{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T04:56:03Z","timestamp":1772600163459,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mgmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.ymgme.2016.11.003","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T17:00:42Z","timestamp":1478710842000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["An MRspec database query and visualization engine with applications as a clinical diagnostic and research tool"],"prefix":"10.1016","volume":"119","author":[{"given":"Filip","family":"Miscevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Foong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8891-5106","authenticated-orcid":false,"given":"Susan","family":"Blaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brudno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8491-1095","authenticated-orcid":false,"given":"Andreas","family":"Schulze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ymgme.2016.11.003_bb0005","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ymgme.2011.06.020","article-title":"New frontiers in neuroimaging applications to inborn errors of metabolism","volume":"104","author":"Prust","year":"2011","journal-title":"Mol. Genet. Metab."},{"issue":"10","key":"10.1016\/j.ymgme.2016.11.003_bb0010","first-page":"1989","article-title":"Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging","volume":"24","author":"Law","year":"2003","journal-title":"Am. J. Neuroradiol."},{"issue":"2","key":"10.1016\/j.ymgme.2016.11.003_bb0015","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.neuroimage.2004.06.022","article-title":"Improved delineation of brain tumors: an automated method for segmentation based on pathologic changes of 1H-MRSI metabolites in gliomas","volume":"23","author":"Stadlbauer","year":"2004","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.ymgme.2016.11.003_bb0020","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11307-007-0087-2","article-title":"MR spectroscopy in neurodegenerative disease","volume":"9","author":"Martin","year":"2007","journal-title":"Mol. Imaging Biol."},{"issue":"6","key":"10.1016\/j.ymgme.2016.11.003_bb0025","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","article-title":"Estimation of metabolite concentrations from localized in vivo proton NMR spectra","volume":"30","author":"Provencher","year":"1993","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.ymgme.2016.11.003_bb0030","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1086\/230638","article-title":"Statistical methods for comparing regression coefficients between models","author":"Clogg","year":"1995","journal-title":"Am. J. Sociol."},{"issue":"5","key":"10.1016\/j.ymgme.2016.11.003_bb0035","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1469-8749.1995.tb12023.x","article-title":"Developmental brain changes investigated with proton magnetic resonance spectroscopy","volume":"37","author":"Hashimoto","year":"1995","journal-title":"Dev. Med. Child Neurol."},{"issue":"7","key":"10.1016\/j.ymgme.2016.11.003_bb0040","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1093\/cercor\/11.7.598","article-title":"A proton magnetic resonance spectroscopy study of age-related changes in frontal lobe metabolite concentrations","volume":"11","author":"Brooks","year":"2001","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.ymgme.2016.11.003_bb0045","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1203\/00006450-199910000-00019","article-title":"Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS","volume":"46","author":"Pouwels","year":"1999","journal-title":"Pediatr. Res."},{"issue":"6","key":"10.1016\/j.ymgme.2016.11.003_bb0050","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1002\/mrm.1910360610","article-title":"Lactate, N-acetylaspartate, choline and creatine concentrations, and spin-spin relaxation in thalamic and occipito-parietal regions of developing human brain","volume":"36","author":"Cady","year":"1996","journal-title":"Magn. Reson. Med."},{"issue":"5","key":"10.1016\/j.ymgme.2016.11.003_bb0055","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1002\/jmri.1880040510","article-title":"Metabolite concentrations in the developing brain estimated with proton MR spectroscopy","volume":"4","author":"Toft","year":"1994","journal-title":"J. Magn. Reson. Imaging"},{"issue":"12","key":"10.1016\/j.ymgme.2016.11.003_bb0060","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1093\/cercor\/bhs283","article-title":"Metabolic maturation of the human brain from birth through adolescence: insights from in vivo magnetic resonance spectroscopy","volume":"23","author":"Bluml","year":"2013","journal-title":"Cereb. Cortex"},{"issue":"2","key":"10.1016\/j.ymgme.2016.11.003_bb0065","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.sult.2013.10.008","article-title":"Congenital genetic inborn errors of metabolism presenting as an adult or persisting into adulthood: neuroimaging in the more common or recognizable disorders","volume":"35","author":"Krishna","year":"2014","journal-title":"Semin. Ultrasound CT MR"},{"issue":"4","key":"10.1016\/j.ymgme.2016.11.003_bb0070","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/mrm.1910300405","article-title":"Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy","volume":"30","author":"Kreis","year":"1993","journal-title":"Magn. Reson. Med."