{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:12:09Z","timestamp":1791234729421,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":372,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.ymthe.2020.03.011","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:54:17Z","timestamp":1584622457000},"page":"1731-1740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium"],"prefix":"10.1016","volume":"28","author":[{"given":"Johanna","family":"L\u00e4hteenvuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli-Pekka","family":"H\u00e4tinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Kuivanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenni","family":"Huusko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Paananen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"L\u00e4hteenvuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jussi","family":"Nurro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja","family":"Hedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Hartikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihay","family":"Laham-Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"M\u00e4kinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"R\u00e4s\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Alitalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Rosenzweig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Yl\u00e4-Herttuala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2020.03.011_bib1","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1161\/01.CIR.101.16.1960","article-title":"Relationship between regional cardiac hyperinnervation and ventricular arrhythmia","volume":"101","author":"Cao","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2020.03.011_bib2","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.hrthm.2006.02.005","article-title":"Spatial distribution of nerve sprouting after myocardial infarction in mice","volume":"3","author":"Oh","year":"2006","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.ymthe.2020.03.011_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0008-6363(00)00308-4","article-title":"Sympathetic nerve sprouting, electrical remodeling and the mechanisms of sudden cardiac death","volume":"50","author":"Chen","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.ymthe.2020.03.011_bib4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nm1570","article-title":"Sema3a maintains normal heart rhythm through sympathetic innervation patterning","volume":"13","author":"Ieda","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2020.03.011_bib5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/01.RES.0000133678.22968.e3","article-title":"Mechanisms of cardiac nerve sprouting after myocardial infarction in dogs","volume":"95","author":"Zhou","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2020.03.011_bib6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ceb.2008.12.012","article-title":"VEGFs and receptors involved in angiogenesis versus lymphangiogenesis","volume":"21","author":"Lohela","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.ymthe.2020.03.011_bib7","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1161\/CIRCULATIONAHA.108.816454","article-title":"Vascular endothelial growth factor-B induces myocardium-specific angiogenesis and arteriogenesis via vascular endothelial growth factor receptor-1- and neuropilin receptor-1-dependent mechanisms","volume":"119","author":"L\u00e4hteenvuo","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2020.03.011_bib8","doi-asserted-by":"crossref","first-page":"17272","DOI":"10.1073\/pnas.1407227111","article-title":"VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions","volume":"111","author":"Guaiquil","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.03.011_bib9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ydbio.2005.10.016","article-title":"Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration","volume":"289","author":"Sun","year":"2006","journal-title":"Dev. Biol."},{"key":"10.1016\/j.ymthe.2020.03.011_bib10","doi-asserted-by":"crossref","first-page":"E5944","DOI":"10.1073\/pnas.1510245112","article-title":"VEGF-B-Neuropilin-1 signaling is spatiotemporally indispensable for vascular and neuronal development in zebrafish","volume":"112","author":"Jensen","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.03.011_bib11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/emmm.201303147","article-title":"VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart","volume":"6","author":"Kivel\u00e4","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2020.03.011_bib12","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1073\/pnas.83.10.3537","article-title":"Growth-associated protein, GAP-43, a polypeptide that is induced when neurons extend axons, is a component of growth cones and corresponds to pp46, a major polypeptide of a subcellular fraction enriched in growth cones","volume":"83","author":"Meiri","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.03.011_bib13","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1161\/CIRCULATIONAHA.110.957332","article-title":"Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation","volume":"122","author":"Bry","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2020.03.011_bib14","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJM198709243171302","article-title":"Ventricular arrhythmias in patients with hypertensive left ventricular hypertrophy","volume":"317","author":"McLenachan","year":"1987","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2020.03.011_bib15","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCRESAHA.108.180679","article-title":"Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart","volume":"103","author":"Tadimalla","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2020.03.011_bib16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1423-0127-21-27","article-title":"The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed","volume":"21","author":"Alavian","year":"2014","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.ymthe.2020.03.011_bib17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.neulet.2007.06.041","article-title":"Nurr1 is phosphorylated by ERK2 in\u00a0vitro and its phosphorylation upregulates tyrosine hydroxylase expression in SH-SY5Y cells","volume":"423","author":"Zhang","year":"2007","journal-title":"Neurosci. Lett."