{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:06:08Z","timestamp":1792670768129,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.ymthe.2018.11.018","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:26:59Z","timestamp":1544056019000},"page":"785-793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":173,"title":["mRNA-Based Protein Replacement Therapy for the Heart"],"prefix":"10.1016","volume":"27","author":[{"given":"Ajit","family":"Magadum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerat","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lior","family":"Zangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2018.11.018_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.15420\/cfr.2016:25:2","article-title":"Global public health burden of heart failure","volume":"3","author":"Savarese","year":"2017","journal-title":"Card. Fail. Rev."},{"key":"10.1016\/j.ymthe.2018.11.018_bib2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2010.165","article-title":"Epidemiology and risk profile of heart failure","volume":"8","author":"Bui","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"issue":"Suppl 2","key":"10.1016\/j.ymthe.2018.11.018_bib3","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1136\/hrt.2005.062018","article-title":"Heart failure post-myocardial infarction: a review of the issues","volume":"91","author":"Dargie","year":"2005","journal-title":"Heart"},{"key":"10.1016\/j.ymthe.2018.11.018_bib4","first-page":"e28","article-title":"Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2018.11.018_bib5","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cardfail.2008.02.005","article-title":"Design of a phase 1\/2 trial of intracoronary administration of AAV1\/SERCA2a in patients with heart failure","volume":"14","author":"Hajjar","year":"2008","journal-title":"J.\u00a0Card. Fail."},{"key":"10.1016\/j.ymthe.2018.11.018_bib6","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0140-6736(16)00082-9","article-title":"Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial","volume":"387","author":"Greenberg","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2018.11.018_bib7","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2018.11.018_bib8","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1101\/gad.1306705","article-title":"p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes","volume":"19","author":"Engel","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.ymthe.2018.11.018_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein agrin promotes heart regeneration in mice","volume":"547","author":"Bassat","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.11.018_bib10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature15372","article-title":"Epicardial FSTL1 reconstitution regenerates the adult mammalian heart","volume":"525","author":"Wei","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.11.018_bib11","doi-asserted-by":"crossref","first-page":"15546","DOI":"10.1073\/pnas.0607382103","article-title":"FGF1\/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction","volume":"103","author":"Engel","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2018.11.018_bib12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nm1619","article-title":"Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair","volume":"13","author":"K\u00fchn","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2018.11.018_bib13","doi-asserted-by":"crossref","first-page":"E66","DOI":"10.1161\/hh1101.092004","article-title":"Overwhelming evidence of the beneficial effects of SERCA gene transfer in heart failure","volume":"88","author":"del Monte","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature10407","article-title":"SUMO1-dependent modulation of SERCA2a in heart failure","volume":"477","author":"Kho","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.11.018_bib15","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2010.07.002","article-title":"Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors","volume":"142","author":"Ieda","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2018.11.018_bib16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nature11139","article-title":"Heart repair by reprogramming non-myocytes with cardiac transcription factors","volume":"485","author":"Song","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.11.018_bib17","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1161\/01.CIR.0000061911.47710.8A","article-title":"The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis","volume":"107","author":"Henry","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2018.11.018_bib18","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1161\/01.CIR.101.2.118","article-title":"Effect of intracoronary recombinant human vascular endothelial growth factor on myocardial perfusion: evidence for a dose-dependent effect","volume":"101","author":"Hendel","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2018.11.018_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0735-1097(00)01144-X","article-title":"Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia","volume":"37","author":"Sato","year":"2001","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.ymthe.2018.11.018_bib20","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1161\/01.CIR.0000070540.80780.92","volume":"107","author":"Hedman","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2018.11.018_bib21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/mt.2009.70","article-title":"VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial","volume":"17","author":"Stewart","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib22","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/sj.gt.3302802","article-title":"Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment","volume":"13","author":"Stewart","year":"2006","journal-title":"Gene Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib23","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1161\/01.CIR.98.25.2800","article-title":"Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia","volume":"98","author":"Losordo","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2018.11.018_bib24","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1161\/01.CIR.90.5.2414","article-title":"Direct