{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:42:02Z","timestamp":1792507322476,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773341"],"award-info":[{"award-number":["81773341"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073458"],"award-info":[{"award-number":["82073458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830096"],"award-info":[{"award-number":["81830096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772917"],"award-info":[{"award-number":["81772917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81620108024"],"award-info":[{"award-number":["81620108024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012176","name":"Project 211","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["B20017"],"award-info":[{"award-number":["B20017"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ymthe.2021.03.013","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T15:15:33Z","timestamp":1616080533000},"page":"2321-2334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":124,"title":["Inhibition of xCT suppresses the efficacy of anti-PD-1\/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization"],"prefix":"10.1016","volume":"29","author":[{"given":"Nian","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiangLin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoduan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeye","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianda","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-5490","authenticated-orcid":false,"given":"Cong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2021.03.013_bib1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The Emerging Hallmarks of Cancer Metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2021.03.013_bib2","doi-asserted-by":"crossref","first-page":"9533","DOI":"10.1073\/pnas.1814932116","article-title":"Cystine-glutamate antiporter xCT deficiency suppresses tumor growth while preserving antitumor immunity","volume":"116","author":"Arensman","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.013_bib3","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1158\/0008-5472.CAN-13-1803","article-title":"IGF-I regulates redox status in breast cancer cells by activating the amino acid transport molecule xC-","volume":"74","author":"Yang","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41389-018-0098-7","article-title":"Participation of xCT in melanoma cell proliferation in\u00a0vitro and tumorigenesis in\u00a0vivo","volume":"7","author":"Shin","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ymthe.2021.03.013_bib5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/s41419-018-0340-4","article-title":"Glucose metabolism and NRF2 coordinate the antioxidant response in melanoma resistant to MAPK inhibitors","volume":"9","author":"Khamari","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2021.03.013_bib6","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1158\/1078-0432.CCR-13-2805","article-title":"Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine\/glutamate exchanger SLC7A11","volume":"20","author":"Drayton","year":"2014","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccr.2013.08.020","article-title":"Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target","volume":"24","author":"Timmerman","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ymthe.2021.03.013_bib8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.7150\/ijbs.6475","article-title":"Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications","volume":"9","author":"Willard","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.ymthe.2021.03.013_bib9","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1172\/JCI81568","article-title":"RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation","volume":"126","author":"Jones","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2021.03.013_bib10","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1158\/0008-5472.CAN-17-0720","article-title":"Administering xCT Inhibitors Based on Circadian Clock Improves Antitumor Effects","volume":"77","author":"Okazaki","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib11","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1038\/sj.leu.2402238","article-title":"Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug","volume":"15","author":"Gout","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.ymthe.2021.03.013_bib12","doi-asserted-by":"crossref","first-page":"5951","DOI":"10.1038\/onc.2015.60","article-title":"Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion","volume":"34","author":"Sleire","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.ymthe.2021.03.013_bib13","first-page":"7","article-title":"Cancer Statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ymthe.2021.03.013_bib14","doi-asserted-by":"crossref","first-page":"4410","DOI":"10.2174\/1381612823666170710144759","article-title":"Targeting CD147 is a Novel Strategy for Antitumor Therapy","volume":"23","author":"Lian","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ymthe.2021.03.013_bib15","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ymthe.2021.03.013_bib16","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1016\/j.jid.2020.03.950","article-title":"TRAF6 activates fibroblasts to cancer-associated fibroblasts (CAFs) through FGF19 in tumor microenvironment to benefit the malignant phenotype of melanoma cells","volume":"140","author":"Guo","year":"2020","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.ymthe.2021.03.013_bib17","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nrclinonc.2017.43","article-title":"Targeted agents and immunotherapies: optimizing outcomes in melanoma","volume":"14","author":"Luke","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ymthe.2021.03.013_bib18","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/ni.3868","article-title":"Oxidative stress controls regulatory T\u00a0cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor","volume":"18","author":"Maj","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.ymthe.2021.03.013_bib19","doi-asserted-by":"crossref","first-page":"e1002309","DOI":"10.1371\/journal.pmed.1002309","article-title":"Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis","volume":"14","author":"Snyder","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.ymthe.2021.03.013_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature14404","article-title":"Melanoma-intrinsic \u03b2-catenin signalling prevents anti-tumour immunity","volume":"523","author":"Spranger","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.013_bib21","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.ctrv.2016.11.007","article-title":"Resistance to PD1\/PDL1 checkpoint inhibition","volume":"52","author":"O\u2019Donnell","year":"2017","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.ymthe.2021.03.013_bib22","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbcan.2017.10.007","article-title":"Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1\/PD-L1 