{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:51:30Z","timestamp":1792036290056,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.ymgme.2007.10.002","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T22:09:44Z","timestamp":1196114984000},"page":"341-346","source":"Crossref","is-referenced-by-count":29,"title":["Low plasma total cholesterol in patients with Huntington\u2019s disease and first-degree relatives"],"prefix":"10.1016","volume":"93","author":[{"given":"Manolis","family":"Markianos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios","family":"Panas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kalfakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrios","family":"Vassilopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2007.10.002_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0005-2736(03)00024-5","article-title":"Role of cholesterol in synapse formation and function","volume":"1610","author":"Pfrieger","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ymgme.2007.10.002_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pneurobio.2006.09.005","article-title":"Cholesterol dysfunction in neurodegenerative diseases: is Huntington\u2019s disease in the list?","volume":"80","author":"Valenza","year":"2006","journal-title":"Progr. Neurobiol."},{"key":"10.1016\/j.ymgme.2007.10.002_bib3","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/hmg\/11.17.1953","article-title":"Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses","volume":"11","author":"Sipione","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymgme.2007.10.002_bib4","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1523\/JNEUROSCI.3355-05.2005","article-title":"Dysfunction of the cholesterol biosynthetic pathway in Huntington\u2019s disease","volume":"25","author":"Valenza","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ymgme.2007.10.002_bib5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1046\/j.1471-4159.1995.64020895.x","article-title":"Cholesterol for synthesis of myelin is made locally, not transported into brain","volume":"64","author":"Jurevics","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ymgme.2007.10.002_bib6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/0896-6273(93)90127-D","article-title":"Huntington\u2019s disease gene (IT15) is widely expressed in human and rat tissues","volume":"11","author":"Li","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.ymgme.2007.10.002_bib7","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1136\/jnnp.47.12.1283","article-title":"Increased rate of suicide among patients with Huntington\u2019s disease","volume":"47","author":"Schoenfeld","year":"1984","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ymgme.2007.10.002_bib8","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1034\/j.1600-0404.2000.102003150.x","article-title":"High suicidal ideation in persons testing for Huntington\u2019s disease","volume":"102","author":"Robins Wahlin","year":"2000","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.ymgme.2007.10.002_bib9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/00001648-200103000-00007","article-title":"Low serum cholesterol concentration and risk of suicide","volume":"12","author":"Ellison","year":"2001","journal-title":"Epidemiology"},{"key":"10.1016\/j.ymgme.2007.10.002_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s004060200007","article-title":"Biogenic amine turnover and serum cholesterol in suicide attempt","volume":"252","author":"Tripodianakis","year":"2002","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.ymgme.2007.10.002_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/mcpr.1993.1034","article-title":"A new polymerase chain reaction (PCR) assay for the trinucleotide repeat that is unstable and expanded on Huntington\u2019s disease chromosomes","volume":"7","author":"Warner","year":"1993","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/j.ymgme.2007.10.002_bib12","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/0140-6736(91)92823-K","article-title":"Apolipoprotein E genotyping by one-stage PCR","volume":"337","author":"Wenham","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.ymgme.2007.10.002_bib13","doi-asserted-by":"crossref","unstructured":"Huntington Study Group, Unified Huntington\u2019s Disease Rating Scale. Reliability and consistency, Mov. Disord. 11 (1996) 136\u2013142.","DOI":"10.1002\/mds.870110204"},{"key":"10.1016\/j.ymgme.2007.10.002_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1212\/WNL.29.1.1","article-title":"Huntington\u2019s disease: clinical care and evaluation","volume":"29","author":"Shoulson","year":"1979","journal-title":"Neurology"},{"key":"10.1016\/j.ymgme.2007.10.002_bib15","doi-asserted-by":"crossref","unstructured":"C. Pitsavos, D.B. Panagiotakos, C. Chrysohoou, C. Stefanadis, Epidemiology of cardiovascular risk factors in Greece: aims, design and baseline characteristics of the ATTICA study, BMC Public Health 3 (2003) 32. Available from: <http:\/\/www.biomedcentral.com\/1471-2458\/3\/32>.","DOI":"10.1186\/1471-2458-3-32"},{"key":"10.1016\/j.ymgme.2007.10.002_bib16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0022-2275(20)39976-4","article-title":"Familial hypobetalipoproteinemia","volume":"34","author":"Linton","year":"1993","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ymgme.2007.10.002_bib17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/sj.mp.4001910","article-title":"Violent behavior associated with hypocholesterolemia due to a novel APOB gene mutation","volume":"12","author":"Edgar","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ymgme.2007.10.002_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/mgme.2001.3226","article-title":"Genetic disorders of cholesterol biosynthesis in mice and humans","volume":"74","author":"Nwokoro","year":"2001","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2007.10.002_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1086\/301936","article-title":"Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith\u2013Lemli\u2013Opitz syndrome","volume":"63","author":"Wassif","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ymgme.2007.10.002_bib20","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/S0022-2275(20)33456-8","article-title":"Sterol balance in the Smith\u2013Lemli\u2013Opitz syndrome: reduction in whole body cholesterol