{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:51:06Z","timestamp":1779105066798,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"The Carol Ann Foundation"},{"name":"Angelo R. Cali & Mary V. Cali Family Foundation, Inc"},{"name":"The Vain and Harry Fish Foundation, Inc"},{"name":"The Bennett Foundation"},{"name":"Jacob Randall Foundation"},{"name":"Austrian and Japanese MPS societies"},{"name":"Nemours Funds"},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP18gk0110017"],"award-info":[{"award-number":["JP18gk0110017"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30GM114736"],"award-info":[{"award-number":["P30GM114736"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism Reports"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.ymgmr.2019.100455","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T20:12:18Z","timestamp":1549397538000},"page":"100455","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Biomarkers in patients with mucopolysaccharidosis type II and IV"],"prefix":"10.1016","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9115-4982","authenticated-orcid":false,"given":"Honoka","family":"Fujitsuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuki","family":"Sawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hira","family":"Peracha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Mackenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Orii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Orii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Fukao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Tomatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymgmr.2019.100455_bb0005","series-title":"Chapter 10, Mucopolysaccharidosis Type II: Clinical Features, Biochemistry, Diagnosis, Genetics and Treatment, Mucopolysaccharidoses Update vol.1","first-page":"165","volume":"1","author":"Tomatsu","year":"2018"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0010","series-title":"Chapter 12, Mucopolysaccharidosis Type IVA: Clinical Features, Biochemistry, Diagnosis, Genetics and Treatment, Mucopolysaccharidoses Update vol.1","first-page":"235","volume":"1","author":"Sawamoto","year":"2018"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0015","series-title":"Chapter 13, Mucopolysaccharidosis Type IVB: Clinical Features, Biochemistry, Diagnosis, Genetics and Treatment, Mucopolysaccharidoses Update vol.1","first-page":"273","volume":"1","author":"Higaki","year":"2018"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0020","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1203\/01.PDR.0000156510.96253.5A","article-title":"Joint and bone disease in mucopolysaccharidoses VI and VII: identification of new therapeutic targets and biomarkers using animal models","volume":"57","author":"Simonaro","year":"2005","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0025","series-title":"Chapter 6, Inflammation and Its Role in the Lysosomal Storage Disorders, Mucopolysaccharidoses Update vol.1","first-page":"75","volume":"vol. 1","author":"Simonaro","year":"2018"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0030","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1073\/pnas.0912937107","article-title":"Involvement of the Toll-like receptor 4 pathway and use of TNF- antagonists for treatment of the mucopolysaccharidoses","volume":"107","author":"Simonaro","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054459","article-title":"Pentosan polysulfate: a novel therapy for the mucopolysaccharidoses","volume":"8","author":"Schuchman","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0045","doi-asserted-by":"crossref","first-page":"112","DOI":"10.2353\/ajpath.2008.070564","article-title":"Mechanism of glycosaminoglycan-mediated bone and joint disease implications for the mucopolysaccharidoses and other connective tissue diseases","volume":"172","author":"Simonaro","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.ymgmr.2019.100455_bb0050","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s10545-016-9974-5","article-title":"Treatment with pentosan polysulphate in patients with MPS I: results from an open label, randomized, monocentric phase II study","volume":"39","author":"Hennermann","year":"2016","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0055","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1016\/j.ymgme.2015.12.384","article-title":"Safety study of sodium pentosan polysulfate for adult patients with mucopolysaccharidosis type II","volume":"117","author":"Orii","year":"2016","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0060","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ymgme.2016.01.012","article-title":"Elevated TNF-\u03b1 is associated with pain and physical disability in mucopolysaccharidosis types I, II, and VI","volume":"117","author":"Polgreen","year":"2016","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0065","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/j.bbadis.2016.05.021","article-title":"Oxidative