{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:29:12Z","timestamp":1790713752904,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.ymgme.2006.09.008","type":"journal-article","created":{"date-parts":[[2006,11,2]],"date-time":"2006-11-02T16:40:16Z","timestamp":1162485616000},"page":"148-156","source":"Crossref","is-referenced-by-count":37,"title":["Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease"],"prefix":"10.1016","volume":"90","author":[{"given":"Graham B.","family":"Sinclair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Jevon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen E.","family":"Colobong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick R.","family":"Randall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Y.M.","family":"Choy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorne A.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2006.09.008_bib1","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"3645","article-title":"Gaucher disease","author":"Beutler","year":"2001"},{"key":"10.1016\/j.ymgme.2006.09.008_bib2","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1073\/pnas.95.5.2503","article-title":"Mice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedure (SIMP)","volume":"95","author":"Liu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgme.2006.09.008_bib3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/357407a0","article-title":"Animal model of Gaucher\u2019s disease from targeted disruption of the mouse glucocerebrosidase gene","volume":"357","author":"Tybulewicz","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.ymgme.2006.09.008_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/BF03402150","article-title":"A chimeric mouse model of Gaucher disease","volume":"8","author":"Beutler","year":"2002","journal-title":"Mol. Med."},{"key":"10.1016\/j.ymgme.2006.09.008_bib5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/mthe.2002.0650","article-title":"Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model","volume":"6","author":"Marshall","year":"2002","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymgme.2006.09.008_bib6","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1172\/JCI0214530","article-title":"Systemic inflammation in glucocerebrosidase-deficient mice with minimal glycosylceramide storage","volume":"109","author":"Mizukami","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymgme.2006.09.008_bib7","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1194\/jlr.M500202-JLR200","article-title":"Gaucher disease mouse models: point mutation at the acid \u03b2-glucosidase locus combined with low-level prosaposin expression lead to disease variants","volume":"46","author":"Sun","year":"2005","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ymgme.2006.09.008_bib8","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0002-9440(10)63566-3","article-title":"Viable mouse models of acid \u03b2-glucosidase deficiency","volume":"163","author":"Xu","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ymgme.2006.09.008_bib9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.193.6.741","article-title":"Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow","volume":"193","author":"Koni","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.ymgme.2006.09.008_bib10","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1093\/nar\/24.21.4256","article-title":"Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination","volume":"24","author":"Buckhoz","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymgme.2006.09.008_bib11","series-title":"Gene Targeting: A Practical Approach","first-page":"101","article-title":"Production of targeted embryonic stem cell clones","author":"Matise","year":"2000"},{"key":"10.1016\/j.ymgme.2006.09.008_bib12","series-title":"Gene Targeting: A Practical Approach","first-page":"133","article-title":"Production of chimeras by blastocyst and morula injection of targeted ES cells","author":"Papaioannou","year":"2000"},{"key":"10.1016\/j.ymgme.2006.09.008_bib13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"10.1016\/j.ymgme.2006.09.008_bib14","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1073\/pnas.93.12.5860","article-title":"Efficient in vivo manipulation of mouse genomic sequences at the zygote stage","volume":"93","author":"Lakso","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgme.2006.09.008_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1182\/blood.V33.2.379.379","article-title":"Gaucher cells in chronic myelocytic leukaemia: an acquired abnormality","volume":"33","author":"Kattlove","year":"1969","journal-title":"Blood"},{"key":"10.1016\/j.ymgme.2006.09.008_bib16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1046\/j.1365-2184.2001.00195.x","article-title":"Cell kinetic status of haematopoietic stem cells","volume":"34","author":"Mackey","year":"2001","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ymgme.2006.09.008_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1651-2227.2003.tb00223.x","article-title":"Are animal models useful for understanding the pathophysiology of lysosomal storage disease?","volume":"433","author":"Suzuki","year":"2003","journal-title":"Acta Paediatr. Suppl."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719206003015?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719206003015?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:47:14Z","timestamp":1707353234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719206003015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1096719206003015"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2006.09.008","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}