},{"issue":"Pt B","key":"10.1016\/j.ymthe.2020.03.011_bib18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.nbd.2016.07.009","article-title":"Unconventional neurotrophic factors CDNF and MANF: structure, physiological functions and therapeutic potential","volume":"97","author":"Lindahl","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.ymthe.2020.03.011_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.yjmcc.2013.09.018","article-title":"Roles for ATF6 and the sarco\/endoplasmic reticulum protein quality control system in the heart","volume":"71","author":"Glembotski","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.ymthe.2020.03.011_bib20","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1161\/ATVBAHA.109.191163","article-title":"NR4A orphan nuclear receptors: transcriptional regulators of gene expression in metabolism and vascular biology","volume":"30","author":"Zhao","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ymthe.2020.03.011_bib21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nature10284","article-title":"Direct generation of functional dopaminergic neurons from mouse and human fibroblasts","volume":"476","author":"Caiazzo","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2020.03.011_bib22","doi-asserted-by":"crossref","first-page":"25893","DOI":"10.1074\/jbc.M112.356345","article-title":"Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco\/endoplasmic reticulum calcium depletion","volume":"287","author":"Glembotski","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2020.03.011_bib23","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/j.1471-4159.2006.03829.x","article-title":"Neuropilin1 is a direct downstream target of Nurr1 in the developing brain stem","volume":"97","author":"Hermanson","year":"2006","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.ymthe.2020.03.011_bib24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature11464","article-title":"Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes","volume":"490","author":"Hagberg","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2020.03.011_bib25","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1161\/CIRCRESAHA.108.178459","article-title":"Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy","volume":"103","author":"Karpanen","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2020.03.011_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1161\/01.CIR.104.3.358","article-title":"Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect","volume":"104","author":"Aase","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2020.03.011_bib27","doi-asserted-by":"crossref","first-page":"E29","DOI":"10.1161\/01.RES.86.2.e29","article-title":"Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia","volume":"86","author":"Bellomo","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2020.03.011_bib28","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1161\/01.RES.59.5.534","article-title":"Sympathetic innervation alters growth and intrinsic heart rate of fetal rat atria maturing in oculo","volume":"59","author":"Tucker","year":"1986","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2020.03.011_bib29","doi-asserted-by":"crossref","first-page":"13144","DOI":"10.1073\/pnas.1616168113","article-title":"VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection","volume":"113","author":"R\u00e4s\u00e4nen","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.03.011_bib30","doi-asserted-by":"crossref","first-page":"e13096","DOI":"10.14814\/phy2.13096","article-title":"Left ventricular remodeling leads to heart failure in mice with cardiac-specific overexpression of VEGF-B167: echocardiography and magnetic resonance imaging study","volume":"5","author":"Lottonen-Raikaslehto","year":"2017","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.ymthe.2020.03.011_bib31","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1161\/CIRCRESAHA.110.220855","article-title":"Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy","volume":"106","author":"Pepe","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2020.03.011_bib32","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1161\/CIRCULATIONAHA.118.036099","article-title":"Endothelial cells regulate physiological cardiomyocyte growth via VEGFR2-mediated paracrine signaling","volume":"139","author":"Kivel\u00e4","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2020.03.011_bib33","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1182\/blood.V97.6.1671","article-title":"Exogenous clustered neuropilin 1 enhances vasculogenesis and angiogenesis","volume":"97","author":"Yamada","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2020.03.011_bib34","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12872-016-0192-8","article-title":"Semaphorin 3A attenuates cardiac autonomic disorders and reduces inducible ventricular arrhythmias in rats with experimental myocardial infarction","volume":"16","author":"Hu","year":"2016","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.ymthe.2020.03.011_bib35","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.yjmcc.2010.10.008","article-title":"Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure","volume":"51","author":"Glembotski","year":"2011","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.ymthe.2020.03.011_bib36","first-page":"1365","article-title":"Angiogenic gene therapy in cardiovascular diseases: dream or vision?","volume":"38","author":"Yl\u00e4-Herttuala","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.ymthe.2020.03.011_bib37","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/mt.2008.258","article-title":"Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice","volume":"17","author":"Sallinen","year":"2009","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.03.011_bib38","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/heartjnl-2016-309373","article-title":"AdVEGF-B186 and AdVEGF-D\u0394N\u0394C induce angiogenesis and increase perfusion in porcine myocardium","volume":"102","author":"Nurro","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.ymthe.2020.03.011_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14814\/phy2.12639","article-title":"Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: development and validation of ECG analysis algorithm in mice","volume":"3","author":"Merentie","year":"2015","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.ymthe.2020.03.011_bib40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0021-9150(02)00130-2","article-title":"Patterns of oxidized epitopes, but not NF-\u03ba B expression, change during atherogenesis in WHHL rabbits","volume":"166","author":"Br\u00e4sen","year":"2003","journal-title":"Atherosclerosis"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001620301453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001620301453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:57:14Z","timestamp":1761501434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001620301453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S1525001620301453"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2020.03.011","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Susceptibility to Cardiac Arrhythmias and Sympathetic Nerve Growth in VEGF-B Overexpressing Myocardium","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2020.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2020.06.014","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}