{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:31:45Z","timestamp":1789201905036,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.ymgme.2007.02.002","type":"journal-article","created":{"date-parts":[[2007,3,29]],"date-time":"2007-03-29T07:18:11Z","timestamp":1175152691000},"page":"48-54","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["The effects of large neutral amino acid supplements in PKU: An MRS and neuropsychological study"],"prefix":"10.1016","volume":"91","author":[{"given":"Suzanne","family":"Schindeler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suparna","family":"Ghosh-Jerath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Rocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Joy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Rae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Wilcken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Christodoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2007.02.002_bib1","first-page":"259","article-title":"Phenylpyruvic oligophrenia (phenylketonuria)","volume":"33","author":"Jervis","year":"1953","journal-title":"Res. Public Assoc. Res. Nerv. Ment. Disord."},{"key":"10.1016\/j.ymgme.2007.02.002_bib2","first-page":"35","article-title":"Intellectual development in 12-year-old children treated for phenylketonuria","volume":"145","author":"Azen","year":"1991","journal-title":"Am. J. Dis. Child."},{"issue":"Suppl.","key":"10.1016\/j.ymgme.2007.02.002_bib3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1651-2227.1994.tb13464.x","article-title":"Review of neuropsychological functioning in treated phenylketonuria: an information processing approach","volume":"407","author":"Waisbren","year":"1994","journal-title":"Acta Paediatr."},{"key":"10.1016\/j.ymgme.2007.02.002_bib4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1203\/00006450-199703000-00011","article-title":"Neuropsychologic functions of early treated patients with phenylketonuria, on and off diet: results of a cross-national and cross-sectional study","volume":"41","author":"Burgard","year":"1997","journal-title":"Pediatr. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.ymgme.2007.02.002_bib5","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1007\/PL00014258","article-title":"Effects of concurrent phenylalanine levels on sustained attention and calculation speed in patients treated early for phenylketonuria","volume":"155","author":"Schmidt","year":"1996","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ymgme.2007.02.002_bib6","first-page":"255","article-title":"Neuropsychological studies on adolescents with phenylketonuria returned to phenylalanine-restricted diets","volume":"92","author":"Clarke","year":"1987","journal-title":"Am. J. Ment. Retard."},{"issue":"Suppl. 2","key":"10.1016\/j.ymgme.2007.02.002_bib7","first-page":"S94","article-title":"Behaviour in early treated phenylketonuria: a systematic review","volume":"159","author":"Smith","year":"2000","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ymgme.2007.02.002_bib8","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1542\/peds.106.5.1136","article-title":"Benefits of mutation analysis and examination of brain Phenylalanine levels in the management of Phenylketonuria","volume":"106","author":"Koch","year":"2000","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ymgme.2007.02.002_bib9","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1542\/peds.106.5.1093","article-title":"Blood\u2013brain phenylalanine relationships in persons with phenylketonuria","volume":"106","author":"Koch","year":"2000","journal-title":"Pediatrics"},{"issue":"Suppl. 2","key":"10.1016\/j.ymgme.2007.02.002_bib10","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1007\/PL00014374","article-title":"In vivo proton magnetic resonance spectroscopy in phenylketonuria","volume":"159","author":"Moller","year":"2000","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ymgme.2007.02.002_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1023\/A:1021234730512","article-title":"Individual blood\u2013brain barrier phenylalanine transport in siblings with classical phenylketonuria","volume":"25","author":"Weglage","year":"2002","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgme.2007.02.002_bib12","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1542\/peds.112.S4.1575","article-title":"Brain phenylalanine concentrations in phenylketonuria: research and treatment of adults","volume":"112","author":"Moats","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.ymgme.2007.02.002_bib13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1096-7192(03)00078-7","article-title":"Large neutral amino acid therapy and phenylketonuria: a promising approach to treatment","volume":"79","author":"Koch","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2007.02.002_bib14","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1172\/JCI5017","article-title":"Large neutral amino acids block phenylalanine transport into brain tissue in patients with phenylketonuria","volume":"103","author":"Pietz","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymgme.2007.02.002_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1001\/archpedi.1990.02150290033020","article-title":"Valine, Isoleucine, and Leucine \u2013 a new treatment for Phenylketonuria","volume":"144","author":"Berry","year":"1990","journal-title":"Am. J. Dis. Child."