{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:03:15Z","timestamp":1790708595050,"version":"4.1.0"},"reference-count":96,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["NS054120"],"award-info":[{"award-number":["NS054120"]}]},{"name":"National Gaucher Foundation"},{"DOI":"10.13039\/100007920","name":"University of Massachusetts Medical School","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007920","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Roy and Beatrice Backus Foundation"},{"name":"SRI International SBT Award"}],"content-domain":{"domain":["mgmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.ymgme.2013.12.003","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T20:15:44Z","timestamp":1386792944000},"page":"152-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"title":["Neuroinflammation and \u03b1-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction"],"prefix":"10.1016","volume":"111","author":[{"given":"Edward I.","family":"Ginns","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally K.-K.","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novie","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Karlgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Schahram","family":"Akbarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian P.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arlene","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Samuelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary L.","family":"LaMarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Vazquez-DeRose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy B.","family":"Manning-Bo\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9680","key":"10.1016\/j.ymgme.2013.12.003_bb0005","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1016\/S0140-6736(09)60492-X","article-title":"Parkinson's disease","volume":"373","author":"Lees","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.ymgme.2013.12.003_bb0010","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cbpa.2007.05.035","article-title":"Gaucher disease","volume":"11","author":"Butters","year":"2007","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"9","key":"10.1016\/j.ymgme.2013.12.003_bb0015","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/qjmed\/89.9.691","article-title":"Occurrence of Parkinson's syndrome in type I Gaucher disease","volume":"89","author":"Neudorfer","year":"1996","journal-title":"QJM"},{"issue":"3","key":"10.1016\/j.ymgme.2013.12.003_bb0020","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/(SICI)1096-8652(199907)61:3<216::AID-AJH12>3.0.CO;2-B","article-title":"Parkinson's syndrome preceding clinical manifestation of Gaucher's disease","volume":"61","author":"Machaczka","year":"1999","journal-title":"Am. J. Hematol."},{"issue":"4","key":"10.1016\/j.ymgme.2013.12.003_bb0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/mgme.2001.3201","article-title":"Gaucher disease and parkinsonism: a phenotypic and genotypic characterization","volume":"73","author":"Tayebi","year":"2001","journal-title":"Mol. Genet. Metab."},{"issue":"4","key":"10.1016\/j.ymgme.2013.12.003_bb0030","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ajmg.a.10028","article-title":"Gaucher disease associated with parkinsonism: four further case reports","volume":"116A","author":"Varkonyi","year":"2003","journal-title":"Am. J. Med. Genet. A"},{"issue":"1","key":"10.1016\/j.ymgme.2013.12.003_bb0035","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1212\/01.WNL.0000072482.70963.D7","article-title":"Gaucher's disease with Parkinson's disease: clinical and pathological aspects","volume":"61","author":"Bembi","year":"2003","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.ymgme.2013.12.003_bb0040","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/jmg.2004.024455","article-title":"Parkinsonism among Gaucher disease carriers","volume":"41","author":"Goker-Alpan","year":"2004","journal-title":"J. Med. Genet."},{"issue":"1","key":"10.1016\/j.ymgme.2013.12.003_bb0045","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ymgme.2003.11.004","article-title":"Glucocerebrosidase mutations in subjects with parkinsonism","volume":"81","author":"Lwin","year":"2004","journal-title":"Mol. Genet. Metab."},{"issue":"3","key":"10.1016\/j.ymgme.2013.12.003_bb0050","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bcmd.2006.02.004","article-title":"Increased incidence of Parkinson disease among relatives of patients with Gaucher disease","volume":"36","author":"Halperin","year":"2006","journal-title":"Blood Cells Mol. Dis."