{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:30:45Z","timestamp":1793302245094,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.ymgme.2021.02.004","type":"journal-article","created":{"date-parts":[[2021,2,21]],"date-time":"2021-02-21T16:31:28Z","timestamp":1613925088000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Skeletal muscle specific mitochondrial dysfunction and altered energy metabolism in a murine model (oim\/oim) of severe osteogenesis imperfecta"],"prefix":"10.1016","volume":"132","author":[{"given":"Victoria L.","family":"Gremminger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily N.","family":"Harrelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara K.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Ohler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Scott","family":"Rector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte L.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2021.02.004_bb0005","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.matbio.2018.03.010","article-title":"Osteogenesis imperfecta and therapeutics","volume":"71\u201372","author":"Morello","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0010","doi-asserted-by":"crossref","first-page":"17052","DOI":"10.1038\/nrdp.2017.52","article-title":"Osteogenesis imperfecta","volume":"3","author":"Marini","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1136\/jmg.16.2.101","article-title":"Genetic heterogeneity in osteogenesis imperfecta","volume":"16","author":"Sillence","year":"1979","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0020","first-page":"1","article-title":"Muscle abnormalities in osteogenesis imperfecta","volume":"17","author":"Veilleux","year":"2017","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0025","doi-asserted-by":"crossref","first-page":"E356","DOI":"10.1210\/jc.2013-3209","article-title":"Muscle anatomy and dynamic muscle function in osteogenesis imperfecta type I","volume":"99","author":"Veilleux","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0030","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00223-017-0287-y","article-title":"Muscle function in osteogenesis imperfecta type IV","volume":"101","author":"Veilleux","year":"2017","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0035","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.matbio.2010.06.006","article-title":"Skeletal muscle weakness in osteogenesis imperfecta mice","volume":"29","author":"Gentry","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0040","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1073\/pnas.90.5.1701","article-title":"Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta","volume":"90","author":"Chipman","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0045","unstructured":"A. Pouliot-Laforte, L.N. Veilleux, F. Rauch, M. Lemay, Physical activity in youth with osteogenesis imperfecta type I. J. Musculoskelet. Neuronal Interact. 15 (2015) 171\u2013176. \/pmc\/articles\/PMC5133720\/?report=abstract (accessed October 9, 2020)."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0050","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s11914-018-0456-6","article-title":"Osteogenesis imperfecta: muscle\u2013bone interactions when bi-directionally compromised","volume":"16","author":"Phillips","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ghir.2006.10.004","article-title":"The \u2018functional muscle-bone unit\u2019: probing the relevance of mechanical signals for bone development in children and adolescents","volume":"17","author":"Fricke","year":"2007","journal-title":"Growth Hormon. IGF Res."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0060","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/ar.a.10119","article-title":"Bone's mechanostat: a 2003 update","volume":"275A","author":"Frost","year":"2003","journal-title":"Anat. Rec. Part A Discov. Mol. Cell. Evol. Biol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0065","article-title":"Skeletal response to soluble activin receptor type IIB in mouse models of osteogenesis imperfecta","volume":"0","author":"Jeong","year":"2018","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/jbmr.3732","article-title":"Compromised exercise capacity and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) mouse model","volume":"34","author":"Gremminger","year":"2019","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0075","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1542\/peds.49.3.375","article-title":"Physiological evidence of hypermetabolism in osteogenesis imperfecta","volume":"49","author":"Cropp","year":"1972","journal-title":"Pediatrics."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1530\/JOE-17-0335","article-title":"Metabolic phenotype in the mouse model of osteogenesis imperfecta","volume":"234","author":"Boraschi-Diaz","year":"2017","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0085","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1365-2044.1996.tb12619.x","article-title":"Osteogenesis imperfecta and malignant hyperthermia","volume":"51","author":"Porsborg","year":"1996","journal-title":"Anaesthesia."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0090","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.bone.2007.12.215","article-title":"Role of genetic background in determining phenotypic severity throughout postnatal development and at peak bone mass in Col1a2 deficient mice (oim)","volume":"42","author":"Carleton","year":"2008","journal-title":"Bone."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0095","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1249\/MSS.0000000000000223","article-title":"Impact of various exercise modalities on hepatic mitochondrial function","volume":"46","author":"Fletcher","year":"2014","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0100","first-page":"E1198","article-title":"High-sucrose diet increases ROS generation, FFA accumulation, UCP2 level, and proton leak in liver mitochondria","volume":"301","author":"Ruiz-Ram\u00edrez","year":"2011","journal-title":"Am. J. Physiol. Metab."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0105","doi-asserted-by":"crossref","first-page":"G979","DOI":"10.1152\/ajpgi.00169.2012","article-title":"PGC-1\u03b1 overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion","volume":"303","author":"Morris","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0110","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jacbts.2019.02.004","article-title":"Western diet-fed, aortic-banded Ossabaw swine: a preclinical model of cardio-metabolic heart failure","volume":"4","author":"Olver","year":"2019","journal-title":"JACC Basic to Transl. Sci."