{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T14:30:09Z","timestamp":1769956209170,"version":"3.49.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":371,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL111932"],"award-info":[{"award-number":["R01 HL111932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY003790"],"award-info":[{"award-number":["P30EY003790"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006022","name":"Saha Cardiovascular Research Center, University of Kentucky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ymthe.2021.03.014","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T15:15:14Z","timestamp":1616080514000},"page":"2281-2293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-2825","authenticated-orcid":false,"given":"Gopalan","family":"Gnanaguru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Wagschal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kahira L.","family":"Saez-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan E.","family":"Temel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Kleinman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders M.","family":"N\u00e4\u00e4r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia A.","family":"D\u2019Amore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2021.03.014_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12944-017-0647-7","article-title":"Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN","volume":"17","author":"Xu","year":"2018","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ymthe.2021.03.014_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1194\/jlr.R002238","article-title":"Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration","volume":"51","author":"Curcio","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib3","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1136\/bjophthalmol-2011-300344","article-title":"The oil spill in ageing Bruch membrane","volume":"95","author":"Curcio","year":"2011","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1167\/iovs.08-2373","article-title":"7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation","volume":"50","author":"Moreira","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2021.03.014_bib5","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1002\/humu.21577","article-title":"Evidence of association of APOE with age-related macular degeneration: a pooled analysis of 15 studies","volume":"32","author":"McKay","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.ymthe.2021.03.014_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40662-016-0063-5","article-title":"Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors","volume":"3","author":"Pennington","year":"2016","journal-title":"Eye Vis. (Lond.)"},{"key":"10.1016\/j.ymthe.2021.03.014_bib7","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1093\/hmg\/ddr270","article-title":"Common variants near FRK\/COL10A1 and VEGFA are associated with advanced age-related macular degeneration","volume":"20","author":"Yu","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.ymthe.2021.03.014_bib8","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1167\/iovs.10-7070","article-title":"Association of variants in the LIPC and ABCA1 genes with intermediate and large drusen and advanced age-related macular degeneration","volume":"52","author":"Yu","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2021.03.014_bib9","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1136\/bjophthalmol-2019-314813","article-title":"Diet patterns and the incidence of age-related macular degeneration in the Atherosclerosis Risk in Communities (ARIC) study","volume":"104","author":"Dighe","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib10","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1167\/iovs.07-0808","article-title":"ApoB100,LDLR-\/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina","volume":"49","author":"Bretillon","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2021.03.014_bib11","doi-asserted-by":"crossref","first-page":"11900","DOI":"10.1073\/pnas.0503015102","article-title":"Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration","volume":"102","author":"Malek","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.014_bib12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1076\/0271-3683(200001)2011-HFT008","article-title":"Pathologic changes in the retinal pigment epithelium and Bruch\u2019s membrane of fat-fed atherogenic mice","volume":"20","author":"Miceli","year":"2000","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib13","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1080\/02713683.2019.1694156","article-title":"Diet Mimicking \u201cFast Food\u201d Causes Structural Changes to the Retina Relevant to Age-Related Macular Degeneration","volume":"45","author":"Roddy","year":"2020","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib14","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1073\/pnas.1814014116","article-title":"Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice","volume":"116","author":"Landowski","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.014_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.preteyeres.2017.09.001","article-title":"Complement factor H in AMD: Bridging genetic associations and pathobiology","volume":"62","author":"Toomey","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuron.2012.06.018","article-title":"Mechanisms of age-related macular degeneration","volume":"75","author":"Ambati","year":"2012","journal-title":"Neuron"},{"issue":"10, Suppl","key":"10.1016\/j.ymthe.2021.03.014_bib17","first-page":"S172","article-title":"Review of neovascular age-related macular degeneration treatment options","volume":"25","author":"Holekamp","year":"2019","journal-title":"Am. J. Manag. Care"},{"key":"10.1016\/j.ymthe.2021.03.014_bib18","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ebiom.2016.01.033","article-title":"Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment","volume":"5","author":"Vavvas","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.ymthe.2021.03.014_bib19","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1136\/bjo.2005.085076","article-title":"High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture","volume":"90","author":"Ishida","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib20","doi-asserted-by":"crossref","first-page":"e45100","DOI":"10.7554\/eLife.45100","article-title":"Impaired