{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:45:00Z","timestamp":1790675100871,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":368,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.ymthe.2020.09.010","type":"journal-article","created":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T07:26:46Z","timestamp":1599377206000},"page":"2442-2457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Lactate Induces Production of the tRNAHis Half to Promote B-lymphoblastic Cell Proliferation"],"prefix":"10.1016","volume":"28","author":[{"given":"Xiaohui","family":"Mo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7147-0953","authenticated-orcid":false,"given":"Qiliang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2020.09.010_bib1","doi-asserted-by":"crossref","first-page":"D93","DOI":"10.1093\/nar\/gkn787","article-title":"GtRNAdb: a database of transfer RNA genes detected in genomic sequence","volume":"37","author":"Chan","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2020.09.010_bib2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1101\/gad.1049103","article-title":"tRNA transfers to the limelight","volume":"17","author":"Hopper","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.ymthe.2020.09.010_bib3","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1126\/science.282.5396.2082","article-title":"Proofreading and aminoacylation of tRNAs before export from the nucleus","volume":"282","author":"Lund","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2020.09.010_bib4","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.cell.2005.04.029","article-title":"RNA degradation by the exosome is promoted by a nuclear polyadenylation complex","volume":"121","author":"LaCava","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2020.09.010_bib5","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1371\/journal.pbio.0030189","article-title":"A new yeast poly(A) polymerase complex involved in RNA quality control","volume":"3","author":"Van\u00e1cov\u00e1","year":"2005","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib6","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1073\/pnas.1206761110","article-title":"tRNA-derived microRNA modulates proliferation and the DNA damage response and is down-regulated in B cell lymphoma","volume":"110","author":"Maute","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.09.010_bib7","doi-asserted-by":"crossref","first-page":"E3816","DOI":"10.1073\/pnas.1510077112","article-title":"Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers","volume":"112","author":"Honda","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.09.010_bib8","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.4161\/rna.27177","article-title":"Slicing tRNAs to boost functional ncRNA diversity","volume":"10","author":"Gebetsberger","year":"2013","journal-title":"RNA Biol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/wrna.96","article-title":"Transfer RNA-derived fragments: origins, processing, and functions","volume":"2","author":"Sobala","year":"2011","journal-title":"Wiley Interdiscip. Rev. RNA"},{"key":"10.1016\/j.ymthe.2020.09.010_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.07.001","article-title":"Stressing out over tRNA cleavage","volume":"138","author":"Thompson","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2020.09.010_bib11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1083\/jcb.200811119","article-title":"The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae","volume":"185","author":"Thompson","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib12","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1128\/MCB.00136-14","article-title":"Angiogenin-cleaved tRNA halves interact with cytochrome c, protecting cells from apoptosis during osmotic stress","volume":"34","author":"Saikia","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/genes9050246","article-title":"tRNA-Derived Small RNA: A Novel Regulatory Small Non-Coding RNA","volume":"9","author":"Li","year":"2018","journal-title":"Genes"},{"key":"10.1016\/j.ymthe.2020.09.010_bib14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s13402-019-00426-2","article-title":"Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma","volume":"42","author":"Afonso","year":"2019","journal-title":"Cell Oncol. (Dordr.)"},{"key":"10.1016\/j.ymthe.2020.09.010_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.trsl.2011.08.008","article-title":"Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma","volume":"159","author":"Schaefer","year":"2012","journal-title":"Transl. Res."},{"key":"10.1016\/j.ymthe.2020.09.010_bib16","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.pathol.1.110304.100209","article-title":"Spectrum of Epstein-Barr virus-associated diseases","volume":"1","author":"Kutok","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib17","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1128\/JVI.80.5.2548-2565.2006","article-title":"Virus and cell RNAs expressed during Epstein-Barr virus replication","volume":"80","author":"Yuan","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib18","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1128\/JVI.01180-16","article-title":"Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1","volume":"90","author":"Martin","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib19","doi-asserted-by":"crossref","first-page":"7291","DOI":"10.1158\/0008-5472.CAN-11-1715","article-title":"IKK\u03b2 and NF-\u03baB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1","volume":"71","author":"Sommermann","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2020.09.010_bib20","doi-asserted-by":"crossref","first-page":"e00033-18","DOI":"10.1128\/JVI.00033-18","article-title":"Lactic Acid Downregulates Viral MicroRNA To Promote Epstein-Barr Virus-Immortalized B Lymphoblastic Cell Adhesion and Growth","volume":"92","author":"Mo","year":"2018","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4161\/rna.8.1.14300","article-title":"Deep-sequencing of human Argonaute-associated small RNAs provides insight into miRNA sorting and reveals Argonaute association with RNA fragments of diverse origin","volume":"8","author":"Burroughs","year":"2011","journal-title":"RNA Biol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib22","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1093\/nar\/gku137","article-title":"Novel functional small RNAs are selectively loaded onto mammalian Ago1","volume":"42","author":"Yamakawa","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2020.09.010_bib23","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature08170","article-title":"Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps","volume":"460","author":"Chi","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2020.09.010_bib24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/nar\/gku1242","article-title":"Assessing the gene