{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:17:50Z","timestamp":1760188670880},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.ymgme.2005.07.029","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T11:16:56Z","timestamp":1127992616000},"page":"379-383","source":"Crossref","is-referenced-by-count":10,"title":["Crohn\u2019s disease associated CARD15 (NOD2) variants are not involved in the susceptibility to type 1 diabetes"],"prefix":"10.1016","volume":"86","author":[{"given":"Pegah","family":"Ghandil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Chelala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dani\u00e8le","family":"Dubois-Laforgue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Sen\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Caillat-Zucman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Kockum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holgar","family":"Luthman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorn","family":"Nerup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming","family":"Pociot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Julier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2005.07.029_bib1","first-page":"170","article-title":"Type 1 diabetes mellitus of man: genetic susceptibility and resistance","volume":"552","author":"Pugliese","year":"2004","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib2","doi-asserted-by":"crossref","unstructured":"European Consortium for IDDM Genome Studies, A genome-wide scan for type 1 diabetes susceptibility genes in Scandinavian families. Identification of new loci with evidence of interactions, Am. J. Hum. Genet. 69 (2001) 1301\u20131313.","DOI":"10.1086\/324341"},{"key":"10.1016\/j.ymgme.2005.07.029_bib3","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1086\/323501","article-title":"Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families","volume":"69","author":"Cox","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ymgme.2005.07.029_bib4","doi-asserted-by":"crossref","first-page":"9979","DOI":"10.1073\/pnas.95.17.9979","article-title":"Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases","volume":"95","author":"Becker","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgme.2005.07.029_bib5","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/ni0901-802","article-title":"The genetics of complex autoimmune diseases: non-MHC susceptibility genes","volume":"2","author":"Wandstrat","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib6","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1086\/320119","article-title":"International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16","volume":"68","author":"Cavanaugh","year":"2001","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ymgme.2005.07.029_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/35079107","article-title":"Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn\u2019s disease","volume":"411","author":"Hugot","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ymgme.2005.07.029_bib8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/35079114","article-title":"A frameshift mutation in NOD2 associated with susceptibility to Crohn\u2019s disease","volume":"411","author":"Ogura","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ymgme.2005.07.029_bib9","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.gde.2004.04.004","article-title":"Molecular genetics of Crohn\u2019s disease","volume":"14","author":"Russell","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.ymgme.2005.07.029_bib10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1086\/378076","article-title":"CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis","volume":"73","author":"Rahman","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ymgme.2005.07.029_bib11","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1067\/mai.2003.1336","article-title":"Association between polymorphisms in caspase recruitment domain containing protein 15 and allergy in two German populations","volume":"111","author":"Kabesch","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib12","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/ni1092","article-title":"NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses","volume":"5","author":"Watanabe","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib13","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.1103685","article-title":"Nod2 mutation in Crohn\u2019s disease potentiates NF-kappaB activity and IL-1beta processing","volume":"307","author":"Maeda","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ymgme.2005.07.029_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00281-003-0148-9","article-title":"Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders","volume":"25","author":"Rook","year":"2004","journal-title":"Springer Semin. Immunopathol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1159\/000154096","article-title":"A haplotype-based \u2019haplotype relative risk\u2019 approach to detecting allelic associations","volume":"42","author":"Terwilliger","year":"1992","journal-title":"Hum. Hered."},{"key":"10.1016\/j.ymgme.2005.07.029_bib16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ng720","article-title":"CARD15 mutations in Blau syndrome","volume":"29","author":"Miceli-Richard","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymgme.2005.07.029_bib17","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1182\/blood-2004-07-2972","article-title":"Early-onset sarcoidosis and CARD15 mutations with constitutive nuclear factor-kappaB activation: common genetic etiology with Blau syndrome","volume":"105","author":"Kanazawa","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.ymgme.2005.07.029_bib18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1093\/rheumatology\/keg192","article-title":"The three most common CARD15 mutations associated with Crohn\u2019s disease and the chromosome 16 susceptibility locus for systemic lupus erythematosus","volume":"42","author":"Ferreiros-Vidal","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ymgme.2005.07.029_bib19","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/rheumatology\/keg091","article-title":"Development of rheumatoid arthritis is not associated with two polymorphisms in the Crohn\u2019s disease gene CARD15","volume":"42","author":"Steer","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.ymgme.2005.07.029_bib20","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/art.10196","article-title":"CARD15\/NOD2 analyses in spondylarthropathy","volume":"46","author":"Miceli-Richard","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ymgme.2005.07.029_bib21","first-page":"102","article-title":"Lack of association of ankylosing spondylitis with the most common NOD2 susceptibility alleles to Crohn\u2019s disease","volume":"30","author":"Ferreiros-Vidal","year":"2003","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib22","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1136\/jnnp.74.8.1157","article-title":"Crohn\u2019s associated NOD2 gene variants are not involved in determining susceptibility to multiple sclerosis","volume":"74","author":"Sawcer","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ymgme.2005.07.029_bib23","first-page":"540","article-title":"Exclusion of CARD15\/NOD2 as a candidate susceptibility gene to psoriasis in the Italian population","volume":"12","author":"Borgiani","year":"2002","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib24","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1111\/j.0022-202X.2004.22524.x","article-title":"Psoriatic arthritis and CARD15 gene polymorphisms: no evidence for association in the Italian population","volume":"122","author":"Giardina","year":"2004","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ymgme.2005.07.029_bib25","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/ard.2004.029157","article-title":"Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort","volume":"64","author":"Lascorz","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.ymgme.2005.07.029_bib26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1073\/pnas.261567999","article-title":"Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p","volume":"99","author":"Hampe","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719205002520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719205002520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T11:51:28Z","timestamp":1553601088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719205002520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S1096719205002520"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2005.07.029","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]}}}