{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:22:26Z","timestamp":1778800946364,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62372159"],"award-info":[{"award-number":["62372159"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62302156"],"award-info":[{"award-number":["62302156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62472152"],"award-info":[{"award-number":["62472152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62202153"],"award-info":[{"award-number":["62202153"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62522110"],"award-info":[{"award-number":["62522110"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JJ4015"],"award-info":[{"award-number":["2024JJ4015"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Methods"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ymeth.2025.11.006","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T09:36:18Z","timestamp":1763631378000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Unravelling cell heterogeneity and gene regulation mechanisms in multiple myeloma through single-cell RNA-seq"],"prefix":"10.1016","volume":"246","author":[{"given":"Jing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junlin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuansheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ymeth.2025.11.006_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/leu.2008.291","article-title":"Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma","volume":"23","author":"Kyle","year":"2009","journal-title":"Leukemia"},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.006_b0010","first-page":"e4716","article-title":"Laboratory features of newly diagnosed multiple myeloma patients","volume":"11","author":"Hussain","year":"2019","journal-title":"Cureus"},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.006_b0015","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1038\/leu.2008.142","article-title":"Clinical and biological significance of RAS mutations in multiple myeloma","volume":"22","author":"Chng","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.ymeth.2025.11.006_b0020","doi-asserted-by":"crossref","first-page":"7164","DOI":"10.1038\/ncomms8164","article-title":"Directional cell movement through tissues is controlled by exosome secretion","volume":"6","author":"Sung","year":"2015","journal-title":"Nat. Commun."},{"issue":"R1","key":"10.1016\/j.ymeth.2025.11.006_b0025","doi-asserted-by":"crossref","first-page":"R40","DOI":"10.1093\/hmg\/ddy100","article-title":"Cell type discovery using single-cell transcriptomics: implications for ontological representation","volume":"27","author":"Aevermann","year":"2018","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.006_b0030","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1186\/s12967-025-07098-7","article-title":"Single-cell transcriptomics identifies PDIA4 as a marker of progression and therapeutic vulnerability in multiple myeloma","volume":"23","author":"Yu","year":"2025","journal-title":"J. Transl. Med."},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.006_b0035","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1158\/0008-5472.CAN-22-1769","article-title":"Single-cell discovery and multiomic characterization of therapeutic targets in multiple myeloma","volume":"83","author":"Yao","year":"2023","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.006_b0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13059-019-1713-4","article-title":"Single-cell transcriptomics unveils gene regulatory network plasticity","volume":"20","author":"Iacono","year":"2019","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.006_b0045","doi-asserted-by":"crossref","first-page":"36723","DOI":"10.1038\/s41598-025-20615-4","article-title":"Single-cell and bulk transcriptomics uncovers PRKD2-driven tumor stemness and progression in multiple myeloma","volume":"15","author":"Zhang","year":"2025","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.006_b0050","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.soncn.2017.05.001","article-title":"Multiple myeloma genomics: a systematic review","volume":"33","author":"Weaver","year":"2017","journal-title":"Semin. Oncol. Nurs."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.006_b0055","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1365-2141.2008.07281.x","article-title":"Pathogenic ATM mutations occur rarely in a subset of multiple myeloma patients","volume":"142","author":"Austen","year":"2008","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.006_b0060","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/bjh.12633","article-title":"AT-101 downregulates BCL2 and MCL1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and Waldenstrom macroglobulinaemia","volume":"164","author":"Paulus","year":"2014","journal-title":"Br. J. Haematol."},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.006_b0065","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1111\/cas.14109","article-title":"Immunohistochemistry for identification of CCND1, NSD2, and MAF gene rearrangements in plasma cell myeloma","volume":"110","author":"Murase","year":"2019","journal-title":"Cancer Sci."