934-019-1251-5","article-title":"Growth of the facultative chemolithoautotroph Ralstonia eutropha on organic waste materials: growth characteristics, redox regulation and hydrogenase activity","volume":"18","author":"Poladyan","year":"2019","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib219","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.nbt.2012.11.019","article-title":"Polyhydroxyalkanoate biosynthesis by Hydrogenophaga pseudoflava DSM1034 from structurally unrelated carbon sources","volume":"30","author":"Povolo","year":"2013","journal-title":"N. Biotech."},{"key":"10.1016\/j.ymben.2026.05.003_bib220","doi-asserted-by":"crossref","first-page":"4853","DOI":"10.1002\/cctc.202000763","article-title":"Dihydrogen\u2010driven NADPH recycling in imine reduction and p450\u2010catalyzed oxidations mediated by an engineered o2 \u2010tolerant hydrogenase","volume":"12","author":"Preissler","year":"2020","journal-title":"ChemCatChem"},{"key":"10.1016\/j.ymben.2026.05.003_bib221","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1128\/jb.174.20.6590-6599.1992","article-title":"Identification and molecular characterization of the acetyl coenzyme A synthetase gene (acoE) of Alcaligenes eutrophus","volume":"174","author":"Priefert","year":"1992","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib222","doi-asserted-by":"crossref","DOI":"10.1007\/BF00176656","article-title":"Lactose- and galactose-utilizing strains of poly(hydroxyalkanoic acid)-accumulating Alcaligenes eutrophus and Pseudomonas saccharophila obtained by recombinant DNA technology","volume":"33","author":"Pries","year":"1990","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib223","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41576-021-00409-w","article-title":"A new era in functional genomics screens","volume":"23","author":"Przybyla","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ymben.2026.05.003_bib224","series-title":"Engineering Mixotrophy in the Chemolithoautotrophic Cupriavidus necator through Hydrogenase Induction","author":"Pu","year":"2026"},{"key":"10.1016\/j.ymben.2026.05.003_bib225","doi-asserted-by":"crossref","DOI":"10.1016\/j.nexus.2025.100601","article-title":"Biomanufacturing from gaseous C1 feedstocks: A perspective on opportunities and challenges","volume":"20","author":"Rachbauer","year":"2025","journal-title":"Energy Nexus"},{"key":"10.1016\/j.ymben.2026.05.003_bib226","article-title":"Design and analysis of synthetic carbon fixation pathways based on novel enzymatic reactions","author":"Rainaldi","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.ymben.2026.05.003_bib227","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3109\/10242422.2011.615393","article-title":"Systematic evaluation of the dihydrogen-oxidising and NAD+ -reducing soluble [NiFe]-hydrogenase from Ralstonia eutropha H16 as a cofactor regeneration catalyst","volume":"29","author":"Ratzka","year":"2011","journal-title":"Biocatal. Biotransform."},{"key":"10.1016\/j.ymben.2026.05.003_bib228","doi-asserted-by":"crossref","first-page":"10540","DOI":"10.1039\/D2CC02411J","article-title":"A hydrogen-driven biocatalytic approach to recycling synthetic analogues of NAD(P)H","volume":"58","author":"Reeve","year":"2022","journal-title":"Chem. Commun."},{"key":"10.1016\/j.ymben.2026.05.003_bib229","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/nrmicro2354","article-title":"Bacterial polymers: biosynthesis, modifications and applications","volume":"8","author":"Rehm","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib230","first-page":"91","article-title":"Ralstonia eutropha strain H16 as model organism for PHA metabolism and for biotechnological production of technically interesting biopolymers","volume":"16","author":"Reinecke","year":"2009","journal-title":"J. Mol. Microbiol. Biotechnol."},{"issue":"3","key":"10.1016\/j.ymben.2026.05.003_bib231","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1128\/jb.107.3.712-717.1971","article-title":"Bicarbonate Requirement for Elimination of the Lag Period of Hydrogenomonas eutropha","volume":"107","author":"Repaske","year":"1971","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib232","series-title":"Biohydrogen","year":"2015"},{"key":"10.1016\/j.ymben.2026.05.003_bib233","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2024.131846","article-title":"Long-chain fatty acids as sole carbon source in polyhydroxyalkanoates production by Cupriavidus necator H16","volume":"417","author":"Ridella","year":"2025","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib234","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00253-013-5430-8","article-title":"Lipid and fatty acid metabolism in ralstonia eutropha: relevance for the biotechnological production of value-added