in\u00a0vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors","volume":"90","author":"French","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2018.11.018_bib25","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/hum.2004.15.1157","article-title":"The innate immune response to adenovirus vectors","volume":"15","author":"Muruve","year":"2004","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib26","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib27","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0022-5223(03)00082-5","article-title":"Direct comparison of efficiency and stability of gene transfer into the mammalian heart using adeno-associated virus versus adenovirus vectors","volume":"126","author":"Chu","year":"2003","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.ymthe.2018.11.018_bib28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0167-5273(02)00554-5","article-title":"Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and arteries in\u00a0vivo: a comparative study with adenovirus vectors","volume":"90","author":"Vassalli","year":"2003","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.ymthe.2018.11.018_bib29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1182\/blood-2013-01-306647","article-title":"Immune responses to AAV vectors: overcoming barriers to successful gene therapy","volume":"122","author":"Mingozzi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2018.11.018_bib30","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature11739","article-title":"Functional screening identifies miRNAs inducing cardiac regeneration","volume":"492","author":"Eulalio","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2018.11.018_bib31","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ncrna.2018.04.002","article-title":"Long non-coding RNAs in the failing heart and vasculature","volume":"3","author":"Hermans-Beijnsberger","year":"2018","journal-title":"Noncoding RNA Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib32","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/CIRCRESAHA.108.193102","article-title":"Downregulation of miR-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes","volume":"104","author":"Rane","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib33","doi-asserted-by":"crossref","first-page":"239rv1","DOI":"10.1126\/scitranslmed.3006681","article-title":"Strategies for cardiac regeneration and repair","volume":"6","author":"Lin","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2018.11.018_bib34","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1126\/science.1690918","article-title":"Direct gene transfer into mouse muscle in\u00a0vivo","volume":"247","author":"Wolff","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2018.11.018_bib35","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1038\/mt.2008.200","article-title":"Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability","volume":"16","author":"Karik\u00f3","year":"2008","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib36","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nbt.1733","article-title":"Expression of therapeutic proteins after delivery of chemically modified mRNA in mice","volume":"29","author":"Kormann","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2018.11.018_bib37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/978-1-4939-6588-5_8","article-title":"Synthesis of modified mRNA for myocardial delivery","volume":"1521","author":"Kondrat","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2018.11.018_bib38","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bbrc.2005.12.105","article-title":"mRNA transfection of dendritic cells: synergistic effect of ARCA mRNA capping with Poly(A) chains in cis and in trans for a high protein expression level","volume":"340","author":"Mockey","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ymthe.2018.11.018_bib39","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10741-011-9285-8","article-title":"Angiogenic therapy for cardiac repair based on protein delivery systems","volume":"17","author":"Formiga","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.ymthe.2018.11.018_bib40","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1517\/14712598.2011.570749","article-title":"Gene therapy for ischemic heart disease","volume":"11","author":"Hinkel","year":"2011","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib41","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7150\/thno.3682","article-title":"Vascular endothelial growth factor-delivery systems for cardiac repair: an overview","volume":"2","author":"Sim\u00f3n-Yarza","year":"2012","journal-title":"Theranostics"},{"key":"10.1016\/j.ymthe.2018.11.018_bib42","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.biomaterials.2010.08.098","article-title":"Infarct stabilization and cardiac repair with a VEGF-conjugated, injectable hydrogel","volume":"32","author":"Wu","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.ymthe.2018.11.018_bib43","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1089\/ten.tea.2011.0105","article-title":"A myocardial patch made of collagen membranes loaded with collagen-binding human vascular endothelial growth factor accelerates healing of the injured rabbit heart","volume":"17","author":"Gao","year":"2011","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.ymthe.2018.11.018_bib44","doi-asserted-by":"crossref","first-page":"146ra109","DOI":"10.1126\/scitranslmed.3003841","article-title":"Instructive nanofiber scaffolds with VEGF create a microenvironment for arteriogenesis and cardiac repair","volume":"4","author":"Lin","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2018.11.018_bib45","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/nbt.2682","article-title":"Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction","volume":"31","author":"Zangi","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2018.11.018_bib46","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/cr.2013.112","article-title":"Driving