{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:51:59Z","timestamp":1774774319438,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002832","name":"Centro de Investigaci\u00f3n M\u00e9dica Aplicada, Universidad de Navarra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002832","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CSD2008-00005"],"award-info":[{"award-number":["CSD2008-00005"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2013-48983-R"],"award-info":[{"award-number":["SAF2013-48983-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SAF2016-80895-R"],"award-info":[{"award-number":["SAF2016-80895-R"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["SEV-2013-0317"],"award-info":[{"award-number":["SEV-2013-0317"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006671","name":"Fundaci\u00f3n Caja Navarra","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ymthe.2018.05.013","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T12:43:24Z","timestamp":1529066604000},"page":"1965-1972","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["RNAi-Based GluN3A Silencing Prevents and Reverses Disease Phenotypes Induced by Mutant huntingtin"],"prefix":"10.1016","volume":"26","author":[{"given":"Sonia","family":"Marco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Murillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"P\u00e9rez-Ota\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2018.05.013_bib1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1001\/jamaneurol.2014.3953","article-title":"Modulation of GluN3A expression in Huntington disease: a new n-methyl-D-aspartate receptor-based therapeutic approach?","volume":"72","author":"Wesseling","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.ymthe.2018.05.013_bib2","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/mt.2009.17","article-title":"Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington\u2019s disease mice","volume":"17","author":"Boudreau","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.05.013_bib3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuron.2012.05.009","article-title":"Sustained therapeutic reversal of Huntington\u2019s disease by transient repression of huntingtin synthesis","volume":"74","author":"Kordasiewicz","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2018.05.013_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ana.21569","article-title":"Sustained effects of nonallele-specific Huntingtin silencing","volume":"65","author":"Drouet","year":"2009","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2018.05.013_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/ng1362","article-title":"Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease","volume":"36","author":"Ravikumar","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2018.05.013_bib6","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ymthe.2018.05.013_bib7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nchembio.1790","article-title":"siRNA screen identifies QPCT as a druggable target for Huntington\u2019s disease","volume":"11","author":"Jimenez-Sanchez","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ymthe.2018.05.013_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington\u2019s disease: from molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ymthe.2018.05.013_bib9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tins.2010.08.002","article-title":"Early synaptic pathophysiology in neurodegeneration: insights from Huntington\u2019s disease","volume":"33","author":"Milnerwood","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ymthe.2018.05.013_bib10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.conb.2017.10.019","article-title":"Molecular insights into cortico-striatal miscommunications in Huntington\u2019s disease","volume":"48","author":"Veldman","year":"2018","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ymthe.2018.05.013_bib11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.3155875","article-title":"Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington\u2019s disease","volume":"227","author":"Graveland","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2018.05.013_bib12","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1523\/JNEUROSCI.11-12-03877.1991","article-title":"Proliferative and degenerative changes in striatal spiny neurons in Huntington\u2019s disease: a combined study using the section-Golgi method and calbindin D28k immunocytochemistry","volume":"11","author":"Ferrante","year":"1991","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2018.05.013_bib13","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: the 12-month longitudinal analysis","volume":"10","author":"Tabrizi","year":"2011","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ymthe.2018.05.013_bib14","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: analysis of 36-month observational data","volume":"12","author":"Tabrizi","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ymthe.2018.05.013_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/brb3.185","article-title":"Neuroanatomical correlates of cognitive functioning in prodromal Huntington disease","volume":"4","author":"Harrington","year":"2014","journal-title":"Brain Behav."},{"key":"10.1016\/j.ymthe.2018.05.013_bib16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrn.2016.92","article-title":"Emerging roles of GluN3-containing NMDA receptors in the CNS","volume":"17","author":"P\u00e9rez-Ota\u00f1o","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2018.05.013_bib17","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1038\/nm.3246","article-title":"Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington\u2019s disease models","volume":"19","author":"Marco","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2018.05.013_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2016.04.001","article-title":"GluN3A promotes NMDA spiking by enhancing synaptic transmission in Huntington\u2019s disease models","volume":"93","author":"Mahfooz","year":"2016","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ymthe.2018.05.013_bib19","doi-asserted-by":"crossref","first-page":"9213","DOI":"10.1523\/JNEUROSCI.5183-13.2014","article-title":"GluN3A promotes dendritic spine pruning and destabilization during postnatal development","volume":"34","author":"Kehoe","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2018.05.013_bib20","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/mt.2013.285","article-title":"Recombinant AAV as a platform for translating the therapeutic potential of RNA interference","volume":"22","author":"Borel","year":"2014","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.05.013_bib21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrg2968","article-title":"Current prospects for RNA interference-based therapies","volume":"12","author":"Davidson","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ymthe.2018.05.013_bib22","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.neuron.2013.07.050","article-title":"Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors","volume":"80","author":"Yuan","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2018.05.013_bib23","doi-asserted-by":"crossref","first-page":"e76310","DOI":"10.1371\/journal.pone.0076310","article-title":"Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain","volume":"8","author":"Aschauer","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2018.05.013_bib24","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/mt.2008.166","article-title":"Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain","volume":"16","author":"Cearley","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.05.013_bib25","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.ymthe.2018.05.013_bib26","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymthe.2018.05.013_bib27","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/bies.201600048","article-title":"Diminishing return for mechanistic therapeutics with neurodegenerative disease duration?: There may be a point in the course of a neurodegenerative condition where therapeutics targeting disease-causing mechanisms are futile","volume":"38","author":"Rubinsztein","year":"2016","journal-title":"BioEssays"},{"key":"10.1016\/j.ymthe.2018.05.013_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/01.WNL.0000132965.14653.D1","article-title":"Onset and rate of striatal atrophy in preclinical Huntington disease","volume":"63","author":"Aylward","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.ymthe.2018.05.013_bib29","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/nm.2056","article-title":"Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin","volume":"15","author":"Okamoto","year":"2009","journal-title":"Nat. Med."},{"issue":"R1","key":"10.1016\/j.ymthe.2018.05.013_bib30","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1093\/hmg\/ddv442","article-title":"Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington\u2019s disease and spinocerebellar ataxia","volume":"25","author":"Keiser","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymthe.2018.05.013_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ymthe.2016.11.010","article-title":"CRISPR\/Cas9 editing of the mutant Huntingtin allele in\u00a0vitro and in\u00a0vivo","volume":"25","author":"Monteys","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.05.013_bib32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/cge.12385","article-title":"Personalized gene silencing therapeutics for Huntington disease","volume":"86","author":"Kay","year":"2014","journal-title":"Clin. Genet."},{"key":"10.1016\/j.ymthe.2018.05.013_bib33","doi-asserted-by":"crossref","DOI":"10.3791\/2376","article-title":"Assessment of motor balance and coordination in mice using the balance beam","author":"Luong","year":"2011","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.ymthe.2018.05.013_bib34","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1523\/JNEUROSCI.1197-04.2004","article-title":"Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington\u2019s disease","volume":"24","author":"Canals","year":"2004","journal-title":"J.\u00a0Neurosci."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618302168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618302168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:52:32Z","timestamp":1761501152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001618302168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1525001618302168"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.05.013","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNAi-Based GluN3A Silencing Prevents and Reverses Disease Phenotypes Induced by Mutant huntingtin","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}