},{"issue":"19","key":"10.1016\/j.ymgme.2013.12.003_bb0055","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1056\/NEJMoa033277","article-title":"Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi Jews","volume":"351","author":"Aharon-Peretz","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.ymgme.2013.12.003_bb0060","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/mds.22538","article-title":"The association between mutations in the lysosomal protein glucocerebrosidase and parkinsonism","volume":"24","author":"DePaolo","year":"2009","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.ymgme.2013.12.003_bb0065","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1212\/01.wnl.0000230215.41296.18","article-title":"Glucocerebrosidase mutations are an important risk factor for Lewy body disorders","volume":"67","author":"Goker-Alpan","year":"2006","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.ymgme.2013.12.003_bb0070","first-page":"78549","article-title":"Gaucher disease and the synucleinopathies","volume":"2006","author":"Hruska","year":"2006","journal-title":"J. Biomed. Biotechnol."},{"issue":"1\u20132","key":"10.1016\/j.ymgme.2013.12.003_bb0075","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ymgme.2004.08.015","article-title":"Gaucher disease: complexity in a \u201csimple\u201d disorder","volume":"83","author":"Sidransky","year":"2004","journal-title":"Mol. Genet. Metab."},{"issue":"4","key":"10.1016\/j.ymgme.2013.12.003_bb0080","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ajmg.a.10028","article-title":"Gaucher disease associated with parkinsonism: four further case reports","volume":"116A","author":"Varkonyi","year":"2003","journal-title":"Am. J. Med. Genet. Part A"},{"issue":"9","key":"10.1016\/j.ymgme.2013.12.003_bb0085","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1001\/archneurol.2010.194","article-title":"Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study","volume":"67","author":"Alcalay","year":"2010","journal-title":"Arch. Neurol."},{"issue":"12","key":"10.1016\/j.ymgme.2013.12.003_bb0090","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1212\/01.wnl.0000276989.17578.02","article-title":"Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease","volume":"69","author":"Clark","year":"2007","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.ymgme.2013.12.003_bb0095","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1212\/01.wnl.0000176987.47875.28","article-title":"Mutations in the glucocerebrosidase gene and Parkinson disease: phenotype\u2013genotype correlation","volume":"65","author":"Aharon-Peretz","year":"2005","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.ymgme.2013.12.003_bb0105","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/mds.20319","article-title":"Analysis of the glucocerebrosidase gene in Parkinson's disease","volume":"20","author":"Sato","year":"2005","journal-title":"Mov. Disord."},{"issue":"Pt 7","key":"10.1016\/j.ymgme.2013.12.003_bb0110","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1093\/brain\/awp044","article-title":"Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease","volume":"132","author":"Neumann","year":"2009","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.ymgme.2013.12.003_bb0115","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1177\/0891988710383572","article-title":"The genetics of Parkinson disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J. Geriatr. Psychiatry Neurol."},{"issue":"17","key":"10.1016\/j.ymgme.2013.12.003_bb0120","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Fahn","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.ymgme.2013.12.003_bb0125","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ymgme.2004.04.011","article-title":"Neuropathology provides clues to the pathophysiology of Gaucher disease","volume":"82","author":"Wong","year":"2004","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.ymgme.2013.12.003_bb0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00690463","article-title":"Neuropathology of the Norrbottnian type of Gaucher disease. Morphological and biochemical studies","volume":"65","author":"Conradi","year":"1984","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0135","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0079-6123(08)00687-0","article-title":"Horizontal saccadic palsy associated with gliosis of the brainstem midline","volume":"171","author":"Buttner-Ennever","year":"2008","journal-title":"Prog. Brain Res."},{"issue":"11","key":"10.1016\/j.ymgme.2013.12.003_bb0140","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1017\/S0022215100142483","article-title":"Brainstem pathology of infantile Gaucher's disease with only wave I and II of auditory brainstem response","volume":"112","author":"Kaga","year":"1998","journal-title":"J. Laryngol. Otol."