vascular endothelial cell fate of human multipotent Isl1+ heart progenitors with VEGF modified mRNA","volume":"23","author":"Lui","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.omtm.2018.04.003","article-title":"Biocompatible, purified VEGF-A mRNA improves cardiac function after intracardiac injection 1\u00a0week post-myocardial infarction in Swine","volume":"9","author":"Carlsson","year":"2018","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.ymthe.2018.11.018_bib48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.omtn.2018.08.021","article-title":"Ablation of a single N-glycosylation site in human FSTL 1 induces cardiomyocyte proliferation and cardiac regeneration","volume":"13","author":"Magadum","year":"2018","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ymthe.2018.11.018_bib49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2174\/1568010033484098","article-title":"Inflammatory mechanisms in myocardial infarction","volume":"2","author":"Ren","year":"2003","journal-title":"Curr. Drug Targets Inflamm. Allergy"},{"key":"10.1016\/j.ymthe.2018.11.018_bib50","doi-asserted-by":"crossref","first-page":"e1367","DOI":"10.1002\/wsbm.1367","article-title":"Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease","volume":"9","author":"Hadas","year":"2017","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"10.1016\/j.ymthe.2018.11.018_bib51","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.ymthe.2017.03.016","article-title":"Optimizing cardiac delivery of modified mRNA","volume":"25","author":"Sultana","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib52","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1021\/mp5006239","article-title":"Synthetic chemically modified mrna-based delivery of cytoprotective factor promotes early cardiomyocyte survival post-acute myocardial infarction","volume":"12","author":"Huang","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ymthe.2018.11.018_bib53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/CIRCULATIONAHA.116.022064","article-title":"Insulin-like growth factor 1 receptor-dependent pathway drives epicardial adipose tissue formation after myocardial injury","volume":"135","author":"Zangi","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2018.11.018_bib54","doi-asserted-by":"crossref","first-page":"864","DOI":"10.5114\/aoms.2016.63259","article-title":"Clinical importance of epicardial adipose tissue","volume":"13","author":"Nagy","year":"2017","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.ymthe.2018.11.018_bib55","doi-asserted-by":"crossref","first-page":"6835","DOI":"10.1073\/pnas.0401347101","article-title":"TLR7: a new sensor of viral infection","volume":"101","author":"Crozat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2018.11.018_bib56","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2015.08.051","article-title":"N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice","volume":"217","author":"Andries","year":"2015","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2018.11.018_bib57","article-title":"M3RNA drives targeted gene delivery in acute myocardial infarction","author":"Singh","year":"2018","journal-title":"Tissue Eng. Part A."},{"key":"10.1016\/j.ymthe.2018.11.018_bib58","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/mt.2015.193","article-title":"Myocardial delivery of lipidoid nanoparticle carrying modRNA induces rapid and transient expression","volume":"24","author":"Turnbull","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib59","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-6588-5_10","article-title":"Lipidoid mRNA nanoparticles for myocardial delivery in rodents","volume":"1521","author":"Turnbull","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2018.11.018_bib60","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1093\/nar\/gkx135","article-title":"N1-methyl-pseudouridine in mRNA enhances translation through eIF2\u03b1-dependent and independent mechanisms by increasing ribosome density","volume":"45","author":"Svitkin","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2174\/1566523044578077","article-title":"Promoters and control elements: designing expression cassettes for gene therapy","volume":"4","author":"Papadakis","year":"2004","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.ymthe.2018.11.018_bib62","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1089\/hgtb.2012.129","article-title":"Enhancing the utility of adeno-associated virus gene transfer through inducible tissue-specific expression","volume":"24","author":"Chen","year":"2013","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.ymthe.2018.11.018_bib63","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1161\/CIRCRESAHA.114.302331","article-title":"Adeno-associated virus vectors as therapeutic and investigational tools in the cardiovascular system","volume":"114","author":"Zacchigna","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib64","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1093\/cvr\/cvx016","article-title":"Osteopontin RNA aptamer can prevent and reverse pressure overload-induced heart failure","volume":"113","author":"Li","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ymthe.2018.11.018_bib65","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1038\/mtna.2014.21","article-title":"Cell-type-specific, aptamer-functionalized agents for targeted disease therapy","volume":"3","author":"Zhou","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618305847?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001618305847?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:32:32Z","timestamp":1775295152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001618305847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1525001618305847"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.11.018","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"mRNA-Based Protein Replacement Therapy for the Heart","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2018.11.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}