products","volume":"98","author":"Riedel","year":"2014","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib235","article-title":"A robust isotope ratio LC-MS\/MS workflow for high-throughput metabolic profiling of bacteria","author":"Rocha","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.ymben.2026.05.003_bib236","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/BF01570161","article-title":"Chlorate and nitrate reduction in the phototrophic bacteriaRhodobacter capsulatus andRhodobacter sphaeroides","volume":"29","author":"Rold\u00e1n","year":"1994","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib237","doi-asserted-by":"crossref","first-page":"12160","DOI":"10.1039\/D3SC01718D","article-title":"Biocatalytic reductive amination as a route to isotopically labelled amino acids suitable for analysis of large proteins by NMR","volume":"14","author":"Rowbotham","year":"2023","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ymben.2026.05.003_bib238","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.130187","article-title":"Development of Cupriavidus necator H16 as a host for heterologous production of formate dehydrogenase I of methylorubrum extorquens: possibilities and limitations","volume":"394","author":"Ryu","year":"2024","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib239","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1097-0290(19970705)55:1<28::AID-BIT4>3.0.CO;2-Z","article-title":"Production of poly(3-hydroxybutyrate) by high cell density fed-batch culture of alcaligenes eutrophus with phospate limitation","volume":"55","author":"Ryu","year":"1997","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2020.124021","article-title":"Impact of substrate and growth conditions on microbial protein production and composition","volume":"317","author":"Sakarika","year":"2020","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib241","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ymben.2022.10.014","article-title":"Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid","volume":"74","author":"Salinas","year":"2022","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib242","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nbt.1568","article-title":"Automated design of synthetic ribosome binding sites to control protein expression","volume":"27","author":"Salis","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib243","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymben.2019.08.004","article-title":"The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology","volume":"56","author":"Sandberg","year":"2019","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib244","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s00253-024-13284-2","article-title":"Synthetic biology toolkit of Ralstonia eutropha (Cupriavidus necator)","volume":"108","author":"Santolin","year":"2024","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib245","doi-asserted-by":"crossref","first-page":"5536","DOI":"10.1038\/s41467-019-13483-w","article-title":"The Escherichia coli transcriptome mostly consists of independently regulated modules","volume":"10","author":"Sastry","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymben.2026.05.003_bib246","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1111\/febs.13774","article-title":"RubisCO selection using the vigorously aerobic and metabolically versatile bacterium Ralstonia eutropha","volume":"283","author":"Satagopan","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.ymben.2026.05.003_bib247","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jbiosc.2013.05.026","article-title":"Construction of a stable plasmid vector for industrial production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by a recombinant Cupriavidus necator H16 strain","volume":"116","author":"Sato","year":"2013","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib248","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1021\/sb500221v","article-title":"A set of versatile brick vectors and promoters for the assembly, expression, and integration of synthetic operons in Methylobacterium extorquens AM1 and other alphaproteobacteria","volume":"4","author":"Schada von Borzyskowski","year":"2015","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib249","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0378-1119(94)90324-7","article-title":"Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum","volume":"145","author":"Sch\u00e4fer","year":"1994","journal-title":"Gene"},{"key":"10.1016\/j.ymben.2026.05.003_bib250","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/191463a0","article-title":"Formation and utilization of Poly-\u03b2-Hydroxybutyric acid by knallgas bacteria (Hydrogenomonas)","volume":"191","author":"Schlegel","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.ymben.2026.05.003_bib251","first-page":"249","article-title":"Verwertung von glucose durch eine mutante von Hydrogenomonas H16","author":"Schlegel","year":"1965","journal-title":"Biochim. Z."