ABCA1\/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration","volume":"8","author":"Storti","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.ymthe.2021.03.014_bib21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.exer.2017.09.008","article-title":"Regulated efflux of photoreceptor outer segment-derived cholesterol by human RPE cells","volume":"165","author":"Storti","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib22","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cmet.2013.03.009","article-title":"Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration","volume":"17","author":"Sene","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2021.03.014_bib23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature02871","article-title":"The functions of animal microRNAs","volume":"431","author":"Ambros","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.014_bib24","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.cell.2012.02.005","article-title":"MicroRNAs in stress signaling and human disease","volume":"148","author":"Mendell","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2021.03.014_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nrm3313","article-title":"MicroRNAs in metabolism and metabolic disorders","volume":"13","author":"Rottiers","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib26","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1101\/gad.12.19.3020","article-title":"Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in\u00a0vitro","volume":"12","author":"N\u00e4\u00e4r","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.ymthe.2021.03.014_bib27","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/19789","article-title":"Composite co-activator ARC mediates chromatin-directed transcriptional activation","volume":"398","author":"N\u00e4\u00e4r","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.014_bib28","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.cell.2011.09.045","article-title":"A conserved SREBP-1\/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans","volume":"147","author":"Walker","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2021.03.014_bib29","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1101\/gad.1901210","article-title":"Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid\/cholesterol regulator SREBP","volume":"24","author":"Walker","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.ymthe.2021.03.014_bib30","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature04942","article-title":"An ARC\/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis","volume":"442","author":"Yang","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.014_bib31","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.1189123","article-title":"MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis","volume":"328","author":"Najafi-Shoushtari","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2021.03.014_bib32","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nature10486","article-title":"Inhibition of miR-33a\/b in non-human primates raises plasma HDL and lowers VLDL triglycerides","volume":"478","author":"Rayner","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.03.014_bib33","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1172\/JCI57275","article-title":"Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis","volume":"121","author":"Rayner","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.ymthe.2021.03.014_bib34","doi-asserted-by":"crossref","first-page":"212ra162","DOI":"10.1126\/scitranslmed.3006840","article-title":"Pharmacological inhibition of a microRNA family in nonhuman primates by a seed-targeting 8-mer antimiR","volume":"5","author":"Rottiers","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ymthe.2021.03.014_bib35","doi-asserted-by":"crossref","first-page":"33652","DOI":"10.1074\/jbc.M110.152090","article-title":"Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation","volume":"285","author":"Gerin","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2021.03.014_bib36","doi-asserted-by":"crossref","first-page":"17321","DOI":"10.1073\/pnas.1008499107","article-title":"MicroRNA-33 encoded by an intron of sterol regulatory element-binding protein 2 (Srebp2) regulates HDL in\u00a0vivo","volume":"107","author":"Horie","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.014_bib37","doi-asserted-by":"crossref","first-page":"12228","DOI":"10.1073\/pnas.1005191107","article-title":"miR-33 links SREBP-2 induction to repression of sterol transporters","volume":"107","author":"Marquart","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.014_bib38","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1126\/science.1189862","article-title":"MiR-33 contributes to the regulation of cholesterol homeostasis","volume":"328","author":"Rayner","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2021.03.014_bib39","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1161\/ATVBAHA.113.301732","article-title":"Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-\/- mice--brief report","volume":"33","author":"Rotllan","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib40","doi-asserted-by":"crossref","first-page":"e003376","DOI":"10.1161\/JAHA.112.003376","article-title":"MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-\/- mice","volume":"1","author":"Horie","year":"2012","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.ymthe.2021.03.014_bib41","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1038\/nm.3980","article-title":"Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis","volume":"21","author":"Wagschal","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2021.03.014_bib42","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.cell.2020.09.017","article-title":"A MicroRNA Linking Human Positive Selection and Metabolic Disorders","volume":"183","author":"Wang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2021.03.014_bib43","doi-asserted-by":"crossref","first-page":"9232","DOI":"10.1073\/pnas.1102281108","article-title":"miR-33a\/b contribute to the regulation of fatty acid metabolism and insulin signaling","volume":"108","author":"D\u00e1valos","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.014_bib44","doi-asserted-by":"crossref","first-page":"26280","DOI":"10.1073\/pnas.1902292116","article-title":"The primate model for understanding and restoring