{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:26:11Z","timestamp":1786998371678,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.ymgme.2025.109069","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T11:30:37Z","timestamp":1740742237000},"page":"109069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of cardiac function in pediatric patients diagnosed with mucopolysaccharidosis (MPS) and use of annular plane systolic excursion (APSE) to evaluate systolic function"],"prefix":"10.1016","volume":"144","author":[{"given":"Kerem","family":"Erta\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"G\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe Erg\u00fcl","family":"Bozac\u0131","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Bilgin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ymgme.2025.109069_bb0005","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s10545-011-9359-8","article-title":"Cardiac disease in patients with mucopolysaccharidosis: presentation, diagnosis and management","volume":"34","author":"Braunlin","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.ymgme.2025.109069_bb0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.echo.2023.11.015","article-title":"Guidelines for performing a comprehensive pediatric transthoracic echocardiogram: recommendations from the American Society of Echocardiography","volume":"37","author":"Lopez","year":"2024","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"10","key":"10.1016\/j.ymgme.2025.109069_bb0015","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.echo.2008.07.016","volume":"21","author":"Mizuguchi","year":"2008","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"3","key":"10.1016\/j.ymgme.2025.109069_bb0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/ehjci\/jes240","article-title":"Clinical implication of mitral annular plane systolic excursion for patients with cardiovascular disease","volume":"14","author":"Hu","year":"2013","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"10.1016\/j.ymgme.2025.109069_bb0025","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1476-7120-11-16","article-title":"Mitral annular plane systolic excursion (MAPSE) in shock: a valuable echocardiographic parameter in intensive care patients","volume":"11","author":"Bergenzaun","year":"2013","journal-title":"Cardiovasc. Ultrasound"},{"issue":"9","key":"10.1016\/j.ymgme.2025.109069_bb0030","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.echo.2012.06.011","article-title":"Mitral annular plane systolic excursion as a surrogate for left ventricular ejection fraction","volume":"25","author":"Matos","year":"2012","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"12","key":"10.1016\/j.ymgme.2025.109069_bb0035","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.earlhumdev.2013.09.006","article-title":"Longitudinal assessment of atrioventricular annulus excursion by grey-scale m-mode and colour tissue Doppler imaging in premature infants","volume":"89","author":"Eriksen","year":"2013","journal-title":"Early Hum. Dev."},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0040","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ahj.2012.05.004","article-title":"Left ventricular long-axis function: reference values of the mitral annular plane systolic excursion in 558 healthy children and calculation of z-score values","volume":"164","author":"Koestenberger","year":"2012","journal-title":"Am. Heart J."},{"issue":"6","key":"10.1016\/j.ymgme.2025.109069_bb0045","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.echo.2009.03.026","article-title":"Right ventricular function in infants, children and adolescents: reference values of the tricuspid annular plane systolic excursion (TAPSE) in 640 healthy patients and calculation of z score values","volume":"22","author":"Koestenberger","year":"2009","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0050","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1054\/bjoc.2001.1859","article-title":"Body surface area estimation in children using weight alone: application in paediatric oncology","volume":"85","author":"Sharkey","year":"2001","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.ymgme.2025.109069_bb0055","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1093\/ejcts\/ezs455","article-title":"Guidelines on the management of valvular heart disease (version 2012): the joint task force on the management of Valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"42","author":"Vahanian","year":"2012","journal-title":"Euro. J. Cardio-Thoracic Surg."},{"issue":"3","key":"10.1016\/j.ymgme.2025.109069_bb0060","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1017\/S104795110999062X","article-title":"Echocardiographic study of paediatric patients with mucopolysaccharidosis","volume":"20","author":"Leal","year":"2010","journal-title":"Cardiol. Young"},{"issue":"2","key":"10.1016\/j.ymgme.2025.109069_bb0065","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10545-011-9444-z","article-title":"Mucopolysaccharidosis: cardiologic features and effects of enzyme-replacement therapy in 24 children with MPS I, II and VI","volume":"36","author":"Brands","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.ymgme.2025.109069_bb0070","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/jimd.12015","article-title":"Cardiac disease in mucopolysaccharidosis type III","volume":"42","author":"Nijmeijer","year":"2019","journal-title":"J. Inherit. Metab. Dis."