{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:42:19Z","timestamp":1792122139798,"version":"4.4.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013041","name":"Shiraz University of Medical Sciences Vice Chancellor of Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["27980"],"award-info":[{"award-number":["27980"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Methods"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.ymeth.2025.02.011","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T00:15:38Z","timestamp":1740615338000},"page":"19-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Chitosan-based xerogel film incorporating Nystatin: Synthesis, structural Analysis, and biological evaluation"],"prefix":"10.1016","volume":"237","author":[{"given":"Zahra","family":"Zareshahrabadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Shenavari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forough","family":"Karami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hashem","family":"Hashempur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khorram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Arabimonfard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mohammad","family":"Tamaddon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamhossein","family":"Yousefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiar","family":"Zomorodian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymeth.2025.02.011_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121156","article-title":"Chitosan-based emulgel and xerogel film containing Thymus pubescens essential oil as a potential wound dressing","volume":"318","author":"Karami","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ymeth.2025.02.011_b0010","first-page":"23","article-title":"Evaluation of Candida albicans biofilm formation on conventional and computer-aided-design\/computer-aided manufacturing (CAD\/CAM) denture base materials","volume":"8","author":"Larijani","year":"2022","journal-title":"Current Medical Mycology"},{"key":"10.1016\/j.ymeth.2025.02.011_b0015","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ijbiomac.2019.09.036","article-title":"Augmented control of drug-resistant Candida spp. via fluconazole loading into fungal chitosan nanoparticles","volume":"141","author":"El Rabey","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fcimb.2020.00206","article-title":"Evaluation of molecular epidemiology, clinical characteristics, antifungal susceptibility profiles, and molecular mechanisms of antifungal resistance of Iranian Candida parapsilosis species complex blood isolates","volume":"10","author":"Arastehfar","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0025","first-page":"5","article-title":"Morphogenesis and pathogenesis regulation of Candida albicans by probiotic bacterium\u2013Pediococcus acidilactici","volume":"2021","author":"Zareshahrabadi","year":"2021","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"key":"10.1016\/j.ymeth.2025.02.011_b0030","doi-asserted-by":"crossref","DOI":"10.55251\/jmbfs.5592","article-title":"Isolation of prominent opportunistic yeasts, Candida spp., from coin-operated washing machines","author":"Pintong","year":"2023","journal-title":"J. Microbiol. Biotechnol. Food Sci."},{"issue":"2","key":"10.1016\/j.ymeth.2025.02.011_b0035","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jbm.b.31904","article-title":"Synthesis, characterization, and light\u2010controlled antibiotic application of a composite material derived from polyurethane and silica xerogel with embedded photoactive manganese nitrosyl","volume":"99","author":"Heilman","year":"2011","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"10.1016\/j.ymeth.2025.02.011_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.matchemphys.2019.122117","article-title":"Nystatin complexation with \u03b2-cyclodextrin: spectroscopic evaluation of inclusion by FT-Raman, photoacoustic spectroscopy, and 1H NMR","volume":"239","author":"Somer","year":"2020","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.ymeth.2025.02.011_b0045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jddst.2017.02.004","article-title":"Preparation, physicochemical characterization and anti-fungal evaluation of the Nystatin-loaded Eudragit RS100\/PLGA nanoparticles","volume":"38","author":"Mohammadi","year":"2017","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.explore.2023.04.005","article-title":"The efficacy of complementary treatment with marshmallow (Althaea officinalis L.) on vulvovaginal candidiasis: a randomized double-blinded controlled clinical trial","author":"Amini","year":"2023","journal-title":"Explore"},{"key":"10.1016\/j.ymeth.2025.02.011_b0055","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/3423440","article-title":"Chemical composition and antifungal and antibiofilm effects of vitex pseudo-negundo essential oil against pathogenic fungal strains","volume":"2023","author":"Zareshahrabadi","year":"2023","journal-title":"Evid. Based Complement. Alternat. Med."