{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:38:52Z","timestamp":1767425932066,"version":"3.48.0"},"reference-count":236,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Methods"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.ymeth.2025.11.009","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T16:42:54Z","timestamp":1764348174000},"page":"62-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Fabrication of advanced microneedle-based targeted intravaginal drug delivery devices: therapeutic opportunities and translational challenges"],"prefix":"10.1016","volume":"246","author":[{"given":"Tejas S.","family":"Patil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepvardhan P.","family":"Chaudhari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utkarsh U.","family":"Bhamare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahesh B.","family":"Palkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahendra R.","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6513-3336","authenticated-orcid":false,"given":"Sopan N.","family":"Nangare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymeth.2025.11.009_b0005","article-title":"Anatomy, abdomen and pelvis: female external genitalia","author":"Nguyen","year":"2025","journal-title":"StatPearls"},{"key":"10.1016\/j.ymeth.2025.11.009_b0010","article-title":"Vagina, a promising route for drug delivery","volume":"93","author":"Yang","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0015","doi-asserted-by":"crossref","first-page":"884","DOI":"10.3390\/pharmaceutics13060884","article-title":"Wroty\u0144ska-Barczy\u0144ska, Recent advances in polymer-based vaginal drug delivery systems","volume":"13","author":"Osma\u0142ek","year":"2021","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.104012","article-title":"Vaginal drug delivery system: a promising route of drug administration for local and systemic diseases","volume":"29","author":"Subi","year":"2024","journal-title":"Drug Discov. Today"},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0025","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3390\/pharmaceutics12060568","article-title":"The vaginal-PVPA: a vaginal mucosa-mimicking in vitro permeation tool for evaluation of mucoadhesive formulations","volume":"12","author":"Falavigna","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0030","series-title":"Microneedles (MNs)-Based Technology","first-page":"43","article-title":"Designing microneedles for intravaginal delivery: current challenges and prospects","author":"Nangare","year":"2025"},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0035","doi-asserted-by":"crossref","first-page":"775","DOI":"10.3390\/polym16060775","article-title":"Hydrogel- and nanocomposite-based drug-delivery strategies in the treatment of vaginal infections","volume":"16","author":"AlAnsari","year":"2024","journal-title":"Polymers"},{"issue":"22","key":"10.1016\/j.ymeth.2025.11.009_b0040","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1001\/jama.2022.9256","article-title":"Premenopausal vaginitis","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0045","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.mcna.2015.01.008","article-title":"Common vaginal and vulvar disorders","volume":"99","author":"Prabhu","year":"2015","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.ymeth.2025.11.009_b0050","article-title":"The female vaginal microbiome in health and bacterial vaginosis","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0055","article-title":"Anatomy, abdomen and pelvis: female internal genitals","author":"Hoare","year":"2020","journal-title":"StatPearls"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0060","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41418-020-0565-5","article-title":"Organoid systems to study the human female reproductive tract and pregnancy","volume":"28","author":"Alzamil","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ymeth.2025.11.009_b0065","article-title":"Engineering drug delivery systems to overcome the vaginal mucosal barrier: current understanding and research agenda of mucoadhesive formulations for vaginal delivery","volume":"70","author":"Valamla","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.643422","article-title":"Role of vaginal microbiota dysbiosis in gynecological diseases and the potential interventions","volume":"12","author":"Han","year":"2021","journal-title":"Front. Microbiol."},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0075","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.3390\/diagnostics11111996","article-title":"Vaginal pH value for clinical diagnosis and treatment of common vaginitis","volume":"11","author":"Lin","year":"2021","journal-title":"Diagnostics"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0080","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/polym13010026","article-title":"Promising drug delivery approaches to treat microbial infections in the vagina: a recent update","volume":"13","author":"Pandey","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.ymeth.2025.11.009_b0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.919728","article-title":"Host and microbiome interplay shapes the vaginal microenvironment","volume":"13","author":"Kwon","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0090","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/microorganisms11020298","article-title":"The vaginal microbiome in health and disease-what role do common intimate hygiene practices play?","volume":"11","author":"Holdcroft","year":"2023","journal-title":"Microorganisms"},{"key":"10.1016\/j.ymeth.2025.11.009_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.792787","article-title":"Contribution of Lactobacillus iners to vaginal health and diseases: a systematic review","volume":"11","author":"Zheng","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0100","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12934-020-01464-4","article-title":"Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health","volume":"19","author":"Chee","year":"2020","journal-title":"Microb. Cell Fact."},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0105","first-page":"139","article-title":"Bacterial vaginosis is a dangerous disease","volume":"19","author":"Olimjonovna","year":"2025","journal-title":"Mod. Educ. Dev."},{"key":"10.1016\/j.ymeth.2025.11.009_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.860589","article-title":"Correlation analysis of vaginal microbiome changes and bacterial vaginosis plus vulvovaginal candidiasis mixed vaginitis prognosis","volume":"12","author":"Xiao","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12978-021-01292-8","article-title":"The pathogenesis of prevalent aerobic bacteria in aerobic vaginitis and adverse pregnancy outcomes: a narrative review","volume":"19","author":"Ma","year":"2022","journal-title":"Reprod. Health"},{"issue":"23","key":"10.1016\/j.ymeth.2025.11.009_b0120","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1056\/NEJMra1808418","article-title":"Bacterial vaginosis and desquamative inflammatory vaginitis","volume":"379","author":"Paavonen","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.009_b0125","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/myc.12920","article-title":"Vaginal yeast colonisation: from a potential harmless condition to clinical implications and management approaches-a literature review","volume":"62","author":"Chatzivasileiou","year":"2019","journal-title":"Mycoses"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0130","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1186\/s12879-021-06192-7","article-title":"Prevalence, species distribution and antifungal susceptibility of Candida albicans causing vaginal discharge among symptomatic non-pregnant women of reproductive age at a tertiary care hospital, Vietnam","volume":"21","author":"Anh","year":"2021","journal-title":"BMC Infect. Dis."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0135","article-title":"Prevalence and risk factors of vulvovaginal candidosis during pregnancy: a review","volume":"2022","author":"Disha","year":"2022","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/CRT.1000342","article-title":"Female reproductive tract health: prevalence and risk factors associated with infections in Lom\u00e9","volume":"7","author":"Katawa","year":"2021","journal-title":"Clin. Res. Trials"},{"key":"10.1016\/j.ymeth.2025.11.009_b0150","unstructured":"J. Kim, O. De Jesus, Medication routes of administration, StatPearls (2021). Medication Routes of Administration \u2013 PubMed."