{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T20:21:37Z","timestamp":1794255697846,"version":"4.9.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.ymgme.2026.110276","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:23:54Z","timestamp":1790688234000},"page":"110276","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Porphyria cutanea tarda: cutaneous manifestations and management"],"prefix":"10.1016","volume":"149","author":[{"given":"Lina","family":"Rebeiz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenore K.","family":"Yalom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca K.","family":"Leaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgme.2026.110276_bb0005","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.mayocp.2020.12.025","article-title":"Porphyria cutanea tarda","volume":"96","author":"Jin","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ymgme.2026.110276_bb0010","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ymgme.2019.01.004","article-title":"Porphyria cutanea tarda: recent update","volume":"128","author":"Singal","year":"2019","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgme.2026.110276_bb0015","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1056\/NEJMra1608634","article-title":"Porphyria","volume":"377","author":"Bissell","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ymgme.2026.110276_bb0020","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1182\/hematology.2024000664","article-title":"Porphyria cutanea tarda: a unique iron-related disorder","volume":"2024","author":"Leaf","year":"2024","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"10.1016\/j.ymgme.2026.110276_bb0025","doi-asserted-by":"crossref","first-page":"5079","DOI":"10.1073\/pnas.0700547104","article-title":"A porphomethene inhibitor of uroporphyrinogen decarboxylase causes porphyria cutanea tarda","volume":"104","author":"Phillips","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgme.2026.110276_bb0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1055\/s-2007-1007142","article-title":"Porphyria cutanea tarda","volume":"18","author":"Elder","year":"1998","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.ymgme.2026.110276_bb0035","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/archderm.1980.01640250048014","article-title":"Porphyria turcica twenty years after hexachlorobenzene intoxication","volume":"116","author":"Cripps","year":"1980","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0040","first-page":"567","article-title":"Porphyria turcica: hexachlorobenzene-induced porphyria","volume":"77","author":"Gocmen","year":"1986","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.ymgme.2026.110276_bb0045","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1001\/archderm.135.4.459","article-title":"Hexachlorobenzene and porphyria cutanea tarda","volume":"135","author":"Kim","year":"1999","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0050","first-page":"36","article-title":"Hexachlorobenzene episode in Turkey","volume":"2","author":"Gocmen","year":"1989","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.ymgme.2026.110276_bb0055","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/ijd.12305","article-title":"Cutaneous porphyrias, part I: epidemiology, pathogenesis, presentation, diagnosis, and treatment","volume":"52","author":"Horner","year":"2013","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0060","first-page":"316","article-title":"The porphyrias","volume":"20","author":"Muschalek","year":"2022","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"key":"10.1016\/j.ymgme.2026.110276_bb0065","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1111\/ijd.13580","article-title":"Porphyria cutanea tarda: an intriguing genetic disease and marker","volume":"56","author":"Handler","year":"2017","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0070","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1111\/liv.15980","article-title":"The clinical management of porphyria cutanea tarda: an update","volume":"44","author":"Sarkany","year":"2024","journal-title":"Liver Int."},{"key":"10.1016\/j.ymgme.2026.110276_bb0075","series-title":"GeneReviews\u00ae","article-title":"Congenital erythropoietic porphyria","author":"Erwin","year":"2021"},{"key":"10.1016\/j.ymgme.2026.110276_bb0080","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4065\/76.5.488","article-title":"Pseudoporphyria: a clinical and biochemical study of 20 patients","volume":"76","author":"Schanbacher","year":"2001","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ymgme.2026.110276_bb0085","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.abd.2021.09.010","article-title":"Epidermolysis bullosa acquisita","volume":"97","author":"Miyamoto","year":"2022","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0090","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1056\/NEJM198204013061302","article-title":"Decreased hepatic uroporphyrinogen decarboxylase activity in porphyria cutanea tarda","volume":"306","author":"Felsher","year":"1982","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ymgme.2026.110276_bb0095","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1093\/emboj\/cdg606","article-title":"Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase","volume":"22","author":"Phillips","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.ymgme.2026.110276_bb0100","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1182\/blood-2008-02-138222","article-title":"Down-regulation of hepcidin in porphyria cutanea tarda","volume":"112","author":"Ajioka","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.ymgme.2026.110276_bb0105","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1182\/blood.V95.5.1565.005k42_1565_1571","article-title":"Hemochromatosis genes and other factors contributing to the pathogenesis of porphyria cutanea tarda","volume":"95","author":"Bulaj","year":"2000","journal-title":"Blood"},{"issue":"Suppl. 1","key":"10.1016\/j.ymgme.2026.110276_bb0110","first-page":"37","article-title":"Environmental chemical exposures and disturbances of heme synthesis","volume":"105","author":"Daniell","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.ymgme.2026.110276_bb0115","first-page":"2248","article-title":"Reactivation of porphyria cutanea tarda as a possible side effect of imatinib at high dosage in chronic myeloid leukemia","volume":"17","author":"Breccia","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.ymgme.2026.110276_bb0120","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1093\/clinids\/20.2.348","article-title":"Human immunodeficiency virus infection and porphyria cutanea tarda: coexistence of risk factors or causative association?","volume":"20","author":"McAlister","year":"1995","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.ymgme.2026.110276_bb0125","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1007\/s10620-023-07859-8","article-title":"Ledipasvir\/sofosbuvir is effective as sole treatment of porphyria cutanea tarda with chronic hepatitis C","volume":"68","author":"Bonkovsky","year":"2023","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.ymgme.2026.110276_bb0130","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1046\/j.1440-0960.2000.00437.x","article-title":"Porphyria cutanea tarda","volume":"41","author":"Bleasel","year":"2000","journal-title":"Australas. J. Dermatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0135","first-page":"27","article-title":"Liver iron overload and desferrioxamine treatment of porphyria cutanea tarda","volume":"182","author":"Rocchi","year":"1991","journal-title":"Dermatologica"},{"key":"10.1016\/j.ymgme.2026.110276_bb0140","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.cgh.2012.08.038","article-title":"Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda","volume":"10","author":"Singal","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0145","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.0954-6820.1971.tb04337.x","article-title":"The effect of phlebotomy therapy in porphyria cutanea tarda: its relation to the phlebotomy-induced reduction of iron stores","volume":"189","author":"Lundvall","year":"1971","journal-title":"Acta Med. Scand."},{"key":"10.1016\/j.ymgme.2026.110276_bb0150","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1365-2230.2007.02579.x","article-title":"Sclerodermatous changes of face, neck and scalp associated with familial porphyria cutanea tarda","volume":"33","author":"Thomas","year":"2008","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.ymgme.2026.110276_bb0155","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2022-253203","article-title":"Porphyria cutanea tarda: an under-recognised manifestation of haemochromatosis","volume":"16","author":"Goh","year":"2023","journal-title":"BMJ Case Rep."},{"key":"10.1016\/j.ymgme.2026.110276_bb0160","doi-asserted-by":"crossref","DOI":"10.1111\/jocd.70056","article-title":"Treatment of porphyria cutanea tarda scarring with combination laser treatment and a pilot use of artificial intelligence to quantify laser results","volume":"24","author":"Kesty","year":"2025","journal-title":"J. Cosmet. Dermatol."}],"container-title":["Molecular Genetics and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719226005597?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1096719226005597?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T19:30:23Z","timestamp":1794252623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1096719226005597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S1096719226005597"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgme.2026.110276","relation":{},"ISSN":["1096-7192"],"issn-type":[{"value":"1096-7192","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porphyria cutanea tarda: cutaneous manifestations and management","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgme.2026.110276","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110276"}}