{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T08:06:45Z","timestamp":1789200405845,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009053","name":"Wellcome Trust DBT India Alliance","doi-asserted-by":"publisher","award":["IA\/CRC\/20\/1\/600002"],"award-info":[{"award-number":["IA\/CRC\/20\/1\/600002"]}],"id":[{"id":"10.13039\/501100009053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Genetics and Metabolism Reports"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ymgmr.2026.101341","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:05:22Z","timestamp":1784689522000},"page":"101341","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Proteomic alterations in patient bone-derived stromal cells and their secretomes in osteogenesis imperfecta"],"prefix":"10.1016","volume":"48","author":[{"given":"Kishore","family":"Garapati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Gi","family":"Mun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rex","family":"Devasahayam Arokia Balaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Saraswat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Renuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Trahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Kandasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Deyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ymgmr.2026.101341_bb0005","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/ajmg.a.36545","article-title":"Osteogenesis imperfecta: clinical diagnosis, nomenclature and severity assessment","volume":"164A","author":"Van Dijk","year":"2014","journal-title":"Am. J. Med. Genet. A"},{"issue":"6","key":"10.1016\/j.ymgmr.2026.101341_bb0010","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00223-024-01266-5","article-title":"Update on the genetics of osteogenesis imperfecta","volume":"115","author":"Jovanovic","year":"2024","journal-title":"Calcif. Tissue Int."},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1210\/endrev\/bnab017","article-title":"Osteogenesis imperfecta: mechanisms and signaling pathways connecting classical and rare OI types","volume":"43","author":"Jovanovic","year":"2022","journal-title":"Endocr. Rev."},{"issue":"7","key":"10.1016\/j.ymgmr.2026.101341_bb0020","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1096\/fasebj.5.7.2010058","article-title":"Mutations in collagen genes: causes of rare and some common diseases in humans","volume":"5","author":"Kuivaniemi","year":"1991","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.ymgmr.2026.101341_bb0025","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nm.3544","article-title":"Excessive transforming growth factor-beta signaling is a common mechanism in osteogenesis imperfecta","volume":"20","author":"Grafe","year":"2014","journal-title":"Nat. Med."},{"issue":"5661","key":"10.1016\/j.ymgmr.2026.101341_bb0030","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1126\/science.1088757","article-title":"Gene targeting in stem cells from individuals with osteogenesis imperfecta","volume":"303","author":"Chamberlain","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0035","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/mt.2011.209","article-title":"Normal collagen and bone production by gene-targeted human osteogenesis imperfecta iPSCs","volume":"20","author":"Deyle","year":"2012","journal-title":"Mol. Ther."},{"issue":"3","key":"10.1016\/j.ymgmr.2026.101341_bb0040","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/S0021-9258(18)89655-7","article-title":"Altered triple helical structure of type I procollagen in lethal perinatal osteogenesis imperfecta","volume":"260","author":"Bonadio","year":"1985","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.ymgmr.2026.101341_bb0045","doi-asserted-by":"crossref","DOI":"10.1172\/JCI152571","article-title":"Targeting TGF-beta for treatment of osteogenesis imperfecta","volume":"132","author":"Song","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0050","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1096\/fj.00-0078com","article-title":"NOSIP, a novel modulator of endothelial nitric oxide synthase activity","volume":"15","author":"Dedio","year":"2001","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.ymgmr.2026.101341_bb0055","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1006\/bbrc.2000.3164","article-title":"The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent","volume":"274","author":"Mancini","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"43","key":"10.1016\/j.ymgmr.2026.101341_bb0060","doi-asserted-by":"crossref","first-page":"E10099","DOI":"10.1073\/pnas.1814552115","article-title":"Noncanonical autophagy at ER exit sites regulates procollagen turnover","volume":"115","author":"Omari","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"17","key":"10.1016\/j.ymgmr.2026.101341_bb0065","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.246322","article-title":"Microautophagy - distinct molecular mechanisms handle cargoes of many sizes","volume":"133","author":"Schuck","year":"2020","journal-title":"J. Cell Sci."},{"issue":"8","key":"10.1016\/j.ymgmr.2026.101341_bb0070","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/s41556-023-01178-w","article-title":"The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets","volume":"25","author":"Chung","year":"2023","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.ymgmr.2026.101341_bb0075","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2314093121","article-title":"Spartin-mediated lipid transfer facilitates lipid droplet turnover","volume":"121","author":"Wan","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.ymgmr.2026.101341_bb0080","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1002\/stem.1107","article-title":"Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: a new target for osteogenesis imperfecta pharmacological therapy","volume":"30","author":"Gioia","year":"2012","journal-title":"Stem Cells"},{"issue":"9","key":"10.1016\/j.ymgmr.2026.101341_bb0085","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.chembiol.2019.05.006","article-title":"6-Phosphogluconate dehydrogenase links cytosolic carbohydrate metabolism to protein secretion via modulation of glutathione levels","volume":"26","author":"Li","year":"2019","journal-title":"Cell Chem. Biol."},{"issue":"8","key":"10.1016\/j.ymgmr.2026.101341_bb0090","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s00439-021-02302-2","article-title":"Collagen transport and related pathways in osteogenesis imperfecta","volume":"140","author":"Claeys","year":"2021","journal-title":"Hum. Genet."