{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:25:43Z","timestamp":1768256743925,"version":"3.49.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81500750"],"award-info":[{"award-number":["81500750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["P30EY019007"],"award-info":[{"award-number":["P30EY019007"]}]},{"name":"NIH","award":["R01EY018213"],"award-info":[{"award-number":["R01EY018213"]}]},{"name":"NIH","award":["R01EY024698"],"award-info":[{"award-number":["R01EY024698"]}]},{"name":"NIH","award":["R01EY026682"],"award-info":[{"award-number":["R01EY026682"]}]},{"name":"NIH","award":["R21AG050437"],"award-info":[{"award-number":["R21AG050437"]}]},{"name":"National Cancer Institute Core","award":["5P30CA013696"],"award-info":[{"award-number":["5P30CA013696"]}]},{"name":"Research to Prevent Blindness (RPB) Physician-Scientist Award"},{"name":"RPB"},{"name":"Tistou and Charlotte Kerstan Foundation"},{"name":"Schneeweiss Stem Cell Fund, New York State","award":["C029572"],"award-info":[{"award-number":["C029572"]}]},{"name":"Foundation Fighting Blindness","award":["TA-NMT-0116-06-COLU"],"award-info":[{"award-number":["TA-NMT-0116-06-COLU"]}]},{"name":"Gebroe Family Foundation"},{"name":"RPB Medical Student Eye Research Fellowship"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.ymthe.2018.06.014","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T18:20:45Z","timestamp":1529605245000},"page":"1953-1964","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa"],"prefix":"10.1016","volume":"26","author":[{"given":"Lijuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Jauregui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Sophia","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Justus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ting","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy K.","family":"Duong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Wei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Hsuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine L.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyuan-Sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen H.","family":"Tsang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2018.06.014_bib1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1189\/jlb.0207114","article-title":"Microglia activation in retinal degeneration","volume":"81","author":"Langmann","year":"2007","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Kettenmann","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.ymthe.2018.06.014_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.immunol.021908.132528","article-title":"Microglial physiology: unique stimuli, specialized responses","volume":"27","author":"Ransohoff","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00592-017-0984-z","article-title":"Modulation of microglia in the retina: new insights into diabetic retinopathy","volume":"54","author":"Arroba","year":"2017","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib5","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in\u00a0vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2018.06.014_bib6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0166-2236(96)10049-7","article-title":"Microglia: a sensor for pathological events in the CNS","volume":"19","author":"Kreutzberg","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3892\/ijmm.2012.1179","article-title":"Activated microglia provide a neuroprotective role by balancing glial cell-line derived neurotrophic factor and tumor necrosis factor-\u03b1 secretion after subacute cerebral ischemia","volume":"31","author":"Wang","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.ymthe.2018.06.014_bib8","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1742-2094-9-142","article-title":"Transient early neurotrophin release and delayed inflammatory cytokine release by microglia in response to PAR-2 stimulation","volume":"9","author":"Chen","year":"2012","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2018.06.014_bib9","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nri3086","article-title":"Microglial cell origin and phenotypes in health and disease","volume":"11","author":"Saijo","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuron.2009.08.039","article-title":"Immune activation in brain aging and neurodegeneration: too much or too little?","volume":"64","author":"Lucin","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2018.06.014_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/00207454.2013.833510","article-title":"Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer\u2019s disease","volume":"124","author":"Cai","year":"2014","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0014-4835(02)00332-9","article-title":"Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration","volume":"76","author":"Gupta","year":"2003","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2018.06.014_bib13","doi-asserted-by":"crossref","first-page":"a017129","DOI":"10.1101\/cshperspect.a017129","article-title":"Genes and Mutations Causing Autosomal Dominant Retinitis Pigmentosa","volume":"5","author":"Daiger","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.ymthe.2018.06.014_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/ajmg.c.31534","article-title":"Gene and cell-based therapies for inherited retinal disorders: An update","volume":"172","author":"Sengillo","year":"2016","journal-title":"Am. J. Med. Genet. C. Semin. Med. Genet."