{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:57:28Z","timestamp":1777078648483,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T00:00:00Z","timestamp":1558828800000},"content-version":"am","delay-in-days":359,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000900","name":"California Institute for Regenerative Medicine","doi-asserted-by":"publisher","award":["TR4-06831 to GSL"],"award-info":[{"award-number":["TR4-06831 to GSL"]}],"id":[{"id":"10.13039\/100000900","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5 R01 NS100979-01"],"award-info":[{"award-number":["5 R01 NS100979-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5T32GM08243-29"],"award-info":[{"award-number":["5T32GM08243-29"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.ymgme.2018.04.005","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T14:21:44Z","timestamp":1524320504000},"page":"114-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice"],"prefix":"10.1016","volume":"124","author":[{"given":"Stephanie A.K.","family":"Angarita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Truong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7065-9156","authenticated-orcid":false,"given":"Suhail","family":"Khoja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Nitzahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abha K.","family":"Rajbhandari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Zhuravka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex K.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen D.","family":"Cederbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald S.","family":"Lipshutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.ymgme.2018.04.005_bb0005","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1023\/A:1005313809037","article-title":"The human arginases and arginase deficiency","volume":"21","author":"Iyer","year":"1998","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0010","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/088307389701200502","article-title":"Argininemia: a treatable genetic cause of progressive spastic diplegia simulating cerebral palsy: case reports and literature review","volume":"12","author":"Prasad","year":"1997","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0015","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/mt.2009.65","article-title":"Short-term correction of arginase deficiency in a neonatal murine model with a helper-dependent adenoviral vector","volume":"17","author":"Gau","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0020","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1038\/mt.2012.129","article-title":"Long-term survival of the juvenile lethal arginase-deficient mouse with AAV gene therapy","volume":"20","author":"Lee","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0025","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/gt.2012.99","article-title":"AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse","volume":"20","author":"Lee","year":"2013","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0030","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1038\/mt.2014.99","article-title":"Myocyte-mediated arginase expression controls hyperargininemia but not hyperammonemia in arginase-deficient mice","volume":"22","author":"Hu","year":"2014","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0035","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/gt.2014.106","article-title":"Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy","volume":"22","author":"Hu","year":"2015","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0040","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ymgme.2013.06.020","article-title":"Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse","volume":"110","author":"Kasten","year":"2013","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080001","article-title":"Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism","volume":"8","author":"Sin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ymgme.2018.04.005_bb0050","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0021-9673(01)90918-5","article-title":"O-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids","volume":"266","author":"Jones","year":"1983","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0055","doi-asserted-by":"crossref","first-page":"e394","DOI":"10.1038\/mtna.2016.98","article-title":"Restoring ureagenesis in hepatocytes by CRISPR\/Cas9-mediated genomic addition to arginase-deficient induced pluripotent stem cells","volume":"5","author":"Lee","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ymgme.2018.04.005_bb0060","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s003359900551","article-title":"Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment","volume":"8","author":"Rogers","year":"1997","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ymgme.2018.04.005_bb0065","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/BF00401402","article-title":"Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse","volume":"13","author":"Irwin","year":"1968","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.ymgme.2018.04.005_bb0070","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s003350010149","article-title":"Testing of SHIRPA, a mouse phenotypic assessment protocol, on Dmd(mdx) and Dmd(mdx3cv) dystrophin-deficient mice","volume":"11","author":"Rafael","year":"2000","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ymgme.2018.04.005_bb0075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03001163","article-title":"Conditioned and unconditional components of post-shock freezing","volume":"15","author":"Fanselow","year":"1980","journal-title":"Pavlov J. Biol. Sci."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0080","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nbt1326","article-title":"Robust expansion of human hepatocytes in Fah\u2212\/\u2212\/Rag2\u2212\/\u2212\/Il2rg\u2212\/\u2212 mice","volume":"25","author":"Azuma","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0085","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1053\/j.gastro.2013.09.009","article-title":"Mice with human livers","volume":"145","author":"Grompe","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ymgme.2018.04.005_bb0090","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ni.1671","article-title":"Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens","volume":"9","author":"El Kasmi","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0095","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(91)90615-6","article-title":"Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene","volume":"66","author":"Sandgren","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.ymgme.2018.04.005_bb0100","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/jgm.1496","article-title":"RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy","volume":"12","author":"Hu","year":"2010","journal-title":"J. Gene Med."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0105","first-page":"54","article-title":"Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency","volume":"9","author":"Ballantyne","year":"2016","journal-title":"Mol. Genet. Metab. Rep."},{"key":"10.1016\/j.ymgme.2018.04.005_bb0110","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/978-1-60761-688-7_27","article-title":"Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity","volume":"640","author":"Strom","year":"2010","journal-title":"Methods Mol. Biol."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719218300726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719218300726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:21:28Z","timestamp":1761088888000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719218300726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S1096719218300726"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2018.04.005","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2018.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}