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0155","doi-asserted-by":"crossref","first-page":"618","DOI":"10.3390\/pathogens11060618","article-title":"Role of vaginal mucosa, host immunity and microbiota in vulvovaginal candidiasis","volume":"11","author":"Balakrishnan","year":"2022","journal-title":"Pathogens"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0160","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s44294-024-00047-7","article-title":"The biomechanics of the vagina: a complete review of incomplete data","volume":"3","author":"Dubik","year":"2025","journal-title":"npj Women\u2019s Health"},{"issue":"15","key":"10.1016\/j.ymeth.2025.11.009_b0165","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3390\/cells13151236","article-title":"Unraveling the dynamics of estrogen and progesterone signaling in the endometrium: an overview","volume":"13","author":"Dias Da Silva","year":"2024","journal-title":"Cells"},{"issue":"36","key":"10.1016\/j.ymeth.2025.11.009_b0170","doi-asserted-by":"crossref","first-page":"26683","DOI":"10.1074\/jbc.M601522200","article-title":"Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor \u03b1 binding to classical estrogen response elements","volume":"281","author":"O\u2019Brien","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.009_b0175","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1177\/1933719115570906","article-title":"Characterization of a hormone-responsive organotypic human vaginal tissue model: morphologic and immunologic effects","volume":"22","author":"Ayehunie","year":"2015","journal-title":"Reprod. Sci."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.31033\/ijrasb.7.6.33","article-title":"Intra vaginal drug delivery system (novel drug delivery system)","volume":"7","author":"Kumar","year":"2020","journal-title":"Int. J. Res. Appl. Sci. Biotechnol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114543","article-title":"In vitro and ex vivo models for evaluating vaginal drug delivery systems","volume":"191","author":"Shapiro","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0195","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/gels8020099","article-title":"Application of sol-gels for treatment of gynaecological conditions-physiological perspectives and emerging concepts in intravaginal drug delivery","volume":"8","author":"Thapa","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.ymeth.2025.11.009_b0200","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.addr.2021.04.009","article-title":"Vaginal drug delivery approaches for localized management of cervical cancer","volume":"174","author":"Wang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ymeth.2025.11.009_b0205","series-title":"Theory and Practice of Contemporary Pharmaceutics","first-page":"455","article-title":"Rectal and Vaginal Routes of Drug Delivery","author":"Shitut","year":"2021"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22159\/ijpps.2022v14i1.42595","article-title":"Review on formulation and evaluation of solid lipid nanoparticles for vaginal application","volume":"14","author":"Priyanka","year":"2022","journal-title":"Int. J. Pharm. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.ymeth.2025.11.009_b0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.24018\/ejpharma.2023.3.4.68","article-title":"Modern aspects of suppositories: a review","volume":"3","author":"Kumar","year":"2023","journal-title":"Eur. J. Pharm. Res."},{"issue":"9","key":"10.1016\/j.ymeth.2025.11.009_b0220","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3390\/pharmaceutics12090859","article-title":"Recent advances in the development of in situ gelling drug delivery systems for non-parenteral administration routes","volume":"12","author":"Vigani","year":"2020","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0225","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12951-023-01800-x","article-title":"Low intensity ultrasound-mediated drug-loaded nanoparticles intravaginal drug delivery: an effective synergistic therapy scheme for treatment of vulvovaginal candidiasis","volume":"21","author":"Yang","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0230","series-title":"Applications of Polymers in Drug Delivery","first-page":"281","article-title":"Polymers in vaginal drug delivery: Recent advancements","author":"Lalan","year":"2021"},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0235","first-page":"678","article-title":"Mucoadhesive polymeric systems for vaginal drug delivery: a systemic review","volume":"44","author":"Hern\u00e1ndez-Gonz\u00e1lez","year":"2023","journal-title":"Rev. Mex. Ing. Biom\u00e9d."},{"key":"10.1016\/j.ymeth.2025.11.009_b0240","series-title":"Engineering Drug Delivery Systems","first-page":"111","article-title":"Implantable drug delivery systems","author":"Major","year":"2020"},{"issue":"07","key":"10.1016\/j.ymeth.2025.11.009_b0245","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1055\/a-1369-9395","article-title":"Development of hormonal intravaginal rings: technology and challenges","volume":"81","author":"Rafiei","year":"2021","journal-title":"Geburtshilfe Frauenheilkd."},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.009_b0250","doi-asserted-by":"crossref","first-page":"6455","DOI":"10.3390\/ijms22126455","article-title":"Emulsion-based multicompartment vaginal drug carriers: from nanoemulsions to nanoemulgels","volume":"22","author":"Smole\u0144ski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymeth.2025.11.009_b0255","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jconrel.2020.08.032","article-title":"Design, fabrication and characterisation of drug-loaded vaginal films: State-of-the-art","volume":"327","author":"Notario-P\u00e9rez","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ymeth.2025.11.009_b0260","unstructured":"Y.L. Traore, Development and characterization of stimuli-responsive drug delivery systems to prevent HIV infection and the treatment of chronic wounds, (2021). Content."},{"key":"10.1016\/j.ymeth.2025.11.009_b0265","series-title":"Concepts and Models for Drug Permeability Studies","first-page":"401","article-title":"J. das Neves, Tissue-based models for vaginal permeability studies","author":"Machado","year":"2024"},{"key":"10.1016\/j.ymeth.2025.11.009_b0270","series-title":"Women's Health and Corporate Marketing: Our Bodies, Their Business","first-page":"1","author":"Hunter","year":"2024"},{"key":"10.1016\/j.ymeth.2025.11.009_b0275","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jconrel.2024.07.038","article-title":"Advanced drug delivery technologies for postmenopausal effects","volume":"373","author":"Md","year":"2024","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0280","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12866-023-02916-8","article-title":"Glycogen availability and pH variation in a medium simulating vaginal fluid influence the growth of vaginal Lactobacillus species and Gardnerella vaginalis","volume":"23","author":"Navarro","year":"2023","journal-title":"BMC Microbiol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0285","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3390\/nano11020311","article-title":"Recent advances in nanosystems and strategies for vaginal delivery of antimicrobials","volume":"11","author":"Chindamo","year":"2021","journal-title":"Nanomaterials"},{"key":"10.1016\/j.ymeth.2025.11.009_b0290","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1007\/s00203-021-02414-3","article-title":"Vaginal microbiome: normalcy vs dysbiosis","volume":"203","author":"Saraf","year":"2021","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0295","doi-asserted-by":"crossref","unstructured":"H. Woerdenbag, J.C. Visser, T. Kauss, M. Sznitowska, Rectal and Vaginal, In: P. L. Brun, S. C.-Manciet, I. Kr\u00e4mer, J. Smith, H.Woerdenbag (Eds), Practical Pharmaceutics: An International Guideline for the Preparation, Care and Use of Medicinal Products, Springer, Cham, 2023, pp. 405-437.","DOI":"10.1007\/978-3-031-20298-8_19"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0300","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1186\/s40001-022-00938-y","article-title":"Barriers and facilitators of adherence to treatment among women with vulvovaginal candidiasis: a qualitative study","volume":"27","author":"Erfaninejad","year":"2022","journal-title":"Eur. J. Med. Res."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.009_b0305","first-page":"71","article-title":"Urinary incontinence and pelvic organ prolapse in women: prevention and treatment","volume":"120","author":"Tunn","year":"2023","journal-title":"Deutsches \u00c4rztebl. Int."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0310","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/17425247.2022.2020242","article-title":"Drug-releasing vaginal rings for HIV\/STI and pregnancy prevention: a review of recent advances and clinical applications","volume":"19","author":"Palanee-Phillips","year":"2022","journal-title":"Expert Opin. Drug Deliv."