{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:59:10Z","timestamp":1791331150221,"version":"4.3.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1016\/j.ymgme.2008.03.004","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T09:21:22Z","timestamp":1208251282000},"page":"336-342","source":"Crossref","is-referenced-by-count":42,"title":["Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice"],"prefix":"10.1016","volume":"94","author":[{"given":"Liyuan","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Lee","family":"Elmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea K.","family":"Lawrance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowena G.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Rozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2008.03.004_bib1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1093\/ajcn\/82.1.188","article-title":"Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice","volume":"82","author":"Li","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ymgme.2008.03.004_bib2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0022-3476(99)70102-2","article-title":"Congenital heart defects and maternal derangement of homocysteine metabolism","volume":"135","author":"Kapusta","year":"1999","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ymgme.2008.03.004_bib3","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/oxfordjournals.aje.a010291","article-title":"Occurrence of congenital heart defects in relation to maternal mulitivitamin use","volume":"151","author":"Botto","year":"2000","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ymgme.2008.03.004_bib4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/tera.10040","article-title":"Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model","volume":"65","author":"Burgoon","year":"2002","journal-title":"Teratology"},{"key":"10.1016\/j.ymgme.2008.03.004_bib5","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/eurheartj\/ehi815","article-title":"Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation","volume":"27","author":"van Beynum","year":"2006","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ymgme.2008.03.004_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/molehr\/gah252","article-title":"Maternal and offspring MTHFR gene C677T polymorphism as predictors of congenital atrial septal defect and patent ductus arteriosus","volume":"12","author":"Zhu","year":"2006","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.ymgme.2008.03.004_bib7","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0008-6363(01)00286-3","article-title":"Infant methylenetetrahydrofolate reductase 677TT genotype is a risk factor for congenital heart disease","volume":"51","author":"Junker","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ymgme.2008.03.004_bib8","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1067\/mob.2001.113845","article-title":"Association of the C677T methylenetetrahydrofolate reductase mutation and elevated homocysteine levels with congenital cardiac malformations","volume":"184","author":"Wenstrom","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.ymgme.2008.03.004_bib9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1006\/mgme.1999.2879","article-title":"A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida","volume":"67","author":"Wilson","year":"1999","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2008.03.004_bib10","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1021\/bi035910i","article-title":"Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase","volume":"43","author":"Olteanu","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymgme.2008.03.004_bib11","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ymgme.2005.02.003","article-title":"Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association","volume":"85","author":"O\u2019Leary","year":"2005","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2008.03.004_bib12","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s00109-006-0093-x","article-title":"The methionine synthase reductase 66A>G polymorphism is a maternal risk factor for spina bifida","volume":"84","author":"van der Linden","year":"2006","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.ymgme.2008.03.004_bib13","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1515\/CCLM.2006.254","article-title":"MTRR 66A>G polymorphism in relation to congenital heart defects","volume":"44","author":"van Beynum","year":"2006","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.ymgme.2008.03.004_bib14","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s00394-006-0622-y","article-title":"Dietary intake of B-vitamins in mothers born a child with a congenital heart defect","volume":"45","author":"Verkleij-Hagoort","year":"2006","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.ymgme.2008.03.004_bib15","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ymgme.2008.03.004_bib16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00801907","article-title":"Incidence of congenital heart disease: I. Postnatal incidence","volume":"16","author":"Hoffman","year":"1995","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.ymgme.2008.03.004_bib17","first-page":"1","article-title":"Deaths: final data for 2002","volume":"53","author":"Kochanek","year":"2004","journal-title":"Natl. Vital Stat. Rep."},{"key":"10.1016\/j.ymgme.2008.03.004_bib18","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/01.RES.87.10.856","article-title":"Apoptosis during cardiovascular development","volume":"87","author":"Fisher","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymgme.2008.03.004_bib19","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1203\/01.PDR.0000148710.69159.61","article-title":"Basics of cardiac development for the understanding of congenital heart malformations","volume":"57","author":"Gittenberger-de Groot","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ymgme.2008.03.004_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/ajcn\/81.1.147","article-title":"Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism","volume":"81","author":"Hobbs","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ymgme.2008.03.004_bib21","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1073\/pnas.062066299","article-title":"A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status","volume":"99","author":"Friso","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgme.2008.03.004_bib22","doi-asserted-by":"crossref","first-page":"13217","DOI":"10.1073\/pnas.95.22.13217","article-title":"A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells","volume":"95","author":"Bagley","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgme.2008.03.004_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"Jacques","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ymgme.2008.03.004_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ymgme.2007.02.001","article-title":"Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase","volume":"91","author":"Elmore","year":"2007","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2008.03.004_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.2563174","article-title":"Chromosome mapping and expression of a putative testis-determining gene in mouse","volume":"243","author":"Nagamine","year":"1989","journal-title":"Science"},{"issue":"Suppl 3","key":"10.1016\/j.ymgme.2008.03.004_bib26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000091506","article-title":"Imprinted genes, placental development and fetal growth","volume":"65","author":"Fowden","year":"2006","journal-title":"Horm. Res."},{"key":"10.1016\/j.ymgme.2008.03.004_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/gene.10152","article-title":"What cardiovascular defect does my prenatal mouse mutant have, and why?","volume":"35","author":"Conway","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.ymgme.2008.03.004_bib28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymgme.2008.03.004_bib29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1365-2141.2005.05913.x","article-title":"Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap","volume":"132","author":"Smulders","year":"2006","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ymgme.2008.03.004_bib30","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1093\/jn\/136.7.1774","article-title":"Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart","volume":"136","author":"Li","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.ymgme.2008.03.004_bib31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.yjmcc.2005.09.006","article-title":"The spectrum of cardiovascular anomalies in CHF1\/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturation","volume":"40","author":"Sakata","year":"2006","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.ymgme.2008.03.004_bib32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jacc.2005.11.013","article-title":"Maternal homocysteine and congenital heart defects","volume":"47","author":"Hobbs","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ymgme.2008.03.004_bib33","doi-asserted-by":"crossref","first-page":"15227","DOI":"10.1073\/pnas.93.26.15227","article-title":"Homocysteine induces congenital defects of the heart and neural tube: effect of folic acid","volume":"93","author":"Rosenquist","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgme.2008.03.004_bib34","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/dvdy.21101","article-title":"Microarray analysis of homocysteine-responsive genes in cardiac neural crest cells in vitro","volume":"236","author":"Rosenquist","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.ymgme.2008.03.004_bib35","doi-asserted-by":"crossref","first-page":"13378","DOI":"10.1021\/bi020536s","article-title":"Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase","volume":"41","author":"Olteanu","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymgme.2008.03.004_bib36","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/humu.20563","article-title":"Polymorphic background of methionine synthase reductase modulates the phenotype of a disease-causing mutation","volume":"28","author":"Gherasim","year":"2007","journal-title":"Hum. Mutat."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719208000784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719208000784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T06:02:21Z","timestamp":1557468141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719208000784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S1096719208000784"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2008.03.004","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}