regulatory properties of Argonaute-bound small RNAs of diverse genomic origin","volume":"43","author":"Thomson","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2020.09.010_bib25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.cell.2012.05.017","article-title":"The structure of human argonaute-2 in complex with miR-20a","volume":"150","author":"Elkayam","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2020.09.010_bib26","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2217\/fon-2017-0490","article-title":"miRNA-20a upregulates TAK1 and increases proliferation in osteosarcoma cells","volume":"14","author":"Yuan","year":"2018","journal-title":"Future Oncol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib27","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.biopha.2018.04.165","article-title":"MiRNA-20a-5p promotes the growth of triple-negative breast cancer cells through targeting RUNX3","volume":"103","author":"Bai","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ymthe.2020.09.010_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fcimb.2016.00134","article-title":"microRNA-20a Inhibits Autophagic Process by Targeting ATG7 and ATG16L1 and Favors Mycobacterial Survival in Macrophage Cells","volume":"6","author":"Guo","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cellsig.2018.06.003","article-title":"MiR-20a-3p regulates TGF-\u03b21\/Survivin pathway to affect keratinocytes proliferation and apoptosis by targeting SFMBT1 in\u00a0vitro","volume":"49","author":"Li","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ymthe.2020.09.010_bib30","doi-asserted-by":"crossref","first-page":"E3816","DOI":"10.1073\/pnas.1510077112","article-title":"Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers","volume":"112","author":"Honda","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.09.010_bib31","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/cbdd.12994","article-title":"tRF-Leu-CAG promotes cell proliferation and cell cycle in non-small cell lung cancer","volume":"90","author":"Shao","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.ymthe.2020.09.010_bib32","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.molcel.2011.06.022","article-title":"Angiogenin-induced tRNA fragments inhibit translation initiation","volume":"43","author":"Ivanov","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ymthe.2020.09.010_bib33","doi-asserted-by":"crossref","first-page":"42744","DOI":"10.1074\/jbc.M510356200","article-title":"Starvation-induced cleavage of the tRNA anticodon loop in Tetrahymena thermophila","volume":"280","author":"Lee","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2020.09.010_bib34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.febslet.2008.12.043","article-title":"Stress induces tRNA cleavage by angiogenin in mammalian cells","volume":"583","author":"Fu","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ymthe.2020.09.010_bib35","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1101\/gad.1837609","article-title":"A novel class of small RNAs: tRNA-derived RNA fragments (tRFs)","volume":"23","author":"Lee","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.ymthe.2020.09.010_bib36","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.molbiopara.2010.02.003","article-title":"A population of tRNA-derived small RNAs is actively produced in Trypanosoma cruzi and recruited to specific cytoplasmic granules","volume":"171","author":"Garcia-Silva","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib37","first-page":"1578","article-title":"Hypoxia-induced up-regulation of angiogenin in human malignant melanoma","volume":"59","author":"Hartmann","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2020.09.010_bib38","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1093\/ndt\/gfl041","article-title":"Hypoxic conditions stimulate the production of angiogenin and vascular endothelial growth factor by human renal proximal tubular epithelial cells in culture","volume":"21","author":"Nakamura","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.ymthe.2020.09.010_bib39","first-page":"27","article-title":"tRNA-Derived Short Non-coding RNA as Interacting Partners of Argonaute Proteins","volume":"9","author":"Shigematsu","year":"2015","journal-title":"Gene Regul. Syst. Bio."},{"key":"10.1016\/j.ymthe.2020.09.010_bib40","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1261\/rna.066126.118","article-title":"tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer independent manner","volume":"24","author":"Kuscu","year":"2018","journal-title":"RNA"},{"key":"10.1016\/j.ymthe.2020.09.010_bib41","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1261\/rna.1560209","article-title":"SNPs in human miRNA genes affect biogenesis and function","volume":"15","author":"Sun","year":"2009","journal-title":"RNA"},{"key":"10.1016\/j.ymthe.2020.09.010_bib42","doi-asserted-by":"crossref","first-page":"e1003750","DOI":"10.1371\/journal.ppat.1003750","article-title":"A unique SUMO-2-interacting motif within LANA is essential for KSHV latency","volume":"9","author":"Cai","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.ymthe.2020.09.010_bib43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.200811106","article-title":"Angiogenin cleaves tRNA and promotes stress-induced translational repression","volume":"185","author":"Yamasaki","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2020.09.010_bib44","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.15252\/embj.201488641","article-title":"Genome-wide identification of miR-200 targets reveals a regulatory network controlling cell invasion","volume":"33","author":"Bracken","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.ymthe.2020.09.010_bib45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nmeth.1314","article-title":"SUnSET, a nonradioactive method to monitor protein synthesis","volume":"6","author":"Schmidt","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.ymthe.2020.09.010_bib46","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1016\/j.celrep.2019.02.106","article-title":"Viral-Mediated AURKB Cleavage Promotes Cell Segregation and Tumorigenesis","volume":"26","author":"Zhu","year":"2019","journal-title":"Cell Rep."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001620304676?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001620304676?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T17:58:13Z","timestamp":1761501493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001620304676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S1525001620304676"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2020.09.010","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactate Induces Production of the tRNAHis Half to Promote B-lymphoblastic Cell Proliferation","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2020.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}