{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:41:20Z","timestamp":1790523680512,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 AI110154"],"award-info":[{"award-number":["R21 AI110154"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U19 AI096111"],"award-info":[{"award-number":["U19 AI096111"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U19 HL129902"],"award-info":[{"award-number":["U19 HL129902"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["UM1 AI126623"],"award-info":[{"award-number":["UM1 AI126623"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL116217"],"award-info":[{"award-number":["R01 HL116217"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fred Hutch Core Center Grant","award":["CCSG P30 CA015704"],"award-info":[{"award-number":["CCSG P30 CA015704"]}]},{"name":"Markey Molecular Medicine Investigator"},{"name":"Jose Carreras\/E. Donnall Thomas Endowed Chair for Cancer Research"},{"name":"Fred Hutch Endowed Chair for Cell and Gene Therapy"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.ymthe.2018.09.017","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T03:50:24Z","timestamp":1538020224000},"page":"164-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice"],"prefix":"10.1016","volume":"27","author":[{"given":"Anne-Sophie","family":"Kuhlmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Haworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac M.","family":"Barber-Axthelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Ironside","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan A.","family":"Giese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"Kiem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2018.09.017_bib1","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1080\/17512433.2016.1221760","article-title":"Key toxicity issues with the WHO-recommended first-line antiretroviral therapy regimen","volume":"9","author":"Mouton","year":"2016","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12640-016-9646-0","article-title":"Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics","volume":"30","author":"Shah","year":"2016","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.ymthe.2018.09.017_bib3","doi-asserted-by":"crossref","first-page":"6222","DOI":"10.1038\/s41598-017-05594-5","article-title":"Escape from humoral immunity is associated with treatment failure in HIV-1-infected patients receiving long-term antiretroviral therapy","volume":"7","author":"Ouyang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2018.09.017_bib4","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1128\/JVI.02454-15","article-title":"Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs","volume":"90","author":"Bolton","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib5","doi-asserted-by":"crossref","first-page":"16538","DOI":"10.1073\/pnas.1315295110","article-title":"HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice","volume":"110","author":"Horwitz","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2018.09.017_bib6","doi-asserted-by":"crossref","first-page":"13151","DOI":"10.1073\/pnas.1414148111","article-title":"Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir","volume":"111","author":"Chun","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2018.09.017_bib7","doi-asserted-by":"crossref","first-page":"10844","DOI":"10.1038\/ncomms10844","article-title":"Elimination of HIV-1-infected cells by broadly neutralizing antibodies","volume":"7","author":"Bruel","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2018.09.017_bib8","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.cell.2014.07.043","article-title":"Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice","volume":"158","author":"Halper-Stromberg","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2018.09.017_bib9","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nm.3471","article-title":"Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission","volume":"20","author":"Balazs","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature14411","article-title":"Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117","volume":"522","author":"Caskey","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.09.017_bib11","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1093\/infdis\/jiw203","article-title":"Protection of humanized mice from repeated intravaginal HIV challenge by passive immunization: A model for studying the efficacy of neutralizing antibodies in\u00a0vivo","volume":"214","author":"Deruaz","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.ymthe.2018.09.017_bib12","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.aaf1279","article-title":"Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in\u00a0vivo","volume":"352","author":"Lu","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2018.09.017_bib13","doi-asserted-by":"crossref","first-page":"319ra206","DOI":"10.1126\/scitranslmed.aad5752","article-title":"Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection","volume":"7","author":"Lynch","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib14","doi-asserted-by":"crossref","first-page":"5895","DOI":"10.1128\/JVI.00210-15","article-title":"Sustained delivery of a broadly neutralizing antibody in nonhuman primates confers long-term protection against Simian\/Human Immunodeficiency Virus infection","volume":"89","author":"Saunders","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib15","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1126\/science.aaf0972","article-title":"HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1","volume":"352","author":"Schoofs","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2018.09.017_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nm.4268","article-title":"Antibody 10-1074 suppresses viremia in HIV-1-infected individuals","volume":"23","author":"Caskey","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib17","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.cell.2014.08.023","article-title":"Broadly neutralizing anti-HIV-1 antibodies require Fc effector functions for in\u00a0vivo activity","volume":"158","author":"Bournazos","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2018.09.017_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature21435","article-title":"Early antibody therapy can induce long-lasting immunity to SHIV","volume":"543","author":"Nishimura","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.09.017_bib19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/cei.12692","article-title":"Safety, pharmacokinetics and neutralization of the broadly neutralizing HIV-1 human monoclonal antibody VRC01 in healthy adults","volume":"182","author":"Ledgerwood","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature17677","article-title":"A single injection of\u00a0anti-HIV-1 antibodies protects against repeated SHIV challenges","volume":"533","author":"Gautam","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.09.017_bib21","doi-asserted-by":"crossref","first-page":"12669","DOI":"10.1128\/JVI.02213-14","article-title":"Enhanced potency of a broadly neutralizing HIV-1 antibody in\u00a0vitro improves protection against lentiviral infection in\u00a0vivo","volume":"88","author":"Rudicell","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib22","doi-asserted-by":"crossref","first-page":"e1002435","DOI":"10.1371\/journal.pmed.1002435","article-title":"Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial","volume":"14","author":"Mayer","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0140-6736(16)30374-9","article-title":"Lentiviral haemopoietic stem-cell gene therapy in early-onset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1\/2 trial","volume":"388","author":"Sessa","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2018.09.017_bib24","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1128\/JVI.02339-09","article-title":"Inhibition of in\u00a0vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody","volume":"84","author":"Joseph","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib25","doi-asserted-by":"crossref","first-page":"eaan1145","DOI":"10.1126\/scitranslmed.aan1145","article-title":"A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates","volume":"9","author":"Radtke","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.omtm.2017.05.004","article-title":"In\u00a0vivo