{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:56:52Z","timestamp":1790787412659,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K19893"],"award-info":[{"award-number":["JP16K19893"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K17617"],"award-info":[{"award-number":["JP20K17617"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.ymthe.2021.05.015","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T16:52:22Z","timestamp":1621615942000},"page":"2920-2930","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-2307","authenticated-orcid":false,"given":"Yoshihiko","family":"Kakiuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-1253","authenticated-orcid":false,"given":"Shinji","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Kanaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8098-8263","authenticated-orcid":false,"given":"Kento","family":"Kumon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Tsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0329-5110","authenticated-orcid":false,"given":"Masashi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiaki","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoma","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-7571","authenticated-orcid":false,"given":"Yuki","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-0696","authenticated-orcid":false,"given":"Satoru","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Nishizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3610-8211","authenticated-orcid":false,"given":"Shunsuke","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4658-1050","authenticated-orcid":false,"given":"Hiroshi","family":"Tazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Urata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-6051","authenticated-orcid":false,"given":"Toshiyoshi","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2021.05.015_bib1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib2","doi-asserted-by":"crossref","first-page":"C29","DOI":"10.1152\/ajpcell.00280.2019","article-title":"Extracellular vesicles as biomarkers and therapeutic targets for cancer","volume":"318","author":"Urabe","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib3","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1080\/14686996.2019.1629835","article-title":"Latest advances in extracellular vesicles: From bench to bedside","volume":"20","author":"Yamamoto","year":"2019","journal-title":"Sci. Technol. Adv. Mater."},{"key":"10.1016\/j.ymthe.2021.05.015_bib4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/cas.12896","article-title":"Extracellular vesicle transfer of cancer pathogenic components","volume":"107","author":"Fujita","year":"2016","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ymthe.2021.05.015_bib5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41571-018-0036-9","article-title":"Extracellular vesicles in cancer\u2014Implications for future improvements in cancer care","volume":"15","author":"Xu","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature15756","article-title":"Tumour exosome integrins determine organotropic metastasis","volume":"527","author":"Hoshino","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.05.015_bib7","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/s41598-017-01731-2","article-title":"Labeling extracellular vesicles for nanoscale flow cytometry","volume":"7","author":"Morales-Kastresana","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2021.05.015_bib8","doi-asserted-by":"crossref","first-page":"1597603","DOI":"10.1080\/20013078.2019.1597603","article-title":"High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer","volume":"8","author":"Morales-Kastresana","year":"2019","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2021.05.015_bib9","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2021.05.015_bib10","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cell.2019.02.016","article-title":"Suppression of exosomal PD-L1 induces systemic anti-tumor immunity and memory","volume":"177","author":"Poggio","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2021.05.015_bib11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib12","doi-asserted-by":"crossref","first-page":"1703244","DOI":"10.1080\/20013078.2019.1703244","article-title":"Inhibiting extracellular vesicles formation and release: A review of EV inhibitors","volume":"9","author":"Catalano","year":"2019","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2021.05.015_bib13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1259\/0007-1285-26-305-234","article-title":"Whole body irradiation; radiobiology or medicine?","volume":"26","author":"Mole","year":"1953","journal-title":"Br. J. Radiol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib14","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1056\/NEJMoa1112824","article-title":"Immunologic correlates of the abscopal effect in a patient with melanoma","volume":"366","author":"Postow","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2021.05.015_bib15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nature14292","article-title":"Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer","volume":"520","author":"Twyman-Saint Victor","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.05.015_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrc.2018.6","article-title":"Using immunotherapy to boost the abscopal effect","volume":"18","author":"Ngwa","year":"2018","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ymthe.2021.05.015_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41571-018-0119-7","article-title":"Time to abandon single-site irradiation for inducing abscopal effects","volume":"16","author":"Brooks","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.omto.2018.10.005","article-title":"Abscopal effect in non-injected tumors achieved with cytokine-armed oncolytic adenovirus","volume":"11","author":"Havunen","year":"2018","journal-title":"Mol. Ther. Oncolytics"},{"key":"10.1016\/j.ymthe.2021.05.015_bib19","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3390\/cancers11040539","article-title":"Strategies to improve cancer immune checkpoint inhibitors efficacy, other than abscopal effect: A systematic review","volume":"11","author":"Longo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.ymthe.2021.05.015_bib20","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.ymthe.2020.01.003","article-title":"Immune