},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0060","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1038\/s41598-023-33095-1","article-title":"An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver","volume":"13","author":"Abbasi","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymeth.2025.02.011_b0065","article-title":"Enrichment of creatine-gelatin cryogel with zataria multiflora essential oil and titanium dioxide nanoparticles as a potential wound dressing","volume":"38","author":"Hashempur","year":"2024","journal-title":"Mater. Today Chem."},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00914037.2019.1581780","article-title":"Composite hydrogels based on gelatin, chitosan and polyvinyl alcohol to biomedical applications: A review","volume":"69","author":"Rodr\u00edguez-Rodr\u00edguez","year":"2020","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"10.1016\/j.ymeth.2025.02.011_b0075","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.carbpol.2016.03.002","article-title":"Preparation and characterization of chitosan\/gelatin\/PVA hydrogel for wound dressings","volume":"146","author":"Fan","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ymeth.2025.02.011_b0080","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/193293a0","article-title":"Formation of the scab and the rate of epithelialization of supercial wounds in the skin of the young domestic pig","volume":"193","author":"Winter","year":"1962","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.ymeth.2025.02.011_b0085","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.biortech.2007.01.051","article-title":"Extraction and characterization of chitin and chitosan from local sources","volume":"99","author":"Abdou","year":"2008","journal-title":"Bioresour. Technol."},{"issue":"4","key":"10.1016\/j.ymeth.2025.02.011_b0090","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/(SICI)1097-4636(19990915)46:4<520::AID-JBM10>3.0.CO;2-9","article-title":"Evaluationof gelatin hydrogel crosslinked with various crosslinking agents asbioadhesives: in vitro study","volume":"46","author":"Sung","year":"1999","journal-title":"J. Biomed. Mater. Res. A"},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0095","first-page":"256","article-title":"Gelatin as a delivery vehicle for the controlled release of bioactive molecules","volume":"109","author":"S, y.,","year":"2005","journal-title":"J Controll Release"},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0100","first-page":"125","article-title":"Radiation-induced crosslinking of collagen gelatin into a stable hydrogel","volume":"275","author":"F, C.,","year":"2007","journal-title":"J Radioanal Nucl Chem"},{"key":"10.1016\/j.ymeth.2025.02.011_b0105","series-title":"5 - Entrapment of Essential Oils in Hydrogels for Biomedical Applications, in Polymeric Gels","first-page":"125","author":"Syed","year":"2018"},{"issue":"3","key":"10.1016\/j.ymeth.2025.02.011_b0110","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.carbpol.2007.12.008","article-title":"Investigation of PVA\/ws-chitosan hydrogels prepared by combined \u03b3-irradiation and freeze-thawing","volume":"73","author":"Yang","year":"2008","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ymeth.2025.02.011_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125073","article-title":"Encapsulation of Zataria multiflora essential oil in polyvinyl alcohol\/chitosan\/gelatin thermo-responsive hydrogel: Synthesis, physico-chemical properties, and biological investigations","volume":"243","author":"Torabiardekani","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.02.011_b0120","first-page":"108","article-title":"Streptococcus spp. and Fusobacterium nucleatum in tongue dorsum biofilm from halitosis patients: A fluorescence in situ hybridization (FISH) and confocal laser scanning microscopy (CLSM) study","volume":"42","author":"Bernardi","year":"2019","journal-title":"New Microbiol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0125","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ijbiomac.2018.12.085","article-title":"Evaluation of electrospun poly (vinyl alcohol)-based nanofiber mats incorporated with Zataria multiflora essential oil as potential wound dressing","volume":"125","author":"Ardekani","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ejpb.2015.07.018","article-title":"Bioadhesive vaginal drug delivery of nystatin using a derivatized polymer: Development and characterization","volume":"96","author":"Bassi","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ymeth.2025.02.011_b0135","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.ijbiomac.2019.03.160","article-title":"Feasibility of poly-vinyl