},{"key":"10.1016\/j.ymben.2026.05.003_bib252","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.113018","article-title":"Isopropanol production from carbon dioxide by Cupriavidus necator using a zero-gap cell with culture broth as catholyte","volume":"28","author":"Schoenmakers","year":"2025","journal-title":"iScience"},{"issue":"31","key":"10.1016\/j.ymben.2026.05.003_bib253","doi-asserted-by":"crossref","first-page":"40973","DOI":"10.1021\/acsami.4c07363","article-title":"Integrated Proteomics and Metabolomics Reveal Altered Metabolic Regulation of Xanthobacter autotrophicus under Electrochemical Water-Splitting Conditions","volume":"16","author":"Schuman","year":"2024","journal-title":"ACS Appl. Mater. Interf."},{"key":"10.1016\/j.ymben.2026.05.003_bib254","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1126\/science.aah5237","article-title":"A synthetic pathway for the fixation of carbon dioxide in vitro","volume":"354","author":"Schwander","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ymben.2026.05.003_bib255","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1128\/JB.181.18.5684-5692.1999","article-title":"Positive transcriptional feedback controls hydrogenase expression in Alcaligenes eutrophus H16","volume":"181","author":"Schwartz","year":"1999","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib256","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-2836(03)00894-5","article-title":"Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H2-based lithoautotrophy and anaerobiosis","volume":"332","author":"Schwartz","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib257","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1002\/pmic.200900333","article-title":"A proteomic view of the facultatively chemolithoautotrophic lifestyle of Ralstonia eutropha H16","volume":"9","author":"Schwartz","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/j.ymben.2026.05.003_bib258","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1128\/AEM.02700-09","article-title":"Requirements for construction of a functional hybrid complex of photosystem I and [NiFe]-hydrogenase","volume":"76","author":"Schwarze","year":"2010","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib259","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13568-016-0206-z","article-title":"Global changes in the proteome of Cupriavidus necator H16 during poly-(3-hydroxybutyrate) synthesis from various biodiesel by-product substrates","volume":"6","author":"Sharma","year":"2016","journal-title":"AMB Express"},{"key":"10.1016\/j.ymben.2026.05.003_bib260","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/1471-2180-13-169","article-title":"Detection of phase-dependent transcriptomic changes and Rubisco-mediated CO2 fixation into poly (3-hydroxybutyrate) under heterotrophic condition in Ralstonia eutropha H16 based on RNA-seq and gene deletion analyses","volume":"13","author":"Shimizu","year":"2013","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib261","doi-asserted-by":"crossref","DOI":"10.1038\/srep11617","article-title":"New insight into the role of the calvin cycle: reutilization of CO2 emitted through sugar degradation","volume":"5","author":"Shimizu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymben.2026.05.003_bib262","doi-asserted-by":"crossref","DOI":"10.1038\/srep27961","article-title":"Corrigendum: new insight into the role of the calvin cycle: reutilization of CO2 emitted through sugar degradation","volume":"6","author":"Shimizu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymben.2026.05.003_bib263","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1128\/AEM.01977-10","article-title":"Extension of the substrate utilization range of Ralstonia eutropha strain H16 by metabolic engineering to include mannose and glucose","volume":"77","author":"Sichwart","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib264","author":"Sinisalo"},{"key":"10.1016\/j.ymben.2026.05.003_bib265","doi-asserted-by":"crossref","DOI":"10.1002\/biot.202300577","article-title":"Fast-track adaptive laboratory evolution of Cupriavidus necator H16 with divalent metal cations","volume":"19","author":"Sitompul","year":"2024","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.ymben.2026.05.003_bib266","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1101\/gr.145600","article-title":"Biosynthesis of isoprenoids via mevalonate in archaea: the lost pathway","volume":"10","author":"Smit","year":"2000","journal-title":"Genome Res."