},{"issue":"2","key":"10.1016\/j.ymgme.2013.12.003_bb0145","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ana.410200208","article-title":"Type 2 and type 3 Gaucher disease: a morphological and biochemical study","volume":"20","author":"Kaye","year":"1986","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.ymgme.2013.12.003_bb0150","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-0028-1091508","article-title":"Infantile Gaucher's disease: neuropathology, acid hydrolase activities and negative staining observations","volume":"8","author":"Verity","year":"1977","journal-title":"Neuropadiatrie"},{"issue":"1","key":"10.1016\/j.ymgme.2013.12.003_bb0155","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00005072-197201000-00010","article-title":"Astrocytic gliosis of vascular adventitia and arachnoid membrane in infantile Gaucher's disease","volume":"31","author":"Levine","year":"1972","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"9","key":"10.1016\/j.ymgme.2013.12.003_bb0160","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1172\/JCI0214530","article-title":"Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage","volume":"109","author":"Mizukami","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.ymgme.2013.12.003_bb0175","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.neuro.2009.06.009","article-title":"Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism","volume":"30","author":"Manning-Bog","year":"2009","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.ymgme.2013.12.003_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2011.06.001","article-title":"Gaucher disease glucocerebrosidase and alpha-synuclein form a bidirectional pathogenic loop in synucleinopathies","volume":"146","author":"Mazzulli","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.ymgme.2013.12.003_bb0185","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ymgme.2010.12.014","article-title":"Accumulation and distribution of alpha-synuclein and ubiquitin in the CNS of Gaucher disease mouse models","volume":"102","author":"Xu","year":"2011","journal-title":"Mol. Genet. Metab."},{"issue":"29","key":"10.1016\/j.ymgme.2013.12.003_bb0190","doi-asserted-by":"crossref","first-page":"12101","DOI":"10.1073\/pnas.1108197108","article-title":"CNS expression of glucocerebrosidase corrects alpha-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy","volume":"108","author":"Sardi","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.ymgme.2013.12.003_bb0195","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1002\/ana.22400","article-title":"Acid beta-glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter alpha-synuclein processing","volume":"69","author":"Cullen","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0200","article-title":"Neuronal accumulation of glucosylceramide in a mouse model of neuronopathic Gaucher disease leads to neurodegeneration","author":"Farfel-Becker","year":"2013","journal-title":"Hum. Mol. Genet."},{"issue":"Pt 6","key":"10.1016\/j.ymgme.2013.12.003_bb0205","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/brain\/aws095","article-title":"Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease","volume":"135","author":"Vitner","year":"2012","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.ymgme.2013.12.003_bb0210","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/hmg\/ddr019","article-title":"Spatial and temporal correlation between neuron loss and neuroinflammation in a mouse model of neuronopathic Gaucher disease","volume":"20","author":"Farfel-Becker","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"Pt 8","key":"10.1016\/j.ymgme.2013.12.003_bb0215","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1093\/brain\/aws174","article-title":"The neurobiology of glucocerebrosidase-associated parkinsonism: a positron emission tomography study of dopamine synthesis and regional cerebral blood flow","volume":"135","author":"Goker-Alpan","year":"2012","journal-title":"Brain"},{"issue":"7","key":"10.1016\/j.ymgme.2013.12.003_bb0220","doi-asserted-by":"crossref","first-page":"e69190","DOI":"10.1371\/journal.pone.0069190","article-title":"Dopaminergic neuronal imaging in genetic Parkinson's disease: insights into pathogenesis","volume":"8","author":"McNeill","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.ymgme.2013.12.003_bb0225","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/mds.23213","article-title":"Functional brain imaging in glucocerebrosidase mutation carriers with and without parkinsonism","volume":"25","author":"Kono","year":"2010","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.ymgme.2013.12.003_bb0230","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bcmd.2012.09.007","article-title":"Commentary on \u201cPilot study using ambroxol as a pharmacological chaperone in type 1 Gaucher disease\u201d by Zimran et al","volume":"50","author":"Goker-Alpan","year":"2013","journal-title":"Blood Cells Mol. Dis."},{"issue":"2","key":"10.1016\/j.ymgme.2013.12.003_bb0235","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0003-9861(76)90547-6","article-title":"Differentiation of beta-glucocerebrosidase from beta-glucosidase in human tissues using sodium taurocholate","volume":"175","author":"Peters","year":"1976","journal-title":"Arch. Biochem. Biophys."},{"issue":"2\u20133","key":"10.1016\/j.ymgme.2013.12.003_bb0240","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF02962142","article-title":"A biochemical and ultrastructural evaluation of the type 2 Gaucher mouse","volume":"24","author":"Willemsen","year":"1995","journal-title":"Mol. Chem. Neuropathol."},{"issue":"9","key":"10.1016\/j.ymgme.2013.12.003_bb0245","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/archneur.1982.00510210020005","article-title":"Brain glucocerebrosidase in Gaucher's disease","volume":"39","author":"Daniels","year":"1982","journal-title":"Arch. Neurol."