alcohol\/starch\/glycerol\/citric acid composite films for wound dressing applications","volume":"131","author":"Das","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.ymeth.2025.02.011_b0140","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1111\/j.1745-4549.2008.00307.x","article-title":"Antimicrobial, physical and mechanical properties of chitosan\u2010based films incorporated with thyme, clove and cinnamon essential oils","volume":"33","author":"Hosseini","year":"2009","journal-title":"Journal of Food Processing Preservation"},{"key":"10.1016\/j.ymeth.2025.02.011_b0145","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijbiomac.2016.12.079","article-title":"Optimization, characterization, and in vitro assessment of alginate-pectin ionic cross-linked hydrogel film for wound dressing applications","volume":"97","author":"Rezvanian","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2020.101536","article-title":"A novel multilayer hydrogel wound dressing for antibiotic release","volume":"58","author":"Tamahkar","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.02.011_b0155","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00289-018-2395-x","article-title":"Development of gelatin hydrogel pads incorporated with Eupatorium adenophorum essential oil as antibacterial wound dressing","volume":"76","author":"Chuysinuan","year":"2019","journal-title":"Polym. Bull."},{"issue":"3","key":"10.1016\/j.ymeth.2025.02.011_b0160","doi-asserted-by":"crossref","DOI":"10.1111\/jfs.12774","article-title":"Gelatin\/pectin\u2010based film incorporated with essential oils: Functional characteristics and shelf life extension of tilapia fillets under refrigeration","volume":"40","author":"Aitboulahsen","year":"2020","journal-title":"J. Food Saf."},{"issue":"5","key":"10.1016\/j.ymeth.2025.02.011_b0165","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00706-020-02592-8","article-title":"Synthesis and evaluation of biological activities of tripodal imines and \u03b2-lactams attached to the 1, 3, 5-triazine nucleus","volume":"151","author":"Bashiri","year":"2020","journal-title":"Monatshefte F\u00fcr Chemie-Chemical Monthly"},{"issue":"32","key":"10.1016\/j.ymeth.2025.02.011_b0170","doi-asserted-by":"crossref","first-page":"35856","DOI":"10.1021\/acsami.0c08285","article-title":"Multifunctional tissue-adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"10.1016\/j.ymeth.2025.02.011_b0175","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/acs.biomac.9b01732","article-title":"Injectable antimicrobial conductive hydrogels for wound disinfection and infectious wound healing","volume":"21","author":"Liang","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.ymeth.2025.02.011_b0180","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5577760","article-title":"Characterization and physical and biological properties of tissue conditioner incorporated with Carum copticum L","volume":"2021","author":"Hejazi","year":"2021","journal-title":"Biomed Res. Int."},{"issue":"6","key":"10.1016\/j.ymeth.2025.02.011_b0185","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/psc.2886","article-title":"Membrane damage as first and DNA as the secondary target for anti\u2010candidal activity of antimicrobial peptide P7 derived from cell\u2010penetrating peptide ppTG20 against Candida albicans","volume":"22","author":"Li","year":"2016","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.ymeth.2025.02.011_b0190","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.ijbiomac.2022.09.244","article-title":"Magnetic chitosan nanoparticles loaded with Amphotericin B: Synthesis, properties and potentiation of antifungal activity against common human pathogenic fungal strains","volume":"222","author":"Zareshahrabadi","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"10","key":"10.1016\/j.ymeth.2025.02.011_b0195","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3390\/life11101016","article-title":"Hydrogel preparation methods and biomaterials for wound dressing","volume":"11","author":"Su","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.ymeth.2025.02.011_b0200","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.carbpol.2015.02.034","article-title":"Carboxyl-modified poly (vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing","volume":"125","author":"Zhang","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ymeth.2025.02.011_b0205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.carbpol.2017.03.053","article-title":"Fabrication and evaluation of thermosensitive chitosan\/collagen\/\u03b1, \u03b2-glycerophosphate hydrogels for tissue regeneration","volume":"167","author":"Dang","year":"2017","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ymeth.2025.02.011_b0210","doi-asserted-by":"crossref","first-page":"E119","DOI":"10.1111\/j.1365-2621.2006.tb15624.x","article-title":"Properties of chitosan films as a function of pH and solvent type","volume":"71","author":"Kim","year":"2006","journal-title":"J. Food Sci."