},{"issue":"11\u201312","key":"10.1016\/j.ymeth.2025.11.009_b0315","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1515\/znc-2024-0239","article-title":"Enhancing vaginal drug delivery: the nanoemulsion gel strategy","volume":"80","author":"Basu","year":"2025","journal-title":"Z. Naturforsch. C J Biosci."},{"key":"10.1016\/j.ymeth.2025.11.009_b0320","series-title":"Peptide and Protein Drug Delivery","first-page":"303","article-title":"Enzymatic barriers to peptide and protein drug delivery","author":"Lee","year":"2024"},{"key":"10.1016\/j.ymeth.2025.11.009_b0325","doi-asserted-by":"crossref","unstructured":"L. Lopez-Vidal, K. Juskaite, I.K. Ram\u00f6ller, D.A. Real, P.E. McKenna, J. Priotti, et al., Advanced drug delivery systems for the management of local conditions, Ther. Deliv. 16(3)(2024):285-303.","DOI":"10.1080\/20415990.2024.2437978"},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0330","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jconrel.2004.11.034","article-title":"The vagina as a route for systemic drug delivery","volume":"103","author":"Hussain","year":"2005","journal-title":"J. Control. Release"},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0335","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/pharmaceutics16111398","article-title":"Revolutionizing eye care: exploring the potential of microneedle drug delivery","volume":"16","author":"Rojekar","year":"2024","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0340","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/pharmaceutics7030090","article-title":"Transdermal delivery of drugs with microneedles-potential and challenges","volume":"7","author":"Ita","year":"2015","journal-title":"Pharmaceutics"},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0345","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/mi12111321","article-title":"Microneedles in drug delivery: progress and challenges","volume":"12","author":"Avcil","year":"2021","journal-title":"Micromachines (Basel)"},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.009_b0350","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.3390\/pharmaceutics15082165","article-title":"Advance and challenges in the treatment of skin diseases with the transdermal drug delivery system","volume":"15","author":"Cheng","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0355","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.1032041","article-title":"Microneedle-mediated drug delivery for cutaneous diseases","volume":"10","author":"Chen","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0360","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3390\/pharmaceutics12060569","article-title":"Microneedle-based delivery: An overview of current applications and trends","volume":"12","author":"Guillot","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0365","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jconrel.2021.08.054","article-title":"Recent advances in microneedles-based drug delivery device in the diagnosis and treatment of cancer","volume":"338","author":"Singh","year":"2021","journal-title":"J. Control Release"},{"key":"10.1016\/j.ymeth.2025.11.009_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105339","article-title":"A new computational method of modeling and evaluation of dissolving microneedle for drug delivery applications: Extension to theoretical modeling of a novel design of microneedle (array in array) for efficient drug delivery","volume":"150","author":"Zoudani","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ymeth.2025.11.009_b0375","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s13346-021-00922-9","article-title":"Non-dermal applications of microneedle drug delivery systems","volume":"12","author":"Panda","year":"2022","journal-title":"Drug Deliv Transl. Res."},{"issue":"8","key":"10.1016\/j.ymeth.2025.11.009_b0380","doi-asserted-by":"crossref","DOI":"10.1002\/marc.202200037","article-title":"Recent advances in polymer microneedles for drug transdermal delivery: Design strategies and applications","volume":"43","author":"Wang","year":"2022","journal-title":"Macromol. Rapid Commun."},{"issue":"20","key":"10.1016\/j.ymeth.2025.11.009_b0385","doi-asserted-by":"crossref","DOI":"10.1063\/5.0008983","article-title":"Solid and hollow metallic glass microneedles for transdermal drug-delivery","volume":"116","author":"Hu","year":"2020","journal-title":"Appl. Phys. Lett."},{"issue":"7","key":"10.1016\/j.ymeth.2025.11.009_b0390","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.7150\/thno.69999","article-title":"Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment","volume":"12","author":"Qu","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0395","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3390\/pharmaceutics15010277","article-title":"Microneedle-mediated transdermal delivery of biopharmaceuticals","volume":"15","author":"Nguyen","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0400","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bioactmat.2023.04.003","article-title":"Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration","volume":"27","author":"Lyu","year":"2023","journal-title":"Bioactive Mater."},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0405","doi-asserted-by":"crossref","first-page":"e1690","DOI":"10.1002\/wnan.1690","article-title":"Recent advances in combination of microneedles and nanomedicines for lymphatic targeted drug delivery","volume":"13","author":"Permana","year":"2021","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0410","article-title":"Recent advances in microneedle designs and their applications in drug and cosmeceutical delivery","volume":"75","author":"Parhi","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0415","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/scipharm91020027","article-title":"Polymeric microneedles: an emerging paradigm for advanced biomedical applications","volume":"91","author":"Kulkarni","year":"2023","journal-title":"Scientia Pharm."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0420","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2174\/1567201819666220413131243","article-title":"Emerging trends and potential prospects in vaginal drug delivery","volume":"20","author":"Mahant","year":"2023","journal-title":"Curr Drug Deliv."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0425","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1177\/25165984241237357","article-title":"Evolution of 3D printing technology in fabrication of microfluidic devices and biological applications: a comprehensive review","volume":"7","author":"Saha","year":"2024","journal-title":"J. Micromanuf."},{"key":"10.1016\/j.ymeth.2025.11.009_b0430","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.matpr.2021.10.320","article-title":"A review on polymer hydrogel and polymer microneedle based transdermal drug delivery system","volume":"61","author":"Swain","year":"2022","journal-title":"Mater. Today Proc."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.009_b0435","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.addr.2003.10.023","article-title":"Microneedles for transdermal drug delivery","volume":"56","author":"Prausnitz","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0440","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s10544-023-00658-y","article-title":"Microneedles: materials, fabrication, and biomedical applications","volume":"25","author":"Luo","year":"2023","journal-title":"Biomed Microdevices."},{"key":"10.1016\/j.ymeth.2025.11.009_b0445","article-title":"Current trends in polymer microneedle for transdermal drug delivery","volume":"587","author":"Al-Japairai","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ymeth.2025.11.009_b0450","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actbio.2020.12.004","article-title":"Microneedle-mediated transdermal drug delivery for treating diverse skin diseases","volume":"121","author":"Yang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ymeth.2025.11.009_b0455","article-title":"A review of recent advances in microneedle technology for transdermal drug delivery","volume":"59","author":"Nagarkar","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119877","article-title":"Panorama of dissolving microneedles for transdermal drug delivery","volume":"284","author":"Dalvi","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ymeth.2025.11.009_b0465","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jconrel.2021.10.001","article-title":"Dissolving microneedle patches loaded with amphotericin B microparticles for localised and sustained intradermal delivery: potential for enhanced treatment of cutaneous fungal infections","volume":"339","author":"Peng","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ymeth.2025.11.009_b0470","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.ijbiomac.2019.12.184","article-title":"Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules","volume":"146","author":"Vora","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0475","first-page":"213","article-title":"Levothyroxine sodium loaded dissolving microneedle arrays for transdermal delivery","volume":"10","author":"Ghazi","year":"2022","journal-title":"ADMET DMPK"},{"key":"10.1016\/j.ymeth.2025.11.009_b0480","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s40005-021-00512-4","article-title":"Microneedle for transdermal drug delivery: current trends and fabrication","volume":"51","author":"Jung","year":"2021","journal-title":"J. Pharm. Investig."