},{"key":"10.1016\/j.ymben.2026.05.003_bib267","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2021.125693","article-title":"Chemoautotroph Cupriavidus necator as a potential game-changer for global warming and plastic waste problem: a review","volume":"340","author":"Sohn","year":"2021","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib268","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1021\/acssynbio.4c00806","article-title":"Xanthomoclo\u2500a robust modular cloning genetic toolkit for the genera xanthobacter and roseixanthobacter","volume":"14","author":"Soltysiak","year":"2025","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib269","doi-asserted-by":"crossref","first-page":"5925","DOI":"10.1128\/AEM.68.12.5925-5932.2002","article-title":"A novel high-cell-density protein expression system based on Ralstonia eutropha","volume":"68","author":"Srinivasan","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib270","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/bit.10756","article-title":"Production of recombinant proteins using multiple-copy gene integration in high-cell-density fermentations of Ralstonia eutropha","volume":"84","author":"Srinivasan","year":"2003","journal-title":"Biotechnol. Bioeng."},{"key":"10.1016\/j.ymben.2026.05.003_bib271","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1002\/cssc.202001235","article-title":"From CO2 to bioplastic - coupling the electrochemical CO2 reduction with a microbial product generation by Drop-in electrolysis","volume":"13","author":"St\u00f6ckl","year":"2020","journal-title":"ChemSusChem"},{"key":"10.1016\/j.ymben.2026.05.003_bib272","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1007\/BF00262457","article-title":"Excretion of pyruvate by mutants of Alcaligenes eutrophus, which are impaired in the accumulation of poly(\u03b2-hydroxybutyric acid) (PHB), under conditions permitting synthesis of PHB","volume":"31","author":"Steinb\u00fcchel","year":"1989","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib273","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01873-21","article-title":"Insights into the degradation of medium-chain-length dicarboxylic acids in Cupriavidus necator H16 reveal \u03b2-Oxidation differences between dicarboxylic acids and fatty acids","volume":"88","author":"Strittmatter","year":"2022","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib274","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1007\/s00253-022-11842-0","article-title":"The reliance of glycerol utilization by Cupriavidus necator on CO2 fixation and improved glycerol catabolism","volume":"106","author":"Strittmatter","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib275","doi-asserted-by":"crossref","DOI":"10.1128\/aem.01428-22","article-title":"Medium-chain-length fatty acid catabolism in Cupriavidus necator H16: transcriptome sequencing reveals differences from long-chain-length fatty acid \u03b2-Oxidation and involvement of several homologous genes","volume":"89","author":"Strittmatter","year":"2023","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib276","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/pr8060657","article-title":"Dynamic metabolic analysis of Cupriavidus necator DSM545 producing Poly(3-hydroxybutyric acid) from glycerol","volume":"8","author":"Sun","year":"2020","journal-title":"Processes"},{"key":"10.1016\/j.ymben.2026.05.003_bib277","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1128\/jb.172.1.424-430.1990","article-title":"Glycerol facilitator of Escherichia coli: cloning of glpF and identification of the glpF product","volume":"172","author":"Sweet","year":"1990","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib278","article-title":"Autotrophic production of the sesquiterpene \u03b1-Humulene with Cupriavidus necator in a controlled bioreactor","volume":"10","author":"Sydow","year":"2023","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.ymben.2026.05.003_bib279","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/elsc.201600252","article-title":"Growth medium and electrolyte-how to combine the different requirements on the reaction solution in bioelectrochemical systems using Cupriavidus necator","volume":"17","author":"Sydow","year":"2017","journal-title":"Eng. Life Sci."},{"key":"10.1016\/j.ymben.2026.05.003_bib280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiotec.2017.10.002","article-title":"Expanding the genetic tool box for Cupriavidus necator by a stabilized L-rhamnose inducible plasmid system","volume":"263","author":"Sydow","year":"2017","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib281","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/bit.260450312","article-title":"Production of poly(D-3-hydroxybutyrate) from CO(2), H(2), and O(2) by high cell density autotrophic cultivation of Alcaligenes eutrophus","volume":"45","author":"Tanaka","year":"1995","journal-title":"Biotechnol. Bioeng."