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.006_b0070","doi-asserted-by":"crossref","first-page":"e337","DOI":"10.1038\/oncsis.2017.36","article-title":"Molecular signaling in multiple myeloma: association of RAS\/RAF mutations and MEK\/ERK pathway activation","volume":"6","author":"Xu","year":"2017","journal-title":"Oncogenesis"},{"issue":"10","key":"10.1016\/j.ymeth.2025.11.006_b0075","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1101\/gr.190595.115","article-title":"Defining cell types and states with single-cell genomics","volume":"25","author":"Trapnell","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.ymeth.2025.11.006_b0080","article-title":"The multiple myeloma genome project: development of a molecular segmentation strategy for the clinical classification of multiple myeloma","author":"Walker","year":"2016","journal-title":"Am. Soc. Hematol."},{"issue":"19","key":"10.1016\/j.ymeth.2025.11.006_b0085","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1111\/j.1742-4658.2012.08727.x","article-title":"Regulation of self-renewal in normal and cancer stem cells","volume":"279","author":"Verga Falzacappa","year":"2012","journal-title":"FEBS J."},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.006_b0090","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jbiosc.2013.03.003","article-title":"Actin-based biomechanical features of suspended normal and cancer cells","volume":"116","author":"Haghparast","year":"2013","journal-title":"J. Biosci. Bioeng."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.006_b0095","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41408-018-0160-x","article-title":"Molecular signatures of multiple myeloma progression through single cell RNA-Seq","volume":"9","author":"Jang","year":"2019","journal-title":"Blood Cancer J."},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.006_b0100","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/s41591-018-0269-2","article-title":"Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma","volume":"24","author":"Ledergor","year":"2018","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.006_b0105","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1101\/gr.228080.117","article-title":"Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data","volume":"28","author":"Fan","year":"2018","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.ymeth.2025.11.006_b0110","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1158\/1078-0432.CCR-19-0694","article-title":"Alterations in the transcriptional programs of myeloma cells and the microenvironment during extramedullary progression affect proliferation and immune evasion","volume":"26","author":"Ryu","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.006_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v023.i12","article-title":"CCA: an R package to extend canonical correlation analysis","volume":"23","author":"Gonz\u00e1lez","year":"2008","journal-title":"J. Stat. Softw."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.006_b0120","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.006_b0125","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymeth.2025.11.006_b0130","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-8794-3-21","article-title":"SEURAT: visual analytics for the integrated analysis of microarray data","volume":"3","author":"Gribov","year":"2010","journal-title":"BMC Med. Genomics"},{"issue":"6237","key":"10.1016\/j.ymeth.2025.11.006_b0135","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1126\/science.aab1601","article-title":"Multiplex single cell profiling of chromatin accessibility by combinatorial cellular indexing","volume":"348","author":"Cusanovich","year":"2015","journal-title":"Science"},{"issue":"W1","key":"10.1016\/j.ymeth.2025.11.006_b0140","doi-asserted-by":"crossref","first-page":"W275","DOI":"10.1093\/nar\/gkaa394","article-title":"IRIS3: integrated cell-type-specific regulon inference server from single-cell RNA-Seq","volume":"48","author":"Ma","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.006_b0145","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymeth.2025.11.006_b0150","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"issue":"W1","key":"10.1016\/j.ymeth.2025.11.006_b0155","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymeth.2025.11.006_b0160","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinf."},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.006_b0165","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/s41587-019-0332-7","article-title":"Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia","volume":"37","author":"Granja","year":"2019","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.006_b0170","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0145-2126(01)00192-8","article-title":"Relationship between CD4(+)\/CD8(+) T cell ratio and T cell activation in multiple myeloma: reference to IL-16","volume":"26","author":"Koike","year":"2002","journal-title":"Leuk. Res."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.006_b0175","first-page":"129","article-title":"Multiple myeloma: altered CD4\/CD8 ratio in bone marrow","volume":"75","author":"Redoglia","year":"1990","journal-title":"Haematologica"},{"key":"10.1016\/j.ymeth.2025.11.006_b0180","doi-asserted-by":"crossref","DOI":"10.1038\/s41375-020-0734-z","article-title":"B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches","author":"Shah","year":"2020","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.006_b0185","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11523-017-0538-x","article-title":"The role of B-cell maturation antigen in the biology and management of, and as a potential therapeutic target in multiple myeloma","volume":"13","author":"Sanchez","year":"2018","journal-title":"Target. Oncol."