synthesis and normal bile acid production","volume":"41","author":"Steiner","year":"2000","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.ymgme.2007.10.002_bib21","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1176\/appi.ajp.161.11.2123","article-title":"Cholesterol metabolism and suicidality in Smith\u2013Lemli\u2013Opitz syndrome carriers","volume":"161","author":"Lalovic","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.ymgme.2007.10.002_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/10623329709079868","article-title":"Enhancement of membrane fluidity in cholesterol-poor endothelial cells pre-treated with simvastatin","volume":"5","author":"Morita","year":"1997","journal-title":"Endothelium"},{"key":"10.1016\/j.ymgme.2007.10.002_bib23","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.294.5545.1354","article-title":"CNS synaptogenesis promoted by glia-derived cholesterol","volume":"294","author":"Mauch","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.ymgme.2007.10.002_bib24","first-page":"1","article-title":"Cholesterol content in brains of suicide completers","volume":"17","author":"Lalovic","year":"2007","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ymgme.2007.10.002_bib25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.mad.2005.09.020","article-title":"Cholesterol and Alzheimer\u2019s disease\u2014is there a relation?","volume":"127","author":"Sjogren","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.ymgme.2007.10.002_bib26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/archneur.64.2.261","article-title":"Apolipoprotein E gene polymorphism, total plasma cholesterol level, and Parkinson disease dementia","volume":"64","author":"Jasinska-Myga","year":"2007","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.ymgme.2007.10.002_bib27","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1212\/WNL.38.5.769","article-title":"Huntington\u2019s disease mortality in the United States","volume":"38","author":"Lanska","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.ymgme.2007.10.002_bib28","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1136\/jmg.29.12.911","article-title":"Causes of death in patients with Huntington\u2019s disease and in unaffected first degree relatives","volume":"29","author":"Sorensen","year":"1992","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ymgme.2007.10.002_bib29","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1002\/(SICI)1097-0142(19991001)86:7<1342::AID-CNCR33>3.0.CO;2-3","article-title":"Significantly lower incidence of cancer among patients with Huntington disease","volume":"86","author":"Sorensen","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.ymgme.2007.10.002_bib30","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1054\/jcaf.2002.0804216","article-title":"Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure","volume":"8","author":"Horwich","year":"2002","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.ymgme.2007.10.002_bib31","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.jacc.2003.09.005","article-title":"Cholesterol and mortality in heart failure: the bad gone good?","volume":"42","author":"Fonarow","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ymgme.2007.10.002_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0140-6736(01)05553-2","article-title":"Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study","volume":"358","author":"Schatz","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ymgme.2007.10.002_bib33","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1046\/j.1365-2389.2003.51313.x","article-title":"Low total cholesterol and increased risk of dying: are low levels clinical warning signs in the elderly? Results from the Italian longitudinal study on aging","volume":"51","author":"Brescianini","year":"2003","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.ymgme.2007.10.002_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1532-5415.2005.53106.x","article-title":"Relationship between plasma lipids and all-cause mortality in nondemented elderly","volume":"53","author":"Schupf","year":"2005","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.ymgme.2007.10.002_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.atherosclerosis.2006.08.022","article-title":"Serum total cholesterol levels and risk of mortality from stroke and coronary heart disease in Japanese: The JACC study","volume":"194","author":"Cui","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.ymgme.2007.10.002_bib36","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/oxfordjournals.aje.a010273","article-title":"Low cholesterol and nonatherosclerotic disease risk: a persistently perplexing question","volume":"151","author":"Jacobs","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ymgme.2007.10.002_bib37","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/aje\/kwj283","article-title":"Serum cholesterol levels and the risk of Parkinson\u2019s disease","volume":"164","author":"De Lau","year":"2006","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ymgme.2007.10.002_bib38","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/01.STR.0000217384.03237.9c","article-title":"Reduced risk factors for vascular disorders in Parkinson disease patients. A case-control study","volume":"37","author":"Scigliano","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.ymgme.2007.10.002_bib39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/mds.21290","article-title":"Lower low-density lipoprotein cholesterol levels are associated with Parkinson\u2019s disease","volume":"15","author":"Huang","year":"2007","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ymgme.2007.10.002_bib40","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.ATV.0000120374.59826.1b","article-title":"Brain cholesterol: long secret life behind a barrier","volume":"24","author":"Bjorkhem","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719207004441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719207004441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,29]],"date-time":"2021-08-29T03:15:36Z","timestamp":1630206936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719207004441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S1096719207004441"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2007.10.002","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}