},{"issue":"4","key":"10.1016\/j.ymeth.2025.02.011_b0215","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3390\/polym14040689","article-title":"Chitosan-based therapeutic systems for superficial candidiasis treatment. synergetic activity of nystatin and propolis","volume":"14","author":"Humelnicu","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.ymeth.2025.02.011_b0220","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/187961","article-title":"Synthesis and characterization of chemically cross-linked acrylic acid\/gelatin hydrogels: effect of pH and composition on swelling and drug release","volume":"2015","author":"Bukhari","year":"2015","journal-title":"International Journal of Polymer Science"},{"issue":"7","key":"10.1016\/j.ymeth.2025.02.011_b0225","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1021\/bm900036s","article-title":"Evaluation of Cross-Linking Methods for Electrospun Gelatin on Cell Growth and Viability","volume":"10","author":"Sisson","year":"2009","journal-title":"Biomacromolecules"},{"issue":"5","key":"10.1016\/j.ymeth.2025.02.011_b0230","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1080\/01932691.2019.1611437","article-title":"Interactions between gelatin and sodium alginate: UV and FTIR studies","volume":"41","author":"Derkach","year":"2020","journal-title":"J. Dispers. Sci. Technol."},{"issue":"13","key":"10.1016\/j.ymeth.2025.02.011_b0235","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.3390\/polym14132610","article-title":"Fabrication of Gelatin Nanofibers by Electrospinning\u2014Mixture of Gelatin and Polyvinyl Alcohol","volume":"14","author":"Chi","year":"2022","journal-title":"Polymers"},{"issue":"8","key":"10.1016\/j.ymeth.2025.02.011_b0240","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1745-7270.2007.00320.x","article-title":"Fourier Transform Infrared Spectroscopic Analysis of Protein Secondary Structures","volume":"39","author":"Kong","year":"2007","journal-title":"Acta Biochim. Biophy. Sin."},{"issue":"5","key":"10.1016\/j.ymeth.2025.02.011_b0245","doi-asserted-by":"crossref","first-page":"397","DOI":"10.3390\/ph14050397","article-title":"Development of a solid dispersion of nystatin with maltodextrin as a carrier agent: improvements in antifungal efficacy against Candida spp","volume":"14","author":"Benavent","year":"2021","journal-title":"Biofilm Infections. Pharmaceuticals"},{"key":"10.1016\/j.ymeth.2025.02.011_b0250","first-page":"1227","article-title":"Sustained release of nystatin from polyurethane membranes for biomedical applications","volume":"6","author":"Mandru","year":"2011","journal-title":"Dig. J. Nanomater. Biostruct"},{"issue":"8","key":"10.1016\/j.ymeth.2025.02.011_b0255","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.reactfunctpolym.2007.05.010","article-title":"Synthesis and characterization of hybrid polymeric networks (HPN) based on polyvinyl alcohol\/chitosan","volume":"67","author":"Rodrigues","year":"2007","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.ymeth.2025.02.011_b0260","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jddst.2018.08.023","article-title":"Development of a gum base formulation for nystatin; a new drug delivery approach for treatment of oral candidiasis","volume":"48","author":"Samiei","year":"2018","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.02.011_b0265","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.carbpol.2008.10.015","article-title":"Preparation and characterization of novel chitosan\/gelatin membranes using chitosan hydrogel","volume":"76","author":"Nagahama","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ymeth.2025.02.011_b0270","first-page":"572","article-title":"Design and applications of interpenetrating polymer network hydrogels","volume":"243","author":"Dragan","year":"2014","journal-title":"A Review. Chemical Engineering Journal"},{"issue":"12","key":"10.1016\/j.ymeth.2025.02.011_b0275","doi-asserted-by":"crossref","first-page":"6017","DOI":"10.1021\/cr030441b","article-title":"Chitosan chemistry and pharmaceutical perspectives","volume":"104","author":"Kumar","year":"2004","journal-title":"Chem. Rev."},{"issue":"8","key":"10.1016\/j.ymeth.2025.02.011_b0280","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1002\/jps.21210","article-title":"Wound healing dressings and drug delivery systems: a review","volume":"97","author":"Boateng","year":"2008","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.ymeth.2025.02.011_b0285","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jare.2017.01.005","article-title":"A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings","volume":"8","author":"Kamoun","year":"2017","journal-title":"J. Adv. Res."