},{"issue":"10","key":"10.1016\/j.ymgme.2013.12.003_bb0250","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.febslet.2013.04.001","article-title":"Evidence of oxidative stress in young and aged DJ-1-deficient mice","volume":"587","author":"Raman","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0255","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2012.10.009","article-title":"Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability","volume":"228","author":"Chou","year":"2013","journal-title":"Neuroscience"},{"issue":"8","key":"10.1016\/j.ymgme.2013.12.003_bb0260","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1523\/JNEUROSCI.23-08-03095.2003","article-title":"Alpha-synuclein overexpression protects against paraquat-induced neurodegeneration","volume":"23","author":"Manning-Bog","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0265","first-page":"627","article-title":"The Gaucher mouse","volume":"95","author":"Kanfer","year":"1982","journal-title":"Prog. Clin. Biol. Res."},{"issue":"1","key":"10.1016\/j.ymgme.2013.12.003_bb0270","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuron.2009.12.023","article-title":"Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis","volume":"65","author":"Nemani","year":"2010","journal-title":"Neuron"},{"issue":"Pt 7","key":"10.1016\/j.ymgme.2013.12.003_bb0275","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1093\/brain\/awq132","article-title":"SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson's disease","volume":"133","author":"Garcia-Reitbock","year":"2010","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.ymgme.2013.12.003_bb0280","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.cell.2005.09.028","article-title":"Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration","volume":"123","author":"Chandra","year":"2005","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.ymgme.2013.12.003_bb0285","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1523\/JNEUROSCI.20-09-03214.2000","article-title":"Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons","volume":"20","author":"Murphy","year":"2000","journal-title":"J. Neurosci."},{"issue":"52","key":"10.1016\/j.ymgme.2013.12.003_bb0290","doi-asserted-by":"crossref","first-page":"21093","DOI":"10.1073\/pnas.1112061109","article-title":"Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets","volume":"108","author":"Agostini","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.ymgme.2013.12.003_bb0295","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1083\/jcb.201103006","article-title":"Targeting of the Arpc3 actin nucleation factor by miR-29a\/b regulates dendritic spine morphology","volume":"194","author":"Lippi","year":"2011","journal-title":"J. Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.ymgme.2013.12.003_bb0300","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jneuroim.2012.02.012","article-title":"MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions","volume":"246","author":"Lescher","year":"2012","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.ymgme.2013.12.003_bb0305","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1159\/000226221","article-title":"Micromanaging vascular biology: tiny microRNAs play big band","volume":"46","author":"Sen","year":"2009","journal-title":"J. Vasc. Res."},{"issue":"5","key":"10.1016\/j.ymgme.2013.12.003_bb0310","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1073\/pnas.95.5.2503","article-title":"Mice with type 2 and 3 Gaucher disease point mutations generated by a single insertion mutagenesis procedure","volume":"95","author":"Liu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"32","key":"10.1016\/j.ymgme.2013.12.003_bb0315","doi-asserted-by":"crossref","first-page":"28080","DOI":"10.1074\/jbc.M111.237859","article-title":"Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases","volume":"286","author":"Yap","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.ymgme.2013.12.003_bb0320","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ymgme.2013.03.015","article-title":"Glucosylceramide modulates endolysosomal pH in Gaucher disease","volume":"109","author":"Sillence","year":"2013","journal-title":"Mol. Genet. Metab."},{"issue":"18","key":"10.1016\/j.ymgme.2013.12.003_bb0325","doi-asserted-by":"crossref","first-page":"13621","DOI":"10.1074\/jbc.M109.074617","article-title":"Lysosomal degradation of alpha-synuclein in vivo","volume":"285","author":"Mak","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"8","key":"10.1016\/j.ymgme.2013.12.003_bb0330","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1523\/JNEUROSCI.3809-03.2004","article-title":"Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway","volume":"24","author":"Lee","year":"2004","journal-title":"J. Neurosci."