{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:44:10Z","timestamp":1791373450872,"version":"4.3.1"},"reference-count":67,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81501055"],"award-info":[{"award-number":["81501055"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81772060"],"award-info":[{"award-number":["81772060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81720108015"],"award-info":[{"award-number":["81720108015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81671221"],"award-info":[{"award-number":["81671221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Municipal Science and Technology Commission Natural Fund Project","award":["18JCQNJC81100"],"award-info":[{"award-number":["18JCQNJC81100"]}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.ymthe.2019.11.017","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T19:51:35Z","timestamp":1574797895000},"page":"503-522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":222,"title":["Increased Microglial Exosomal miR-124-3p Alleviates Neurodegeneration and Improves Cognitive Outcome after rmTBI"],"prefix":"10.1016","volume":"28","author":[{"given":"Xintong","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengtian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianpeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanglian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoyun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunsheng","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongcai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2019.11.017_bib1","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1038\/nature16035","article-title":"Global neurotrauma research challenges and opportunities","volume":"527","author":"Rubiano","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2019.11.017_bib2","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","article-title":"Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1474-4422(12)70262-4","article-title":"Incidence of traumatic brain injury in New Zealand: a population-based study","volume":"12","author":"Feigin","year":"2013","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib4","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1089\/neu.2013.2984","article-title":"Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study","volume":"31","author":"McMahon","year":"2014","journal-title":"J.\u00a0Neurotrauma"},{"issue":"Pt B","key":"10.1016\/j.ymthe.2019.11.017_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mcn.2015.03.001","article-title":"Epidemiology of mild traumatic brain injury and neurodegenerative disease","volume":"66","author":"Gardner","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib6","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S1474-4422(15)00002-2","article-title":"Diagnosis, prognosis, and clinical management of mild traumatic brain injury","volume":"14","author":"Levin","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib7","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1111\/j.1532-5415.2006.00894.x","article-title":"Traumatic brain injury in older adults: epidemiology, outcomes, and future implications","volume":"54","author":"Thompson","year":"2006","journal-title":"J.\u00a0Am. Geriatr. Soc."},{"key":"10.1016\/j.ymthe.2019.11.017_bib8","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.bbrc.2016.07.123","article-title":"Amyloid-beta and tau pathology following repetitive mild traumatic brain injury","volume":"483","author":"Edwards","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ymthe.2019.11.017_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrn2808","article-title":"Traumatic brain injury and amyloid-\u03b2 pathology: a link to Alzheimer\u2019s disease?","volume":"11","author":"Johnson","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1750-3639.2008.00176.x","article-title":"A lack of amyloid beta plaques despite persistent accumulation of amyloid beta in axons of long-term survivors of traumatic brain injury","volume":"19","author":"Chen","year":"2009","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2018.01.021","article-title":"Traumatic brain injury and Alzheimer\u2019s disease: the cerebrovascular link","volume":"28","author":"Ramos-Cejudo","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ymthe.2019.11.017_bib12","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/cdd.2013.180","article-title":"Microglia convert aggregated amyloid-\u03b2 into neurotoxic forms through the shedding of microvesicles","volume":"21","author":"Joshi","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.ymthe.2019.11.017_bib13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bcp.2017.12.020","article-title":"Microglia-derived extracellular vesicles in Alzheimer\u2019s disease: a double-edged sword","volume":"148","author":"Trotta","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jneuroim.2015.09.006","article-title":"Microvesicles in the brain: biomarker, messenger or mediator?","volume":"288","author":"Porro","year":"2015","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib15","doi-asserted-by":"crossref","first-page":"11982","DOI":"10.1523\/JNEUROSCI.3158-09.2009","article-title":"CD14 and toll-like receptors 2 and 4 are required for fibrillar Abeta-stimulated microglial activation","volume":"29","author":"Reed-Geaghan","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3389\/fnins.2017.00229","article-title":"Exosomes as carriers of Alzheimer\u2019s amyloid-\u00df","volume":"11","author":"Yuyama","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nn.3028","article-title":"The toxic A\u03b2 oligomer and Alzheimer\u2019s disease: an emperor in need of clothes","volume":"15","author":"Benilova","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib18","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/ana.24235","article-title":"Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease","volume":"76","author":"Agosta","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib19","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1021\/acschemneuro.8b00029","article-title":"A\u03b242 protofibrils interact with and are trafficked through microglial-derived microvesicles","volume":"9","author":"Gouwens","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib20","doi-asserted-by":"crossref","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer\u2019s disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib21","doi-asserted-by":"crossref","first-page":"e1779","DOI":"10.1038\/cddis.2015.151","article-title":"Microglia-derived IL-1\u03b2 triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells","volume":"6","author":"Guadagno","year":"2015","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2019.11.017_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jneumeth.2018.07.021","article-title":"A novel repetitive mild traumatic brain injury mouse model for chronic traumatic encephalopathy research","volume":"308","author":"Ge","year":"2018","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.ymthe.2019.11.017_bib23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1096\/fj.201700673r","article-title":"Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons","volume":"32","author":"Huang","year":"2018","journal-title":"FASEB J."