},{"issue":"4","key":"10.1016\/j.ymeth.2025.02.011_b0290","doi-asserted-by":"crossref","first-page":"22","DOI":"10.7603\/s40681-015-0022-9","article-title":"Wound dressings\u2013a review","volume":"5","author":"Dhivya","year":"2015","journal-title":"Biomedicine"},{"key":"10.1016\/j.ymeth.2025.02.011_b0295","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2165\/00128071-200405040-00002","article-title":"Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus aureus","volume":"5","author":"Rippke","year":"2004","journal-title":"Am. J. Clin. Dermatol."},{"issue":"4","key":"10.1016\/j.ymeth.2025.02.011_b0300","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jab.2016.05.002","article-title":"Evaluation of mucoadhesive oral films containing nystatin","volume":"14","author":"Gajdo\u0161ov\u00e1","year":"2016","journal-title":"J. Appl. Biomed."},{"issue":"2","key":"10.1016\/j.ymeth.2025.02.011_b0305","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.carbpol.2008.11.002","article-title":"Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone","volume":"76","author":"Muzzarelli","year":"2009","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0310","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijpharm.2013.09.028","article-title":"Design of antibiotic containing hydrogel wound dressings: biomedical properties and histological study of wound healing","volume":"457","author":"Singh","year":"2013","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.ymeth.2025.02.011_b0315","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.3390\/ma12101628","article-title":"Fabrication and characterization of low methoxyl pectin\/gelatin\/carboxymethyl cellulose absorbent hydrogel film for wound dressing applications","volume":"12","author":"Jantrawut","year":"2019","journal-title":"Materials"},{"issue":"12","key":"10.1016\/j.ymeth.2025.02.011_b0320","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/wound.2020.1232","article-title":"Moist wound healing with commonly available dressings","volume":"10","author":"Nuutila","year":"2021","journal-title":"Adv. Wound Care"},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0325","first-page":"1","article-title":"Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement","volume":"6","author":"Xu","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.ymeth.2025.02.011_b0330","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/gels8080495","article-title":"Evaluation of physically and\/or chemically modified chitosan hydrogels for proficient release of insoluble nystatin in simulated fluids","volume":"8","author":"Enache","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.ymeth.2025.02.011_b0335","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.foodhyd.2013.10.013","article-title":"Combined effects of two kinds of essential oils on physical, mechanical and structural properties of chitosan films","volume":"36","author":"Peng","year":"2014","journal-title":"Food Hydrocoll."},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0340","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0939-6411(03)00161-9","article-title":"Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications","volume":"57","author":"Berger","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"10","key":"10.1016\/j.ymeth.2025.02.011_b0345","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.3109\/03639049309063012","article-title":"Relationship Between Swelling and Drug Release in a Hydrophilic Matrix","volume":"19","author":"Wan","year":"1993","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ymeth.2025.02.011_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120086","article-title":"Bilayer mucoadhesive buccal films with prolonged release of ciclopirox olamine for the treatment of oral candidiasis: In vitro development, ex vivo permeation testing, pharmacokinetic and efficacy study in rabbits","volume":"592","author":"Gajdo\u0161ov\u00e1","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ymeth.2025.02.011_b0355","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.ijbiomac.2018.02.107","article-title":"\u03b3-Irradiated chitosan based injectable hydrogels for controlled release of drug (Montelukast sodium)","volume":"114","author":"Hafeez","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0360","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.2147\/IJN.S190502","article-title":"Natamycin solid lipid nanoparticles \u2013 sustained ocular delivery system of higher corneal penetration against deep fungal keratitis: preparation and optimization","volume":"14","author":"Khames","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.ymeth.2025.02.011_b0365","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.carbpol.2019.02.018","article-title":"Mentha piperita essential oils loaded in a chitosan nanogel with inhibitory effect on biofilm formation against S. mutans on the dental surface","volume":"212","author":"Ashrafi","year":"2019","journal-title":"Carbohydr. Polym."