},{"issue":"36","key":"10.1016\/j.ymgme.2013.12.003_bb0335","doi-asserted-by":"crossref","first-page":"9678","DOI":"10.1021\/bi800699v","article-title":"Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species","volume":"47","author":"Sevlever","year":"2008","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.ymgme.2013.12.003_bb0340","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00401-010-0741-7","article-title":"Glucocerebrosidase is present in alpha-synuclein inclusions in Lewy body disorders","volume":"120","author":"Goker-Alpan","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"2","key":"10.1016\/j.ymgme.2013.12.003_bb0345","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-5793(94)00833-7","article-title":"SNAP-25 is present in a SNARE complex in adrenal chromaffin cells","volume":"351","author":"Roth","year":"1994","journal-title":"FEBS Lett."},{"issue":"12","key":"10.1016\/j.ymgme.2013.12.003_bb0350","doi-asserted-by":"crossref","first-page":"8623","DOI":"10.1016\/S0021-9258(17)37010-2","article-title":"In chromaffin cells, the mammalian Sec1p homologue is a syntaxin 1A-binding protein associated with chromaffin granules","volume":"269","author":"Hodel","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0355","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1040-7952(06)80008-X","article-title":"Intracellular membrane fusion","volume":"29","author":"Rothman","year":"1994","journal-title":"Adv. Second Messenger Phosphoprotein Res."},{"issue":"6418","key":"10.1016\/j.ymgme.2013.12.003_bb0360","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/362318a0","article-title":"SNAP receptors implicated in vesicle targeting and fusion","volume":"362","author":"Sollner","year":"1993","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.ymgme.2013.12.003_bb0365","doi-asserted-by":"crossref","first-page":"11681","DOI":"10.1016\/S0021-9258(19)49748-2","article-title":"Members of the VAMP family of synaptic vesicle proteins are components of glucose transporter-containing vesicles from rat adipocytes","volume":"267","author":"Cain","year":"1992","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.ymgme.2013.12.003_bb0370","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.116.3.761","article-title":"Synaptic vesicle membrane proteins interact to form a multimeric complex","volume":"116","author":"Bennett","year":"1992","journal-title":"J. Cell Biol."},{"issue":"24","key":"10.1016\/j.ymgme.2013.12.003_bb0375","doi-asserted-by":"crossref","first-page":"8083","DOI":"10.1523\/JNEUROSCI.1091-10.2010","article-title":"A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration","volume":"30","author":"Scott","year":"2010","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.ymgme.2013.12.003_bb0380","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s11064-012-0708-2","article-title":"Neuroinflammation and synaptic loss","volume":"37","author":"Rao","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0385","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2202-13-50","article-title":"Dose-dependent changes in neuroinflammatory and arachidonic acid cascade markers with synaptic marker loss in rat lipopolysaccharide infusion model of neuroinflammation","volume":"13","author":"Kellom","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0390","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/1742-2094-9-106","article-title":"Tumor necrosis factor-alpha synthesis inhibitor 3,6\u2032-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease","volume":"9","author":"Tweedie","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.ymgme.2013.12.003_bb0395","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.expneurol.2012.09.019","article-title":"Neuroprotective effect of Pycnogenol(R) following traumatic brain injury","volume":"239","author":"Scheff","year":"2013","journal-title":"Exp. Neurol."},{"issue":"1\u20134","key":"10.1016\/j.ymgme.2013.12.003_bb0400","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000333122","article-title":"Hippocampal drebrin loss in mild cognitive impairment","volume":"10","author":"Counts","year":"2012","journal-title":"Neurodegener. Dis."},{"issue":"6","key":"10.1016\/j.ymgme.2013.12.003_bb0405","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/00005072-199906000-00008","article-title":"Loss of proteins regulating synaptic plasticity in normal aging of the human brain and in Alzheimer disease","volume":"58","author":"Hatanpaa","year":"1999","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"12","key":"10.1016\/j.ymgme.2013.12.003_bb0410","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1523\/JNEUROSCI.23-12-05219.2003","article-title":"Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein+presenilin-1 transgenic mice","volume":"23","author":"Dickey","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.ymgme.2013.12.003_bb0415","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.brainres.2007.10.066","article-title":"Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: consequences to morphology and viability on enzyme suppression in cultured primary neurons","volume":"1191","author":"Marks","year":"2008","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.ymgme.2013.12.003_bb0420","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0197-4580(96)00104-2","article-title":"In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis","volume":"17","author":"Sheng","year":"1996","journal-title":"Neurobiol. Aging"},{"issue":"21","key":"10.1016\/j.ymgme.2013.12.003_bb0425","doi-asserted-by":"crossref","first-page":"19453","DOI":"10.1074\/jbc.M301938200","article-title":"Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus","volume":"278","author":"Kelly","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.ymgme.2013.12.003_bb0430","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/exnr.2002.7966","article-title":"Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses","volume":"176","author":"Hauss-Wegrzyniak","year":"2002","journal-title":"Exp. Neurol."