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0485","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal drug delivery systems: from concept to clinical applications","volume":"65","author":"Allen","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0490","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.nano.2015.03.002","article-title":"Advances in drug delivery systems to release growth factors for wound healing and skin regeneration","volume":"11","author":"Gainza","year":"2015","journal-title":"Nanomedicine (Lond.)"},{"issue":"19","key":"10.1016\/j.ymeth.2025.11.009_b0495","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.3390\/molecules26195912","article-title":"Advances of microneedles in biomedical applications","volume":"26","author":"Xu","year":"2021","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.009_b0500","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1016\/j.apsb.2024.08.013","article-title":"Microneedles as transdermal drug delivery system for enhancing skin disease treatment","volume":"14","author":"Wu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"15","key":"10.1016\/j.ymeth.2025.11.009_b0505","first-page":"2405","article-title":"Recent advances in microneedle platforms for transdermal drug delivery technologies","volume":"13","author":"Mdanda","year":"2021","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0510","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s43094-023-00553-6","article-title":"Biomimetic microneedles: exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins","volume":"9","author":"Umeyor","year":"2023","journal-title":"Future J. Pharm. Sci."},{"key":"10.1016\/j.ymeth.2025.11.009_b0515","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejpb.2020.12.006","article-title":"Microneedle array systems for long-acting drug delivery","volume":"159","author":"Vora","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ymeth.2025.11.009_b0520","first-page":"3454","article-title":"Microneedles: uses in insulin-dependent diabetes mellitus through transdermal drug delivery","volume":"11","author":"Jadhav","year":"2022","journal-title":"Int. J. Innov. Res. Sci. Eng. Technol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0525","first-page":"611","article-title":"The growing role of hydrogel microneedles in transdermal drug delivery","volume":"11","author":"Sabeeh","year":"2021","journal-title":"Int. J. Drug Deliv. Technol."},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0530","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/mi11110961","article-title":"Microneedles: characteristics, materials, production methods and commercial development","volume":"11","author":"Tucak","year":"2020","journal-title":"Micromachines"},{"issue":"7","key":"10.1016\/j.ymeth.2025.11.009_b0535","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/gels9070523","article-title":"Polymer-based hydrogels applied in drug delivery: an overview","volume":"9","author":"Thang","year":"2023","journal-title":"Gels"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0540","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s43094-020-00176-1","article-title":"Emerging era of microneedle array for pharmaceutical and biomedical applications: recent advances and toxicological perspectives","volume":"7","author":"Dugam","year":"2021","journal-title":"Future J. Pharm. Sci."},{"key":"10.1016\/j.ymeth.2025.11.009_b0545","article-title":"Progressive microneedles for targeting and intelligent drug delivery","author":"Li","year":"2025","journal-title":"Asian J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.009_b0550","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3390\/gels10050295","article-title":"Biomedical trends in stimuli-responsive hydrogels with emphasis on chitosan-based formulations","volume":"10","author":"Kruczkowska","year":"2024","journal-title":"Gels"},{"issue":"13","key":"10.1016\/j.ymeth.2025.11.009_b0555","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.3390\/ma16134805","article-title":"Hydrogel-forming microneedles with applications in oral diseases management","volume":"16","author":"Li","year":"2023","journal-title":"Materials"},{"issue":"34","key":"10.1016\/j.ymeth.2025.11.009_b0560","doi-asserted-by":"crossref","first-page":"47857","DOI":"10.1021\/acsami.5c06128","article-title":"Enzyme-responsive peptide-prodrug integrated biphasic microneedle patch for enhanced transdermal delivery and hypertension therapy","volume":"17","author":"Zhang","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"33","key":"10.1016\/j.ymeth.2025.11.009_b0565","doi-asserted-by":"crossref","first-page":"10118","DOI":"10.1039\/D5TB01029B","article-title":"Manufacture and application of antibacterial biofilm microneedles","volume":"13","author":"Wang","year":"2025","journal-title":"J. Mater. Chem. B"},{"issue":"33","key":"10.1016\/j.ymeth.2025.11.009_b0570","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202002129","article-title":"Advances in antimicrobial microneedle patches for combating infections","volume":"32","author":"Jamaledin","year":"2020","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ymeth.2025.11.009_b0575","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.787119","article-title":"The antibiofilm role of biotics family in vaginal fungal infections","volume":"13","author":"Boahen","year":"2022","journal-title":"Front. Microbiol."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0580","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/mi13020164","article-title":"Microelectromechanical systems (MEMS) for biomedical applications","volume":"13","author":"Chircov","year":"2022","journal-title":"Micromachines"},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0585","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1109\/JSEN.2021.3104715","article-title":"Technology development for MEMS: a tutorial","volume":"22","author":"French","year":"2021","journal-title":"IEEE Sens. J."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0590","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s13346-021-01045-x","article-title":"Recent advances in porous microneedles: materials, fabrication, and transdermal applications","volume":"12","author":"Bao","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.009_b0595","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/mi13050657","article-title":"In-plane Si microneedles: fabrication, characterization, modeling and applications","volume":"13","author":"Mamun","year":"2022","journal-title":"Micromachines"},{"key":"10.1016\/j.ymeth.2025.11.009_b0600","doi-asserted-by":"crossref","unstructured":"S. Moradi, F. Nargesi Azam, H. Abdollahi, N. Rajabifar, A. Rostami, P. Guzman, et al, Graphene-based polymeric microneedles for biomedical applications: a comprehensive review, ACS Appl. Bio Mater. 8 (2025) 1835-1861.","DOI":"10.1021\/acsabm.4c01884"},{"issue":"10","key":"10.1016\/j.ymeth.2025.11.009_b0605","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3390\/bios12100801","article-title":"Electrochemical microneedles: innovative instruments in health care","volume":"12","author":"Liao","year":"2022","journal-title":"Biosensors"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0610","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1039\/D3BM01551C","article-title":"Advances in biomedical systems based on microneedles: design, fabrication, and application","volume":"12","author":"Wang","year":"2024","journal-title":"Biomater. Sci."