{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:13:20Z","timestamp":1791216800240,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.ymgme.2003.10.012","type":"journal-article","created":{"date-parts":[[2004,2,17]],"date-time":"2004-02-17T10:08:37Z","timestamp":1077012517000},"page":"38-44","source":"Crossref","is-referenced-by-count":204,"special_numbering":"S","title":["Arginases I and II: do their functions overlap?"],"prefix":"10.1016","volume":"81","author":[{"given":"Stephen D","family":"Cederbaum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne W","family":"Grody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita M","family":"Kern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramaswamy K","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.ymgme.2003.10.012_BIB1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1023\/A:1005313809037","article-title":"The human arginases and arginase deficiency","volume":"21","author":"Iyer","year":"1998","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1042\/bj1330779","article-title":"Purification and properties of arginase of rat kidney","volume":"133","author":"Kaysen","year":"1973","journal-title":"Biochem. J."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB3","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1016\/S0021-9258(19)43572-2","article-title":"Arginase isozymes of rat mammary gland, liver and other tissues","volume":"248","author":"Glass","year":"1973","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1203\/00006450-198312000-00003","article-title":"Immunologic studies of arginase in tissues of normal human adults and arginase-deficient patients","volume":"17","author":"Spector","year":"1983","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1006\/geno.1996.0606","article-title":"Cloning and characterization of the human type II arginase gene","volume":"38","author":"Vockley","year":"1996","journal-title":"Genomics"},{"key":"10.1016\/j.ymgme.2003.10.012_BIB6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-5793(96)01015-0","article-title":"Molecular cloning of cDNA for non-hepatic arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line","volume":"395","author":"Gotoh","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-1119(97)00099-1","article-title":"Human type II arginase: sequence analysis and tissue-specific expression","volume":"193","author":"Morris","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.ymgme.2003.10.012_BIB8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1006\/bbrc.1995.1757","article-title":"Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide","volume":"210","author":"Wang","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB9","first-page":"H1988","article-title":"Arginase activity in endothelial cells: inhibition by NG-hydroxyarginine during high output NO production","volume":"271","author":"Buga","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB10","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1074\/jbc.272.6.3689","article-title":"Co-induction of nitric oxide synthase and arginase I in cultured rat peritoneal macrophages and rat tissues in vivo by lipopolysaccharide","volume":"272","author":"Sonoki","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB11","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.1021\/bi034340j","article-title":"Human arginase II: crystal structure and physiological role in male and female sexual arousal","volume":"42","author":"Cama","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymgme.2003.10.012_BIB12","first-page":"E740","article-title":"Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells","volume":"275","author":"Morris","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/mgme.2001.3277","article-title":"Cloning and characterization of human agmatinase","volume":"75","author":"Iyer","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB14","first-page":"G375","article-title":"Cloning of human agmatinase. An alternative path for polyamine synthesis induced in liver by hepatitis B virus","volume":"282","author":"Mistry","year":"2002","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB15","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/sj.bjp.0701143","article-title":"Inhibition of arginase in rat and rabbit alveolar macrophages by N\u03c9-hydroxy-d,l-indospicine, effects on l-arginine utilization by nitric oxide synthase","volume":"121","author":"Hey","year":"1997","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB16","first-page":"3305","article-title":"Arginase activity in human breast cancer cell lines: N-hydroxyarginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB 468 cells","volume":"60","author":"Singh","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB17","first-page":"R1256","article-title":"NG-hydroxy-l-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms","volume":"275","author":"Buga","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB18","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1002\/cncr.10563","article-title":"Serum arginase activity in postsurgical monitoring of patients with colorectal carcinoma","volume":"94","author":"Porembska","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ymgme.2003.10.012_BIB19","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/jnr.1233","article-title":"Expression of arginase isozymes in mouse brain","volume":"66","author":"Yu","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0925-4773(02)00089-8","article-title":"Arginase expression in mouse embryonic development","volume":"115","author":"Yu","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB21","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1177\/002215540305100905","article-title":"Widespread expression of arginase I in mouse tissues: biochemical and physiological implications","volume":"51","author":"Yu","year":"2003","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB22","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1172\/JCI200317912","article-title":"Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis","volume":"111","author":"Zimmerman","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/MCB.21.3.811-813.2001","article-title":"Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene","volume":"21","author":"Shi","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB24","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1128\/MCB.22.13.4491-4498.2002","article-title":"Mouse model for human arginase deficiency","volume":"22","author":"Iyer","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1067\/mpd.2003.97","article-title":"Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema","volume":"142","author":"Picker","year":"2003","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB26","doi-asserted-by":"crossref","DOI":"10.1023\/A:1025964401618","article-title":"Prenatal diagnosis of arginase deficiency: a case report submitted","author":"Hewson","year":"2003","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgme.2003.10.012_BIB27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/ajmg.1320550220","article-title":"Prenatal diagnosis of urea cycle diseases: a survey of European cases","volume":"55","author":"Kamoun","year":"1995","journal-title":"Am. J. Med. Genet."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719204000113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719204000113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T19:08:25Z","timestamp":1623697705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719204000113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":27,"alternative-id":["S1096719204000113"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2003.10.012","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}