},{"key":"10.1016\/j.ymthe.2018.06.014_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-1-40","article-title":"Retinitis pigmentosa","volume":"1","author":"Hamel","year":"2006","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.ymthe.2018.06.014_bib16","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1164\/rccm.201402-0342OC","article-title":"Genotype-phenotype correlations for infants and children with ABCA3 deficiency","volume":"189","author":"Wambach","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ymthe.2018.06.014_bib17","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1111\/aos.13141","article-title":"A review of the mechanisms of cone degeneration in retinitis pigmentosa","volume":"94","author":"Narayan","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib18","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1073\/pnas.92.8.3249","article-title":"Mutation spectrum of the gene encoding the beta subunit of rod phosphodiesterase among patients with autosomal recessive retinitis pigmentosa","volume":"92","author":"McLaughlin","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2018.06.014_bib19","first-page":"1859","article-title":"Frequency of mutations in the gene encoding the alpha subunit of rod cGMP-phosphodiesterase in autosomal recessive retinitis pigmentosa","volume":"40","author":"Dryja","year":"1999","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib20","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.preteyeres.2016.06.002","article-title":"Structural and molecular bases of rod photoreceptor morphogenesis and disease","volume":"55","author":"Wensel","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ymthe.2018.06.014_bib21","first-page":"263","article-title":"From mice to men: the cyclic GMP phosphodiesterase gene in vision and disease. The Proctor Lecture","volume":"36","author":"Farber","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib22","first-page":"103","article-title":"Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis)","volume":"112","author":"Tsang","year":"2014","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"10.1016\/j.ymthe.2018.06.014_bib23","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1073\/pnas.1615394114","article-title":"Genetic rescue models refute nonautonomous rod cell death in retinitis pigmentosa","volume":"114","author":"Koch","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2018.06.014_bib24","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1172\/JCI82462","article-title":"Halting progressive neurodegeneration in advanced retinitis pigmentosa","volume":"125","author":"Koch","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2018.06.014_bib25","doi-asserted-by":"crossref","first-page":"13475","DOI":"10.1523\/JNEUROSCI.0419-13.2013","article-title":"Therapeutic margins in a novel preclinical model of retinitis pigmentosa","volume":"33","author":"Davis","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib26","first-page":"8090918","article-title":"CX3CL1\/CX3CR1 in Alzheimer\u2019s Disease: A Target for Neuroprotection","volume":"2016","author":"Chen","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.ymthe.2018.06.014_bib27","doi-asserted-by":"crossref","first-page":"15077","DOI":"10.18632\/oncotarget.3730","article-title":"Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis","volume":"6","author":"Feng","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ymthe.2018.06.014_bib28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s12640-015-9557-5","article-title":"CX3CR1 Disruption Differentially Influences Dopaminergic Neuron Degeneration in Parkinsonian Mice Depending on the Neurotoxin and Route of Administration","volume":"29","author":"Trist\u00e3o","year":"2016","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ymthe.2018.06.014_bib29","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1007\/s12035-016-9787-4","article-title":"Analysis of the Role of CX3CL1 (Fractalkine) and Its Receptor CX3CR1 in Traumatic Brain and Spinal Cord Injury: Insight into Recent Advances in Actions of Neurochemokine Agents","volume":"54","author":"Poniatowski","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib30","doi-asserted-by":"crossref","DOI":"10.1042\/CS20171025","article-title":"CX3CR1 modulates the anti-inflammatory activity of hepatic dendritic cells in response to acute liver injury","author":"Sutti","year":"2017","journal-title":"Clin. Sci. (Lond.)."},{"key":"10.1016\/j.ymthe.2018.06.014_bib31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4049\/jimmunol.1502559","article-title":"CX3CR1+ Cell-Mediated Salmonella Exclusion Protects the Intestinal Mucosa during the Initial Stage of Infection","volume":"198","author":"Man","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1096\/fj.14-270090","article-title":"CX3CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions","volume":"30","author":"Zhao","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.ymthe.2018.06.014_bib33","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.exer.2016.03.027","article-title":"Astrocyte structural reactivity and plasticity in models of retinal detachment","volume":"150","author":"Luna","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2018.06.014_bib34","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2014.05.065","article-title":"Microglial NADPH oxidase activation mediates rod cell death in the retinal degeneration in rd mice","volume":"275","author":"Zeng","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.ymthe.2018.06.014_bib35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.neuron.2013.04.005","article-title":"Innate immunity in the CNS: redefining the relationship between the CNS and Its environment","volume":"78","author":"Lampron","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2018.06.014_bib36","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1007\/s12035-013-8620-6","article-title":"Phagocytosis of microglia in the central nervous system