{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:06:25Z","timestamp":1773655585660,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012655","name":"Qilu Hospital of Shandong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Methods"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.ymeth.2025.08.001","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T21:43:40Z","timestamp":1754430220000},"page":"187-199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A newly developed ferroptosis-related gene signature for forecasting prognosis in uveal melanoma"],"prefix":"10.1016","volume":"242","author":[{"given":"Yifei","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ymeth.2025.08.001_b0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10555-017-9663-3","article-title":"The biology of uveal melanoma","volume":"36","author":"Amaro","year":"2017","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"10.1016\/j.ymeth.2025.08.001_b0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/acel.12538","article-title":"Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease","volume":"16","author":"Ansari","year":"2017","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.ymeth.2025.08.001_b0015","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2024.03.019","article-title":"Ironing out the role of ferroptosis in immunity","volume":"57","author":"Bell","year":"2024","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.ymeth.2025.08.001_b0020","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41419-018-0459-3","article-title":"Endogenous c-Jun N-terminal kinase (JNK) activity marks the boundary between normal and malignant granulosa cells","volume":"9","author":"Bildik","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymeth.2025.08.001_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2021.101030","article-title":"Regulation of epigenetic homeostasis in uveal melanoma and retinoblastoma","volume":"89","author":"Chai","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"issue":"1","key":"10.1016\/j.ymeth.2025.08.001_b0030","doi-asserted-by":"crossref","first-page":"22804","DOI":"10.1038\/s41598-023-50205-1","article-title":"Development of a ferroptosis-based molecular markers for predicting RFS in prostate cancer patients","volume":"13","author":"Chen","year":"2023","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ymeth.2025.08.001_b0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.ymeth.2025.08.001_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113132","article-title":"Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma","volume":"42","author":"Gentien","year":"2023","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.ymeth.2025.08.001_b0045","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41420-023-01446-6","article-title":"Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target","volume":"9","author":"Groenewoud","year":"2023","journal-title":"Cell Death Discov."},{"issue":"3","key":"10.1016\/j.ymeth.2025.08.001_b0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s12032-021-01476-z","article-title":"Bexarotene inhibits cell proliferation by inducing oxidative stress, DNA damage and apoptosis via PPAR\u03b3\/NF-\u03baB signaling pathway in C6 glioma cells","volume":"38","author":"Hacioglu","year":"2021","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.ymeth.2025.08.001_b0055","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41572-020-0158-0","article-title":"Uveal melanoma","volume":"6","author":"Jager","year":"2020","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"7","key":"10.1016\/j.ymeth.2025.08.001_b0060","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1016\/j.apsb.2024.04.020","article-title":"Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer","volume":"14","author":"Jin","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"Suppl_1","key":"10.1016\/j.ymeth.2025.08.001_b0065","doi-asserted-by":"crossref","first-page":"i389","DOI":"10.1093\/bioinformatics\/btaa462","article-title":"Improved survival analysis by learning shared genomic information from pan-cancer data","volume":"36","author":"Kim","year":"2020","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.ymeth.2025.08.001_b0070","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.trecan.2021.07.002","article-title":"Pannexin biology and emerging linkages to cancer","volume":"7","author":"Laird","year":"2021","journal-title":"Trends Cancer."},{"issue":"4","key":"10.1016\/j.ymeth.2025.08.001_b0075","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","article-title":"The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions","volume":"42","author":"Lei","year":"2024","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ymeth.2025.08.001_b0080","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.canlet.2021.04.007","article-title":"SIRT3 inhibits gallbladder cancer by induction of AKT-dependent ferroptosis and blockade of epithelial-mesenchymal transition","volume":"510","author":"Liu","year":"2021","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.ymeth.2025.08.001_b0085","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3390\/diagnostics11020219","article-title":"A novel ferroptosis-associated gene signature to predict prognosis in patients with uveal melanoma","volume":"11","author":"Luo","year":"2021","journal-title":"Diagnostics (Basel)."},{"issue":"7","key":"10.1016\/j.ymeth.2025.08.001_b0090","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.3390\/ijms26073035","article-title":"Proteasome inhibitor MG-132 and PKC-\u03b9-specific inhibitor ICA-1S degrade mutant p53 and induce apoptosis in ovarian cancer cell lines","volume":"26","author":"Marzan","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymeth.2025.08.001_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132906","article-title":"Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells","volume":"463","author":"Park","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.ymeth.2025.08.001_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101041","article-title":"Metastatic uveal melanoma: the final frontier","volume":"90","author":"Rantala","year":"2022","journal-title":"Prog. Retin. Eye Res."},{"issue":"13","key":"10.1016\/j.ymeth.2025.08.001_b0105","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1182\/blood.2022019274","article-title":"BRD4 inhibition sensitizes diffuse large B-cell lymphoma cells to ferroptosis","volume":"142","author":"Schmitt","year":"2023","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.ymeth.2025.08.001_b0110","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.ymeth.2025.08.001_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2021.108872","article-title":"Identification of critical ferroptosis regulators in lung adenocarcinoma that RRM2 facilitates tumor immune infiltration by inhibiting ferroptotic death","volume":"232","author":"Tang","year":"2021","journal-title":"Clin. Immunol."},{"issue":"1","key":"10.1016\/j.ymeth.2025.08.001_b0120","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41420-023-01773-8","article-title":"1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature","volume":"10","author":"Tonelotto","year":"2024","journal-title":"Cell Death Discov."},{"issue":"12","key":"10.1016\/j.ymeth.2025.08.001_b0125","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.ymeth.2025.08.001_b0130","article-title":"Highly tumoricidal efficiency of non-oxidized MXene-Ti(3)C(2)Tx quantum dots on human uveal melanoma","volume":"10","author":"Zhang","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"10","key":"10.1016\/j.ymeth.2025.08.001_b0135","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/s41556-018-0178-0","article-title":"BAP1 links metabolic regulation of ferroptosis to tumour suppression","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"16","key":"10.1016\/j.ymeth.2025.08.001_b0140","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.3390\/cells11162596","article-title":"The role of SIRT3 in exercise and aging","volume":"11","author":"Zhou","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ymeth.2025.08.001_b0145","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaa021","article-title":"FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations","volume":"2020","author":"Zhou","year":"2020","journal-title":"Database (Oxford)"},{"issue":"1","key":"10.1016\/j.ymeth.2025.08.001_b0150","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.gendis.2022.11.022","article-title":"Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer","volume":"11","author":"Zuo","year":"2024","journal-title":"Genes Dis."}],"container-title":["Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325001677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325001677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T09:26:41Z","timestamp":1773653201000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1046202325001677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":30,"alternative-id":["S1046202325001677"],"URL":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.08.001","relation":{},"ISSN":["1046-2023"],"issn-type":[{"value":"1046-2023","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A newly developed ferroptosis-related gene signature for forecasting prognosis in uveal melanoma","name":"articletitle","label":"Article Title"},{"value":"Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}