{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:48:15Z","timestamp":1792446495222,"version":"4.5.0"},"reference-count":154,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1105404"],"award-info":[{"award-number":["2018YFC1105404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473145"],"award-info":[{"award-number":["81473145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.ymthe.2020.11.030","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T21:25:41Z","timestamp":1606944341000},"page":"13-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":720,"title":["Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms"],"prefix":"10.1016","volume":"29","author":[{"given":"Haseeb Anwar","family":"Dad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Wei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao-Qing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9763-383X","authenticated-orcid":false,"given":"Li-Hua","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2020.11.030_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib2","doi-asserted-by":"crossref","first-page":"eaba2735","DOI":"10.1126\/sciadv.aba2735","article-title":"Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL-programmed therapy against melanoma","volume":"6","author":"Peng","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2020.11.030_bib3","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/acs.chemrev.7b00534","article-title":"New technologies for analysis of extracellular vesicles","volume":"118","author":"Shao","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.ymthe.2020.11.030_bib4","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1083\/jcb.97.2.329","article-title":"Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes","volume":"97","author":"Harding","year":"1983","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in\u00a0vitro: selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2020.11.030_bib6","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/oxfordjournals.aob.a084221","article-title":"Membrane systems associated with the plasmalemma of plant cells","volume":"32","author":"Marchant","year":"1968","journal-title":"Ann. Bot."},{"key":"10.1016\/j.ymthe.2020.11.030_bib7","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0022-5320(67)80128-X","article-title":"Ultrastructural changes during growth and embryogenesis in carrot cell cultures","volume":"18","author":"Halperin","year":"1967","journal-title":"J.\u00a0Ultrastruct. Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/IJN.S596","article-title":"Drug delivery and nanoparticles: applications and hazards","volume":"3","author":"De Jong","year":"2008","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ymthe.2020.11.030_bib9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/mt.2015.188","article-title":"Grapefruit-derived nanovectors delivering therapeutic miR17 through an intranasal route inhibit brain tumor progression","volume":"24","author":"Zhuang","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4161\/psb.2.1.3596","article-title":"Do plant cells secrete exosomes derived from multivesicular bodies?","volume":"2","author":"An","year":"2007","journal-title":"Plant Signal. Behav."},{"key":"10.1016\/j.ymthe.2020.11.030_bib11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jnutbio.2014.12.002","article-title":"Effective detection and quantification of dietetically absorbed plant microRNAs in human plasma","volume":"26","author":"Liang","year":"2015","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.ymthe.2020.11.030_bib12","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.3390\/ijms20225695","article-title":"Extracellular vesicles\u2014connecting kingdoms","volume":"20","author":"Woith","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib13","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1021\/acs.jafc.8b06369","article-title":"Extracellular vesicles as vehicles for the delivery of food bioactives","volume":"67","author":"Reiner","year":"2019","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ymthe.2020.11.030_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fsufs.2019.00023","article-title":"Naturally occurring exosome vesicles as potential delivery vehicle for bioactive compounds","volume":"3","author":"Akuma","year":"2019","journal-title":"Front. Sustain. Food Syst."},{"key":"10.1016\/j.ymthe.2020.11.030_bib15","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1094\/Phyto-67-462","article-title":"Ultrastructure of cell-wall thickenings and paramural bodies induced by barley stripe mosaic virus","volume":"67","author":"McMullen","year":"1977","journal-title":"Phytopathology"},{"key":"10.1016\/j.ymthe.2020.11.030_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/BF02055774","article-title":"Cell wall structure in the xylem parenchyma of Cryptomeria","volume":"81","author":"Chafe","year":"1974","journal-title":"Protoplasma"},{"key":"10.1016\/j.ymthe.2020.11.030_bib17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1469-8137.1969.tb06446.x","article-title":"Vesicular involvement in differentiating plant vascular cells","volume":"68","author":"Robards","year":"1969","journal-title":"New Phytol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF01281026","article-title":"The morphology of multivesicular bodies in soybean protoplasts and their role in endocytosis","volume":"138","author":"Tanchak","year":"1987","journal-title":"Protoplasma"},{"key":"10.1016\/j.ymthe.2020.11.030_bib19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1111\/j.1462-5822.2006.00683.x","article-title":"Multivesicular