},{"key":"10.1016\/j.ymgme.2007.02.002_bib16","unstructured":"Commonwealth Dept of Community Services and Health, NUTTAB89 Nutrient data table for use in Australia, Canberra, Australian Government Publishing Service, 1989."},{"key":"10.1016\/j.ymgme.2007.02.002_bib17","series-title":"McCance and Widdowson\u2019s The Composition of Foods","author":"Paul","year":"1978"},{"key":"10.1016\/j.ymgme.2007.02.002_bib18","doi-asserted-by":"crossref","unstructured":"Wechsler Abbreviated Scale of Intelligence, The Psychological Corporation, San Antonio, TX, 1999.","DOI":"10.1037\/t15170-000"},{"key":"10.1016\/j.ymgme.2007.02.002_bib19","unstructured":"C.K. Conners, Multi-Health Systems Staff, Conners\u2019 Continuous Performance Test, Multi-Health Systems, Toronto, 1995."},{"key":"10.1016\/j.ymgme.2007.02.002_bib20","unstructured":"CANTAB for Windows, CeNeS Ltd. CeNeS, Cambridge, 1999."},{"key":"10.1016\/j.ymgme.2007.02.002_bib21","series-title":"Delis-Kaplan Executive Function System","author":"Delis","year":"2001"},{"key":"10.1016\/j.ymgme.2007.02.002_bib22","series-title":"Manual for the Depression Anxiety Stress Scales","author":"Lovibond","year":"1995"},{"key":"10.1016\/j.ymgme.2007.02.002_bib23","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02668096","article-title":"Java-based graphical user interface for the MRUI quantitation package","volume":"12","author":"Naressi","year":"2001","journal-title":"Magma"},{"key":"10.1016\/j.ymgme.2007.02.002_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/jmre.1997.1244","article-title":"Improved method for accurate and efficient quantification of MRS data with use of prior knowledge","volume":"129","author":"Vanhamme","year":"1997","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.ymgme.2007.02.002_bib25","first-page":"122","article-title":"SVD-based quantification of magnetic resonance signals","volume":"97","author":"Pijnappel","year":"1992","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.ymgme.2007.02.002_bib26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0006-8993(97)01054-8","article-title":"Kinetics of phenylalanine transport at the human blood\u2013brain barrier investigated in vivo","author":"Moller","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.ymgme.2007.02.002_bib27","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/sj.ijo.0801376","article-title":"Critical evaluation of energy intake using the Goldeberg cut-off for energy intake:basal metabolic rate. A practical guide to its calculation","volume":"24","author":"Black","year":"2000","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.ymgme.2007.02.002_bib28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/A:1005638627604","article-title":"Brain phenylalanine concentration in the management of adults with phenylketonuria","volume":"23","author":"Moats","year":"2000","journal-title":"J. Inher. Metab. Dis."},{"key":"10.1016\/j.ymgme.2007.02.002_bib29","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1023\/B:BOLI.0000042985.02049.ff","article-title":"Neuropsychological outcome of subjects participating in the PKU adult collaborative study: a preliminary review","volume":"27","author":"Brumm","year":"2004","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgme.2007.02.002_bib30","doi-asserted-by":"crossref","first-page":"2780","DOI":"10.1093\/jn\/130.11.2780","article-title":"Transport mechanisms of the large neutral amino acid l-phenylalanine in the human intestinal epithelial Caco-2 Cell Line","volume":"130","author":"Berger","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.ymgme.2007.02.002_bib31","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s10545-006-0395-8","article-title":"Large neutral amino acids in the treatment of phenylketonuria (PKU)","volume":"29","author":"Matalon","year":"2006","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719207000674?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719207000674?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:18:06Z","timestamp":1761088686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719207000674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S1096719207000674"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2007.02.002","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of large neutral amino acid supplements in PKU: An MRS and neuropsychological study","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2007.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}