{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:13:36Z","timestamp":1793157216911,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.ymthe.2019.04.019","type":"journal-article","created":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T04:48:37Z","timestamp":1556340517000},"page":"1286-1298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2"],"prefix":"10.1016","volume":"27","author":[{"given":"Ara","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Ra","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Rim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungyoon","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyi","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Hum","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hwa-Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In-Sun","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2019.04.019_bib1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.rbmo.2013.06.012","article-title":"Uterine plasticity and reproductive fitness","volume":"27","author":"Lucas","year":"2013","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.ymthe.2019.04.019_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4103\/0976-9668.92329","article-title":"Menstrual pattern among unmarried women from south India","volume":"2","author":"Omidvar","year":"2011","journal-title":"J.\u00a0Nat. Sci. Biol. Med."},{"key":"10.1016\/j.ymthe.2019.04.019_bib3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humupd\/dms043","article-title":"The ageing ovary and uterus: new biological insights","volume":"19","author":"Nelson","year":"2013","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.ymthe.2019.04.019_bib4","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1158\/0008-5472.CAN-10-2451","article-title":"Retraction: Spontaneous human adult stem cell transformation","volume":"70","author":"de la Fuente","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2019.04.019_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.130633","article-title":"When stem cells grow old: phenotypes and mechanisms of stem cell aging","volume":"143","author":"Schultz","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.ymthe.2019.04.019_bib6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11154-012-9221-9","article-title":"Endometrial regeneration and endometrial stem\/progenitor cells","volume":"13","author":"Gargett","year":"2012","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.ymthe.2019.04.019_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.fertnstert.2012.05.004","article-title":"Endometrial reconstruction from stem cells","volume":"98","author":"Gargett","year":"2012","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.ymthe.2019.04.019_bib8","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/stem.2222","article-title":"Loss of Endometrial Plasticity in Recurrent Pregnancy Loss","volume":"34","author":"Lucas","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.ymthe.2019.04.019_bib9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/imr.12295","article-title":"Drivers of age-related inflammation and strategies for healthspan extension","volume":"265","author":"Goldberg","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.ymthe.2019.04.019_bib10","doi-asserted-by":"crossref","first-page":"R159","DOI":"10.1530\/REP-16-0306","article-title":"Success after failure: the role of endometrial stem cells in recurrent miscarriage","volume":"152","author":"Lucas","year":"2016","journal-title":"Reproduction"},{"key":"10.1016\/j.ymthe.2019.04.019_bib11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nrm3598","article-title":"The mechanisms of Hedgehog signalling and its roles in development and disease","volume":"14","author":"Briscoe","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ydbio.2006.07.028","article-title":"Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function","volume":"299","author":"Young","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib13","doi-asserted-by":"crossref","first-page":"E22","DOI":"10.3390\/cancers8020022","article-title":"Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors","volume":"8","author":"Rimkus","year":"2016","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ymthe.2019.04.019_bib14","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1158\/0008-5472.CAN-17-2897","article-title":"A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors","volume":"78","author":"Rahman","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2019.04.019_bib15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s11064-011-0624-x","article-title":"Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders","volume":"37","author":"Al-Ayadhi","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.ymthe.2019.04.019_bib16","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.2119\/molmed.2011.00250","article-title":"Dichotomy in Hedgehog signaling between human healthy vessel and atherosclerotic plaques","volume":"18","author":"Queiroz","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.ymthe.2019.04.019_bib17","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1046\/j.1523-1747.2001.01310.x","article-title":"Retinoic acid upregulates the plasminogen activator system in human epidermal keratinocytes","volume":"116","author":"Braungart","year":"2001","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib18","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1210\/endo.133.4.8404615","article-title":"Retinoic acid potentiates phorbol ester-mediated induction of urokinase and plasminogen activator inhibitor type 2 in human myeloid leukemic cell lines","volume":"133","author":"Schuster","year":"1993","journal-title":"Endocrinology"},{"key":"10.1016\/j.ymthe.2019.04.019_bib19","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1182\/blood.V83.7.1883.1883","article-title":"Induction of differentiation of promyelocytic NB4 cells by retinoic acid is associated with rapid increase in urokinase activity subsequently downregulated by production of inhibitors","volume":"83","author":"Tapiovaara","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2019.04.019_bib20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1046\/j.1365-2141.1999.01698.x","article-title":"Retinoic acid stimulates plasminogen activator inhibitor 2 production by blood mononuclear cells and inhibits urokinase-induced extracellular proteolysis","volume":"107","author":"Montemurro","year":"1999","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jcyt.2017.12.012","article-title":"Human endometrial stem cells: High-yield isolation and characterization","volume":"20","author":"Kovina","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ymthe.2019.04.019_bib22","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0531-5565(00)00180-7","article-title":"Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes","volume":"35","author":"Toussaint","year":"2000","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0531-5565(00)00230-8","article-title":"From cells to organisms: can we learn about aging from cells in culture?","volume":"36","author":"Campisi","year":"2001","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib24","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in\u00a0vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2019.04.019_bib25","doi-asserted-by":"crossref","first-page":"e56496","DOI":"10.1371\/journal.pone.0056496","article-title":"The