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0115","series-title":"Methods Enzymol","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(69)13005-0","article-title":"[1] Citrate synthase: [EC 4.1.3.7. Citrate oxaloacetate-lyase (CoA-acetylating)]","author":"Srere","year":"1969"},{"key":"10.1016\/j.ymgme.2021.02.004_bb0120","first-page":"G619","article-title":"Daily exercise increases hepatic fatty acid oxidation and prevents steatosis in Otsuka Long-Evans Tokushima Fatty rats","volume":"294","author":"Rector","year":"2008","journal-title":"Am. J. Physiol. Liver Physiol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1949.sp004363","article-title":"New methods for calculating metabolic rate with special reference to protein metabolism","volume":"109","author":"Weir","year":"1949","journal-title":"J. Physiol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0130","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.nu.07.070187.001155","article-title":"Assessment of energy expenditure and fuel utilization in man","author":"Jequier","year":"1987","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0135","doi-asserted-by":"crossref","DOI":"10.3791\/52174-v","article-title":"Localization, identification, and excision of murine adipose depots","author":"Mann","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0140","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.4081\/ejh.2014.2254","article-title":"A simplified immunohistochemical classification of skeletal muscle fibres in mouse","volume":"58","author":"Kammoun","year":"2014","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0145","first-page":"89","article-title":"Skeletal muscle fiber types in C57BL6J mice","volume":"21","author":"Augusto","year":"2004","journal-title":"Braz. J. Morphol. Sci."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0150","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3389\/fphys.2017.00689","article-title":"In vivo assessment of mitochondrial dysfunction in clinical populations using near-infrared spectroscopy","volume":"8","author":"Willingham","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0155","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1469-7793.2000.t01-1-00203.x","article-title":"Oxidative capacity and ageing in human muscle","volume":"526","author":"Conley","year":"2000","journal-title":"J. Physiol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev-physiol-020518-114310","article-title":"Maintenance of skeletal muscle mitochondria in health, exercise, and aging","volume":"81","author":"Hood","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpeds.2007.06.029","article-title":"Physical training in children with osteogenesis imperfecta","volume":"152","author":"Van Brussel","year":"2008","journal-title":"J. Pediatr."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0170","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.apmr.2003.08.085","article-title":"Osteogenesis imperfecta in childhood: Impairment and disability. a prospective study with 4-year follow-up11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the a","volume":"85","author":"Engelbert","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0175","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12018-013-9152-3","article-title":"Physiology of Mechanotransduction: how do muscle and bone \u201ctalk\u201d to one another?","volume":"12","author":"Isaacson","year":"2014","journal-title":"Clin. Rev. Bone Miner. Metab."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0180","doi-asserted-by":"crossref","first-page":"327","DOI":"10.4093\/dmj.2017.41.5.327","article-title":"Skeletal muscle thermogenesis and its role in whole body energy metabolism","volume":"41","author":"Periasamy","year":"2017","journal-title":"Diabetes Metab. J."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0185","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1172\/JCI114857","article-title":"Skeletal muscle metabolism is a major determinant of resting energy expenditure","volume":"86","author":"Zurlo","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0190","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00003677-200307000-00005","article-title":"Contractile and nutritional regulation of human muscle growth","volume":"31","author":"Rasmussen","year":"2003","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0195","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/jbmr.2177","article-title":"First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome","volume":"29","author":"Chen","year":"2014","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0200","series-title":"The Rate of Gluconeogenesis from Various Precursors in the Perfused Rat Liver","author":"Ross","year":"1967"},{"key":"10.1016\/j.ymgme.2021.02.004_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-09450-4","article-title":"Glycerol is synthesized and secreted by adipocytes to dispose of excess glucose, via glycerogenesis and increased acyl-glycerol turnover","volume":"7","author":"Rotondo","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0210","doi-asserted-by":"crossref","first-page":"3732","DOI":"10.2337\/dc13-0800","article-title":"Glycerol and fatty acids in serum predict the development of hyperglycemia and type 2 diabetes in Finnish men","volume":"36","author":"Mahendran","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ymgme.2021.02.004_bb0215","first-page":"1172","article-title":"Physiological diversity of mitochondrial oxidative phosphorylation","volume":"291","author":"Benard","year":"2006","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0220","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.mito.2010.09.011","article-title":"Tissue-specific differences in mitochondrial activity and biogenesis","volume":"11","author":"Fern\u00e1ndez-Vizarra","year":"2011","journal-title":"Mitochondrion."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0225","first-page":"689","article-title":"Tissue heterogeneity of the mammalian mitochondrial proteome","volume":"292","author":"Johnson","year":"2007","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0230","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1152\/physrev.00031.2010","article-title":"Fiber types in mammalian skeletal muscles","volume":"91","author":"Schiaffino","year":"2011","journal-title":"Physiol. Rev."},{"issue":"May","key":"10.1016\/j.ymgme.2021.02.004_bb0235","article-title":"Effects of physical activity and inactivity on muscle fatigue","volume":"3","author":"Bogdanis","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0240","series-title":"Effects of Exercise on Mitochondrial Content and Function in Aging Human Skeletal Muscle","author":"Menshikova","year":"2021"},{"key":"10.1016\/j.ymgme.2021.02.004_bb0245","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/mus.25706","article-title":"Soluble activin receptor type IIB decoy receptor differentially impacts murine osteogenesis imperfecta muscle function","volume":"57","author":"Jeong","year":"2017","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.ymgme.2021.02.004_bb0250","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0163-7827(95)00011-9","article-title":"\u03b2-Oxidation of fatty acids in mitochondria, peroxisomes, and bacteria: A century of continued progress","volume":"34","author":"Kunau","year":"1995","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ymgme.2021.02.004_bb0255","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jbmr.2920","article-title":"Fracture rates and fracture sites in patients with osteogenesis imperfecta: a nationwide register-based cohort study","volume":"32","author":"Folkestad","year":"2017","journal-title":"J. Bone Miner. Res."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719221000482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719221000482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T23:27:27Z","timestamp":1761089247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719221000482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S1096719221000482"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2021.02.004","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skeletal muscle specific mitochondrial dysfunction and altered energy metabolism in a murine model (oim\/oim) of severe osteogenesis imperfecta","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2021.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}