},{"issue":"9","key":"10.1016\/j.ymeth.2025.02.011_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02366","article-title":"Surface-modified mucoadhesive microparticles as a controlled release system for oral delivery of insulin","volume":"5","author":"Mumuni","year":"2019","journal-title":"Heliyon"},{"issue":"11","key":"10.1016\/j.ymeth.2025.02.011_b0375","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.7150\/thno.15412","article-title":"Melatonin treatment improves mesenchymal stem cells therapy by preserving stemness during long-term in vitro expansion","volume":"6","author":"Shuai","year":"2016","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0380","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1038\/s41598-020-60364-0","article-title":"Homalomena pineodora essential oil nanoparticle inhibits diabetic wound pathogens","volume":"10","author":"Rozman","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymeth.2025.02.011_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2020.104679","article-title":"Development of encapsulated peppermint essential oil in chitosan nanoparticles: characterization and biological efficacy against stored-grain pest control","volume":"170","author":"Rajkumar","year":"2020","journal-title":"Pestic. Biochem. Physiol."},{"issue":"6","key":"10.1016\/j.ymeth.2025.02.011_b0390","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1111\/ijfs.14107","article-title":"Optimising chitosan\u2013pectin hydrogel beads containing combined garlic and holy basil essential oils and their application as antimicrobial inhibitor","volume":"54","author":"Torpol","year":"2019","journal-title":"Int J Food Sci Technol"},{"issue":"2","key":"10.1016\/j.ymeth.2025.02.011_b0395","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1021\/bm3018577","article-title":"Encapsulation of antitumor drug doxorubicin and its analogue by chitosan nanoparticles","volume":"14","author":"Sanyakamdhorn","year":"2013","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0400","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0939-6411(00)00090-4","article-title":"Hydrogels in pharmaceutical formulations","volume":"50","author":"Peppas","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ymeth.2025.02.011_b0405","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.addr.2012.09.010","article-title":"Hydrogels for biomedical applications","volume":"64","author":"Hoffman","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.ymeth.2025.02.011_b0410","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/mmy\/myaa031","article-title":"Update on Candida krusei, a potential multidrug-resistant pathogen","volume":"59","author":"Jamiu","year":"2021","journal-title":"Med. Mycol."},{"key":"10.1016\/j.ymeth.2025.02.011_b0415","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.msec.2017.02.076","article-title":"An investigation of electrospun Henna leaves extract-loaded chitosan based nanofibrous mats for skin tissue engineering","volume":"75","author":"Yousefi","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"issue":"4","key":"10.1016\/j.ymeth.2025.02.011_b0420","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3390\/jfb5040259","article-title":"Evaluation of nystatin containing chitosan hydrogels as potential dual action bio-active restorative materials: in vitro approach","volume":"5","author":"Perchyonok","year":"2014","journal-title":"Journal of Functional Biomaterials"},{"issue":"19","key":"10.1016\/j.ymeth.2025.02.011_b0425","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.3390\/polym13193256","article-title":"Chitosan: An overview of its properties and applications","volume":"13","author":"Aranaz","year":"2021","journal-title":"Polymers"},{"issue":"9","key":"10.1016\/j.ymeth.2025.02.011_b0430","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrmicro.2016.94","article-title":"Biofilms: an emergent form of bacterial life","volume":"14","author":"Flemming","year":"2016","journal-title":"Nat. Rev. Microbiol."}],"container-title":["Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325000489?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325000489?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:29:32Z","timestamp":1741696172000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1046202325000489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":86,"alternative-id":["S1046202325000489"],"URL":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.02.011","relation":{},"ISSN":["1046-2023"],"issn-type":[{"value":"1046-2023","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chitosan-based xerogel film incorporating Nystatin: Synthesis, structural Analysis, and biological evaluation","name":"articletitle","label":"Article Title"},{"value":"Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}