},{"issue":"11","key":"10.1016\/j.ymben.2026.05.003_bib282","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3390\/bioengineering10111304","article-title":"Production of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from CO2 via pH-Stat Jar Cultivation of an Engineered Hydrogen-Oxidizing Bacterium Cupriavidus necator","volume":"10","author":"Tanaka","year":"2023","journal-title":"Bioengineering"},{"key":"10.1016\/j.ymben.2026.05.003_bib283","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ymben.2020.04.009","article-title":"Metabolic engineering of Cupriavidus necator H16 for improved chemoautotrophic growth and PHB production under oxygen-limiting conditions","volume":"61","author":"Tang","year":"2020","journal-title":"Metab. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib284","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2024.131744","article-title":"Production of \u03b1-amylase from gluconate and carbon dioxide by protein synthesis and secretion optimization in Cupriavidus necator H16","volume":"416","author":"Tang","year":"2025","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib285","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2023.108183","article-title":"Problems and corresponding strategies for converting CO2 into value-added products in Cupriavidus necator H16 cell factories","volume":"67","author":"Tang","year":"2023","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ymben.2026.05.003_bib286","doi-asserted-by":"crossref","DOI":"10.1002\/biot.201700081","article-title":"An efficient transformation method for the bioplastic-producing \u201cKnallgas\u201d bacterium Ralstonia eutropha H16","volume":"12","author":"Tee","year":"2017","journal-title":"Biotechnol. J."},{"key":"10.1016\/j.ymben.2026.05.003_bib287","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41428-020-00409-3","article-title":"The gene dosage effect of carbonic anhydrase on the biosynthesis of poly(3-hydroxybutyrate) under autotrophic and mixotrophic culture conditions","volume":"53","author":"Thorbecke","year":"2021","journal-title":"Polym. J."},{"key":"10.1016\/j.ymben.2026.05.003_bib288","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mib.2020.11.005","article-title":"Bacterial CRISPR screens for gene function","volume":"59","author":"Todor","year":"2021","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib289","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1073\/pnas.1424872112","article-title":"Efficient solar-to-fuels production from a hybrid microbial-water-splitting catalyst system","volume":"112","author":"Torella","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ymben.2026.05.003_bib290","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40643-019-0282-4","article-title":"Metabolic pathway analysis for in silico design of efficient autotrophic production of advanced biofuels","volume":"6","author":"Unrean","year":"2019","journal-title":"Bioresour. Bioprocess."},{"key":"10.1016\/j.ymben.2026.05.003_bib291","article-title":"Optimization of a T7 RNA polymerase expression system for high-yield protein production in Cupriavidus necator H16","author":"Vajente","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.ymben.2026.05.003_bib292","doi-asserted-by":"crossref","DOI":"10.1101\/2024.05.27.596136","article-title":"Using Cupriavidus necator H16 to provide a roadmap for increasing electroporation efficiency in nonmodel bacteria","author":"Vajente","year":"2024","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib293","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/bs.mie.2025.01.079","article-title":"Enzyme expression in Cupriavidus necator H16 for whole-cell biocatalysis","volume":"714","author":"Vajente","year":"2025","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.ymben.2026.05.003_bib294","doi-asserted-by":"crossref","first-page":"47988","DOI":"10.1007\/s11356-022-20637-9","article-title":"An updated review on advancement in fermentative production strategies for biobutanol using clostridium spp","volume":"29","author":"Vamsi Krishna","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.ymben.2026.05.003_bib295","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nmeth.1377","article-title":"Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms","volume":"6","author":"van Opijnen","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymben.2026.05.003_bib296","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1021\/acssynbio.4c00455","article-title":"Creating a genetic toolbox for the carbon-fixing, nitrogen-fixing and dehalogenating bacterium Xanthobacter autotrophicus","volume":"13","author":"Van Voorhis","year":"2024","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib297","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1099\/ijs.0.63247-0","article-title":"Taxonomy of the genus Cupriavidus: a tale of lost and