murine-matured human CD3+ cells as a preclinical model for T\u00a0cell-based immunotherapies","volume":"6","author":"Haworth","year":"2017","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ymthe.2018.09.017_bib27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.gt.3301593","article-title":"Bone marrow stem cell-based gene transfer in a mouse model for metachromatic leukodystrophy: effects on visceral and nervous system disease manifestations","volume":"9","author":"Matzner","year":"2002","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymthe.2018.09.017_bib28","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1038\/mt.2013.141","article-title":"Myeloid\/Microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease","volume":"21","author":"Sergijenko","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.09.017_bib29","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1172\/JCI28873","article-title":"Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice","volume":"116","author":"Biffi","year":"2006","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2018.09.017_bib30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nature14264","article-title":"AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges","volume":"519","author":"Gardner","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.09.017_bib31","doi-asserted-by":"crossref","first-page":"18921","DOI":"10.1073\/pnas.1214785109","article-title":"Highly potent HIV-specific antibody neutralization in\u00a0vitro translates into effective protection against mucosal SHIV challenge in\u00a0vivo","volume":"109","author":"Moldt","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2018.09.017_bib32","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1056\/NEJMoa1608243","article-title":"Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption","volume":"375","author":"Bar","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib33","doi-asserted-by":"crossref","first-page":"6332","DOI":"10.1128\/JVI.72.8.6332-6338.1998","article-title":"Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies","volume":"72","author":"Sullivan","year":"1998","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib34","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature10373","article-title":"Broad neutralization coverage of HIV by multiple highly potent antibodies","volume":"477","author":"Walker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.09.017_bib35","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature11604","article-title":"HIV therapy by a combination of broadly neutralizing antibodies in humanized mice","volume":"492","author":"Klein","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.09.017_bib36","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1128\/JVI.03136-14","article-title":"Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes","volume":"89","author":"Kong","year":"2015","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib37","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.cell.2016.04.050","article-title":"Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency","volume":"165","author":"Bournazos","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2018.09.017_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.aan8630","article-title":"Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques","volume":"358","author":"Xu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2018.09.017_bib39","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1097\/00002030-200012220-00002","article-title":"Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice","volume":"14","author":"Sanhadji","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.ymthe.2018.09.017_bib40","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1182\/blood-2012-04-422303","article-title":"Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice","volume":"120","author":"Hur","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2018.09.017_bib41","doi-asserted-by":"crossref","first-page":"e50438","DOI":"10.1371\/journal.pone.0050438","article-title":"Use of mutated self-cleaving 2A peptides as a molecular rheostat to direct simultaneous formation of membrane and secreted anti-HIV immunoglobulins","volume":"7","author":"Yu","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2018.09.017_bib42","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/mt.2015.148","article-title":"A lentiviral vector allowing physiologically regulated membrane-anchored and secreted antibody expression depending on B-cell maturation status","volume":"23","author":"Fusil","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.09.017_bib43","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1038\/mt.2008.161","article-title":"Erythroid-specific human factor IX delivery from in\u00a0vivo selected hematopoietic stem cells following nonmyeloablative conditioning in hemophilia B mice","volume":"16","author":"Chang","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.09.017_bib44","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.cell.2016.09.011","article-title":"Engineering T\u00a0cells with customized therapeutic response programs using synthetic notch receptors","volume":"167","author":"Roybal","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2018.09.017_bib45","doi-asserted-by":"crossref","first-page":"e91230","DOI":"10.1172\/jci.insight.91230","article-title":"Loss of immune homeostasis dictates SHIV rebound after stem-cell transplantation","volume":"2","author":"Peterson","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.ymthe.2018.09.017_bib46","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nature11398","article-title":"HIV-infected T\u00a0cells are migratory vehicles for viral dissemination","volume":"490","author":"Murooka","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.09.017_bib47","doi-asserted-by":"crossref","first-page":"eaag2285","DOI":"10.1126\/scitranslmed.aag2285","article-title":"Follicular CD8 T\u00a0cells accumulate in HIV infection and can kill infected cells in\u00a0vitro via bispecific antibodies","volume":"9","author":"Petrovas","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/4716","article-title":"In\u00a0vivo migration and function of transferred HIV-1-specific cytotoxic T\u00a0cells","volume":"5","author":"Brodie","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2018.09.017_bib49","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/mi.2017.96","article-title":"Detection of HIV-1-specific gastrointestinal tissue resident CD8(+) T-cells in chronic infection","volume":"11","author":"Kiniry","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.ymthe.2018.09.017_bib50","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/COH.0000000000000485","article-title":"Chimeric antigen receptor T-cell approaches to HIV cure","volume":"13","author":"Kuhlmann","year":"2018","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.ymthe.2018.09.017_bib51","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/COH.0000000000000144","article-title":"Broadly neutralizing antibody and the HIV reservoir in acute HIV infection: a strategy toward HIV remission?","volume":"10","author":"Ananworanich","year":"2015","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.ymthe.2018.09.017_bib52","doi-asserted-by":"crossref","first-page":"13173","DOI":"10.1038\/ncomms13173","article-title":"Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy","volume":"7","author":"Adair","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618304581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618304581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:54:16Z","timestamp":1761501256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001618304581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1525001618304581"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.09.017","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-Term Persistence of Anti-HIV Broadly Neutralizing Antibody-Secreting Hematopoietic Cells in Humanized Mice","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.09.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}