{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:06:20Z","timestamp":1790823980226,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2013]]},"DOI":"10.1016\/j.ymgme.2013.10.006","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T12:01:41Z","timestamp":1381579301000},"page":"S66-S70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"S","title":["Man made disease: Clinical manifestations of low phenylalanine levels in an inadequately treated phenylketonuria patient and mouse study"],"prefix":"10.1016","volume":"110","author":[{"given":"Ben","family":"Pode-Shakked","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach","family":"Shemer-Meiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Harmelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Stettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smadar","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Anikster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2013.10.006_bb0005","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/bmj.2.5255.793","article-title":"Dietary and biochemical control of phenylketonuria","volume":"2","author":"Brimblecombe","year":"1961","journal-title":"Br. Med. J."},{"issue":"2","key":"10.1016\/j.ymgme.2013.10.006_bb0010","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0022-3476(66)80327-X","article-title":"Phenylalanine deficiency syndrome","volume":"69","author":"Rouse","year":"1966","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ymgme.2013.10.006_bb0015","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1203\/00006450-197007000-00002","article-title":"Malnutrition caused by dietary treatment of phenylketonuria","volume":"4","author":"Hanley","year":"1970","journal-title":"Pediatr. Res."},{"issue":"1","key":"10.1016\/j.ymgme.2013.10.006_bb0020","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3181\/00379727-118-29808","article-title":"Effect of phenylalanine deficient diet on bone marrow and amino acid metabolism","volume":"118","author":"Cockburn","year":"1965","journal-title":"Exp. Biol. Med."},{"issue":"2","key":"10.1016\/j.ymgme.2013.10.006_bb0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/ajcn\/30.2.209","article-title":"Phenylalanine\u2013tyrosine deficiency syndrome as a complication of the management of hereditary tyrosinemia","volume":"30","author":"Cohn","year":"1977","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.ymgme.2013.10.006_bb0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3181\/00379727-127-32637","article-title":"Biochemical and behavioral effects of a commercial \u201clow phenylalanine\u201d diet in growing rats","volume":"127","author":"Dierks-Ventling","year":"1968","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"1","key":"10.1016\/j.ymgme.2013.10.006_bb0035","first-page":"87","article-title":"Phenylalanine deficiency in the food of rat. Part I. Phenylalanine-low diet for rats","volume":"33","author":"Dluzniewski","year":"1981","journal-title":"Pol. J. Pharmacol. Pharm."},{"issue":"1","key":"10.1016\/j.ymgme.2013.10.006_bb0040","first-page":"91","article-title":"Phenylalanine deficiency in the food of rat. Part II. Decrease in fertility by phenylalanine deficiency in pregnancy","volume":"33","author":"Dluzniewski","year":"1981","journal-title":"Pol. J. Pharmacol. Pharm."},{"issue":"5","key":"10.1016\/j.ymgme.2013.10.006_bb0045","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/ICO.0b013e31803d1617","article-title":"Use of amniotic membrane graft and corneal transplantation in a patient with bilateral keratomalacia induced by uncontrolled phenylketonuria","volume":"26","author":"Habot-Wilner","year":"2007","journal-title":"Cornea"},{"issue":"5228","key":"10.1016\/j.ymgme.2013.10.006_bb0050","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/bmj.1.5228.763","article-title":"Further experiences in the treatment of phenylketonuria","volume":"1","author":"Moncrieff","year":"1961","journal-title":"Br. Med. J."},{"issue":"3","key":"10.1016\/j.ymgme.2013.10.006_bb0055","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1469-1809.2007.00425.x","article-title":"A mutation analysis of the phenylalanine hydroxylase (PAH) gene in the Israeli population","volume":"72","author":"Bercovich","year":"2008","journal-title":"Ann. Hum. Genet."},{"issue":"5","key":"10.1016\/j.ymgme.2013.10.006_bb0060","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s10038-008-0264-4","article-title":"Genotype\u2013phenotype correlations analysis of mutations in the phenylalanine hydroxylase (PAH) gene","volume":"53","author":"Bercovich","year":"2008","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.ymgme.2013.10.006_bb0065","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000240176","article-title":"Maternal phenylalanine deprivation in the rat. Enzymatic and cellular liver changes in the offspring","volume":"14","author":"Bessman","year":"1969","journal-title":"Biol. Neonate"},{"issue":"Suppl.:S31-9","key":"10.1016\/j.ymgme.2013.10.006_bb0070","article-title":"Follow up of phenylketonuria patients","volume":"104","author":"Demirkol","year":"2011","journal-title":"Mol. Genet. Metab."},{"issue":"3","key":"10.1016\/j.ymgme.2013.10.006_bb0075","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1089\/109065703322537197","article-title":"UBE3A mutation analysis by DHPLC","volume":"7","author":"Bercovich","year":"2003","journal-title":"Genet. Test."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719213003363?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719213003363?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T15:22:23Z","timestamp":1564500143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719213003363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":15,"alternative-id":["S1096719213003363"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2013.10.006","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2013]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Man made disease: Clinical manifestations of low phenylalanine levels in an inadequately treated phenylketonuria patient and mouse study","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2013.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}