},{"issue":"9","key":"10.1016\/j.ymgme.2025.109069_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138622","article-title":"A multiplex assay for the diagnosis of Mucopolysaccharidoses and Mucolipidoses","volume":"10","author":"Langereis","year":"2015","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.ymgme.2025.109069_bb0080","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1093\/eurheartj\/ehv510","article-title":"Beyond ejection fraction: an integrative approach for assessment of cardiac structure and function in heart failure","volume":"37","author":"Cikes","year":"2016","journal-title":"Eur. Heart J."},{"issue":"10","key":"10.1016\/j.ymgme.2025.109069_bb0085","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/j.jacc.2006.08.030","article-title":"Left ventricular structure and function: basic science for cardiac imaging","volume":"48","author":"Sengupta","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ymgme.2025.109069_bb0090","series-title":"StatPearls","article-title":"Left ventricular ejection fraction","author":"Kosaraju","year":"2023"},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0095","doi-asserted-by":"crossref","first-page":"H636","DOI":"10.1152\/ajpheart.01376.2006","article-title":"The quantitative relationship between longitudinal and radial function in left, right, and total heart pumping in humans","volume":"293","author":"Carlsson","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/heart.87.1.23","article-title":"Longitudinal myocardial contraction improves early during titration with metoprolol CR\/XL in patients with heart failure","volume":"87","author":"Andersson","year":"2002","journal-title":"Heart"},{"issue":"9","key":"10.1016\/j.ymgme.2025.109069_bb0105","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/eurjhf\/hfr081","article-title":"Mitral annular plane systolic excursion on exercise: a simple diagnostic tool for heart failure with preserved ejection fraction","volume":"13","author":"Wenzelburger","year":"2011","journal-title":"Eur. J. Heart Fail."},{"issue":"2","key":"10.1016\/j.ymgme.2025.109069_bb0110","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/echo.13444","article-title":"Myocardial deformation in pediatric patients with mucopolysaccharidoses: a two-dimensional speckle tracking echocardiography study","volume":"34","author":"Borgia","year":"2017","journal-title":"Echocardiography"},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13023-021-01743-2","article-title":"Natural progression of cardiac features and long-term effects of enzyme replacement therapy in Taiwanese patients with mucopolysaccharidosis II","volume":"16","author":"Lin","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0120","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13023-019-1112-7","article-title":"Cardiac characteristics and natural progression in Taiwanese patients with mucopolysaccharidosis III","volume":"14","author":"Lin","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"issue":"2","key":"10.1016\/j.ymgme.2025.109069_bb0125","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/diagnostics10020062","article-title":"Cardiac evaluation using two-dimensional speckle-tracking echocardiography and conventional echocardiography in Taiwanese patients with Mucopolysaccharidoses","volume":"10","author":"Lin","year":"2020","journal-title":"Diagnostics"},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0130","first-page":"73","article-title":"Evaluation of cardiac findings in mucopolysaccharidosis","volume":"40","author":"Dehghan","year":"2024","journal-title":"Int. J. Card. Imaging"},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.21037\/cdt.2017.06.01","article-title":"Three-dimensional speckle-tracking echocardiography: benefits and limitations of integrating myocardial mechanics with three-dimensional imaging","volume":"8","author":"Muraru","year":"2018","journal-title":"Cardiovasc. Diagn. Ther."},{"issue":"12","key":"10.1016\/j.ymgme.2025.109069_bb0140","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.echo.2019.08.015","article-title":"A practical guide to assess the reproducibility of echocardiographic measurements","volume":"32","author":"Bunting","year":"2019","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.ymgme.2025.109069_bb0145","article-title":"Sex differences in the agreement between left ventricular ejection fraction measured by myocardial perfusion scintigraphy and by echocardiography","volume":"9","author":"Jaker","year":"2020","journal-title":"JRSM Cardiovasc. Dis."},{"issue":"5","key":"10.1016\/j.ymgme.2025.109069_bb0150","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/echo.13825","article-title":"Relation between mitral annular plane systolic excursion and global longitudinal strain in normal subjects: the HUNT study","volume":"35","author":"St\u00f8ylen","year":"2018","journal-title":"Echocardiography"},{"issue":"3","key":"10.1016\/j.ymgme.2025.109069_bb0155","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ymgme.2011.03.016","article-title":"Laronidase replacement therapy improves myocardial function in mucopolysaccharidosis I","volume":"103","author":"Harada","year":"2011","journal-title":"Mol. Genet. Metab."