},{"issue":"4","key":"10.1016\/j.ymeth.2025.11.009_b0620","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s44222-023-00141-6","article-title":"Microneedle biomedical devices","volume":"2","author":"Zheng","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"key":"10.1016\/j.ymeth.2025.11.009_b0625","series-title":"Disruptive Developments in Biomedical Applications","first-page":"299","article-title":"Recent advances in drug delivery systems","author":"Bhavana","year":"2024"},{"key":"10.1016\/j.ymeth.2025.11.009_b0630","doi-asserted-by":"crossref","unstructured":"I. Podder, T. Fischl, U. Bub, Artificial intelligence applications for MEMS-based sensors and manufacturing process optimization, Telecom (Basel), 42023, 165-197.","DOI":"10.3390\/telecom4010011"},{"key":"10.1016\/j.ymeth.2025.11.009_b0635","doi-asserted-by":"crossref","unstructured":"N. Hossain, M.Z. Al Mahmud, A. Hossain, M.K. Rahman, M.S. Islam, et al., Advances of materials science in MEMS applications: a review, Results Eng. 22(2024) 102115.","DOI":"10.1016\/j.rineng.2024.102115"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0640","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1021\/acs.analchem.2c04527","article-title":"Emerging wearable chemical sensors enabling advanced integrated systems toward personalized and preventive medicine","volume":"95","author":"He","year":"2023","journal-title":"Anal. Chem."},{"issue":"16","key":"10.1016\/j.ymeth.2025.11.009_b0645","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.3390\/nano12162754","article-title":"Evolution in lithography techniques: microlithography to nanolithography","volume":"12","author":"Sharma","year":"2022","journal-title":"Nanomaterials"},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.009_b0650","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.3390\/pharmaceutics14122693","article-title":"A review of 3D-printing of microneedles","volume":"14","author":"Olowe","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0655","doi-asserted-by":"crossref","unstructured":"S. Middya, G.S.K. Schierle, G.G. Malliaras, V.F. Curto, Lithography and electrodes, In: S. Das. S. Dhara (Eds), Chemical Solution Synthesis for Materials Design and Thin Film Device Applications, Elsevier, United Kingdom, 2021, pp. 277-307.","DOI":"10.1016\/B978-0-12-819718-9.00005-4"},{"issue":"10","key":"10.1016\/j.ymeth.2025.11.009_b0660","doi-asserted-by":"crossref","first-page":"4981","DOI":"10.1166\/jnn.2021.19327","article-title":"Nanofabrication techniques: challenges and future prospects","volume":"21","author":"Tahir","year":"2021","journal-title":"J. Nanosci. Nanotechnol."},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0665","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.3390\/ma17112552","article-title":"Recent advances in positive photoresists: mechanisms and fabrication","volume":"17","author":"Hassaan","year":"2024","journal-title":"Materials"},{"issue":"22","key":"10.1016\/j.ymeth.2025.11.009_b0670","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202200476","article-title":"Gentle patterning approaches toward compatibility with bio-organic materials and their environmental aspects","volume":"18","author":"Grebenko","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.ymeth.2025.11.009_b0675","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115082","article-title":"Microneedles for advanced ocular drug delivery","volume":"201","author":"Glover","year":"2023","journal-title":"Adv Drug Deliv."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0680","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/macromol4020019","article-title":"Microneedles\u2019 device: design, fabrication, and applications","volume":"4","author":"Oliveira","year":"2024","journal-title":"Macromol"},{"issue":"18","key":"10.1016\/j.ymeth.2025.11.009_b0685","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202106392","article-title":"The role of 3D printing technology in microengineering of microneedles","volume":"18","author":"Detamornrat","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.ymeth.2025.11.009_b0690","unstructured":"C. Ge, Development of a technology framework for rapid polymer MEMS fabrication process based on SU-8 photoresist, University of British Columbia, Vancouver, 2021. 10.14288\/1.0396684."},{"key":"10.1016\/j.ymeth.2025.11.009_b0695","article-title":"Additive manufacturing of micropatterned functional surfaces: a review","volume":"6","author":"Chivate","year":"2024","journal-title":"Int. J. Extreme Manuf."},{"key":"10.1016\/j.ymeth.2025.11.009_b0700","doi-asserted-by":"crossref","unstructured":"M.A. Mohd Asri, A.N. Nordin, N. Ramli, Low-cost and cleanroom-free prototyping of microfluidic and electrochemical biosensors: techniques in fabrication and bioconjugation, Biomicrofluidics 15 (6) (2021)061502.","DOI":"10.1063\/5.0071176"},{"key":"10.1016\/j.ymeth.2025.11.009_b0705","doi-asserted-by":"crossref","unstructured":"H. de Souza Oliveira, N. Saeedzadeh Khaanghah, G. Elli, L. Petti, G. Cantarella, E. Milana, et al., Mechanical metamaterial sensors: from design to applications, J. Phys. D: Appl. Phys. 58(2024)133002.","DOI":"10.1088\/1361-6463\/adade5"},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.009_b0710","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202306560","article-title":"Microneedle sensors for point-of-care diagnostics","volume":"11","author":"Hu","year":"2024","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.ymeth.2025.11.009_b0715","article-title":"Microneedles in diagnostic, treatment and theranostics: an advancement in minimally-invasive delivery system","volume":"24","author":"Amarnani","year":"2022","journal-title":"Biomed. Microdevices"},{"key":"10.1016\/j.ymeth.2025.11.009_b0720","article-title":"Fabrication of hollow silicon microneedle arrays for transdermal biological fluid extraction","author":"Zhang","year":"2018","journal-title":"University of Waterloo"},{"key":"10.1016\/j.ymeth.2025.11.009_b0725","unstructured":"M. Shojaeian, Self-assembly microfabrication of multilayered helical nanomembrane and its application as microswimming robots, 2021. 10413268.pdf."},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0730","first-page":"1364","article-title":"3D-microneedles: a novel approach for skin-directed delivery and its application","volume":"62","author":"Yadav","year":"2023","journal-title":"Polym.-Plast. Technol. Mater."},{"issue":"21","key":"10.1016\/j.ymeth.2025.11.009_b0735","doi-asserted-by":"crossref","first-page":"9841","DOI":"10.3390\/app14219841","article-title":"Recent advances in black silicon surface modification for enhanced light trapping in photodetectors","volume":"14","author":"Alsolami","year":"2024","journal-title":"Appl. Sci."},{"key":"10.1016\/j.ymeth.2025.11.009_b0740","unstructured":"W. Hu, Fabrication of silicon out-of-plane microneedles for potential drug delivery and interstitial fluid extraction, University of Waterloo, 2024. Hu_Wenhan.pdf."},{"issue":"2228","key":"10.1016\/j.ymeth.2025.11.009_b0745","doi-asserted-by":"crossref","DOI":"10.1098\/rsta.2021.0009","article-title":"Cleanroom strategies for micro- and nano-fabricating flexible implantable neural electronics","volume":"380","author":"Walton","year":"2022","journal-title":"Philos. Trans. R. Soc. A"},{"key":"10.1016\/j.ymeth.2025.11.009_b0750","doi-asserted-by":"crossref","unstructured":"A.S. Raikar, D. Kalaskar, S. Bhilegaonkar, S.N. Somnache, M. Bodaghi, Revolutionizing drug delivery by bioinspired 4D transdermal microneedles: advances and future horizons, Eur. Polym. J. 210 (2024)112952.","DOI":"10.1016\/j.eurpolymj.2024.112952"},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0755","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/cosmetics10020041","article-title":"3D-printed hollow microneedles for treating skin wrinkles using different anti-wrinkle agents: a possible futuristic approach","volume":"10","author":"Islam","year":"2023","journal-title":"Cosmetics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0760","doi-asserted-by":"crossref","unstructured":"R. Kaur, V. Arora, Advancements in microneedle-based drug delivery systems: a painless revolution in transdermal medicine, E3S Web Conf., EDP Sciences, 509(2024) 02002. https:\/\/doi.org\/10.1051\/e3sconf\/202450902002.","DOI":"10.1051\/e3sconf\/202450902002"},{"issue":"7","key":"10.1016\/j.ymeth.2025.11.009_b0765","article-title":"Two-photon polymerization: fundamentals, materials, and chemical modification strategies","volume":"10","author":"O'Halloran","year":"2023","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0770","doi-asserted-by":"crossref","DOI":"10.1038\/s41378-021-00298-3","article-title":"High-resolution two-photon polymerization: the most versatile technique for the fabrication of microneedle arrays","volume":"7","author":"Faraji Rad","year":"2021","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.ymeth.2025.11.009_b0775","article-title":"Smart microneedles for therapy and diagnosis","volume":"2020","author":"Zhang","year":"2020","journal-title":"RSC Rev."