bodies participate in a cell wall-associated defence response in barley leaves attacked by the pathogenic powdery mildew fungus","volume":"8","author":"An","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib20","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nature02076","article-title":"SNARE-protein-mediated disease resistance at the plant cell wall","volume":"425","author":"Collins","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2020.11.030_bib21","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/j.1365-313X.2008.03743.x","article-title":"Extracellular transport and integration of plant secretory proteins into pathogen-induced cell wall compartments","volume":"57","author":"Meyer","year":"2009","journal-title":"Plant J."},{"key":"10.1016\/j.ymthe.2020.11.030_bib22","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/j.febslet.2009.09.041","article-title":"Vesicular fractions of sunflower apoplastic fluids are associated with potential exosome marker proteins","volume":"583","author":"Regente","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ymthe.2020.11.030_bib23","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3389\/fpls.2018.00979","article-title":"Biogenesis and function of multivesicular bodies in plant immunity","volume":"9","author":"Li","year":"2018","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib24","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1093\/jxb\/erx355","article-title":"Plant extracellular vesicles are incorporated by a fungal pathogen and inhibit its growth","volume":"68","author":"Regente","year":"2017","journal-title":"J.\u00a0Exp. Bot."},{"key":"10.1016\/j.ymthe.2020.11.030_bib25","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/jxb\/erx319","article-title":"Plant exosomes: using an unconventional exit to prevent pathogen entry?","volume":"69","author":"Hansen","year":"2017","journal-title":"J.\u00a0Exp. Bot."},{"key":"10.1016\/j.ymthe.2020.11.030_bib26","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.aar4142","article-title":"Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes","volume":"360","author":"Cai","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2020.11.030_bib27","doi-asserted-by":"crossref","first-page":"4655","DOI":"10.1093\/jxb\/ery255","article-title":"Extracellular vesicles: a missing component in plant cell wall remodeling","volume":"69","author":"de la Canal","year":"2018","journal-title":"J.\u00a0Exp. Bot."},{"key":"10.1016\/j.ymthe.2020.11.030_bib28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.7150\/thno.18133","article-title":"Progress in exosome isolation techniques","volume":"7","author":"Li","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.ymthe.2020.11.030_bib29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ejps.2016.09.022","article-title":"Extracellular vesicles in food: experimental evidence of their secretion in grape fruits","volume":"98","author":"P\u00e9rez-Berm\u00fadez","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jplph.2018.07.006","article-title":"Protein biocargo of citrus fruit-derived vesicles reveals heterogeneous transport and extracellular vesicle populations","volume":"229","author":"Pocsfalvi","year":"2018","journal-title":"J.\u00a0Plant Physiol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib31","doi-asserted-by":"crossref","first-page":"e5186","DOI":"10.7717\/peerj.5186","article-title":"Identification of exosome-like nanoparticle-derived microRNAs from 11 edible fruits and vegetables","volume":"6","author":"Xiao","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.ymthe.2020.11.030_bib32","doi-asserted-by":"crossref","first-page":"20360","DOI":"10.3402\/jev.v2i0.20360","article-title":"Standardization of sample collection, isolation and analysis methods in extracellular vesicle research","volume":"2","author":"Witwer","year":"2013","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib33","doi-asserted-by":"crossref","first-page":"3.22.21","DOI":"10.1002\/0471143030.cb0322s30","article-title":"Isolation and characterization of exosomes from cell culture supernatants and biological fluids","volume":"30","author":"Th\u00e9ry","year":"2006","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib34","article-title":"Improved exosome isolation by sucrose gradient fractionation of ultracentrifuged crude exosome pellets","author":"Chiou","year":"2016","journal-title":"Protoc. Exch."},{"key":"10.1016\/j.ymthe.2020.11.030_bib35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1101\/pdb.top074476","article-title":"Strategies for isolation of exosomes","volume":"2015","author":"Zeringer","year":"2015","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.ymthe.2020.11.030_bib36","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1002\/mnfr.201500222","article-title":"Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models","volume":"59","author":"Arntz","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2015.10.020","article-title":"Bovine milk-derived exosomes for drug delivery","volume":"371","author":"Munagala","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ymthe.2020.11.030_bib38","doi-asserted-by":"crossref","first-page":"29509","DOI":"10.3402\/jev.v4.29509","article-title":"High-speed centrifugation induces aggregation of extracellular vesicles","volume":"4","author":"Linares","year":"2015","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-1-4939-2562-9_5","article-title":"Large scale