},{"issue":"11","key":"10.1016\/j.ymgme.2025.109069_bb0160","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/echo.13325","article-title":"Mitral annular plane systolic excursion\/left ventricular length (MAPSE\/L) as a simple index for assessing left ventricular longitudinal function in children","volume":"33","author":"Terada","year":"2016","journal-title":"Echocardiography"},{"issue":"3","key":"10.1016\/j.ymgme.2025.109069_bb0165","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.carpath.2014.01.001","article-title":"Unexpected coronary artery findings in mucopolysaccharidosis. Report of four cases and literature review","volume":"23","author":"Braunlin","year":"2014","journal-title":"Cardiovasc. Pathol."},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymgme.2018.03.004","article-title":"Growth impairment in mucopolysaccharidoses","volume":"124","author":"Melbouci","year":"2018","journal-title":"Mol. Genet. Metab."},{"issue":"9","key":"10.1016\/j.ymgme.2025.109069_bb0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162612","article-title":"Heart and cardiovascular involvement in patients with Mucopolysaccharidosis type IVA (Morquio-a syndrome)","volume":"11","author":"Kampmann","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.ymgme.2025.109069_bb0180","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/0735-1097(94)00473-4","article-title":"Prognosis of left ventricular geometric patterns in the Framingham heart study","volume":"25","author":"Krumholz","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0185","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s12265-019-09907-z","article-title":"Gender differences in cardiac hypertrophy","volume":"13","author":"Wu","year":"2020","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"4","key":"10.1016\/j.ymgme.2025.109069_bb0190","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF03086131","article-title":"Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes","volume":"16","author":"Mihl","year":"2008","journal-title":"Neth. Hear. J."},{"issue":"10","key":"10.1016\/j.ymgme.2025.109069_bb0195","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/gim.2014.25","article-title":"The natural history of MPS I: global perspectives from the MPS I registry","volume":"16","author":"Beck","year":"2014","journal-title":"Genet. Med."},{"issue":"1","key":"10.1016\/j.ymgme.2025.109069_bb0200","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ymgme.2007.01.011","article-title":"The MPS I registry: design, methodology, and early findings of a global disease registry for monitoring patients with Mucopolysaccharidosis type I","volume":"91","author":"Pastores","year":"2007","journal-title":"Mol. Genet. Metab."},{"issue":"7","key":"10.1016\/j.ymgme.2025.109069_bb0205","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/GIM.0b013e31817701e6","article-title":"Initial report from the hunter outcome survey","volume":"10","author":"Wraith","year":"2008","journal-title":"Genet. Med."},{"key":"10.1016\/j.ymgme.2025.109069_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.907175","article-title":"Unmet cardiac clinical needs in adult mucopolysaccharidoses","volume":"9","author":"Stepien","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.ymgme.2025.109069_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2408402","article-title":"Mucopolysaccharidoses I and II: brief review of therapeutic options and supportive\/palliative therapies","volume":"2020","author":"Nan","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"8","key":"10.1016\/j.ymgme.2025.109069_bb0220","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1002\/ajmg.a.62229","article-title":"Evaluation of sleep-disordered breathing and its relationship with respiratory parameters in children with mucopolysaccharidosis type IVA and VI","volume":"185","author":"Ademhan Tural","year":"2021","journal-title":"Am. J. Med. Genet. A"},{"issue":"2","key":"10.1016\/j.ymgme.2025.109069_bb0225","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1590\/S1413-78522013000200009","article-title":"Energy expenditure during gait in patients with mucopolysaccharidosis","volume":"21","author":"Matos","year":"2013","journal-title":"Acta Ortoped. Bras."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719225000605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719225000605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T01:52:12Z","timestamp":1766195532000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719225000605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1096719225000605"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2025.109069","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of cardiac function in pediatric patients diagnosed with mucopolysaccharidosis (MPS) and use of annular plane systolic excursion (APSE) to evaluate systolic function","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2025.109069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109069"}}