},{"issue":"7","key":"10.1016\/j.ymeth.2025.11.009_b0780","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3390\/pharmaceutics16070885","article-title":"Investigating laser ablation process parameters for the fabrication of customized microneedle arrays for therapeutic applications","volume":"16","author":"Aldawood","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0785","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jmapro.2020.12.035","article-title":"Controlling the geometry of laser-ablated microneedle cavities in different mould materials and assessing the replication fidelity within polymer injection moulding","volume":"62","author":"Evens","year":"2021","journal-title":"J. Manuf. Process."},{"key":"10.1016\/j.ymeth.2025.11.009_b0790","unstructured":"D. Joshi, M. Uddin, M. D\u2019Souza, R. Gala, Technology update: laser ablation technology for transdermal immunization, J. Vaccines Vaccin. 12(S15) (2021)1000001. 10.35248\/2157-7560.21.s15.001."},{"key":"10.1016\/j.ymeth.2025.11.009_b0795","unstructured":"P. Papadimitriou, Design and prototype construction of a microneedle drug delivery apparatus, 2022. openarchives.gr | Design and Prototype Construction of a Microneedle Drug Delivery Apparatus."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0800","first-page":"190","article-title":"Microneedle-based natural polysaccharide for drug delivery systems (DDS): progress and challenges","volume":"15","author":"Damiri","year":"2022","journal-title":"Polymers"},{"key":"10.1016\/j.ymeth.2025.11.009_b0805","article-title":"Fabrication of customized microneedle with high 3D capability and high structural precision","volume":"95","author":"Chen","year":"2024","journal-title":"Addit. Manuf."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0810","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s13346-023-01296-w","article-title":"Design, analysis and fabrication of solid polymer microneedle patch using CO2 laser and polymer molding","volume":"13","author":"Anbazhagan","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ymeth.2025.11.009_b0815","series-title":"Laser-based Technologies for Sustainable Manufacturing","first-page":"169","article-title":"Laser micromachining in biomedical industry","author":"Kumar","year":"2023"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0820","first-page":"1034","article-title":"An overview of microneedle applications, materials, and fabrication methods","volume":"12","author":"Rad","year":"2021","journal-title":"Beilstein J. Nanotechnol."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0825","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/bioengineering10010024","article-title":"Metallic microneedles for transdermal drug delivery: applications, fabrication techniques and the effect of geometrical characteristics","volume":"10","author":"Sargioti","year":"2022","journal-title":"Bioengineering"},{"issue":"12","key":"10.1016\/j.ymeth.2025.11.009_b0830","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3390\/mi15121433","article-title":"Advancements in materials for 3D-printed microneedle arrays: enhancing performance and biocompatibility","volume":"15","author":"Razzaghi","year":"2024","journal-title":"Micromachines"},{"key":"10.1016\/j.ymeth.2025.11.009_b0835","doi-asserted-by":"crossref","unstructured":"S.R. Dabbagh, M.R. Sarabi, R. Rahbarghazi, E. Sokullu, A.K. Yetisen, et al., 3D-printed microneedles in biomedical applications, iScience 24(1) (2021)102012.","DOI":"10.1016\/j.isci.2020.102012"},{"key":"10.1016\/j.ymeth.2025.11.009_b0840","unstructured":"J.A. Ninan, Smartphone-enabled biomarker sensing and on-demand drug delivery using 3D-printed hollow microneedle arrays, 2024. https:\/\/hdl.handle.net\/1828\/20866."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0845","doi-asserted-by":"crossref","first-page":"674","DOI":"10.5937\/arhfarm72-40365","article-title":"Digital light processing (DLP) 3D printing technique applied in the fabrication of two-layered tablets: the concept of a combined polypill","volume":"72","author":"Adamov","year":"2022","journal-title":"Arh. Farm."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0850","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1021\/acs.biomac.4c01004","article-title":"Trends in photopolymerization 3D printing for advanced drug delivery applications","volume":"26","author":"Hu","year":"2024","journal-title":"Biomacromolecules"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0855","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41378-023-00537-9","article-title":"Ultra-resolution scalable microprinting","volume":"9","author":"Vidler","year":"2023","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.ymeth.2025.11.009_b0860","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2024.104626","article-title":"Electrohydrodynamic encapsulation: a novel technique to enhance the stability of bioactive compounds in food","volume":"151","author":"Vignesh","year":"2024","journal-title":"Trends Food Sci. Technol."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0865","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3390\/pharmaceutics15061597","article-title":"Three-dimensional printing and its applications focusing on microneedles for drug delivery","volume":"15","author":"Al-Nimry","year":"2023","journal-title":"Pharmaceutics"},{"issue":"9","key":"10.1016\/j.ymeth.2025.11.009_b0870","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1080\/10837450.2021.1965163","article-title":"An overview on the advantages and limitations of 3D printing of microneedles","volume":"26","author":"Ozyilmaz","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.ymeth.2025.11.009_b0875","unstructured":"S.N. Oikonomidou, 3D printed microneedles for transdermal drug delivery, University of Kent (United Kingdom) (2021). https:\/\/doi.org\/10.22024\/UniKent%2F01.02.93435."},{"key":"10.1016\/j.ymeth.2025.11.009_b0880","doi-asserted-by":"crossref","unstructured":"C. Oliveira, J.A. Teixeira, N. Oliveira, S. Ferreira, C. Botelho, Microneedles patch: design, fabrication and applications, 4(2) (2024)320-355.","DOI":"10.3390\/macromol4020019"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b0885","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3390\/technologies9030061","article-title":"Post-processing of 3D-printed polymers","volume":"9","author":"Dizon","year":"2021","journal-title":"Technologies"},{"issue":"18","key":"10.1016\/j.ymeth.2025.11.009_b0890","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.3390\/app131810269","article-title":"Advances in three dimensional bioprinting for wound healing: a comprehensive review","volume":"13","author":"Umur","year":"2023","journal-title":"Appl. Sci."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b0895","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/pharmaceutics17020188","article-title":"AI-driven innovation in skin kinetics for transdermal drug delivery: overcoming barriers and enhancing precision","volume":"17","author":"Albayati","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b0900","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.addr.2021.04.019","article-title":"Emerging 3D printing technologies for drug delivery devices: current status and future perspective","volume":"174","author":"Wang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ymeth.2025.11.009_b0905","first-page":"740","article-title":"Microneedles: multifunctional devices for drug delivery, body fluid extraction, and bio-sensing","author":"Wang","year":"2024","journal-title":"Nanoscale17"},{"key":"10.1016\/j.ymeth.2025.11.009_b0910","doi-asserted-by":"crossref","unstructured":"H. Zhang, H. Zhang, T. Guan, X. Wang, N. Zhang, Prototyping and production of polymeric microfluidic chip, In: S. M. S. Murshed (Eds), Advances in Microfluidics and Nanofluids, IntechOpen (2021). 10.5772\/intechopen.96355.","DOI":"10.5772\/intechopen.96355"},{"key":"10.1016\/j.ymeth.2025.11.009_b0915","doi-asserted-by":"crossref","first-page":"6829","DOI":"10.55522\/jmpas.V13I6.6687","article-title":"Exploring microneedles applications in rheumatoid arthritis: efficacy, safety, and patient benefits","volume":"13","author":"Agarwal","year":"2024","journal-title":"J Med Pharm Allied Sci."