{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:23:24Z","timestamp":1762917804935,"version":"build-2065373602"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Fonds voor Wetenschappelijk Onderzoek-Vlaanderen","award":["OT\/13\/090"],"award-info":[{"award-number":["OT\/13\/090"]}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"crossref","award":["G0A3114N"],"award-info":[{"award-number":["G0A3114N"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fonds voor Wetenschappelijk Onderzoek-Vlaanderen"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.ymthe.2017.07.017","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T17:45:59Z","timestamp":1501609559000},"page":"2513-2525","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice"],"prefix":"10.1016","volume":"25","author":[{"given":"Ilayaraja","family":"Muthuramu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruhul","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Postnov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mudit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph Pierre","family":"Aboumsallem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Dresselaers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Himmelreich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul P.","family":"Van Veldhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Gheysens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"De Geest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2017.07.017_bib1","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1161\/CIRCULATIONAHA.109.830984","article-title":"Relations of lipid concentrations to heart failure incidence: the Framingham Heart Study","volume":"120","author":"Velagaleti","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2017.07.017_bib2","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1056\/NEJMoa0706201","article-title":"Rosuvastatin in older patients with systolic heart failure","volume":"357","author":"Kjekshus","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2017.07.017_bib3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0140-6736(08)61240-4","article-title":"Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial","volume":"372","author":"Tavazzi","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2017.07.017_bib4","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.jacc.2010.03.088","article-title":"Coenzyme Q10 and statins in heart failure: the dog that didn\u2019t bark","volume":"56","author":"Felker","year":"2010","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib5","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/S0140-6736(04)15739-5","article-title":"Selenoprotein synthesis and side-effects of statins","volume":"363","author":"Moosmann","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2017.07.017_bib6","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.4161\/cc.8.11.8619","article-title":"Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling","volume":"8","author":"Glazer","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ymthe.2017.07.017_bib7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.114.302022","article-title":"Mammalian target of rapamycin signaling in cardiac physiology and disease","volume":"114","author":"Sciarretta","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2017.07.017_bib8","doi-asserted-by":"crossref","first-page":"H41","DOI":"10.1152\/ajpheart.00877.2012","article-title":"Regulation of fatty acid metabolism by mTOR in adult murine hearts occurs independently of changes in PGC-1\u03b1","volume":"305","author":"Zhu","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib9","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/hh1501.094115","article-title":"Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy","volume":"89","author":"Cesselli","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2017.07.017_bib10","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.jacc.2008.07.044","article-title":"Coenzyme Q10: an independent predictor of mortality in chronic heart failure","volume":"52","author":"Molyneux","year":"2008","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib11","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1056\/NEJMcibr1402199","article-title":"Keshan disease, selenium deficiency, and the selenoproteome","volume":"370","author":"Loscalzo","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2017.07.017_bib12","doi-asserted-by":"crossref","first-page":"4764","DOI":"10.1073\/pnas.0910872107","article-title":"Cholesterol trafficking is required for mTOR activation in endothelial cells","volume":"107","author":"Xu","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2017.07.017_bib13","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","article-title":"Rapamycin attenuates load-induced cardiac hypertrophy in mice","volume":"107","author":"Shioi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2017.07.017_bib14","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","article-title":"Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2017.07.017_bib15","doi-asserted-by":"crossref","first-page":"12661","DOI":"10.1073\/pnas.1301455110","article-title":"Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1","volume":"110","author":"V\u00f6lkers","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2017.07.017_bib16","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1089\/dna.2013.2164","article-title":"mTOR enhances foam cell formation by suppressing the autophagy pathway","volume":"33","author":"Wang","year":"2014","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib17","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cell.2006.06.055","article-title":"TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth","volume":"126","author":"Inoki","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2017.07.017_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-008-9711-y","article-title":"Compensated cardiac hypertrophy is characterised by a decline in palmitate oxidation","volume":"311","author":"Akki","year":"2008","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.ymthe.2017.07.017_bib19","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/01.HYP.0000144292.69599.0c","article-title":"Mechanisms for increased glycolysis in the hypertrophied rat heart","volume":"44","author":"Nascimben","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.ymthe.2017.07.017_bib20","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1161\/CIRCULATIONAHA.106.668665","article-title":"Recruitment of compensatory pathways to sustain oxidative flux with reduced carnitine palmitoyltransferase I activity characterizes inefficiency in energy metabolism in hypertrophied hearts","volume":"115","author":"Sorokina","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2017.07.017_bib21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1161\/CIRCRESAHA.108.189951","article-title":"Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy","volume":"104","author":"Pound","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2017.07.017_bib22","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1161\/CIRCRESAHA.112.268128","article-title":"Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy","volume":"111","author":"Kolwicz","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2017.07.017_bib23","doi-asserted-by":"crossref","first-page":"25836","DOI":"10.1016\/S0021-9258(19)74465-2","article-title":"Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart","volume":"268","author":"Saddik","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2017.07.017_bib24","doi-asserted-by":"crossref","first-page":"8560","DOI":"10.1074\/jbc.273.15.8560","article-title":"Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor","volume":"273","author":"Mascar\u00f3","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2017.07.017_bib25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2337\/diabetes.51.2.276","article-title":"Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin","volume":"51","author":"Huang","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.ymthe.2017.07.017_bib26","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.cmet.2008.07.007","article-title":"SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth","volume":"8","author":"Porstmann","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2017.07.017_bib27","doi-asserted-by":"crossref","first-page":"R1046","DOI":"10.1016\/j.cub.2009.09.058","article-title":"An emerging role of mTOR in lipid biosynthesis","volume":"19","author":"Laplante","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib28","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.metabol.2007.06.016","article-title":"The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes","volume":"56","author":"Brown","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.ymthe.2017.07.017_bib29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/MOL.0000000000000420","article-title":"MicroRNAs and lipid metabolism","volume":"28","author":"Aryal","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib30","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.1102281108","article-title":"miR-33a\/b contribute to the regulation of fatty acid metabolism and insulin signaling","volume":"108","author":"D\u00e1valos","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2017.07.017_bib31","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1515\/cclm-2016-0575","article-title":"microRNAs in lipoprotein and lipid metabolism: from biological function to clinical application","volume":"55","author":"Desgagn\u00e9","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.ymthe.2017.07.017_bib32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/sj.gt.3303096","article-title":"Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer","volume":"15","author":"Jacobs","year":"2008","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymthe.2017.07.017_bib33","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1089\/hum.2010.055","article-title":"Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale","volume":"21","author":"Lock","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ymthe.2017.07.017_bib34","doi-asserted-by":"crossref","first-page":"H620","DOI":"10.1152\/ajpheart.01236.2006","article-title":"Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload","volume":"293","author":"Buys","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib35","doi-asserted-by":"crossref","first-page":"H1261","DOI":"10.1152\/ajpheart.00108.2003","article-title":"Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload","volume":"285","author":"Hu","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.ymthe.2017.07.017_bib36","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00109-015-1281-3","article-title":"Selective homocysteine-lowering gene transfer attenuates pressure overload-induced cardiomyopathy via reduced oxidative stress","volume":"93","author":"Muthuramu","year":"2015","journal-title":"J.\u00a0Mol. Med. (Berl.)"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001617303581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001617303581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T14:19:54Z","timestamp":1636035594000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001617303581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1525001617303581"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2017.07.017","relation":{},"ISSN":["1525-0016"],"issn-type":[{"type":"print","value":"1525-0016"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2017.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2017.10.008","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}