},{"issue":"8","key":"10.1016\/j.ymgme.2013.12.003_bb0435","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1097\/00001756-200006050-00032","article-title":"LPS-induced neuroinflammatory effects do not recover with time","volume":"11","author":"Hauss-Wegrzyniak","year":"2000","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.ymgme.2013.12.003_bb0440","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-8993(00)01999-5","article-title":"Behavioral and ultrastructural changes induced by chronic neuroinflammation in young rats","volume":"859","author":"Hauss-Wegrzyniak","year":"2000","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.ymgme.2013.12.003_bb0445","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/ana.23677","article-title":"Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease","volume":"72","author":"Shi","year":"2012","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.ymgme.2013.12.003_bb0450","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbagrm.2008.04.008","article-title":"Roles of microRNAs beyond development\u2014metabolism and neural plasticity","volume":"1779","author":"Aumiller","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"Pt 6","key":"10.1016\/j.ymgme.2013.12.003_bb0455","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1042\/BST0361224","article-title":"How do microRNAs regulate gene expression?","volume":"36","author":"Cannell","year":"2008","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.ymgme.2013.12.003_bb0460","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.ymgme.2013.12.003_bb0465","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1261\/rna.5980303","article-title":"A microRNA array reveals extensive regulation of microRNAs during brain development","volume":"9","author":"Krichevsky","year":"2003","journal-title":"RNA"},{"issue":"7\u20138","key":"10.1016\/j.ymgme.2013.12.003_bb0470","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00335-008-9129-6","article-title":"Thinking about RNA? MicroRNAs in the brain","volume":"19","author":"Barbato","year":"2008","journal-title":"Mamm. Genome"},{"issue":"31","key":"10.1016\/j.ymgme.2013.12.003_bb0475","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.0906277106","article-title":"Repression of alpha-synuclein expression and toxicity by microRNA-7","volume":"106","author":"Junn","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.ymgme.2013.12.003_bb0480","doi-asserted-by":"crossref","first-page":"12726","DOI":"10.1074\/jbc.M109.086827","article-title":"Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153","volume":"285","author":"Doxakis","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.ymgme.2013.12.003_bb0485","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1158\/0008-5472.CAN-06-3613","article-title":"Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181","volume":"66","author":"Pekarsky","year":"2006","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.ymgme.2013.12.003_bb0490","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.bbamcr.2013.04.007","article-title":"A role for miR-142-3p in colony-stimulating factor 1-induced monocyte differentiation into macrophages","volume":"1833","author":"Lagrange","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.ymgme.2013.12.003_bb0495","doi-asserted-by":"crossref","first-page":"687","DOI":"10.4161\/onci.19854","article-title":"TLR4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine IL-6 of macrophages via microRNA let-7b","volume":"1","author":"Li","year":"2012","journal-title":"Oncoimmunology"}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719213004150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719213004150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,3,19]],"date-time":"2022-03-19T14:38:56Z","timestamp":1647700736000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719213004150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":96,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S1096719213004150"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2013.12.003","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroinflammation and \u03b1-synuclein accumulation in response to glucocerebrosidase deficiency are accompanied by synaptic dysfunction","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2013.12.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}