{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:16:17Z","timestamp":1790806577784,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Green Cross Corp.","award":["PHO1121123"],"award-info":[{"award-number":["PHO1121123"]}]},{"name":"Samsung Medical Center","award":["GFO1140061"],"award-info":[{"award-number":["GFO1140061"]}]}],"content-domain":{"domain":["mgmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.ymgme.2014.08.009","type":"journal-article","created":{"date-parts":[[2014,8,30]],"date-time":"2014-08-30T19:54:47Z","timestamp":1409428487000},"page":"156-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Safety and efficacy of enzyme replacement therapy with idursulfase beta in children aged younger than 6years with Hunter syndrome"],"prefix":"10.1016","volume":"114","author":[{"given":"Young Bae","family":"Sohn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yoon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghee","family":"Kwun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimm","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Kyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2014.08.009_bb0005","series-title":"The Metabolic and Molecular Basis of Inherited Disease","year":"2001"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0010","doi-asserted-by":"crossref","first-page":"e377","DOI":"10.1542\/peds.2007-1350","article-title":"Recognition and diagnosis of mucopolysaccharidosis II (Hunter syndrome)","volume":"121","author":"Martin","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00431-007-0635-4","article-title":"Mucopolysaccharidosis type II (Hunter syndrome): a clinical review and recommendations for treatment in the era of enzyme replacement therapy","volume":"167","author":"Wraith","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0020","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1750-1172-8-42","article-title":"Phase I\/II clinical trial of enzyme replacement therapy with idursulfase beta in patients with mucopolysaccharidosis II (Hunter syndrome)","volume":"8","author":"Sohn","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ajmg.c.30291","article-title":"Newborn screening for lysosomal storage disorders","volume":"157C","author":"Nakamura","year":"2011","journal-title":"Am. J. Med. Genet. C: Semin. Med. Genet."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0030","series-title":"Newborn Screening for Hunter Disease: A Small-Scale Feasibility Study JIMD reports","author":"Ruijter","year":"2013"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0035","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ymgme.2013.06.007","article-title":"Newborn screening and diagnosis of mucopolysaccharidoses","volume":"110","author":"Tomatsu","year":"2013","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0040","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ymgme.2011.08.029","article-title":"Enzyme replacement therapy attenuates disease progression in two Japanese siblings with mucopolysaccharidosis type VI","volume":"104","author":"Furujo","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0045","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1399-0004.2009.01324.x","article-title":"Enzyme replacement therapy for mucopolysaccharidosis VI from 8weeks of age \u2014 a sibling control study","volume":"77","author":"McGill","year":"2010","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ymgme.2013.11.015","article-title":"Early initiation of enzyme replacement therapy for the mucopolysaccharidoses","volume":"111","author":"Muenzer","year":"2014","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0055","series-title":"NIH Publication #09-7473","article-title":"Common terminology criteria for adverse events v4.0","author":"National Cancer Institute","year":"2009"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0060","series-title":"Enzyme Replacement Therapy in Mucopolysaccharidosis II Patients Under 1 Year of Age JIMD Reports","author":"Lampe","year":"2014"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0065","first-page":"435","article-title":"A multicenter, open-label study evaluating safety and clinical outcomes in children (1.4\u20137.5years) with Hunter syndrome receiving idursulfase enzyme replacement therapy","volume":"16","author":"Giugliani","year":"2014","journal-title":"Genet. Med. Off. J. Am. Coll. Med. Genet."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0070","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s10719-014-9523-0","article-title":"A biochemical and physicochemical comparison of two recombinant enzymes used for enzyme replacement therapies of hunter syndrome","volume":"31","author":"Chung","year":"2014","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0075","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/ajmg.b.30492","article-title":"Acrodysostosis with unusual iridal color changing with age","volume":"144B","author":"Nii","year":"2007","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet. Off. Publ. Int. Soc. Psychiatr. Genet."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0080","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1542\/peds.89.1.91","article-title":"The Denver II: a major revision and restandardization of the Denver Developmental Screening Test","volume":"89","author":"Frankenburg","year":"1992","journal-title":"Pediatrics"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0085","first-page":"63","article-title":"A clinical study of 77 patients with mucopolysaccharidosis type II","volume":"Supplement 96","author":"Schwartz","year":"2007"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0090","first-page":"508","article-title":"Initial report from the Hunter Outcome Survey","volume":"10","author":"Wraith","year":"2008","journal-title":"Genet. Med. Off. J. Am. Coll. Med. Genet."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0095","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1136\/adc.57.11.828","article-title":"Mild form of Hunter's syndrome: clinical delineation based on 31 cases","volume":"57","author":"Young","year":"1982","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0100","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1469-8749.1983.tb13794.x","article-title":"The natural history of the severe form of Hunter's syndrome: a study based on 52 cases","volume":"25","author":"Young","year":"1983","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0105","first-page":"456","article-title":"Growth pattern and growth prediction of body height in children with mucopolysaccharidosis type II","volume":"100","author":"Rozdzynska","year":"2011"},{"key":"10.1016\/j.ymgme.2014.08.009_bb0110","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3346\/jkms.2014.29.2.254","article-title":"Impact of enzyme replacement therapy on linear growth in Korean patients with mucopolysaccharidosis type II (Hunter syndrome)","volume":"29","author":"Cho","year":"2014","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.ymgme.2014.08.009_bb0115","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10545-010-9215-2","article-title":"Effects of enzyme replacement therapy on growth in patients with mucopolysaccharidosis type II","volume":"34","author":"Schulze-Frenking","year":"2011","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719214002741?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719214002741?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:37:49Z","timestamp":1650069469000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719214002741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1096719214002741"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2014.08.009","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and efficacy of enzyme replacement therapy with idursulfase beta in children aged younger than 6years with Hunter syndrome","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2014.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}