{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:57:37Z","timestamp":1778745457454,"version":"3.51.4"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["NS043205"],"award-info":[{"award-number":["NS043205"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005468","name":"Batten Disease Support and Research Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005468","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010446","name":"Batten Disease Family Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010446","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010445","name":"Taylor's Tale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010445","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["mgmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.ymgme.2015.11.004","type":"journal-article","created":{"date-parts":[[2015,11,11]],"date-time":"2015-11-11T21:15:16Z","timestamp":1447276516000},"page":"210-216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Histochemical localization of palmitoyl protein thioesterase-1 activity"],"prefix":"10.1016","volume":"117","author":[{"given":"Joshua T.","family":"Dearborn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subramania","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6451-2847","authenticated-orcid":false,"given":"Charles","family":"Shyng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui-Yun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonah","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L.","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Sands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2015.11.004_bb0005","doi-asserted-by":"crossref","first-page":"22566","DOI":"10.1016\/S0021-9258(18)41567-0","article-title":"Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras","volume":"268","author":"Camp","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0010","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.nbd.2006.09.001","article-title":"Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis","volume":"25","author":"Kielar","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.brainresbull.2012.03.003","article-title":"Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics","volume":"88","author":"Shacka","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2350\/07-03-0242.1","article-title":"A murine model of infantile neuronal ceroid lipofuscinosis-ultrastructural evaluation of storage in the central nervous system and viscera","volume":"11","author":"Galvin","year":"2008","journal-title":"Pediatr. Dev. Pathol."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0025","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1159\/000334838","article-title":"Evaluation of neurodegeneration in a mouse model of infantile batten disease by magnetic resonance imaging and magnetic resonance spectroscopy","volume":"9","author":"Munasinghe","year":"2012","journal-title":"Neurodegener. Dis."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0030","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1469-8749.1974.tb04183.x","article-title":"Infantile type of so-called neuronal ceroid-lipofuscinosis","volume":"16","author":"Santavuori","year":"1974","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0035","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/376584a0","article-title":"Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis","volume":"376","author":"Vesa","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.ymgme.2015.11.004_bb0040","doi-asserted-by":"crossref","first-page":"13566","DOI":"10.1073\/pnas.251485198","article-title":"Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice","volume":"98","author":"Gupta","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0045","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ymgme.2009.12.002","article-title":"Human recombinant palmitoyl-protein thioesterase-1 (PPT1) for preclinical evaluation of enzyme replacement therapy for infantile neuronal ceroid lipofuscinosis","volume":"99","author":"Lu","year":"2010","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/ana.23545","article-title":"Synergistic effects of central nervous system-directed gene therapy and bone marrow transplantation in the murine model of infantile neuronal ceroid lipofuscinosis","author":"Macauley","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0055","doi-asserted-by":"crossref","DOI":"10.1007\/s10545-011-9446-x","article-title":"Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis","author":"Roberts","year":"2012","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0060","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/mt.2009.15","article-title":"AAV9: a potential blood\u2013brain barrier buster","volume":"17","author":"Manfredsson","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0065","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/mgme.1999.2809","article-title":"A rapid fluorogenic palmitoyl-protein thioesterase assay: pre- and postnatal diagnosis of INCL","volume":"66","author":"van Diggelen","year":"1999","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0070","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF00306428","article-title":"Indigogenic methods for glycosidases. II. An improved method for \u03b2-d-galactosidase and is application to localization studies of the enzymes in the intestine and in other tissues","volume":"23","author":"Lojda","year":"1970","journal-title":"Histochemie"},{"key":"10.1016\/j.ymgme.2015.11.004_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymgme.2012.05.009","article-title":"Intravenous high-dose enzyme replacement therapy with recombinant palmitoyl-protein thioesterase reduces visceral lysosomal storage and modestly prolongs survival in a preclinical mouse model of infantile neuronal ceroid lipofuscinosis","author":"Hu","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0080","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nbt.1515","article-title":"Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes","volume":"27","author":"Foust","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymgme.2015.11.004_bb0085","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1038\/mt.2012.100","article-title":"Sialic acid deposition impairs the utility of AAV9, but not peptide-modified AAVs for brain gene therapy in a mouse model of lysosomal storage disease","volume":"20","author":"Chen","year":"2012","journal-title":"Mol. Ther."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719215300743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719215300743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T22:55:50Z","timestamp":1653519350000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719215300743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S1096719215300743"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2015.11.004","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histochemical localization of palmitoyl protein thioesterase-1 activity","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2015.11.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}