purification of RNA nanoparticles by preparative ultracentrifugation","volume":"1297","author":"Jasinski","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib40","doi-asserted-by":"crossref","first-page":"32945","DOI":"10.3402\/jev.v5.32945","article-title":"Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey","volume":"5","author":"Gardiner","year":"2016","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib41","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jconrel.2014.07.049","article-title":"Extracellular vesicles as drug delivery systems: lessons from the liposome field","volume":"195","author":"van der Meel","year":"2014","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2020.11.030_bib42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3390\/molecules22020277","article-title":"Resveratrol and grape extract-loaded solid lipid nanoparticles for the treatment of Alzheimer\u2019s disease","volume":"22","author":"Loureiro","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.ymthe.2020.11.030_bib43","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.plipres.2006.01.005","article-title":"Signaling functions of phosphatidic acid","volume":"45","author":"Wang","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib44","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.7150\/thno.30853","article-title":"Design strategies and application progress of therapeutic exosomes","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ymthe.2020.11.030_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/acsnano.6b07607","article-title":"Re-engineering extracellular vesicles as smart nanoscale therapeutics","volume":"11","author":"Armstrong","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.ymthe.2020.11.030_bib46","doi-asserted-by":"crossref","first-page":"14644","DOI":"10.1038\/s41598-018-32953-7","article-title":"Arrowtail RNA for ligand display on ginger exosome-like nanovesicles to systemic deliver siRNA for cancer suppression","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2020.11.030_bib47","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1080\/07388551.2020.1785385","article-title":"State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review","volume":"40","author":"Donoso-Quezada","year":"2020","journal-title":"Crit. Rev. Biotechnol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib48","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acs.chemmater.9b00050","article-title":"Surface engineering of extracellular vesicles through chemical and biological strategies","volume":"31","author":"Richardson","year":"2019","journal-title":"Chem. Mater."},{"key":"10.1016\/j.ymthe.2020.11.030_bib49","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/bc500291r","article-title":"Surface functionalization of exosomes using click chemistry","volume":"25","author":"Smyth","year":"2014","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.ymthe.2020.11.030_bib50","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.3390\/cancers11121979","article-title":"Engineered extracellular vesicles as a reliable tool in cancer nanomedicine","volume":"11","author":"Susa","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ymthe.2020.11.030_bib51","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1038\/ncomms2886","article-title":"Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids","volume":"4","author":"Wang","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2020.11.030_bib52","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.ymthe.2017.01.025","article-title":"Broccoli-derived nanoparticle inhibits mouse colitis by activating dendritic cell AMP-activated protein kinase","volume":"25","author":"Deng","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib53","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-pharmtox-010814-124630","article-title":"Therapeutic applications of extracellular vesicles: clinical promise and open questions","volume":"55","author":"Gy\u00f6rgy","year":"2015","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib54","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s12010-017-2478-4","article-title":"Curcumin encapsulated in milk exosomes resists human digestion and possesses enhanced intestinal permeability in\u00a0vitro","volume":"183","author":"Vashisht","year":"2017","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib55","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/aps.2017.12","article-title":"Engineering exosomes as refined biological nanoplatforms for drug delivery","volume":"38","author":"Luan","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ymthe.2020.11.030_bib56","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2014.11.029","article-title":"Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins","volume":"205","author":"Fuhrmann","year":"2015","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2020.11.030_bib57","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1038\/mt.2016.159","article-title":"Edible ginger-derived nano-lipids loaded with doxorubicin as a novel drug-delivery approach for colon cancer