vision","volume":"116","author":"Picaud","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.014_bib45","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1038\/s41598-017-14715-z","article-title":"In\u00a0Vivo Multimodal Imaging of Drusenoid Lesions in Rhesus Macaques","volume":"7","author":"Yiu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2021.03.014_bib46","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3390\/cells9020464","article-title":"Characterizing the Retinal Phenotype in the High-Fat Diet and Western Diet Mouse Models of Prediabetes","volume":"9","author":"Asare-Bediako","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ymthe.2021.03.014_bib47","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/nri3459","article-title":"Immunology of age-related macular degeneration","volume":"13","author":"Ambati","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib48","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1440-1827.2011.02695.x","article-title":"Macrophage polarization in the maculae of age-related macular degeneration: a pilot study","volume":"61","author":"Cao","year":"2011","journal-title":"Pathol. Int."},{"key":"10.1016\/j.ymthe.2021.03.014_bib49","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.preteyeres.2009.08.001","article-title":"Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins","volume":"28","author":"Curcio","year":"2009","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib50","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1167\/iovs.14-16274","article-title":"Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration","volume":"56","author":"Ach","year":"2015","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2021.03.014_bib51","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-1-4614-3209-8_25","article-title":"Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration","volume":"801","author":"Chan","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib52","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3109\/02713683.2015.1109129","article-title":"Retinal Pigment Epithelial Cell Apoptosis is Influenced by a Combination of Macrophages and Soluble Mediators Present in Age-Related Macular Degeneration","volume":"41","author":"Devarajan","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib53","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/IIO.0000000000000073","article-title":"Inflammatory Mechanisms of Age-related Macular Degeneration","volume":"55","author":"Knickelbein","year":"2015","journal-title":"Int. Ophthalmol. Clin."},{"key":"10.1016\/j.ymthe.2021.03.014_bib54","first-page":"802059","article-title":"Lipids, lipoproteins, and age-related macular degeneration","volume":"2011","author":"Ebrahimi","year":"2011","journal-title":"J.\u00a0Lipids"},{"key":"10.1016\/j.ymthe.2021.03.014_bib55","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2147\/CIA.S2777","article-title":"Age-related macular degeneration and the aging eye","volume":"3","author":"Ehrlich","year":"2008","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.ymthe.2021.03.014_bib56","doi-asserted-by":"crossref","first-page":"211","DOI":"10.15252\/emmm.201404524","article-title":"Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration","volume":"7","author":"Levy","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.ymthe.2021.03.014_bib57","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/bjo.2009.165563","article-title":"Bruch\u2019s membrane and choroidal macrophages in early and advanced age-related macular degeneration","volume":"94","author":"Cherepanoff","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.ymthe.2021.03.014_bib58","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.ophtha.2017.03.042","article-title":"Mendelian Randomization Implicates High-Density Lipoprotein Cholesterol-Associated Mechanisms in Etiology of Age-Related Macular Degeneration","volume":"124","author":"Burgess","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ymthe.2021.03.014_bib59","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.ophtha.2010.07.009","article-title":"Serum lipid biomarkers and hepatic lipase gene associations with age-related macular degeneration","volume":"117","author":"Reynolds","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ymthe.2021.03.014_bib60","doi-asserted-by":"crossref","first-page":"18277","DOI":"10.1073\/pnas.1109703108","article-title":"Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration","volume":"108","author":"Johnson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.03.014_bib61","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1194\/jlr.M087361","article-title":"Directional ABCA1-mediated cholesterol efflux and apoB-lipoprotein secretion in the retinal pigment epithelium","volume":"59","author":"Lyssenko","year":"2018","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ymthe.2021.03.014_bib62","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1167\/iovs.08-2376","article-title":"Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile","volume":"50","author":"Wang","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2021.03.014_bib63","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1167\/iovs.15-18663","article-title":"Oxidized Lipoprotein Uptake Through the CD36 Receptor Activates the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells","volume":"57","author":"Gnanaguru","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2021.03.014_bib64","doi-asserted-by":"crossref","first-page":"20639","DOI":"10.1038\/srep20639","article-title":"Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis","volume":"6","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2021.03.014_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2012.06.003","article-title":"Novel method for the rapid isolation of RPE cells specifically for RNA extraction and analysis","volume":"102","author":"Xin-Zhao Wang","year":"2012","journal-title":"Exp. Eye Res."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500162100143X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S152500162100143X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:00:10Z","timestamp":1761501610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S152500162100143X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S152500162100143X"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.03.014","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.03.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}