},{"issue":"4","key":"10.1016\/j.ymgmr.2026.101341_bb0095","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.molcel.2014.01.004","article-title":"Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association","volume":"53","author":"Eletto","year":"2014","journal-title":"Mol. Cell"},{"issue":"3","key":"10.1016\/j.ymgmr.2026.101341_bb0100","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1152\/physrev.00038.2021","article-title":"ER-phagy: mechanisms, regulation, and diseases connected to the lysosomal clearance of the endoplasmic reticulum","volume":"102","author":"Reggiori","year":"2022","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.ymgmr.2026.101341_bb0105","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1158\/0008-5472.CAN-06-3241","article-title":"PARC and CUL7 form atypical cullin RING ligase complexes","volume":"67","author":"Skaar","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymgmr.2026.101341_bb0110","doi-asserted-by":"crossref","first-page":"40825","DOI":"10.1038\/srep40825","article-title":"Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels","volume":"7","author":"Hsu","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.ymgmr.2026.101341_bb0115","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1002\/dvdy.20987","article-title":"Sulf1 expression pattern and its role in cartilage and joint development","volume":"235","author":"Zhao","year":"2006","journal-title":"Dev. Dyn."},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ajhg.2010.05.012","article-title":"Mesomelia-synostoses syndrome results from deletion of SULF1 and SLCO5A1 genes at 8q13","volume":"87","author":"Isidor","year":"2010","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/pdp.22.1.23.35","article-title":"Mesomelic dysplasia with specific autopodal synostoses: a third observation and further delineation of the multiple congenital anomaly syndrome","volume":"22","author":"Leroy","year":"2003","journal-title":"Pediatr. Pathol. Mol. Med."},{"issue":"3","key":"10.1016\/j.ymgmr.2026.101341_bb0130","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1073\/pnas.0335507100","article-title":"The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation","volume":"100","author":"Seidah","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymgmr.2026.101341_bb0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.atherosclerosis.2019.07.015","article-title":"PCSK9 inhibition and inflammation: a narrative review","volume":"288","author":"Ruscica","year":"2019","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.ymgmr.2026.101341_bb0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tem.2005.01.003","article-title":"Antagonists of activin signaling: mechanisms and potential biological applications","volume":"16","author":"Harrison","year":"2005","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.ymgmr.2026.101341_bb0145","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13101","article-title":"Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome","volume":"10","author":"Hao","year":"2022","journal-title":"PeerJ"},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0150","doi-asserted-by":"crossref","first-page":"15575","DOI":"10.1038\/s41598-017-15586-0","article-title":"FAM19A5, a brain-specific chemokine, inhibits RANKL-induced osteoclast formation through formyl peptide receptor 2","volume":"7","author":"Park","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.ymgmr.2026.101341_bb0155","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.133.2.417","article-title":"Inhibition of laminin alpha 1-chain expression leads to alteration of basement membrane assembly and cell differentiation","volume":"133","author":"De Arcangelis","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ymgmr.2026.101341_bb0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.diff.2020.05.002","article-title":"Laminins in osteogenic differentiation and pluripotency maintenance","volume":"114","author":"Chen","year":"2020","journal-title":"Differentiation"},{"issue":"7","key":"10.1016\/j.ymgmr.2026.101341_bb0165","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.tibs.2019.01.010","article-title":"ENPP1 in the regulation of mineralization and beyond","volume":"44","author":"Roberts","year":"2019","journal-title":"Trends Biochem. Sci."},{"issue":"6","key":"10.1016\/j.ymgmr.2026.101341_bb0170","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/jbmr.4550","article-title":"Identification of ENPP1 Haploinsufficiency in patients with diffuse idiopathic skeletal hyperostosis and early-onset osteoporosis","volume":"37","author":"Kato","year":"2022","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.ymgmr.2026.101341_bb0175","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev-pathmechdis-051222-121126","article-title":"ENPP1 in blood and bone: skeletal and soft tissue diseases induced by ENPP1 deficiency","volume":"19","author":"Ferreira","year":"2024","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.ymgmr.2026.101341_bb0180","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41440-021-00826-8","article-title":"Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension","volume":"45","author":"Grabowski","year":"2022","journal-title":"Hypertens. Res."},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0185","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13000-019-0887-0","article-title":"Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma","volume":"14","author":"Zhao","year":"2019","journal-title":"Diagn. Pathol."},{"key":"10.1016\/j.ymgmr.2026.101341_bb0190","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/boneres.2016.57","article-title":"Clinical, cellular, microscopic, and ultrastructural studies of a case of fibrogenesis imperfecta ossium","volume":"5","author":"Barron","year":"2017","journal-title":"Bone Res."},{"issue":"2","key":"10.1016\/j.ymgmr.2026.101341_bb0195","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1359\/jbmr.090719","article-title":"Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects","volume":"25","author":"Yao","year":"2010","journal-title":"J. Bone Miner. Res."},{"issue":"17","key":"10.1016\/j.ymgmr.2026.101341_bb0200","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202400991R","article-title":"SCUBE3 promotes osteogenic differentiation and mitophagy in human bone marrow mesenchymal stem cells through the BMP2\/TGF-beta signaling pathway","volume":"38","author":"Chen","year":"2024","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.ymgmr.2026.101341_bb0205","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ajhg.2020.11.015","article-title":"SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling","volume":"108","author":"Lin","year":"2021","journal-title":"Am. J. Hum. Genet."}],"container-title":["Molecular Genetics and Metabolism Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214426926000534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214426926000534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T07:49:07Z","timestamp":1789199347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214426926000534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":41,"alternative-id":["S2214426926000534"],"URL":"https:\/\/doi.org\/10.1016\/j.ymgmr.2026.101341","relation":{},"ISSN":["2214-4269"],"issn-type":[{"value":"2214-4269","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic alterations in patient bone-derived stromal cells and their secretomes in osteogenesis imperfecta","name":"articletitle","label":"Article Title"},{"value":"Molecular Genetics and Metabolism Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymgmr.2026.101341","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101341"}}