{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:26:48Z","timestamp":1792794408152,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Norte Portugal Regional Operational Programme (NORTE 2020)","award":["NORTE-01-0145-FEDER-000012"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000012"]}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["mgmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.ymgme.2018.07.005","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T10:47:39Z","timestamp":1531910859000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The GM2 ganglioside inhibits iNKT cell responses in a CD1d-dependent manner"],"prefix":"10.1016","volume":"125","author":[{"given":"C.S.","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"P\u00e9rez-Cabezas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.T.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Alegrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Le\u00e3o-Teles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.ymgme.2018.07.005_bb0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrd.2017.214","article-title":"Emptying the stores: lysosomal diseases and therapeutic strategies","volume":"17","author":"Platt","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"2","key":"10.1016\/j.ymgme.2018.07.005_bb0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/sj.ejhg.5201044","article-title":"Prevalence of lysosomal storage diseases in Portugal","volume":"12","author":"Pinto","year":"2004","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.ymgme.2018.07.005_bb0015","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"3827","article-title":"The GM2 Gangliosidoses","author":"Gravel","year":"2001"},{"issue":"1\u20132","key":"10.1016\/j.ymgme.2018.07.005_bb0020","first-page":"1","article-title":"Lysosomal storage diseases","volume":"2","author":"Ferreira","year":"2017","journal-title":"Transl. Sci. Rare Dis."},{"key":"10.1016\/j.ymgme.2018.07.005_bb0025","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-immunol-032414-112008","article-title":"The immunology of CD1- and MR1-restricted T cells","volume":"34","author":"Mori","year":"2016","journal-title":"Annu. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.ymgme.2018.07.005_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030502","article-title":"From lysosomal storage diseases to NKT cell activation and back","volume":"18","author":"Pereira","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.ymgme.2018.07.005_bb0035","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2904","article-title":"Presumed guilty: natural killer T cell defects and human disease","volume":"11","author":"Berzins","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"51","key":"10.1016\/j.ymgme.2018.07.005_bb0040","doi-asserted-by":"crossref","first-page":"20490","DOI":"10.1073\/pnas.0710145104","article-title":"Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation","volume":"104","author":"Salio","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.ymgme.2018.07.005_bb0045","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.immuni.2007.08.017","article-title":"Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids","volume":"27","author":"Paget","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.ymgme.2018.07.005_bb0050","doi-asserted-by":"crossref","first-page":"2876275","DOI":"10.1155\/2016\/2876275","article-title":"CD1-restricted T cells at the crossroad of innate and adaptive immunity","volume":"2016","author":"Pereira","year":"2016","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.ymgme.2018.07.005_bb0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1084\/jem.20030446","article-title":"Cross-presentation of disialoganglioside GD3 to natural killer T cells","volume":"198","author":"Wu","year":"2003","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.ymgme.2018.07.005_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000228","article-title":"Recognition of lyso-phospholipids by human natural killer T lymphocytes","volume":"7","author":"Fox","year":"2009","journal-title":"PLoS Biol."},{"issue":"5","key":"10.1016\/j.ymgme.2018.07.005_bb0065","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/ni.2245","article-title":"Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus","volume":"13","author":"Facciotti","year":"2012","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.ymgme.2018.07.005_bb0070","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.immuni.2014.08.017","article-title":"The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian alpha-linked glycosylceramides","volume":"41","author":"Kain","year":"2014","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.ymgme.2018.07.005_bb0075","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1073\/pnas.0915056107","article-title":"Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d","volume":"107","author":"Muindi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ymgme.2018.07.005_bb0080","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2567.2007.02760.x","article-title":"Fine specificity of natural killer T cells against GD3 ganglioside and identification of GM3 as an inhibitory natural killer T-cell ligand","volume":"123","author":"Park","year":"2008","journal-title":"Immunology"},{"issue":"5702","key":"10.1016\/j.ymgme.2018.07.005_bb0085","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1126\/science.1103440","article-title":"Lysosomal glycosphingolipid recognition by NKT cells","volume":"306","author":"Zhou","year":"2004","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.ymgme.2018.07.005_bb0090","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1084\/jem.20060921","article-title":"Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases","volume":"203","author":"Gadola","year":"2006","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.ymgme.2018.07.005_bb0095","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/eji.201545725","article-title":"Globotriaosylceramide inhibits iNKT-cell activation in a CD1d-dependent manner","volume":"46","author":"Pereira","year":"2016","journal-title":"Eur. J. Immunol."},{"issue":"12","key":"10.1016\/j.ymgme.2018.07.005_bb0100","doi-asserted-by":"crossref","first-page":"8197","DOI":"10.1073\/pnas.122636199","article-title":"Inhibition of glycolipid shedding rescues recognition of a CD1+ T cell lymphoma by natural killer T (NKT) cells","volume":"99","author":"Sriram","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.ymgme.2018.07.005_bb0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.1601976","article-title":"Autoreactivity to Sulfatide by human invariant NKT cells","volume":"199","author":"Stax","year":"2017","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.ymgme.2018.07.005_bb0110","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jim.2007.03.006","article-title":"Production and characterization of monoclonal antibodies against complexes of the NKT cell ligand alpha-galactosylceramide bound to mouse CD1d","volume":"323","author":"Yu","year":"2007","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.ymgme.2018.07.005_bb0115","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3389\/fimmu.2017.00710","article-title":"Leishmania infantum exoproducts inhibit human invariant NKT cell expansion and activation","volume":"8","author":"Belo","year":"2017","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.ymgme.2018.07.005_bb0120","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nm.2811","article-title":"Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity","volume":"18","author":"Zeissig","year":"2012","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.ymgme.2018.07.005_bb0125","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.0906-6705.2005.00289.x","article-title":"CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity","volume":"14","author":"Nieuwenhuis","year":"2005","journal-title":"Exp. Dermatol."},{"issue":"4","key":"10.1016\/j.ymgme.2018.07.005_bb0130","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ymgme.2013.01.018","article-title":"Invariant natural killer T cells are phenotypically and functionally altered in Fabry disease","volume":"108","author":"Pereira","year":"2013","journal-title":"Mol. Genet. Metab."},{"issue":"7","key":"10.1016\/j.ymgme.2018.07.005_bb0135","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/eji.201141821","article-title":"Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-pick disease type C","volume":"42","author":"Speak","year":"2012","journal-title":"Eur. J. Immunol."},{"issue":"8","key":"10.1016\/j.ymgme.2018.07.005_bb0140","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1182\/blood-2014-09-600270","article-title":"Type II NKT-TFH cells against Gaucher lipids regulate B-cell immunity and inflammation","volume":"125","author":"Nair","year":"2015","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.ymgme.2018.07.005_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2007.02647.x","article-title":"Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11","volume":"122","author":"Montoya","year":"2007","journal-title":"Immunology"}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719218302713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719218302713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T20:19:55Z","timestamp":1538684395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719218302713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S1096719218302713"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2018.07.005","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The GM2 ganglioside inhibits iNKT cell responses in a CD1d-dependent manner","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2018.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}