},{"issue":"2","key":"10.1016\/j.ymgme.2016.11.003_bb0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pneurobio.2006.12.003","article-title":"N-acetylaspartate in the CNS: from neurodiagnostics to neurobiology","volume":"81","author":"Moffett","year":"2007","journal-title":"Prog. Neurobiol."},{"issue":"14","key":"10.1016\/j.ymgme.2016.11.003_bb0080","doi-asserted-by":"crossref","first-page":"5221","DOI":"10.1073\/pnas.0409184102","article-title":"Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan's disease","volume":"102","author":"Madhavarao","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.ymgme.2016.11.003_bb0085","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1046\/j.1471-4159.2001.00456.x","article-title":"Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis: evidence for myelin-associated aspartoacylase","volume":"78","author":"Chakraborty","year":"2001","journal-title":"J. Neurochem."},{"issue":"10","key":"10.1016\/j.ymgme.2016.11.003_bb0090","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1016\/j.neurobiolaging.2011.12.008","article-title":"Whole brain N-acetylaspartate concentration is conserved throughout normal aging","volume":"33","author":"Wu","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.ymgme.2016.11.003_bb0095","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/schbul\/sbr127","article-title":"N-acetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) in patients with schizophrenia","volume":"39","author":"Jessen","year":"2013","journal-title":"Schizophr. Bull."},{"issue":"7","key":"10.1016\/j.ymgme.2016.11.003_bb0100","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3174\/ajnr.A1576","article-title":"Proton MR spectroscopy correlates of frontal lobe function in healthy children","volume":"30","author":"Ozturk","year":"2009","journal-title":"Am. J. Neuroradiol."},{"issue":"9","key":"10.1016\/j.ymgme.2016.11.003_bb0105","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1118\/1.1501822","article-title":"Proton magnetic resonance spectroscopy in the brain: report of AAPM MR task group #9","volume":"29","author":"Drost","year":"2002","journal-title":"Med. Phys."},{"issue":"5","key":"10.1016\/j.ymgme.2016.11.003_bb0110","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/nbm.713","article-title":"Proton T1 and T2 relaxation times of human brain metabolites at 3Tesla","volume":"14","author":"Mlyn\u00e1rik","year":"2001","journal-title":"NMR Biomed."},{"issue":"2","key":"10.1016\/j.ymgme.2016.11.003_bb0115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/jmri.21453","article-title":"Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T","volume":"28","author":"Li","year":"2008","journal-title":"J. Magn. Reson. Imaging"},{"issue":"Suppl. 3","key":"10.1016\/j.ymgme.2016.11.003_bb0120","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1528-1167.2010.02605.x","article-title":"Modeling new therapies for infantile spasms","volume":"51","author":"Chudomelova","year":"2010","journal-title":"Epilepsia"},{"issue":"6","key":"10.1016\/j.ymgme.2016.11.003_bb0125","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s10545-005-4565-x","article-title":"Clinical, biochemical, magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) findings in a fourth case of combined D- and L-2 hydroxyglutaric aciduria","volume":"28","author":"Read","year":"2005","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719216302840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719216302840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T17:55:51Z","timestamp":1536256551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719216302840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["S1096719216302840"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2016.11.003","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An MRspec database query and visualization engine with applications as a clinical diagnostic and research tool","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2016.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}