},{"issue":"9","key":"10.1016\/j.ymeth.2025.11.009_b0920","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3390\/mi15091137","article-title":"Recent advances in polymer science and fabrication processes for enhanced microfluidic applications: an overview","volume":"15","author":"Alexandre-Franco","year":"2024","journal-title":"Micromachines"},{"issue":"9","key":"10.1016\/j.ymeth.2025.11.009_b0925","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.3390\/mi13091530","article-title":"A review of microinjection moulding of polymeric micro devices","volume":"13","author":"Zhang","year":"2022","journal-title":"Micromachines"},{"issue":"7","key":"10.1016\/j.ymeth.2025.11.009_b0930","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1080\/09205063.2022.2155778","article-title":"PVP-microneedle array for drug delivery: mechanical insight, biodegradation, and recent advances","volume":"34","author":"Mangang","year":"2023","journal-title":"J. Biomater. Sci., Polym. Ed."},{"key":"10.1016\/j.ymeth.2025.11.009_b0935","doi-asserted-by":"crossref","unstructured":"C. Post, P. van den Tempel, P. Herrera S\u00e1nchez, D. Maniar, R.K. Bose, V.S. Voet, et al., Thermoreversible Diels-Alder cross-linking of BHMF-based polyesters: synthesis, characterization and rheology, ACS Sustain. Chem. Eng. 13(2025)3543-3553.","DOI":"10.1021\/acssuschemeng.4c09338"},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.009_b0940","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s00542-022-05265-0","article-title":"Current innovations in roller embossing-A comprehensive review","volume":"28","author":"Deshmukh","year":"2022","journal-title":"Microsyst. Technol."},{"issue":"9","key":"10.1016\/j.ymeth.2025.11.009_b0945","article-title":"Micromolding of thermoplastic polymers for direct fabrication of discrete, multilayered microparticles","volume":"6","author":"Sadeghi","year":"2022","journal-title":"Small Methods"},{"key":"10.1016\/j.ymeth.2025.11.009_b0950","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202422274","article-title":"Dissolving microneedles as in situ chemical reaction chambers: from design strategies to versatile biomedical applications","volume":"35","author":"Tian","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.ymeth.2025.11.009_b0955","article-title":"Microneedle technology: a promising tool for transdermal drug delivery","volume":"3399","author":"Kohale","year":"2024","journal-title":"Biochem. Cell. Arch."},{"issue":"19","key":"10.1016\/j.ymeth.2025.11.009_b0960","doi-asserted-by":"crossref","first-page":"6375","DOI":"10.3390\/ma16196375","article-title":"Micro-injection molding and debinding behavior of hydroxyapatite\/zirconia bi-materials fabricated by two-component micro-powder injection molding process","volume":"16","author":"Basir","year":"2023","journal-title":"Materials"},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b0965","doi-asserted-by":"crossref","first-page":"7015","DOI":"10.1021\/acs.biomac.4c01193","article-title":"Recent advances in degradable biomedical polymers for prevention, diagnosis and treatment of diseases","volume":"25","author":"Zhang","year":"2024","journal-title":"Biomacromolecules"},{"issue":"43","key":"10.1016\/j.ymeth.2025.11.009_b0970","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1039\/D3AY01745A","article-title":"Recent advances of biosensors on microneedles","volume":"15","author":"Ma","year":"2023","journal-title":"Anal. Methods"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b0975","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/15583724.2024.2427184","article-title":"4D printing of physical stimuli-responsive hydrogels for localized drug delivery and tissue engineering","volume":"65","author":"Sadraei","year":"2025","journal-title":"Polymer Rev."},{"issue":"39","key":"10.1016\/j.ymeth.2025.11.009_b0980","doi-asserted-by":"crossref","first-page":"32155","DOI":"10.1039\/D5RA04410C","article-title":"Exploring 4D printing of smart materials for regenerative medicine applications","volume":"15","author":"Alanazi","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.ymeth.2025.11.009_b0985","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1080\/17425247.2025.2531062","article-title":"3D printed hollow microneedles: the latest innovation in drug delivery","volume":"22","author":"Razzaghi","year":"2025","journal-title":"Expert Opin. Drug Deliv."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b0990","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1007\/s13346-023-01510-9","article-title":"Advancements in microneedle fabrication techniques: artificial intelligence assisted 3D-printing technology","volume":"14","author":"Biswas","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ymeth.2025.11.009_b0995","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129638","article-title":"4D-printed microneedles from dual-sensitive chitosan for non-transdermal drug delivery","volume":"261","author":"Che","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ymeth.2025.11.009_b1000","doi-asserted-by":"crossref","DOI":"10.34133\/2020\/7462915","article-title":"Smart microneedles for therapy and diagnosis","volume":"2020","author":"Zhang","year":"2020","journal-title":"Research"},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b1005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3390\/ph15020190","article-title":"Microneedle-based natural polysaccharide for drug delivery systems (DDS): progress and challenges","volume":"15","author":"Damiri","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b1010","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1427651","article-title":"Nanoparticle-based approaches for treating restenosis after vascular injury","volume":"15","author":"Zhao","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.ymeth.2025.11.009_b1015","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s40005-021-00512-4","article-title":"Microneedle for transdermal drug delivery: current trends and fabrication","volume":"51","author":"Jung","year":"2021","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.ymeth.2025.11.009_b1020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12039-019-1666-x","article-title":"Microneedle-based drug delivery: materials of construction","volume":"131","author":"Bhatnagar","year":"2019","journal-title":"J. Chem. Sci."},{"issue":"29","key":"10.1016\/j.ymeth.2025.11.009_b1025","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201705328","article-title":"Advances in biomaterials for drug delivery","volume":"30","author":"Fenton","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ymeth.2025.11.009_b1030","first-page":"445","article-title":"Nanocomposite systems for precise oral delivery of drugs and biologics, Drug Deliv","volume":"11","author":"Andretto","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.ymeth.2025.11.009_b1035","unstructured":"A. Devine, Conductive microneedle patches: developing new approaches to controlled drug delivery, Ulster University (2023). Conductive microneedle patches: developing new approaches to controlled drug delivery - Ulster University."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b1040","first-page":"113","article-title":"Polymeric and composite-based microneedles in drug delivery: regenerative medicine, microbial infection therapy, and cancer treatment","volume":"2","author":"Amourizi","year":"2023","journal-title":"Mater. Chem. Horizons"},{"issue":"18","key":"10.1016\/j.ymeth.2025.11.009_b1045","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.3390\/polym16182568","article-title":"Polymeric microneedle drug delivery systems: mechanisms of treatment, material properties, and clinical applications-A comprehensive review","volume":"16","author":"Liu","year":"2024","journal-title":"Polymers"},{"issue":"10","key":"10.1016\/j.ymeth.2025.11.009_b1050","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.3390\/pharmaceutics15102444","article-title":"Hydrogel-based microneedle as a drug delivery system","volume":"15","author":"Filho","year":"2023","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b1055","doi-asserted-by":"crossref","first-page":"229","DOI":"10.52711\/2231-5713.2024.00038","article-title":"Advancements, applications and future prospects in pharmaceutical delivery","volume":"14","author":"Sarella","year":"2024","journal-title":"Asian J. Pharm. Technol."