diseases","volume":"49","author":"Fu","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nan.12011","article-title":"Review: activation patterns of microglia and their identification in the human brain","volume":"39","author":"Boche","year":"2013","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib38","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11481-012-9347-2","article-title":"Roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina","volume":"8","author":"Kaur","year":"2013","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib39","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2015.06.012","article-title":"Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System","volume":"43","author":"Bruttger","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2018.06.014_bib40","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib41","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib42","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.tins.2007.08.007","article-title":"Neuronal \u2018On\u2019 and \u2018Off\u2019 signals control microglia","volume":"30","author":"Biber","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12974-015-0408-3","article-title":"Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration","volume":"12","author":"Kohno","year":"2015","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2018.06.014_bib44","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/glia.23016","article-title":"Microglial phagocytosis and activation underlying photoreceptor degeneration is regulated by CX3CL1-CX3CR1 signaling in a mouse model of retinitis pigmentosa","volume":"64","author":"Zabel","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.ymthe.2018.06.014_bib45","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1007\/s00109-016-1433-0","article-title":"CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes","volume":"94","author":"Beli","year":"2016","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.ymthe.2018.06.014_bib46","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/sj.gt.3302485","article-title":"Lentiviral vector-mediated gene transfer in adult mouse photoreceptors is impaired by the presence of a physical barrier","volume":"12","author":"Gr\u00fcter","year":"2005","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymthe.2018.06.014_bib47","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/exer.1993.1124","article-title":"Stage-specific binding of peanut agglutinin to aggregates of degenerating photoreceptor cells in the rd mouse retina","volume":"57","author":"Blanks","year":"1993","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2018.06.014_bib48","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/cne.21144","article-title":"Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study","volume":"500","author":"Gargini","year":"2007","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib49","first-page":"85","article-title":"[Conditions for greater survival of neonatally thymectomized Swiss mice (author\u2019s transl)]","volume":"35","author":"Silva","year":"1979","journal-title":"Rev. Esp. Fisiol."},{"key":"10.1016\/j.ymthe.2018.06.014_bib50","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1248\/bpb1978.7.883","article-title":"Effect of hypothermia and\u00a0ether anesthesia on the dispositions of creatinine and urea in mice","volume":"7","author":"Hirate","year":"1984","journal-title":"J.\u00a0Pharmacobiodyn."},{"key":"10.1016\/j.ymthe.2018.06.014_bib51","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1167\/iovs.12-9450","article-title":"Tracking retinal microgliosis in models of retinal ganglion cell damage","volume":"53","author":"Liu","year":"2012","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib52","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.neurobiolaging.2013.03.022","article-title":"Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation","volume":"34","author":"Ma","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ymthe.2018.06.014_bib53","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.5200-13.2014","article-title":"Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa","volume":"34","author":"Peng","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib54","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/jcbfm.2013.146","article-title":"Microglia\/macrophage polarization dynamics in white matter after traumatic brain injury","volume":"33","author":"Wang","year":"2013","journal-title":"J.\u00a0Cereb. Blood Flow Metab."},{"key":"10.1016\/j.ymthe.2018.06.014_bib55","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1167\/iovs.07-1422","article-title":"Functional rescue of degenerating photoreceptors in mice homozygous for a hypomorphic cGMP phosphodiesterase 6\u00a0b allele (Pde6bH620Q)","volume":"49","author":"Davis","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2018.06.014_bib56","doi-asserted-by":"crossref","first-page":"3443","DOI":"10.1167\/iovs.05-0254","article-title":"Genotype-phenotype correlation of mouse pde6b mutations","volume":"46","author":"Hart","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618302739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618302739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T18:16:28Z","timestamp":1589912188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001618302739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":56,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1525001618302739"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.06.014","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic Rescue Reverses Microglial Activation in Preclinical Models of Retinitis Pigmentosa","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}