therapy","volume":"24","author":"Zhang","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib58","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.2217\/nnm-2017-0196","article-title":"Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis","volume":"12","author":"Zhang","year":"2017","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.ymthe.2020.11.030_bib59","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1807","article-title":"Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes","volume":"29","author":"Alvarez-Erviti","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib60","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1093\/nar\/gks463","article-title":"Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes","volume":"40","author":"Wahlgren","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib61","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1021\/acs.molpharmaceut.5b00364","article-title":"Exogenous DNA loading into extracellular vesicles via electroporation is size-dependent and enables limited gene delivery","volume":"12","author":"Lamichhane","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ymthe.2020.11.030_bib62","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/mt.2012.180","article-title":"Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells","volume":"21","author":"Ohno","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib63","doi-asserted-by":"crossref","first-page":"14888","DOI":"10.1073\/pnas.1408301111","article-title":"Quantitative and stoichiometric analysis of the microRNA content of exosomes","volume":"111","author":"Chevillet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.11.030_bib64","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1111\/j.1538-7836.2010.04074.x","article-title":"Optical and non-optical methods for detection and characterization of microparticles and exosomes","volume":"8","author":"van der Pol","year":"2010","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"10.1016\/j.ymthe.2020.11.030_bib65","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/mnfr.201300729","article-title":"Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles","volume":"58","author":"Mu","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib66","doi-asserted-by":"crossref","first-page":"e8577","DOI":"10.1371\/journal.pone.0008577","article-title":"Nanostructural and transcriptomic analyses of human saliva derived exosomes","volume":"5","author":"Palanisamy","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2020.11.030_bib67","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1021\/nn901824n","article-title":"Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy","volume":"4","author":"Sharma","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.ymthe.2020.11.030_bib68","doi-asserted-by":"crossref","first-page":"255102","DOI":"10.1088\/0957-4484\/25\/25\/255102","article-title":"High transfection efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-receptor synergistic targeting","volume":"25","author":"Zhang","year":"2014","journal-title":"Nanotechnology"},{"key":"10.1016\/j.ymthe.2020.11.030_bib69","doi-asserted-by":"crossref","first-page":"485104","DOI":"10.1088\/0957-4484\/23\/48\/485104","article-title":"Targeted quantum dots fluorescence probes functionalized with aptamer and peptide for transferrin receptor on tumor cells","volume":"23","author":"Zhang","year":"2012","journal-title":"Nanotechnology"},{"key":"10.1016\/j.ymthe.2020.11.030_bib70","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.1002\/smll.201300994","article-title":"Tracking the down-regulation of folate receptor-\u03b1 in cancer cells through target specific delivery of quantum dots coupled with antisense oligonucleotide and targeted peptide","volume":"9","author":"Zhang","year":"2013","journal-title":"Small"},{"key":"10.1016\/j.ymthe.2020.11.030_bib71","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-1-4939-3804-9_18","article-title":"Isolation of exosome-like vesicles from plants by ultracentrifugation on sucrose\/deuterium oxide (D2O) density cushions","volume":"1459","author":"Stanly","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib72","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3390\/ijms20020357","article-title":"Extracellular vesicles from fresh and dried plants\u2014simultaneous purification and visualization using gel electrophoresis","volume":"20","author":"Woith","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib73","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-1759(02)00330-7","article-title":"Production and characterization of clinical grade exosomes derived from dendritic cells","volume":"270","author":"Lamparski","year":"2002","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.ymthe.2020.11.030_bib74","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3389\/fphys.2018.01169","article-title":"Exosomes from human cardiac progenitor cells for therapeutic applications: development of a GMP-grade manufacturing method","volume":"9","author":"Andriolo","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib75","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jcyt.2017.01.001","article-title":"A Good Manufacturing Practice-grade standard protocol for exclusively human mesenchymal stromal cell-derived extracellular vesicles","volume":"19","author":"Pachler","year":"2017","journal-title":"Cytotherapy"},{"key":"10.1016\/j.ymthe.2020.11.030_bib76","doi-asserted-by":"crossref","first-page":"1442088","DOI":"10.1080\/20013078.2018.1442088","article-title":"Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15\/lactadherin complexes","volume":"7","author":"Watson","year":"2018","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib77","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1038\/s41598-018-21587-4","article-title":"Vesicle-based secretion in schistosomes: analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni","volume":"8","author":"Samoil","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2020.11.030_bib78","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib79","doi-asserted-by":"crossref","first-page":"28533","DOI":"10.3402\/jev.v4.28533","article-title":"Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content","volume":"4","author":"Smith","year":"2015","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib80","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1039\/C7NR08360B","article-title":"Technical challenges of working with extracellular vesicles","volume":"10","author":"Ramirez","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.ymthe.2020.11.030_bib81","doi-asserted-by":"crossref","first-page":"e0121184","DOI":"10.1371\/journal.pone.0121184","article-title":"Improved characterization of EV preparations based on protein to lipid ratio and lipid properties","volume":"10","author":"Osteikoetxea","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2020.11.030_bib82","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.bbamem.2016.12.005","article-title":"Characterization of extracellular vesicles by IR spectroscopy: fast and simple classification based on amide and CH stretching vibrations","volume":"1859","author":"Mih\u00e1ly","year":"2017","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.ymthe.2020.11.030_bib83","doi-asserted-by":"crossref","first-page":"1401897","DOI":"10.1080\/20013078.2017.1401897","article-title":"A subset of extracellular vesicles carries the bulk of microRNAs in commercial dairy cow\u2019s milk","volume":"6","author":"Benmoussa","year":"2017","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib84","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2019.02.029","article-title":"Reassessment of exosome composition","volume":"177","author":"Jeppesen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2020.11.030_bib85","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1039\/C5BM00583C","article-title":"From structures to functions: insights into exosomes as promising drug delivery vehicles","volume":"4","author":"Ren","year":"2016","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib86","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/mt.2013.64","article-title":"Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis","volume":"21","author":"Ju","year":"2013","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib87","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.biomaterials.2016.06.018","article-title":"Edible ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer","volume":"101","author":"Zhang","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ymthe.2020.11.030_bib88","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.chom.2018.10.001","article-title":"Plant-derived exosomal microRNAs shape the gut microbiota","volume":"24","author":"Teng","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ymthe.2020.11.030_bib89","doi-asserted-by":"crossref","first-page":"26913","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles","volume":"3","author":"L\u00f6tvall","year":"2014","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib90","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1182\/blood-2003-03-0871","article-title":"Lipid raft-associated protein sorting in exosomes","volume":"102","author":"de Gassart","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.ymthe.2020.11.030_bib91","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Th\u00e9ry","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib92","doi-asserted-by":"crossref","first-page":"E968","DOI":"10.1073\/pnas.1521230113","article-title":"Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes","volume":"113","author":"Kowal","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2020.11.030_bib93","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1104\/pp.16.01253","article-title":"Extracellular vesicles isolated from the leaf apoplast carry stress-response proteins","volume":"173","author":"Rutter","year":"2017","journal-title":"Plant Physiol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib94","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4161\/cam.5.2.15081","article-title":"Emerging role for ERM proteins in cell adhesion and migration","volume":"5","author":"Arpin","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"10.1016\/j.ymthe.2020.11.030_bib95","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1042\/BJ20111815","article-title":"Ubiquitin links to cytoskeletal dynamics, cell adhesion and migration","volume":"442","author":"Schaefer","year":"2012","journal-title":"Biochem. J."},{"key":"10.1016\/j.ymthe.2020.11.030_bib96","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1021\/acs.jafc.7b05614","article-title":"Isolation of exosome-like nanoparticles and analysis of microRNAs derived from coconut water based on small RNA high-throughput sequencing","volume":"66","author":"Zhao","year":"2018","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ymthe.2020.11.030_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.12.005","article-title":"Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis","volume":"318","author":"Zhao","year":"2020","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2020.11.030_bib98","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.apsb.2016.02.001","article-title":"Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges","volume":"6","author":"Ha","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ymthe.2020.11.030_bib99","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1758-907X-1-7","article-title":"microRNA