{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:58:06Z","timestamp":1793465886410,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T00:00:00Z","timestamp":1423440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fonds de recherche du Qu\u00e9bec Sant\u00e9, Canada"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO 247"],"award-info":[{"award-number":["KFO 247"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism Reports"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.ymgmr.2015.02.001","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T15:30:24Z","timestamp":1424446224000},"page":"1-4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and \u03b3-aminobutyric acid in brain tissue"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3557-7307","authenticated-orcid":false,"given":"N.M.","family":"Jadavji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Wieske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Dirnagl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgmr.2015.02.001_bb0005","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1471-4159.1981.tb00426.x","article-title":"Decreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-l-homocysteine","volume":"36","author":"Schatz","year":"1981","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0010","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1096\/fasebj.10.4.8647346","article-title":"S-Adenosylmethionine and methylation","volume":"10","author":"Chiang","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0015","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/jnnp.69.2.228","article-title":"Homocysteine, folate, methylation and monoamine metabolism in depression","volume":"69","author":"Bottiglieri","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0020","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","article-title":"Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations","volume":"93","author":"Jacques","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0030","first-page":"171","article-title":"Molecular genetic aspects of hyperhomocysteinemia and its relation to folic acid","volume":"19","author":"Rozen","year":"1996","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0035","series-title":"Encycl. Med. Genomics Proteomics","first-page":"1","article-title":"Methylenetetrahydrofolate reductase gene polymorphism\u2014clinical implications","author":"Rozen","year":"2005"},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/mp.2011.18","article-title":"Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study","volume":"17","author":"Ford","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/ars.2011.4368","article-title":"Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls","volume":"17","author":"Copped\u00e8","year":"2012","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aje\/kwj347","article-title":"Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review","volume":"165","author":"Gilbody","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0055","first-page":"536","article-title":"MR and proton MR spectroscopy of the brain in hyperhomocysteinemia caused by methylenetetrahydrofolate reductase deficiency","volume":"18","author":"Engelbrecht","year":"1997","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0060","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/088307380001500808","article-title":"Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis","volume":"15","author":"Fattal-Valevski","year":"2000","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0065","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/0883073808315410","article-title":"Severe methylenetetrahydrofolate reductase (MTHFR) deficiency: a case report of nonclassical homocystinuria","volume":"23","author":"Bishop","year":"2008","journal-title":"J. Child Neurol."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0070","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/hmg\/10.5.433","article-title":"Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition","volume":"10","author":"Chen","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0075","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ymgme.2012.03.020","article-title":"Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus","volume":"106","author":"Jadavji","year":"2012","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0080","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1093\/jn\/134.11.2975","article-title":"Nutrient\u2013gene interactions mice deficient in methylenetetrahydrofolate reductase exhibit tissue-specific distribution of folates 1","volume":"134","author":"Ghandour","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF02982630","article-title":"Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine","volume":"12","author":"Chan","year":"2008","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0090","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1017\/S1461145708009206","article-title":"Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia","volume":"12","author":"Winter","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0095","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbr.2010.08.031","article-title":"Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice","volume":"216","author":"Levav-rabkin","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2826.1990.tb00385.x","article-title":"Sex differences in neurotransmitter systems","volume":"2","author":"Vries","year":"1990","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0105","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10545-010-9127-1","article-title":"Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes","volume":"34","author":"Lawrance","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0110","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijdevneu.2005.05.007","article-title":"Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase","volume":"23","author":"Chen","year":"2005","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fnagi.2014.00214","article-title":"Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice","volume":"6","author":"Sontag","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0120","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1042\/BJ20030822","article-title":"Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency","volume":"382","author":"Schwahn","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0125","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/j.1471-4159.1984.tb06105.x","article-title":"Regional distribution of homocysteine in the mammalian brain","volume":"43","author":"Broch","year":"1984","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0130","first-page":"117","article-title":"Involvement of N-methyl-d-aspartate receptor and free radical in homocysteine-mediated toxicity on rat cerebellar granule cells in culture","volume":"216","author":"Kim","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0135","first-page":"406","article-title":"Adult Neurogenesis Produces a Large Pool of New Granule Cells in the Dentate Gyrus","volume":"417","author":"Cameron","year":"2001"},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0140","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1096\/fj.02-0456fje","article-title":"Homocysteine\u2013betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency","volume":"17","author":"Schwahn","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0145","series-title":"Folate Heal. Dis.","first-page":"449","article-title":"Folate and choline interrelationships: metabolic and potential health implications","author":"Caudill","year":"2009"},{"key":"10.1016\/j.ymgmr.2015.02.001_bb0150","first-page":"355","article-title":"Folate and neurological disease: basic mechanisms","author":"Bottiglieri","year":"2009"}],"container-title":["Molecular Genetics and Metabolism Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214426915000087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214426915000087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:48:04Z","timestamp":1762001284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214426915000087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":30,"alternative-id":["S2214426915000087"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgmr.2015.02.001","relation":{},"ISSN":["2214-4269"],"issn-type":[{"value":"2214-4269","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and \u03b3-aminobutyric acid in brain tissue","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgmr.2015.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}