found","volume":"54","author":"Vandamme","year":"2004","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib298","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2191-0855-1-11","article-title":"Production of polyhydroxyalkanoates from waste frying oil by Cupriavidus necator","volume":"1","author":"Verlinden","year":"2011","journal-title":"AMB Express"},{"key":"10.1016\/j.ymben.2026.05.003_bib299","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/j.1365-2672.2007.03335.x","article-title":"Bacterial synthesis of biodegradable polyhydroxyalkanoates","volume":"102","author":"Verlinden","year":"2007","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib300","doi-asserted-by":"crossref","DOI":"10.1016\/j.mib.2023.102353","article-title":"Emergent CRISPR-Cas-based technologies for engineering non-model bacteria","volume":"75","author":"Volke","year":"2023","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib301","doi-asserted-by":"crossref","first-page":"978","DOI":"10.3109\/07388551.2015.1079698","article-title":"Engineering the heterotrophic carbon sources utilization range of Ralstonia eutropha H16 for applications in biotechnology","volume":"36","author":"Volodina","year":"2016","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib302","first-page":"797","article-title":"Biosynthesis of multicomponent polyhydroxyalkanoates by Wautersia eutropha","volume":"76","author":"Volova","year":"2007","journal-title":"Mikrobiologiia"},{"key":"10.1016\/j.ymben.2026.05.003_bib303","first-page":"624","article-title":"[Characteristics of proteins synthesized by hydrogen-oxidizing microorganisms]","volume":"46","author":"Volova","year":"2010","journal-title":"Prikl. Biokhim. Mikrobiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib304","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature08187","article-title":"Programming cells by multiplex genome engineering and accelerated evolution","volume":"460","author":"Wang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ymben.2026.05.003_bib305","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2024.130538","article-title":"Heterotrophic and autotrophic production of L-isoleucine and L-valine by engineered Cupriavidus necator H16","volume":"398","author":"Wang","year":"2024","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib306","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.127806","article-title":"Direct conversion of carbon dioxide to glucose using metabolically engineered Cupriavidus necator","volume":"362","author":"Wang","year":"2022","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib307","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.129024","article-title":"Production of N-acetylglucosamine from carbon dioxide by engineering Cupriavidus necator H16","volume":"379","author":"Wang","year":"2023","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib308","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.128321","article-title":"Engineering Cupriavidus necator H16 for heterotrophic and autotrophic production of myo-inositol","volume":"368","author":"Wang","year":"2023","journal-title":"Bioresource Technology"},{"key":"10.1016\/j.ymben.2026.05.003_bib309","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11274-024-04200-x","article-title":"Unlocking the potential of Cupriavidus necator H16 as a platform for bioproducts production from carbon dioxide","volume":"40","author":"Wang","year":"2024","journal-title":"World J. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib310","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2025.108516","article-title":"Recent advances in synthetic biology toolkits and metabolic engineering of Ralstonia eutropha H16 for production of value-added chemicals","volume":"79","author":"Wang","year":"2025","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ymben.2026.05.003_bib311","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1021\/acssynbio.3c00664","article-title":"Establishing CRISPRi for programmable gene repression and genome evolution in Cupriavidus necator","volume":"13","author":"Wang","year":"2024","journal-title":"ACS Synth. Biol."},{"issue":"3","key":"10.1016\/j.ymben.2026.05.003_bib312","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0032-9592(00)00169-2","article-title":"Kinetic analysis on inhibited growth and poly(3-hydroxybutyrate) formation of Alcaligenes eutrophus on acetate under nutrient-rich conditions","volume":"36","author":"Wang","year":"2000","journal-title":"Process Biochem."},{"issue":"3","key":"10.1016\/j.ymben.2026.05.003_bib313","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.jim.7000097","article-title":"Kinetic analysis on formation of poly(3-hydroxybutyrate) from acetic acid by Ralstonia eutropha under chemically defined conditions","volume":"26","author":"Wang","year":"2001","journal-title":"J. Indust. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib314","first-page":"2183","article-title":"Methanol dissimilation in Xanthobacter H4-14: activities, induction and comparison to Pseudomonas AM1 and Paracoccus denitrificans","volume":"131","author":"Weaver","year":"1985","journal-title":"J. Gen. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiotec.2025.03.011","article-title":"Comparative characterisation of autotrophic and heterotrophic isopropanol formation by Cupriavidus necator in shake flasks","volume":"403","author":"Weickardt","year":"2025","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib316","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12934-025-02643-x","article-title":"Physiology-informed use of Cupriavidus necator in biomanufacturing: a review of advances and challenges","volume":"24","author":"Weldon","year":"2025","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.ymben.2026.05.003_bib317","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1013379","article-title":"Mixotrophy for carbon-conserving waste upcycling","volume":"21","author":"Weldon","year":"2025","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib318","first-page":"169","article-title":"Aerobic utilization of methanol for microbial growth and production","volume":"180","author":"Wendisch","year":"2022","journal-title":"Adv. Biochem. Eng. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib319","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2023.128762","article-title":"Co-conversion of lignocellulose-derived glucose, xylose, and aromatics to polyhydroxybutyrate by metabolically engineered Cupriavidus necator","volume":"374","author":"Weng","year":"2023","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.ymben.2026.05.003_bib320","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1178536","article-title":"Improving carbon monoxide tolerance of Cupriavidus necator H16 through adaptive laboratory evolution","volume":"11","author":"Wickham-Smith","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib321","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00446833","article-title":"Enrichment and isolation of nitrogen fixing hydrogen bacteria","volume":"107","author":"Wiegel","year":"1976","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ymben.2026.05.003_bib322","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s13068-017-0952-4","article-title":"Comprehensive characterization of toxicity of fermentative metabolites on microbial growth","volume":"10","author":"Wilbanks","year":"2017","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.ymben.2026.05.003_bib323","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00406429","article-title":"Untersuchungen ber wachstum und speicherstoffsynthese von hydrogenomonas","volume":"43","author":"Wilde","year":"1962","journal-title":"Arch. Mikrobiol."},{"issue":"2","key":"10.1016\/j.ymben.2026.05.003_bib324","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00405198","article-title":"Oxygen tolerance of strictly aerobic hydrogen-oxidizing bacteria","volume":"48","author":"Wilde","year":"1982","journal-title":"Antonie van Leeuwenhoek"},{"key":"10.1016\/j.ymben.2026.05.003_bib325","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1099\/00207713-39-3-319","volume":"39","author":"Willems","year":"1989","journal-title":"Int. J. Syst. Bacteriol."},{"key":"10.1016\/j.ymben.2026.05.003_bib326","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1099\/mic.0.2007\/011346-0","article-title":"Identification of proteins involved in formaldehyde metabolism by Rhodobacter sphaeroides","volume":"154","author":"Wilson","year":"2008","journal-title":"Microbiology (Reading, Engl)"},{"key":"10.1016\/j.ymben.2026.05.003_bib327","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.132943","article-title":"Efficient production of lycopene from CO2 via microbial electrosynthesis","volume":"430","author":"Wu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.ymben.2026.05.003_bib328","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s44296-024-00008-w","article-title":"Microbial conversion of carbon dioxide into premium medium-chain fatty acids: the progress, challenges, and prospects","volume":"2","author":"Wu","year":"2024","journal-title":"npj Mater. Sustain."