and nitrative stress and pro-inflammatory cytokines in Mucopolysaccharidosis type II patients: effect of long-term enzyme replacement therapy and relation with glycosaminoglycan accumulation","volume":"1862","author":"Jacques","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0070","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.bbadis.2015.02.004","article-title":"Oxidative stress and inflammation in mucopolysaccharidosis type IVA patients treated with enzyme replacement therapy","volume":"1852","author":"Donida","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0075","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ymgme.2013.06.007","article-title":"Newborn screening and diagnosis of mucopolysaccharidoses","volume":"110","author":"Tomatsu","year":"2013","journal-title":"Mol. Genet. Metab."},{"issue":"1","key":"10.1016\/j.ymgmr.2019.100455_bb0080","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ab.2007.05.016","article-title":"Analytical method for the determination of disaccharides derived from keratan, heparan, and dermatan sulfates in human serum and plasma by high-performance liquid chromatography\/turbo ionspray ionization tandem mass spectrometry","volume":"368","author":"Oguma","year":"2007","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0085","first-page":"15","article-title":"Chondroitin6-Sulfate as a Novel Biomarker for Mucopolysaccharidosis IVA and VII","volume":"16","author":"Shimada","year":"2014","journal-title":"JIMD Rep."},{"issue":"1\u20132","key":"10.1016\/j.ymgmr.2019.100455_bb0090","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ymgme.2018.04.011","article-title":"Glycosaminoglycans analysis in blood and urine of patients with mucopolysaccharidosis","volume":"125","author":"Khan","year":"2018","journal-title":"Mol. Genet. Metab."},{"issue":"10","key":"10.1016\/j.ymgmr.2019.100455_bb0095","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.bbmt.2017.06.020","article-title":"Hematopoietic stem cell transplantation for patients with mucopolysaccharidosis II","volume":"23","author":"Kubaski","year":"2017","journal-title":"Biol Blood Marrow Transplant."},{"issue":"5013","key":"10.1016\/j.ymgmr.2019.100455_bb0100","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1126\/science.1646484","article-title":"Requirement of heparan sulfate for bFGF-mediated fibroblast growth and myoblast differentiation","volume":"252","author":"Rapraeger","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0105","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10545-005-0069-y","article-title":"Heparan sulfate levels in mucopolysaccharidoses and mucolipidoses","volume":"28","author":"Tomatsu","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0110","first-page":"655","article-title":"Establishment of glycosaminoglycan assays for mucopolysaccharidoses","volume":"4","author":"Tomatsu","year":"2014","journal-title":"Meta"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0115","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.ymgme.2012.09.024","article-title":"Heparan sulfate and dermatan sulfate derived disaccharides are sensitive markers for newborn screening for mucopolysaccharidoses types I, II and III","volume":"107","author":"de Ruijter","year":"2012","journal-title":"Mol. Genet. Metab."},{"issue":"1","key":"10.1016\/j.ymgmr.2019.100455_bb0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10545-016-9981-6","article-title":"Newborn screening for mucopolysaccharidoses: a pilot study of measurement of glycosaminoglycans by tandem mass spectrometry","volume":"40","author":"Kubaski","year":"2017","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0125","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ymgme.2014.12.001","article-title":"Therapies for the bone in mucopolysaccharidoses","volume":"114","author":"Tomatsu","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0130","series-title":"Chapter 126: impairment of body growth in mucopolysaccharidoses, handbook of growth monitoring and health and disease","author":"Tomatsu","year":"2011"},{"issue":"10","key":"10.1016\/j.ymgmr.2019.100455_bb0135","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/ajmg.a.32281","article-title":"Growth charts for patients affected with Morquio a disease","volume":"146A","author":"Monta\u00f1o","year":"2008","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0140","first-page":"31","article-title":"Long-term therapeutic efficacy of allogenic bone marrow transplantation in a patient with mucopolysaccharidosis IVA","volume":"1","author":"Chinen","year":"2014","journal-title":"Mol Genet Metab Rep."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ymgme.2015.09.011","article-title":"Hematopoietic stem cell transplantation for Morquio A syndrome","volume":"117","author":"Yabe","year":"2016","journal-title":"Mol. Genet. Metab."