as a new immune-regulatory agent in breast milk","volume":"1","author":"Kosaka","year":"2010","journal-title":"Silence"},{"key":"10.1016\/j.ymthe.2020.11.030_bib100","doi-asserted-by":"crossref","first-page":"118","DOI":"10.7150\/ijbs.8.118","article-title":"Immune-related microRNAs are abundant in breast milk exosomes","volume":"8","author":"Zhou","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib101","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/mc.20822","article-title":"MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals","volume":"51","author":"Parasramka","year":"2012","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.ymthe.2020.11.030_bib102","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1105\/tpc.18.00872","article-title":"Plant extracellular vesicles contain diverse small RNA species and are enriched in 10- to 17-nucleotide \u201ctiny\u201d RNAs","volume":"31","author":"Baldrich","year":"2019","journal-title":"Plant Cell"},{"key":"10.1016\/j.ymthe.2020.11.030_bib103","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2020.11.030_bib104","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/mt.2013.190","article-title":"Targeted drug delivery to intestinal macrophages by bioactive nanovesicles released from grapefruit","volume":"22","author":"Wang","year":"2014","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib105","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4161\/hv.22218","article-title":"Plant-derived virus-like particles as vaccines","volume":"9","author":"Chen","year":"2013","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.ymthe.2020.11.030_bib106","doi-asserted-by":"crossref","first-page":"e0216533","DOI":"10.1371\/journal.pone.0216533","article-title":"Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate\u2014two randomized phase II clinical trials in 18 to 49 and \u00b350 years old adults","volume":"14","author":"Pillet","year":"2019","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2020.11.030_bib107","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.molmed.2007.07.001","article-title":"From traditional Chinese medicine to rational cancer therapy","volume":"13","author":"Efferth","year":"2007","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.ymthe.2020.11.030_bib108","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.3390\/ijms20194687","article-title":"The role of exo-miRNAs in cancer: a focus on therapeutic and diagnostic applications","volume":"20","author":"Ingenito","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib109","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41417-019-0079-9","article-title":"Human marrow stromal cells secrete microRNA-375-containing exosomes to regulate glioma progression","volume":"27","author":"Deng","year":"2020","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib110","doi-asserted-by":"crossref","first-page":"9388","DOI":"10.1021\/acsami.6b16378","article-title":"Transdermal gene delivery by functional peptide-conjugated cationic gold nanoparticle reverses the progression and metastasis of cutaneous melanoma","volume":"9","author":"Niu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"Suppl 2","key":"10.1016\/j.ymthe.2020.11.030_bib111","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12864-017-3502-3","article-title":"Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi","volume":"18","author":"Liu","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.ymthe.2020.11.030_bib112","doi-asserted-by":"crossref","first-page":"19514","DOI":"10.18632\/oncotarget.4004","article-title":"Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death","volume":"6","author":"Raimondo","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.ymthe.2020.11.030_bib113","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature09637","article-title":"Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts","volume":"469","author":"Sato","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2020.11.030_bib114","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12010-018-2913-1","article-title":"In\u00a0vitro wound healing activity of wheat-derived nanovesicles","volume":"188","author":"\u015eahin","year":"2019","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib115","doi-asserted-by":"crossref","first-page":"28713","DOI":"10.3402\/jev.v4.28713","article-title":"Ginger-derived nanoparticles protect against alcohol-induced liver damage","volume":"4","author":"Zhuang","year":"2015","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2020.11.030_bib116","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/aps.2017.162","article-title":"Exosomes: new molecular targets of diseases","volume":"39","author":"Samanta","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.ymthe.2020.11.030_bib117","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1038\/s41598-017-05002-y","article-title":"Exosomes from metastatic cancer cells transfer amoeboid phenotype to non-metastatic cells and increase endothelial permeability: their emerging role in tumor heterogeneity","volume":"7","author":"Schillaci","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2020.11.030_bib118","series-title":"Application of Nanotechnology in Drug Delivery","first-page":"1","article-title":"Liposomes as potential drug carrier systems for drug delivery","author":"\u00c7a\u011fda\u015f","year":"2014"},{"key":"10.1016\/j.ymthe.2020.11.030_bib119","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jconrel.2020.03.023","article-title":"Transdermal