{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T04:27:57Z","timestamp":1780374477307,"version":"3.54.1"},"reference-count":24,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["mgmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.ymgme.2016.06.010","type":"journal-article","created":{"date-parts":[[2016,6,23]],"date-time":"2016-06-23T04:46:37Z","timestamp":1466657197000},"page":"14-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Physical therapy management of infants and children with hypophosphatasia"],"prefix":"10.1016","volume":"119","author":[{"given":"Dawn","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Case","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Lerma","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Leiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Monfreda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Westlake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya S.","family":"Kishnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2016.06.010_bb0005","series-title":"Genetics of Bone Biology and Skeletal Disease","first-page":"337","article-title":"Hypophosphatasia","author":"Whyte","year":"2013"},{"key":"10.1016\/j.ymgme.2016.06.010_bb0010","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12018-013-9139-0","article-title":"Clinical aspects of hypophosphatasia: an update","volume":"11","author":"Hofmann","year":"2013","journal-title":"Clin. Rev. Bone Miner. Metab."},{"issue":"Suppl. 2","key":"10.1016\/j.ymgme.2016.06.010_bb0015","first-page":"380","article-title":"Hypophosphatasia","volume":"10","author":"Rockman-Greenberg","year":"2013","journal-title":"Pediatr. Endocrinol. Rev."},{"issue":"3","key":"10.1016\/j.ymgme.2016.06.010_bb0020","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1469-1809.2011.00642.x","article-title":"A molecular-based estimation of the prevalence of hypophosphatasia in the European population","volume":"75","author":"Mornet","year":"2011","journal-title":"Ann. Hum. Genet."},{"issue":"12","key":"10.1016\/j.ymgme.2016.06.010_bb0025","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1007\/s00198-015-3272-1","article-title":"Hypophosphatasia: an overview of the disease and its treatment","volume":"26","author":"Bianchi","year":"2015","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.ymgme.2016.06.010_bb0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/8904_2013_224","article-title":"Outcome of perinatal hypophosphatasia in Manitoba Mennonites: a retrospective cohort analysis","volume":"11","author":"Leung","year":"2013","journal-title":"JIMD Rep."},{"key":"10.1016\/j.ymgme.2016.06.010_bb0035","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bone.2015.02.022","article-title":"Hypophosphatasia: validation and expansion of the clinical nosology for children from 25years experience with 173 pediatric patients","volume":"75","author":"Whyte","year":"2015","journal-title":"Bone"},{"key":"10.1016\/j.ymgme.2016.06.010_bb0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/1876525400901010008","article-title":"Hypophosphatasia - recent advances in diagnosis and treatment","volume":"1","author":"Beck","year":"2009","journal-title":"Open Bone J."},{"key":"10.1016\/j.ymgme.2016.06.010_bb0045","series-title":"(Asfotase Alfa) [Prescribing Information]","author":"STRENSIQ","year":"2015"},{"issue":"10","key":"10.1016\/j.ymgme.2016.06.010_bb0050","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1056\/NEJMoa1106173","article-title":"Enzyme-replacement therapy in life-threatening hypophosphatasia","volume":"366","author":"Whyte","year":"2012","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.ymgme.2016.06.010_bb0055","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1210\/jc.2015-3462","article-title":"Asfotase alfa treatment improves survival for perinatal and infantile hypophosphatasia","volume":"101","author":"Whyte","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ymgme.2016.06.010_bb0060","series-title":"Annual Meeting of the American Society for Bone and Mineral Research; September 12\u201315, 2014","article-title":"Asfotase alfa: sustained improvements in hypophosphatasia-related rickets, physical function, and pain during 3years of treatment of severely affected children","author":"Madson","year":"2014"},{"key":"10.1016\/j.ymgme.2016.06.010_bb0065","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85971","article-title":"Asfotase alfa therapy for children with hypophosphatasia","author":"Whyte","year":"2016","journal-title":"JCI Insight"},{"key":"10.1016\/j.ymgme.2016.06.010_bb0070","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/nrurol.2014.342","article-title":"Gait assessment in children with childhood hypophosphatasia: impairments in muscle strength and physical function","volume":"36","author":"Phillips","year":"2015","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/j.ymgme.2016.06.010_bb0075","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/J006v27n04_06","article-title":"Review of the Bruininks-Oseretsky Test of motor proficiency, second edition (BOT-2)","volume":"27","author":"Deitz","year":"2007","journal-title":"Phys. Occup. Ther. Pediatr."},{"issue":"2","key":"10.1016\/j.ymgme.2016.06.010_bb0080","first-page":"180","article-title":"Bayley scales of infant and toddler development - third edition","volume":"25","author":"Bayley","year":"2006","journal-title":"J. Psychoeduc. Assess."},{"issue":"11","key":"10.1016\/j.ymgme.2016.06.010_bb0085","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1093\/ptj\/75.11.939","article-title":"Validity of the Peabody Developmental Gross Motor Scale as an evaluative measure of infants receiving physical therapy","volume":"75","author":"Palisano","year":"1995","journal-title":"Phys. Ther."},{"key":"10.1016\/j.ymgme.2016.06.010_bb0090","unstructured":"D. Phillips, S. Moseley, T. Odrljin, K.P. Fujita, A. Reeves, A. Yakimoski, K.L. Madson, C. Rockman-Greenberg, M.P. Whyte: Significantly improved muscle strength, running speed, and agility in children with hypophosphatasia treated with asfotase alfa. In: ENDO 2015 (Endocrine Society's 97th Annual Meeting and Expo), March 5\u20138, 2015; San Diego, CA."},{"issue":"6","key":"10.1016\/j.ymgme.2016.06.010_bb0095","article-title":"N-PASS: neonatal pain, agitation and sedation scale - reliability and validity","volume":"2","author":"Hummel","year":"2004","journal-title":"Anestesia Pediatrica e Neonatale"},{"issue":"3","key":"10.1016\/j.ymgme.2016.06.010_bb0100","first-page":"293","article-title":"The FLACC: a behavioral scale for scoring postoperative pain in young children","volume":"23","author":"Merkel","year":"1997","journal-title":"Pediatr. Nurs."},{"issue":"6","key":"10.1016\/j.ymgme.2016.06.010_bb0105","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1053\/jpan.2000.19504","article-title":"Pediatric pain, tools, and assessment","volume":"15","author":"Merkel","year":"2000","journal-title":"J. Perianesth. Nurs."},{"issue":"4","key":"10.1016\/j.ymgme.2016.06.010_bb0110","first-page":"445","article-title":"A specialized rehabilitation approach improves mobility in children with osteogenesis imperfecta","volume":"14","author":"Hoyer-Kuhn","year":"2014","journal-title":"J. Musculoskelet. Neuronal Interact."},{"issue":"5","key":"10.1016\/j.ymgme.2016.06.010_bb0115","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/0269215507080763","article-title":"Results of a prospective pilot trial on mobility after whole body vibration in children and adolescents with osteogenesis imperfecta","volume":"22","author":"Semler","year":"2008","journal-title":"Clin. Rehabil."},{"key":"10.1016\/j.ymgme.2016.06.010_bb0120","series-title":"Annual Meeting of the American Society for Bone and Mineral Research; October 9\u201312, 2015; Seattle, WA","article-title":"Improved functional mobility with asfotase alfa treatment in childhood hypophosphatasia","author":"Madson","year":"2015"}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719216301196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719216301196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T22:39:29Z","timestamp":1568068769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719216301196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":24,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S1096719216301196"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2016.06.010","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Physical therapy management of infants and children with hypophosphatasia","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2016.06.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}