effects of Hedgehog on the RNA-binding protein Msi1 in the proliferation and apoptosis of mesenchymal stem cells","volume":"8","author":"Hong","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2019.04.019_bib26","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bone.2013.07.016","article-title":"The effects of hedgehog on RNA binding protein Msi1 during the osteogenic differentiation of human cord blood-derived mesenchymal stem cells","volume":"56","author":"Hong","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.ymthe.2019.04.019_bib27","doi-asserted-by":"crossref","first-page":"e1528","DOI":"10.1038\/cddis.2014.489","article-title":"Characterization of novel markers of senescence and their prognostic potential in cancer","volume":"5","author":"Althubiti","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2019.04.019_bib28","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41598-017-18862-1","article-title":"Human mesenchymal stem cells lose their functional properties after paclitaxel treatment","volume":"8","author":"M\u00fcnz","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2019.04.019_bib29","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1177\/0963689717721221","article-title":"Adipose-Derived Mesenchymal Stem Cells from the Elderly Exhibit Decreased Migration and Differentiation Abilities with Senescent Properties","volume":"26","author":"Liu","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ymthe.2019.04.019_bib30","doi-asserted-by":"crossref","first-page":"e89811","DOI":"10.1371\/journal.pone.0089811","article-title":"2, 3, 7, 8-Tetrachlorodibenzo-P-dioxin (TCDD) induces premature senescence in human and rodent neuronal cells via ROS-dependent mechanisms","volume":"9","author":"Wan","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2019.04.019_bib31","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/jat.3084","article-title":"2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin induces premature senescence of astrocytes via WNT\/\u03b2-catenin signaling and ROS production","volume":"35","author":"Nie","year":"2015","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib32","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41419-018-0748-x","article-title":"SERPINB2 is a novel indicator of stem cell toxicity","volume":"9","author":"Lee","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2019.04.019_bib33","first-page":"605","article-title":"Extent of endometrial shedding during normal menstruation","volume":"26","author":"McLennan","year":"1965","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.ymthe.2019.04.019_bib34","doi-asserted-by":"crossref","first-page":"851367","DOI":"10.1155\/2012\/851367","article-title":"Endometrial stem cells and reproduction","volume":"2012","author":"Morelli","year":"2012","journal-title":"Obstet. Gynecol. Int."},{"key":"10.1016\/j.ymthe.2019.04.019_bib35","doi-asserted-by":"crossref","first-page":"2152435","DOI":"10.1155\/2016\/2152435","article-title":"The Influence of Aging on the Regenerative Potential of Human Adipose Derived Mesenchymal Stem Cells","volume":"2016","author":"Mar\u0119dziak","year":"2016","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.ymthe.2019.04.019_bib36","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1474-9726.2011.00686.x","article-title":"Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal","volume":"10","author":"George","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/j.ymthe.2019.04.019_bib37","doi-asserted-by":"crossref","first-page":"e82582","DOI":"10.1371\/journal.pone.0082582","article-title":"Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure--a pilot study","volume":"8","author":"Murakami","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2019.04.019_bib38","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2337\/diabetes.49.12.2039","article-title":"Hedgehog signaling\u00a0regulation of insulin production by pancreatic beta-cells","volume":"49","author":"Thomas","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.ymthe.2019.04.019_bib39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/gerona\/glt076","article-title":"Sonic hedgehog therapy in a mouse model of age-associated impairment of skeletal muscle regeneration","volume":"69","author":"Piccioni","year":"2014","journal-title":"J.\u00a0Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.ymthe.2019.04.019_bib40","first-page":"99","article-title":"Expression and Role of Sonic Hedgehog in the Process of Fracture Healing with Aging","volume":"30","author":"Matsumoto","year":"2016","journal-title":"In\u00a0Vivo"},{"key":"10.1016\/j.ymthe.2019.04.019_bib41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12967-018-1482-y","article-title":"Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation?","volume":"16","author":"Tersigni","year":"2018","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.ymthe.2019.04.019_bib42","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jdermsci.2010.04.012","article-title":"Role of plasminogen activator inhibitor-2 (PAI-2) in keratinocyte differentiation","volume":"59","author":"Jang","year":"2010","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.ymthe.2019.04.019_bib43","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1006\/excr.1995.1064","article-title":"Plasminogen activator inhibitor type 2: an intracellular keratinocyte differentiation product that is incorporated into the cornified envelope","volume":"217","author":"Jensen","year":"1995","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ymthe.2019.04.019_bib44","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1074\/jbc.272.18.12035","article-title":"S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes","volume":"272","author":"Robinson","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2019.04.019_bib45","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ygeno.2005.12.003","article-title":"Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes","volume":"87","author":"Eichberger","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.ymthe.2019.04.019_bib46","doi-asserted-by":"crossref","first-page":"e102426","DOI":"10.1371\/journal.pone.0102426","article-title":"A p38 MAPK-mediated alteration of COX-2\/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging","volume":"9","author":"Yu","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2019.04.019_bib47","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.canlet.2012.09.009","article-title":"Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model","volume":"328","author":"Choi","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ymthe.2019.04.019_bib48","doi-asserted-by":"crossref","first-page":"22966","DOI":"10.1038\/srep22966","article-title":"The Wnt\/\u03b2-catenin signaling\/Id2 cascade mediates the effects of hypoxia on the hierarchy of colorectal-cancer stem cells","volume":"6","author":"Dong","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001619301856?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001619301856?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:54:14Z","timestamp":1761501254000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001619301856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S1525001619301856"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2019.04.019","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2019.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}