siRNA delivery by pH-switchable micelles with targeting effect suppress skin melanoma progression","volume":"322","author":"Wang","year":"2020","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2020.11.030_bib120","doi-asserted-by":"crossref","first-page":"5772","DOI":"10.1021\/acs.molpharmaceut.8b00921","article-title":"Apple-derived nanoparticles modulate expression of organic-anion-transporting polypeptide (OATP) 2B1 in Caco-2 cells","volume":"15","author":"Fujita","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ymthe.2020.11.030_bib121","first-page":"81","article-title":"Development of liposomal formulations: from concept to clinical investigations","volume":"8","author":"Fan","year":"2013","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.ymthe.2020.11.030_bib122","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2016.02.021","article-title":"Sonoporation enhances liposome accumulation and penetration in tumors with low EPR","volume":"231","author":"Theek","year":"2016","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2020.11.030_bib123","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s13346-018-0583-8","article-title":"Influence of PEG coating on the biodistribution and tumor accumulation of pH-sensitive liposomes","volume":"9","author":"Nunes","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib124","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1517\/17425247.2012.720969","article-title":"Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents","volume":"9","author":"Garay","year":"2012","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ymthe.2020.11.030_bib125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jconrel.2013.07.026","article-title":"The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage","volume":"172","author":"Abu Lila","year":"2013","journal-title":"J.\u00a0Control. Release"},{"issue":"Pt A","key":"10.1016\/j.ymthe.2020.11.030_bib126","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.addr.2016.02.006","article-title":"Extracellular vesicles for drug delivery","volume":"106","author":"Vader","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1 Pt A","key":"10.1016\/j.ymthe.2020.11.030_bib127","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1016\/j.bbagen.2016.07.028","article-title":"Methods for the physical characterization and quantification of extracellular vesicles in biological samples","volume":"1861","author":"Rupert","year":"2017","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"key":"10.1016\/j.ymthe.2020.11.030_bib128","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1016\/j.bbamem.2014.07.026","article-title":"Examination of the specificity of tumor cell derived exosomes with tumor cells in\u00a0vitro","volume":"1838","author":"Smyth","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.ymthe.2020.11.030_bib129","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.trsl.2019.03.008","article-title":"Exosomes on the border of species and kingdom intercommunication","volume":"210","author":"Schuh","year":"2019","journal-title":"Transl. Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib130","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1158\/0008-5472.CAN-14-3095","article-title":"Grapefruit-derived nanovectors use an activated leukocyte trafficking pathway to deliver therapeutic agents to inflammatory tumor sites","volume":"75","author":"Wang","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib131","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/mt.2010.105","article-title":"A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes","volume":"18","author":"Sun","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2020.11.030_bib132","doi-asserted-by":"crossref","first-page":"9506","DOI":"10.1021\/acs.jafc.7b03123","article-title":"Small interfering RNA in milk exosomes is resistant to digestion and crosses the intestinal barrier in\u00a0vitro","volume":"65","author":"Shandilya","year":"2017","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.ymthe.2020.11.030_bib133","doi-asserted-by":"crossref","first-page":"9775","DOI":"10.1039\/C5OB01451D","article-title":"Differential detergent sensitivity of extracellular vesicle subpopulations","volume":"13","author":"Osteikoetxea","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.ymthe.2020.11.030_bib134","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nbt876","article-title":"Small-scale systems for in\u00a0vivo drug delivery","volume":"21","author":"LaVan","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib135","doi-asserted-by":"crossref","first-page":"18965","DOI":"10.1039\/D0NR03698F","article-title":"Outer membrane vesicles derived from E.\u00a0coli as novel vehicles for transdermal and tumor targeting delivery","volume":"12","author":"Gu","year":"2020","journal-title":"Nanoscale"},{"key":"10.1016\/j.ymthe.2020.11.030_bib136","doi-asserted-by":"crossref","first-page":"6179","DOI":"10.1016\/j.vaccine.2011.06.086","article-title":"Transcutaneous vaccines: novel advances in technology and delivery for overcoming the barriers","volume":"29","author":"Li","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2020.11.030_bib137","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3109\/10611869808995860","article-title":"Topical liposome targeting of dyes, melanins, genes, and proteins selectively to hair follicles","volume":"5","author":"Hoffman","year":"1998","journal-title":"J.\u00a0Drug Target."