},{"key":"10.1016\/j.ymben.2026.05.003_bib329","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2026.108810","article-title":"Biomanufacturing polyhydroxyalkanoates from CO2: A critical review of advances, challenges, and solutions for autotrophic and hybrid systems","volume":"88","author":"Wu","year":"2026","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ymben.2026.05.003_bib330","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13068-018-1170-4","article-title":"Genome editing of Ralstonia eutropha using an electroporation-based CRISPR-Cas9 technique","volume":"11","author":"Xiong","year":"2018","journal-title":"Biotechnol. Biofuels"},{"key":"10.1016\/j.ymben.2026.05.003_bib331","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1348-0421.1995.tb03275.x","article-title":"Transfer of two burkholderia and an alcaligenes species to Ralstonia Gen. Nov","volume":"39","author":"Yabuuchi","year":"1995","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.ymben.2026.05.003_bib332","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01581-17","article-title":"Time-resolved transposon insertion sequencing reveals genome-wide fitness dynamics during infection","volume":"8","author":"Yang","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.ymben.2026.05.003_bib333","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1007\/s00253-010-2699-8","article-title":"Optimization of growth media components for polyhydroxyalkanoate (PHA) production from organic acids by Ralstonia eutropha","volume":"87","author":"Yang","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib334","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ijbiomac.2021.02.092","article-title":"Metabolic engineering of methylorubrum extorquens AM1 for poly (3-hydroxybutyrate-co-3-hydroxyvalerate) production using formate","volume":"177","author":"Yoon","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymben.2026.05.003_bib335","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0032-9592(01)00264-3","article-title":"Kinetics modeling of inhibition and utilization of mixed volatile fatty acids in the formation of polyhydroxyalkanoates by Ralstonia eutropha","volume":"37","author":"Yu","year":"2002","journal-title":"Process Biochem."},{"issue":"3","key":"10.1016\/j.ymben.2026.05.003_bib336","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/fermentation4030063","article-title":"Gas Fermentation Enhancement for Chemolithotrophic Growth of Cupriavidus necator on Carbon Dioxide","volume":"4","author":"Yu","year":"2018","journal-title":"Fermentation"},{"key":"10.1016\/j.ymben.2026.05.003_bib337","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s11814-013-0190-9","article-title":"Production of polyhydroxyalkanoates by Ralstonia eutropha from volatile fatty acids","volume":"30","author":"Yun","year":"2013","journal-title":"Kor. J. Chem. Eng."},{"key":"10.1016\/j.ymben.2026.05.003_bib338","article-title":"A review on enhancing Cupriavidus necator fermentation for Poly(3-hydroxybutyrate) (PHB) production from low-cost carbon sources","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib339","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1007\/s12010-022-03887-8","article-title":"The carbon source effect on the production of Ralstonia eutropha H16 and proteomic response underlying targeting the bioconversion with solar fuels","volume":"194","author":"Zhang","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib340","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1021\/acssynbio.1c00146","article-title":"High-yielding terpene-based biofuel production in Rhodobacter capsulatus","volume":"10","author":"Zhang","year":"2021","journal-title":"ACS Synth. Biol."},{"key":"10.1016\/j.ymben.2026.05.003_bib341","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1111\/1751-7915.13805","article-title":"CRISPR\/Cas12a-mediated genome engineering in the photosynthetic bacterium Rhodobacter capsulatus","volume":"14","author":"Zhang","year":"2021","journal-title":"Microb. Biotechnol."},{"key":"10.1016\/j.ymben.2026.05.003_bib342","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1039\/D3SU00126A","article-title":"A review on polyhydroxyalkanoate (PHA) production through the use of lignocellulosic biomass","volume":"1","author":"Zytner","year":"2023","journal-title":"RSC Sustain."}],"container-title":["Metabolic Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096717626000637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096717626000637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:03:55Z","timestamp":1785413035000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096717626000637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":341,"alternative-id":["S1096717626000637"],"URL":"https:\/\/doi.org\/10.1016\/j.ymben.2026.05.003","relation":{},"ISSN":["1096-7176"],"issn-type":[{"value":"1096-7176","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The state of metabolic engineering in the versatile bacterial cell factory Cupriavidus necator H16","name":"articletitle","label":"Article Title"},{"value":"Metabolic Engineering","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymben.2026.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of International Metabolic Engineering Society.","name":"copyright","label":"Copyright"}],"article-number":"102479"}}