},{"key":"10.1016\/j.ymthe.2019.11.017_bib24","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.7150\/thno.30879","article-title":"M2 microglia-derived exosomes protect the mouse brain from ischemia-reperfusion injury via exosomal miR-124","volume":"9","author":"Song","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ymthe.2019.11.017_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib26","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nn.4338","article-title":"A polarizing question: do M1 and M2 microglia exist?","volume":"19","author":"Ransohoff","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s12031-018-1074-6","article-title":"The role of apolipoprotein E and ethanol exposure in age-related changes in choline acetyltransferase and brain-derived neurotrophic factor expression in the mouse hippocampus","volume":"65","author":"Jamal","year":"2018","journal-title":"J.\u00a0Mol. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.brainres.2008.06.037","article-title":"The effects of retinoic acid on the expression of neurogranin after experimental cerebral ischemia","volume":"1226","author":"Li","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.ymthe.2019.11.017_bib29","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3389\/fneur.2017.00641","article-title":"Derivation of a three biomarker panel to improve diagnosis in patients with mild traumatic brain injury","volume":"8","author":"Peacock","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib30","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.jalz.2014.10.009","article-title":"Cerebrospinal fluid levels of the synaptic protein neurogranin correlates with cognitive decline in prodromal Alzheimer\u2019s disease","volume":"11","author":"Kvartsberg","year":"2015","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.ymthe.2019.11.017_bib31","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1212\/WNL.0000000000002423","article-title":"Increased CSF neurogranin concentration is specific to Alzheimer disease","volume":"86","author":"Wellington","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.ymthe.2019.11.017_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1080\/02699052.2017.1418907","article-title":"A novel method for the rapid detection of post-translationally modified visinin-like protein 1 in rat models of brain injury","volume":"32","author":"Bradley-Whitman","year":"2018","journal-title":"Brain Inj."},{"key":"10.1016\/j.ymthe.2019.11.017_bib33","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1001\/jamaneurol.2015.0202","article-title":"Cerebrospinal fluid markers of neurodegeneration and rates of brain atrophy in early Alzheimer disease","volume":"72","author":"Tarawneh","year":"2015","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5507\/bp.2011.049","article-title":"Determination of serum visinin like protein-1 and its potential for the diagnosis of brain injury due to the stroke: a pilot study","volume":"155","author":"Stejskal","year":"2011","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech Repub."},{"key":"10.1016\/j.ymthe.2019.11.017_bib35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/bpa.12248","article-title":"The neuropathology of chronic traumatic encephalopathy","volume":"25","author":"McKee","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib37","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.neuron.2008.04.010","article-title":"ApoE promotes the proteolytic degradation of Abeta","volume":"58","author":"Jiang","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2019.11.017_bib38","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1161\/STROKEAHA.119.025371","article-title":"MiR-126 mediates brain endothelial cell exosome treatment-induced neurorestorative effects after stroke in type 2 diabetes mellitus mice","volume":"50","author":"Venkat","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.ymthe.2019.11.017_bib39","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fimmu.2016.00406","article-title":"miRNA-124 in immune system and immune disorders","volume":"7","author":"Qin","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib40","doi-asserted-by":"crossref","first-page":"6986175","DOI":"10.1155\/2016\/6986175","article-title":"Exploring new inflammatory biomarkers and pathways during LPS-induced M1 polarization","volume":"2016","author":"Cunha","year":"2016","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.ymthe.2019.11.017_bib41","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nm.2266","article-title":"MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C\/EBP-\u03b1-PU.1 pathway","volume":"17","author":"Ponomarev","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2019.11.017_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2016.12.003","article-title":"MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C\/EBP-\u03b1 pathway in intracerebral hemorrhage","volume":"182","author":"Yu","year":"2017","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ymthe.2019.11.017_bib43","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s13311-014-0319-5","article-title":"Chronic neurodegeneration after traumatic brain injury: Alzheimer disease, chronic traumatic encephalopathy, or persistent neuroinflammation?","volume":"12","author":"Faden","year":"2015","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.ymthe.2019.11.017_bib44","doi-asserted-by":"crossref","first-page":"e2710","DOI":"10.1038\/cddis.2017.135","article-title":"RelA\/p65 inhibition prevents tendon adhesion by modulating inflammation, cell proliferation, and apoptosis","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2019.11.017_bib45","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12974-019-1571-8","article-title":"Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles","volume":"16","author":"Dabrowska","year":"2019","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.ymthe.2019.11.017_bib46","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0065-3233(08)60642-7","article-title":"Apolipoprotein E: structure-function relationships","volume":"45","author":"Weisgraber","year":"1994","journal-title":"Adv. Protein Chem."