},{"key":"10.1016\/j.ymthe.2020.11.030_bib138","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.0022-202X.2004.22717.x","article-title":"Penetration profile of microspheres in follicular targeting of terminal hair follicles","volume":"123","author":"Toll","year":"2004","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib139","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ijpharm.2018.08.040","article-title":"Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA","volume":"550","author":"Lu","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ymthe.2020.11.030_bib140","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.nano.2013.06.007","article-title":"Antigen-loaded nanocarriers enhance the migration of stimulated Langerhans cells to draining lymph nodes and induce effective transcutaneous immunization","volume":"10","author":"Li","year":"2014","journal-title":"Nanomedicine (Lond.)"},{"key":"10.1016\/j.ymthe.2020.11.030_bib141","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1081\/LPR-120004787","article-title":"Follicular liposomal delivery systems","volume":"12","author":"Ciotti","year":"2002","journal-title":"J.\u00a0Liposome Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib142","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1038\/sj.jid.5700323","article-title":"Innovative liposomes as a transfollicular drug delivery system: penetration into porcine hair follicles","volume":"126","author":"Jung","year":"2006","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib143","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jare.2020.02.004","article-title":"Plant plasma membrane vesicles interaction with keratinocytes reveals their potential as carriers","volume":"23","author":"Yepes-Molina","year":"2020","journal-title":"J.\u00a0Adv. Res."},{"key":"10.1016\/j.ymthe.2020.11.030_bib144","doi-asserted-by":"crossref","first-page":"18628","DOI":"10.1021\/acsami.5b05065","article-title":"Cell membrane capsules for encapsulation of chemotherapeutic and cancer cell targeting in\u00a0vivo","volume":"7","author":"Peng","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ymthe.2020.11.030_bib145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2015.00286","article-title":"Advances and challenges of liposome assisted drug delivery","volume":"6","author":"Sercombe","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib146","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.foodres.2009.04.016","article-title":"Anti-inflammatory activity of naringin and the biosynthesised naringenin by naringinase immobilized in microstructured materials in a model of DSS-induced colitis in mice","volume":"42","author":"Amaro","year":"2009","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ymthe.2020.11.030_bib147","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1017\/S0007114512005594","article-title":"Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4\/NF-\u03baB signalling","volume":"110","author":"Dou","year":"2013","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.ymthe.2020.11.030_bib148","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nrg3763","article-title":"Non-viral vectors for gene-based therapy","volume":"15","author":"Yin","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.ymthe.2020.11.030_bib149","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2016.06.057","article-title":"Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity","volume":"103","author":"Peng","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ymthe.2020.11.030_bib150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ymthe.2020.11.030_bib151","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2017.09.019","article-title":"Cellular uptake of extracellular vesicles is mediated by clathrin-independent endocytosis and macropinocytosis","volume":"266","author":"Costa Verdera","year":"2017","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2020.11.030_bib152","doi-asserted-by":"crossref","first-page":"4727","DOI":"10.2147\/IJN.S168053","article-title":"Recent advances in \u201csmart\u201d delivery systems for extended drug release in cancer therapy","volume":"13","author":"Kalaydina","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ymthe.2020.11.030_bib153","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1016\/j.biomaterials.2014.03.062","article-title":"TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells","volume":"35","author":"Peng","year":"2014","journal-title":"Biomaterials"},{"key":"10.1016\/j.ymthe.2020.11.030_bib154","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.celrep.2013.10.019","article-title":"Hijacking multivesicular bodies enables long-term and exosome-mediated long-distance action of anthrax toxin","volume":"5","author":"Abrami","year":"2013","journal-title":"Cell Rep."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001620306560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001620306560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:32:13Z","timestamp":1791995533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001620306560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":154,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1525001620306560"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2020.11.030","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plant Exosome-like Nanovesicles: Emerging Therapeutics and Drug Delivery Nanoplatforms","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2020.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}