},{"issue":"1\u20132","key":"10.1016\/j.ymgmr.2019.100455_bb0150","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ymgme.2013.04.002","article-title":"Review of clinical presentation and diagnosis of mucopolysaccharidosis IVA","volume":"110","author":"Hendriksz","year":"2013","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0155","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ymgme.2015.09.007","article-title":"Obstructive airway in Morquio A syndrome, the past, the present and the future","volume":"117","author":"Tomatsu","year":"2016","journal-title":"Mol. Genet. Metab."},{"issue":"4","key":"10.1016\/j.ymgmr.2019.100455_bb0160","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.athoracsur.2016.02.113","article-title":"Surgical reconstruction for severe tracheal obstruction in morquio A syndrome","volume":"102","author":"Pizarro","year":"2016","journal-title":"Ann. Thorac. Surg."},{"issue":"5","key":"10.1016\/j.ymgmr.2019.100455_bb0165","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1111\/j.1651-2227.2009.01135.x","article-title":"Sacral dimple: incidental findings from newborn evaluation","volume":"98","author":"Ohashi","year":"2009","journal-title":"Acta Paediatr."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0170","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ymgme.2015.11.013","article-title":"Bone mineral density in MPS IV A (Morquio syndrome type A)","volume":"117","author":"Kecskemethy","year":"2016","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0175","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ymgme.2016.04.005","article-title":"Activity of daily living for Morquio A syndrome","volume":"118","author":"Yasuda","year":"2016","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10545-007-0529-7","article-title":"International Morquio A registry: clinical manifestation and natural course of Morquio A disease","volume":"30","author":"Monta\u00f1o","year":"2007","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0185","first-page":"59","article-title":"Natural history of Morquio A patient with tracheal obstruction from birth to death","volume":"14","author":"Doherty","year":"2018","journal-title":"Mol Genet Metab Rep."},{"issue":"3","key":"10.1016\/j.ymgmr.2019.100455_bb0190","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ymgme.2013.04.009","article-title":"Pathogenesis of Morquio A syndrome: an autopsied case reveals systemic storage disorder","volume":"109","author":"Yasuda","year":"2013","journal-title":"Mol. Genet. Metab."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0195","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10545-012-9522-x","article-title":"Assessment of bone dysplasia by micro-CT and glycosaminoglycan levels in mouse models for mucopolysaccharidosis type I, IIIA, IVA, and VII","volume":"36","author":"Rowan","year":"2013","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0200","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1182\/blood-2014-06-581207","article-title":"Neonatal bone marrow transplantation prevents bone pathology in a mouse model of mucopolysaccharidosis type I","volume":"125","author":"Pievani","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0205","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10545-009-9013-x","article-title":"Validation of keratan sulfate level in mucopolysaccharidosis type IVA by liquid chromatography-tandem mass spectrometry","volume":"33","author":"Tomatsu","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"issue":"4","key":"10.1016\/j.ymgmr.2019.100455_bb0210","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1203\/01.PDR.0000113767.60140.E9","article-title":"Development and testing of new screening method for keratan sulfate in mucopolysaccharidosis IVA","volume":"55","author":"Tomatsu","year":"2004","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0215","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4137\/BMI.S7451","article-title":"Comparison of liquid chromatography-tandem mass spectrometry and sandwich ELISA for determination of keratan sulfate in plasma and urine","volume":"6","author":"Hintze","year":"2011","journal-title":"Biomark. Insights"},{"key":"10.1016\/j.ymgmr.2019.100455_bb0220","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10545-009-9013-x","article-title":"Validation of keratan sulfate level in mucopolysaccharidosis type IVA by liquid chromatography-tandem mass spectrometry","volume":"33","author":"Tomatsu","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0225","first-page":"1","article-title":"Di-sulfated keratan sulfate as a novel biomarker for mucopolysaccharidosis II, IVA, and IVB","volume":"21","author":"Shimada","year":"2015","journal-title":"JIMD Rep."},{"issue":"1\u20132","key":"10.1016\/j.ymgmr.2019.100455_bb0230","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ymgme.2018.04.011","article-title":"Glycosaminoglycans analysis in blood and urine of mucopolysaccharidoses by tandem mass spectrometry","volume":"125","author":"Khan","year":"2018","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0235","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10545-005-5673-3","article-title":"Keratan sulfate levels in mucopolysaccharidoses and mucolipidoses","volume":"28","author":"Tomatsu","year":"2005","journal-title":"J. Inherit. Metab. Dis."