},{"issue":"4","key":"10.1016\/j.ymeth.2025.11.006_b0190","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3324\/haematol.2011.046821","article-title":"Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma","volume":"97","author":"Kassambara","year":"2012","journal-title":"Haematologica"},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.006_b0195","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1182\/blood-2005-11-013458","article-title":"The molecular classification of multiple myeloma","volume":"108","author":"Zhan","year":"2006","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.ymeth.2025.11.006_b0200","doi-asserted-by":"crossref","first-page":"e465","DOI":"10.3324\/haematol.2018.209999","article-title":"The transcriptomic profile of CD138(+) cells from patients with early progression from smoldering to active multiple myeloma remains substantially unchanged","volume":"104","author":"Storti","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.ymeth.2025.11.006_b0205","doi-asserted-by":"crossref","first-page":"762","DOI":"10.3389\/fendo.2018.00762","article-title":"The role of RNA editing in cancer development and metabolic disorders","volume":"9","author":"Kung","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.006_b0210","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm.2015.4","article-title":"A-to-I editing of coding and non-coding RNAs by ADARs","volume":"17","author":"Nishikura","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"10","key":"10.1016\/j.ymeth.2025.11.006_b0215","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1074\/jbc.M117.779868","article-title":"Adenosine deaminase that acts on RNA 3 (ADAR3) binding to glutamate receptor subunit B pre-mRNA inhibits RNA editing in glioblastoma","volume":"292","author":"Oakes","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.006_b0220","doi-asserted-by":"crossref","DOI":"10.3390\/genes10010012","article-title":"ADAR1 editing and its role in cancer","volume":"10","author":"Xu","year":"2018","journal-title":"Genes"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.006_b0225","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0165-2478(99)00109-1","article-title":"The human immunoglobulin variable lambda locus IGLV9 gene is a monomorphic marker in the urban Brazilian population","volume":"69","author":"da Silva","year":"1999","journal-title":"Immunol. Lett."},{"issue":"20","key":"10.1016\/j.ymeth.2025.11.006_b0230","doi-asserted-by":"crossref","first-page":"6500","DOI":"10.1158\/1078-0432.CCR-11-1036","article-title":"Significant biological role of sp1 transactivation in multiple myeloma","volume":"17","author":"Fulciniti","year":"2011","journal-title":"Clin. Cancer Res.: Offi. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.ymeth.2025.11.006_b0235","doi-asserted-by":"crossref","first-page":"e207","DOI":"10.1038\/bcj.2014.29","article-title":"The role of epigenetics in the biology of multiple myeloma","volume":"4","author":"Dimopoulos","year":"2014","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.ymeth.2025.11.006_b0240","series-title":"Drug-induced Thrombotic Microangiopathy During Maintenance Treatment in a Patient with Multiple Myeloma","first-page":"e192","author":"Higuero Saavedra","year":"2019"},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.006_b0245","doi-asserted-by":"crossref","first-page":"e317","DOI":"10.3324\/haematol.2016.162198","article-title":"Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma","volume":"102","author":"Hofman","year":"2017","journal-title":"Haematologica"},{"issue":"17","key":"10.1016\/j.ymeth.2025.11.006_b0250","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1158\/1078-0432.CCR-24-0545","article-title":"Identification of therapy-induced clonal evolution and resistance pathways in minimal residual clones in multiple myeloma through single-cell sequencing","volume":"30","author":"Cui","year":"2024","journal-title":"Clin. Cancer Res."},{"issue":"26","key":"10.1016\/j.ymeth.2025.11.006_b0255","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1182\/blood.2024025643","article-title":"Aberrant single-cell phenotype and clinical implications of genotypically defined polyclonal plasma cells in myeloma","volume":"145","author":"Da Via","year":"2025","journal-title":"Blood"}],"container-title":["Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325002336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325002336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:37:59Z","timestamp":1767425879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1046202325002336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":51,"alternative-id":["S1046202325002336"],"URL":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.11.006","relation":{},"ISSN":["1046-2023"],"issn-type":[{"value":"1046-2023","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unravelling cell heterogeneity and gene regulation mechanisms in multiple myeloma through single-cell RNA-seq","name":"articletitle","label":"Article Title"},{"value":"Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}