},{"key":"10.1016\/j.ymeth.2025.11.009_b1060","doi-asserted-by":"crossref","first-page":"7759","DOI":"10.2147\/IJN.S435251","article-title":"Advances in formulations of microneedle system for rheumatoid arthritis treatment","volume":"18","author":"Guo","year":"2023","journal-title":"Int. J. Nanomedicine"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b1065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4155\/tde.12.13","article-title":"Microneedle delivery: clinical studies and emerging medical applications","volume":"3","author":"Pettis","year":"2012","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.ymeth.2025.11.009_b1070","doi-asserted-by":"crossref","unstructured":"N.S. Baste, S.H. Shahare, A.S. Mundada, Comprehensive insights into mucoadhesive drug delivery systems, In: A. S. Mundada, A. Chaudhari (Eds), Novel Drug Delivery Systems (Part 1)28 (2024) pp. 169-196.","DOI":"10.2174\/9789815274165124010010"},{"issue":"3","key":"10.1016\/j.ymeth.2025.11.009_b1075","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1021\/acsabm.3c01064","article-title":"Recent advances in nanotechnology-based drug delivery systems for the diagnosis and treatment of reproductive disorders","volume":"7","author":"Acharya","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.ymeth.2025.11.009_b1080","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.eng.2023.05.009","article-title":"Microneedles for enhanced topical treatment of skin disorders: applications, challenges, and prospects","volume":"30","author":"Peng","year":"2023","journal-title":"Engineering"},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b1085","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40580-024-00421-w","article-title":"Microneedle-mediated nanomedicine to enhance therapeutic and diagnostic efficacy","volume":"11","author":"Zuo","year":"2024","journal-title":"Nano Convergence"},{"issue":"9","key":"10.1016\/j.ymeth.2025.11.009_b1090","article-title":"Design, formulation, and evaluation of novel dissolving microarray patches containing rilpivirine for intravaginal delivery","volume":"8","author":"McCrudden","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.ymeth.2025.11.009_b1095","doi-asserted-by":"crossref","unstructured":"P. Udayakumar, N. \u0160kalko-Basnet, C.F.S. Cotaquispe, L.M. Hemmingsen, G. Sotiriou, J. Du, A. Teleki, Microneedles loaded with lipid nanocarriers for local treatment of vulvovaginal candidiasis, 1(2024). https:\/\/doi.org\/10.26434\/chemrxiv-2024-fj3gp.","DOI":"10.26434\/chemrxiv-2024-fj3gp"},{"key":"10.1016\/j.ymeth.2025.11.009_b1100","article-title":"Incorporation of efavirenz inclusion complex in dissolvable microneedle for enhanced effectiveness of intravaginal drug delivery: a proof of concept study","volume":"97","author":"Samma","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ymeth.2025.11.009_b1105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jcis.2023.05.165","article-title":"Development of probiotic-loaded multilayer microcapsules incorporated into dissolving microneedles for potential improvement in treatment of vulvovaginal candidiasis: a proof of concept study","volume":"648","author":"Enggi","year":"2023","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.ymeth.2025.11.009_b1110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40199-025-00555-0","article-title":"Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery","volume":"33","author":"Burhanuddin","year":"2025","journal-title":"DARU J. Pharm. Sci."},{"issue":"6","key":"10.1016\/j.ymeth.2025.11.009_b1115","first-page":"1678","article-title":"Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole, Drug Deliv","volume":"14","author":"Aziz","year":"2024","journal-title":"Transl. Res."},{"key":"10.1016\/j.ymeth.2025.11.009_b1120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jconrel.2016.12.009","article-title":"Combining different types of multifunctional liposomes loaded with ammonium bicarbonate to fabricate microneedle arrays as a vaginal mucosal vaccine adjuvant-dual delivery system (VADDS)","volume":"246","author":"Wang","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ymeth.2025.11.009_b1125","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.110361","article-title":"Validation of spectrophotometric and colorimetric methods for determination of efavirenz in biological matrices: application to dissolvable microneedle-based efavirenz complex inclusion for vaginal delivery","volume":"200","author":"Hidayat","year":"2024","journal-title":"Microchem. J."},{"issue":"10","key":"10.1016\/j.ymeth.2025.11.009_b1140","article-title":"Development of microneedles for antimicrobial drug delivery: a comprehensive review on applications in wound infection management","volume":"4","author":"Haidari","year":"2024","journal-title":"Small Sci."},{"issue":"46","key":"10.1016\/j.ymeth.2025.11.009_b1145","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202401551","article-title":"The core-shell microneedle with probiotic extracellular vesicles for infected wound healing and microbial homeostasis restoration","volume":"20","author":"Qi","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.ymeth.2025.11.009_b1150","doi-asserted-by":"crossref","DOI":"10.34133\/2020\/2760594","article-title":"Living bacterial microneedles for fungal infection treatment","volume":"2020","author":"Wang","year":"2020","journal-title":"Research"},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b1155","doi-asserted-by":"crossref","first-page":"11282","DOI":"10.1021\/acsomega.4c11016","article-title":"Double-layer magnetic microspheres with dual drug delivery of antibacterial and maintenance agents for the treatment of Candida albicans vaginitis","volume":"10","author":"Li","year":"2025","journal-title":"ACS Omega"},{"key":"10.1016\/j.ymeth.2025.11.009_b1160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408347.2024.2427130","article-title":"Hydrogen peroxide quantification using zero-dimensional carbon nanostructured materials: a review","author":"Sharma","year":"2024","journal-title":"Crit. Rev. Anal. Chem."},{"issue":"2","key":"10.1016\/j.ymeth.2025.11.009_b1165","first-page":"656","article-title":"Current advances in lipid nanosystems intended for topical and transdermal drug delivery applications","volume":"15","author":"Akombaetwa","year":"2023","journal-title":"Pharm. (Basel)"},{"issue":"4","key":"10.1016\/j.ymeth.2025.11.009_b1175","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1007\/s13346-021-01004-6","article-title":"Transdermal drug delivery systems for fighting common viral infectious diseases","volume":"11","author":"Wang","year":"2021","journal-title":"Drug Deliv. Transl. Res."},{"issue":"11","key":"10.1016\/j.ymeth.2025.11.009_b1180","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1080\/17425247.2024.2306139","article-title":"3D printing in vaginal drug delivery: a revolution in pharmaceutical manufacturing","volume":"21","author":"Narala","year":"2024","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ymeth.2025.11.009_b1185","article-title":"Therapeutic potential of microneedles-based delivery systems for the management of atopic dermatitis","volume":"84","author":"Shukla","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ymeth.2025.11.009_b1190","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3390\/pharmaceutics14051066","article-title":"Potential of microneedle systems for COVID-19 vaccination: current trends and challenges","volume":"14","author":"Hassan","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ymeth.2025.11.009_b1195","article-title":"Development of long-acting antiviral drug nanoformulations","volume":"524","author":"Cobb","year":"2021","journal-title":"Theses & Dissertations."},{"issue":"700","key":"10.1016\/j.ymeth.2025.11.009_b1200","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add1531","article-title":"Fusobacterium infection facilitates the development of endometriosis through phenotypic transition of endometrial fibroblasts","volume":"15","author":"Muraoka","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymeth.2025.11.009_b1205","doi-asserted-by":"crossref","unstructured":"H.X. Nguyen, Microneedles: the future of drug delivery, CRC Press, Boca Raton, 2023, pp. 1-404. https:\/\/doi.org\/10.1201\/9780429294433\/.","DOI":"10.1201\/9780429294433-1"},{"key":"10.1016\/j.ymeth.2025.11.009_b1210","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jconrel.2023.09.013","article-title":"Microneedle-based cell delivery and cell sampling for biomedical applications","volume":"362","author":"Mbituyimana","year":"2023","journal-title":"J. Control. Release"}],"container-title":["Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325002427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1046202325002427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T07:37:24Z","timestamp":1767425844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1046202325002427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":236,"alternative-id":["S1046202325002427"],"URL":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.11.009","relation":{},"ISSN":["1046-2023"],"issn-type":[{"type":"print","value":"1046-2023"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fabrication of advanced microneedle-based targeted intravaginal drug delivery devices: therapeutic opportunities and translational challenges","name":"articletitle","label":"Article Title"},{"value":"Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymeth.2025.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}