},{"issue":"3","key":"10.1016\/j.ymgmr.2019.100455_bb0240","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ymgme.2016.12.010","article-title":"Glycosaminoglycan levels in dried blood spots of patients with mucopolysaccharidoses and mucolipidoses","volume":"120","author":"Kubaski","year":"2017","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0245","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1517\/21678707.2015.1086640","article-title":"Enzyme replacement therapy for treating mucopolysaccharidosis type IVA (Morquio A syndrome): effect and limitations","volume":"3","author":"Tomatsu","year":"2015","journal-title":"Expert Opin. Orphan Drugs."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0250","first-page":"1","article-title":"Di-sulfated keratan sulfate as a novel biomarker for mucopolysaccharidosis II, IVA, and IVB","volume":"21","author":"Shimada","year":"2015","journal-title":"JIMD Rep."},{"issue":"2","key":"10.1016\/j.ymgmr.2019.100455_bb0255","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0012-1606(87)90306-X","article-title":"Epidermal growth factor potentiates the induction of ornithine decarboxylase activity by prostaglandins in embryonic palate mesenchymal cells: Effects on cell proliferation and glycosaminoglycan synthesis","volume":"122","author":"Pisano","year":"1987","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.ymgmr.2019.100455_bb0260","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1423-0127-16-26","article-title":"Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factordependent pathway","volume":"16","author":"Jak\u00f3bkiewicz-Banecka","year":"2009","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0265","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1359-6101(97)00023-3","article-title":"Interleukin-1","volume":"8","author":"Dinarello","year":"1997","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0270","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10545-010-9051-4","article-title":"Serum MIP-1 \u03b1 level: a biomarker for the follow-up of lentiviral therapy in mucopolysaccharidosis IIIB mice","volume":"33","author":"Natale","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0275","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1750-1172-6-84","article-title":"Biomarker analysis of Morquio syndrome: identification of disease state and drug responsive markers","volume":"6","author":"Martell","year":"2011","journal-title":"Orphanet J Rare Dis."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0280","first-page":"R1203","article-title":"Gelatinase B modulates selective opening of the blood-brain barrier during inflammation","volume":"274","author":"Mun-Bryce","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0285","first-page":"59","article-title":"Differential expression of matrix metalloproteinases in the serum of patients with mucopolysaccharidoses","volume":"3","author":"Batzios","year":"2012","journal-title":"JIMD Rep."},{"issue":"6","key":"10.1016\/j.ymgmr.2019.100455_bb0290","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/1941738109350438","article-title":"The basic science of articular cartilage: structure, composition, and function","volume":"1","author":"Fox","year":"2009","journal-title":"Sports Health."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0295","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/labinvest.3780345","article-title":"Articular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses","volume":"81","author":"Simonaro","year":"2001","journal-title":"Lab. Investig."},{"key":"10.1016\/j.ymgmr.2019.100455_bb0300","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.joca.2007.04.008","article-title":"A molecular and histological characterization of cartilage from patients with Morquio syndrome","volume":"15","author":"Franceschi","year":"2007","journal-title":"Osteoarthr. Cartil."}],"container-title":["Molecular Genetics and Metabolism Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214426918301265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214426918301265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:51:00Z","timestamp":1762001460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214426918301265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":60,"alternative-id":["S2214426918301265"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgmr.2019.100455","relation":{},"ISSN":["2214-4269"],"issn-type":[{"value":"2214-4269","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biomarkers in patients with mucopolysaccharidosis type II and IV","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgmr.2019.100455","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100455"}}