},{"key":"10.1016\/j.ymthe.2019.11.017_bib47","first-page":"337","article-title":"Chronic neurodegenerative consequences of traumatic brain injury","volume":"32","author":"Chauhan","year":"2014","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib48","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0165-5728(97)00021-0","article-title":"Apolipoprotein E suppresses glial cell secretion of TNF alpha","volume":"76","author":"Laskowitz","year":"1997","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib49","doi-asserted-by":"crossref","first-page":"46461","DOI":"10.1038\/srep46461","article-title":"Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model","volume":"7","author":"Laskowitz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2019.11.017_bib50","doi-asserted-by":"crossref","first-page":"e53529","DOI":"10.1371\/journal.pone.0053529","article-title":"The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E","volume":"8","author":"Namjoshi","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2019.11.017_bib51","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2202-13-144","article-title":"Wnt3a induces exosome secretion from primary cultured rat microglia","volume":"13","author":"Hooper","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib52","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2019.11.017_bib53","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/glia.22772","article-title":"Serotonin stimulates secretion of exosomes from microglia cells","volume":"63","author":"Glebov","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.ymthe.2019.11.017_bib54","doi-asserted-by":"crossref","first-page":"14968","DOI":"10.1073\/pnas.1107411108","article-title":"Serotonin signaling is associated with lower amyloid-\u03b2 levels and plaques in transgenic mice and humans","volume":"108","author":"Cirrito","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2019.11.017_bib55","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3171\/2014.11.JNS14770","article-title":"Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury","volume":"122","author":"Zhang","year":"2015","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.ymthe.2019.11.017_bib56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neuint.2016.08.003","article-title":"Systemic administration of cell-free exosomes generated by human bone marrow derived mesenchymal stem cells cultured under 2D and 3D conditions improves functional recovery in rats after traumatic brain injury","volume":"111","author":"Zhang","year":"2017","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ymthe.2019.11.017_bib57","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1073\/pnas.1522297113","article-title":"Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI","volume":"113","author":"Kim","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2019.11.017_bib58","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/ana.25172","article-title":"High complement levels in astrocyte-derived exosomes of Alzheimer disease","volume":"83","author":"Goetzl","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib59","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1096\/fj.201600816R","article-title":"Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer\u2019s disease","volume":"30","author":"Goetzl","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.ymthe.2019.11.017_bib60","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/dna.2015.2800","article-title":"Establishment of lipofection protocol for efficient miR-21 transfection into cortical neurons in\u00a0vitro","volume":"34","author":"Han","year":"2015","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib61","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2016.07.015","article-title":"miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in\u00a0vitro through suppressing inflammation and apoptosis","volume":"1650","author":"Ge","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.ymthe.2019.11.017_bib62","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1007\/s12035-016-9851-0","article-title":"Exosomes derived from mesenchymal stromal cells promote axonal growth of cortical neurons","volume":"54","author":"Zhang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ymthe.2019.11.017_bib63","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1089\/neu.2018.5728","article-title":"Increased miR-21-3p in injured brain microvascular endothelial cells after traumatic brain injury aggravates blood-brain barrier damage by promoting cellular apoptosis and inflammation through targeting MAT2B","volume":"36","author":"Ge","year":"2019","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.ymthe.2019.11.017_bib64","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.brainres.2015.01.009","article-title":"MiR-21 alleviates secondary blood-brain barrier damage after traumatic brain injury in rats","volume":"1603","author":"Ge","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.ymthe.2019.11.017_bib65","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1038\/srep06718","article-title":"miR-21 improves the neurological outcome after traumatic brain injury in rats","volume":"4","author":"Ge","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2019.11.017_bib66","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ymthe.2019.11.017_bib67","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature23282","article-title":"Hypothalamic stem cells control ageing speed partly through exosomal miRNAs","volume":"548","author":"Zhang","year":"2017","journal-title":"Nature"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001619305350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001619305350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:55:40Z","timestamp":1761501340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001619305350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S1525001619305350"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2019.11.017","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Microglial Exosomal miR-124-3p Alleviates Neurodegeneration and Improves Cognitive Outcome after rmTBI","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2019.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}