agents","volume":"1869","author":"Santoni","year":"2018","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.ymthe.2021.03.013_bib23","doi-asserted-by":"crossref","first-page":"127ra37","DOI":"10.1126\/scitranslmed.3003689","article-title":"Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape","volume":"4","author":"Taube","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2021.03.013_bib24","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nrc3239","article-title":"The blockade of immune checkpoints in cancer immunotherapy","volume":"12","author":"Pardoll","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ymthe.2021.03.013_bib25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41589-018-0161-x","article-title":"HIP1R targets PD-L1 to lysosomal degradation to alter T\u00a0cell-mediated cytotoxicity","volume":"15","author":"Wang","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ymthe.2021.03.013_bib26","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ymthe.2021.03.013_bib27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13046-018-0897-x","article-title":"Vitexin compound 1, a novel extraction from a Chinese herb, suppresses melanoma cell growth through DNA damage by increasing ROS levels","volume":"37","author":"Liu","year":"2018","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib28","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1158\/0008-5472.CAN-18-3855","article-title":"Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses","volume":"79","author":"Daher","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib29","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1158\/0008-5472.CAN-15-2121","article-title":"The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(-)","volume":"76","author":"Tsuchihashi","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib30","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cell.2019.02.016","article-title":"Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory","volume":"177","author":"Poggio","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2021.03.013_bib31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12943-019-1074-3","article-title":"The role of exosomal PD-L1 in tumor progression and immunotherapy","volume":"18","author":"Xie","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.ymthe.2021.03.013_bib32","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.013_bib33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s13046-017-0511-7","article-title":"Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells","volume":"36","author":"Song","year":"2017","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib34","doi-asserted-by":"crossref","first-page":"289ra86","DOI":"10.1126\/scitranslmed.aaa8103","article-title":"SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma","volume":"7","author":"Robert","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2021.03.013_bib35","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1158\/2326-6066.CIR-14-0072","article-title":"VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapy","volume":"2","author":"Lines","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib36","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T\u00a0cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.013_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2021.03.013_bib38","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/2326-6066.CIR-18-0272","article-title":"Intracellular Activation of Complement C3 Leads to PD-L1 Antibody Treatment Resistance by Modulating Tumor-Associated Macrophages","volume":"7","author":"Zha","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib39","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature19834","article-title":"PI3K\u03b3 is a molecular switch that controls immune suppression","volume":"539","author":"Kaneda","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.013_bib40","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.tibs.2018.09.004","article-title":"Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy","volume":"43","author":"Zhang","year":"2018","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ymthe.2021.03.013_bib41","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2020.02.006","article-title":"ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis","volume":"37","author":"Liu","year":"2020","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ymthe.2021.03.013_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41389-018-0049-3","article-title":"Tumor-derived exosomes induce PD1+ macrophage population in human gastric cancer that promotes disease progression","volume":"7","author":"Wang","year":"2018","journal-title":"Oncogenesis"},{"key":"10.1016\/j.ymthe.2021.03.013_bib43","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ymthe.2017.11.016","article-title":"Hypoxic Lung-Cancer-Derived Extracellular Vesicle MicroRNA-103a Increases the Oncogenic Effects of Macrophages by Targeting PTEN","volume":"26","author":"Hsu","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2021.03.013_bib44","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41422-018-0060-4","article-title":"Exosomal PD-L1 harbors active defense function to suppress T\u00a0cell killing of breast cancer cells and promote tumor growth","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib45","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s40425-018-0452-5","article-title":"Tumor cell-released autophagosomes (TRAPs) promote immunosuppression through induction of M2-like macrophages with increased expression of PD-L1","volume":"6","author":"Wen","year":"2018","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.ymthe.2021.03.013_bib46","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.yexcr.2017.08.028","article-title":"Upregulation of PD-L1 by SPP1 mediates macrophage polarization and facilitates immune escape in lung adenocarcinoma","volume":"359","author":"Zhang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.ymthe.2021.03.013_bib47","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1073\/pnas.1612920114","article-title":"COX2\/mPGES1\/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells","volume":"114","author":"Prima","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.013_bib48","doi-asserted-by":"crossref","first-page":"11323","DOI":"10.1158\/0008-5472.CAN-06-1536","article-title":"A small interfering CD147-targeting RNA inhibited the proliferation, invasiveness, and metastatic activity of malignant melanoma","volume":"66","author":"Chen","year":"2006","journal-title":"Cancer Res."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001621001428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001621001428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:05:35Z","timestamp":1778616335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001621001428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1525001621001428"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.03.013","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of xCT suppresses the efficacy of anti-PD-1\/L1 melanoma treatment through exosomal PD-L1-induced macrophage M2 polarization","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}