modulation by telomerase-specific oncolytic adenovirus synergistically enhances antitumor efficacy with anti-PD1 antibody","volume":"28","author":"Kanaya","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2021.05.015_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1158\/1078-0432.CCR-1075-3","article-title":"Telomerase-specific replication-selective virotherapy for human cancer","volume":"10","author":"Kawashima","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.ymthe.2021.05.015_bib22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/mt.2009.262","article-title":"A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors","volume":"18","author":"Nemunaitis","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2021.05.015_bib23","doi-asserted-by":"crossref","first-page":"9339","DOI":"10.1158\/0008-5472.CAN-10-2333","article-title":"Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery","volume":"70","author":"Kuroda","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.ymthe.2021.05.015_bib24","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/ags3.12270","article-title":"Multidisciplinary oncolytic virotherapy for gastrointestinal cancer","volume":"3","author":"Fujiwara","year":"2019","journal-title":"Ann. Gastroenterol. Surg."},{"key":"10.1016\/j.ymthe.2021.05.015_bib25","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/SLA.0b013e3181deb69d","article-title":"In\u00a0vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy","volume":"251","author":"Kojima","year":"2010","journal-title":"Ann. Surg."},{"key":"10.1016\/j.ymthe.2021.05.015_bib26","doi-asserted-by":"crossref","first-page":"13109","DOI":"10.1073\/pnas.1221899110","article-title":"Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells","volume":"110","author":"Ramakrishnaiah","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.05.015_bib27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1128\/MMBR.00063-15","article-title":"Extracellular vesicles exploit viral entry routes for cargo delivery","volume":"80","author":"van Dongen","year":"2016","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.ymthe.2021.05.015_bib28","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41564-020-0740-y","article-title":"Exosome mimicry by a HAVCR1-NPC1 pathway of endosomal fusion mediates hepatitis A virus infection","volume":"5","author":"Costafreda","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib29","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1349-7006.2007.00665.x","article-title":"Establishment of biological and pharmacokinetic assays of telomerase-specific replication-selective adenovirus","volume":"99","author":"Hashimoto","year":"2008","journal-title":"Cancer Sci."},{"key":"10.1016\/j.ymthe.2021.05.015_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41571-019-0272-7","article-title":"Oncolysis without viruses\u2014Inducing systemic anticancer immune responses with local therapies","volume":"17","author":"Kepp","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ymthe.2021.05.015_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ymthe.2016.10.009","article-title":"Disruption of circulating extracellular vesicles as a novel therapeutic strategy against cancer metastasis","volume":"25","author":"Nishida-Aoki","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ymthe.2021.05.015_bib32","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.3390\/ijms20194684","article-title":"Challenges in exosome isolation and analysis in health and disease","volume":"20","author":"Ludwig","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ymthe.2021.05.015_bib33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.biotechadv.2012.08.008","article-title":"Exosomes for drug delivery\u2014A novel application for the mesenchymal stem cell","volume":"31","author":"Lai","year":"2013","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.ymthe.2021.05.015_bib34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2017.09.013","article-title":"Cancer-derived exosomes as a delivery platform of CRISPR\/Cas9 confer cancer cell tropism-dependent targeting","volume":"266","author":"Kim","year":"2017","journal-title":"J.\u00a0Control. Release"},{"key":"10.1016\/j.ymthe.2021.05.015_bib35","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.phrs.2016.07.006","article-title":"Modulation of tissue tropism and biological activity of exosomes and other extracellular vesicles: New nanotools for cancer treatment","volume":"111","author":"Kooijmans","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.ymthe.2021.05.015_bib36","first-page":"171","article-title":"Selectively replicating oncolytic adenoviruses combined with chemotherapy, radiotherapy, or molecular targeted therapy for treatment of human cancers","author":"Kuroda","year":"2014"},{"key":"10.1016\/j.ymthe.2021.05.015_bib37","doi-asserted-by":"crossref","first-page":"14177","DOI":"10.1038\/s41598-017-14717-x","article-title":"Liposome-encapsulated plasmid DNA of telomerase-specific oncolytic adenovirus with stealth effect on the immune system","volume":"7","author":"Aoyama","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2021.05.015_bib38","doi-asserted-by":"crossref","first-page":"5681","DOI":"10.7150\/thno.34824","article-title":"Heterologous and cross-species tropism of cancer-derived extracellular vesicles","volume":"9","author":"Garofalo","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.ymthe.2021.05.015_bib39","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/s41422-018-0060-4","article-title":"Exosomal PD-L1 harbors active defense function to suppress T\u00a0cell killing of breast cancer cells and promote tumor growth","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.ymthe.2021.05.015_bib40","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1093\/brain\/aww237","article-title":"Exosome secretion is a key pathway for clearance of pathological TDP-43","volume":"139","author":"Iguchi","year":"2016","journal-title":"Brain"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001621002677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001621002677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T01:19:41Z","timestamp":1739323181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001621002677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1525001621002677"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.05.015","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}