{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:53:02Z","timestamp":1792403582053,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1-18 IBS-329"],"award-info":[{"award-number":["1-18 IBS-329"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32GM108563"],"award-info":[{"award-number":["T32GM108563"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002651","name":"Barth Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008635","name":"University of Texas Health Science Center at San Antonio","doi-asserted-by":"publisher","award":["R01AG055747"],"award-info":[{"award-number":["R01AG055747"]}],"id":[{"id":"10.13039\/100008635","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671240"],"award-info":[{"award-number":["31671240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.ymthe.2021.06.007","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T23:54:03Z","timestamp":1623110043000},"page":"3498-3511","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction"],"prefix":"10.1016","volume":"29","author":[{"given":"Dandan","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Paul","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Rendon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2021.06.007_bib1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.119.040631","article-title":"Assessment and Treatment of Patients With Type 2 Myocardial Infarction and Acute Nonischemic Myocardial Injury","volume":"140","author":"DeFilippis","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.ymthe.2021.06.007_bib2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrcardio.2017.102","article-title":"New and revisited approaches to preserving the reperfused myocardium","volume":"14","author":"Kloner","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib3","doi-asserted-by":"crossref","first-page":"e004678","DOI":"10.1161\/CIRCOUTCOMES.118.004678","article-title":"Stopping \u03b2-Blockers After Myocardial Infarction: Not So Fast!","volume":"11","author":"Ko","year":"2018","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"10.1016\/j.ymthe.2021.06.007_bib4","doi-asserted-by":"crossref","first-page":"C33","DOI":"10.1152\/ajpcell.00243.2006","article-title":"Role of cardiolipin alterations in mitochondrial dysfunction and disease","volume":"292","author":"Chicco","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbalip.2016.08.003","article-title":"Regulation of autophagy by mitochondrial phospholipids in health and diseases","volume":"1862","author":"Hsu","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.ymthe.2021.06.007_bib6","first-page":"6","article-title":"Emerging roles of cardiolipin remodeling in mitochondrial dysfunction associated with diabetes, obesity, and cardiovascular diseases","volume":"24","author":"Shi","year":"2010","journal-title":"J.\u00a0Biomed. Res."},{"key":"10.1016\/j.ymthe.2021.06.007_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tibs.2011.09.003","article-title":"The complexity of cardiolipin in health and disease","volume":"37","author":"Claypool","year":"2012","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ymthe.2021.06.007_bib8","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1194\/jlr.R700018-JLR200","article-title":"Cardiolipin synthesis for the assembly of bacterial and mitochondrial membranes","volume":"49","author":"Schlame","year":"2008","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ymthe.2021.06.007_bib9","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/35036395","article-title":"Cardiolipin provides specificity for targeting of tBid to mitochondria","volume":"2","author":"Lutter","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib10","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nchembio727","article-title":"Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors","volume":"1","author":"Kagan","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib11","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1021\/bi7004015","article-title":"Alterations in myocardial cardiolipin content and composition occur at the very earliest stages of diabetes: a shotgun lipidomics study","volume":"46","author":"Han","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.ymthe.2021.06.007_bib12","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/FJC.0b013e31819b5461","article-title":"Cardiolipin remodeling in the heart","volume":"53","author":"Sparagna","year":"2009","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1161\/01.RES.0000109416.56608.64","article-title":"Decrease in mitochondrial complex I activity in ischemic\/reperfused rat heart: involvement of reactive oxygen species and cardiolipin","volume":"94","author":"Paradies","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.ymthe.2021.06.007_bib14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.cmet.2010.07.003","article-title":"Cardiolipin remodeling by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity","volume":"12","author":"Li","year":"2010","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2021.06.007_bib15","doi-asserted-by":"crossref","first-page":"6975","DOI":"10.1073\/pnas.1120043109","article-title":"Lysocardiolipin acyltransferase 1 (ALCAT1) controls mitochondrial DNA fidelity and biogenesis through modulation of MFN2 expression","volume":"109","author":"Li","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.06.007_bib16","doi-asserted-by":"crossref","first-page":"E647","DOI":"10.1152\/ajpendo.90761.2008","article-title":"ALCAT1 is a polyglycerophospholipid acyltransferase potently regulated by adenine nucleotide and thyroid status","volume":"296","author":"Cao","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.ymthe.2021.06.007_bib17","doi-asserted-by":"crossref","first-page":"e12941","DOI":"10.1111\/acel.12941","article-title":"Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson\u2019s diseases","volume":"18","author":"Song","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.ymthe.2021.06.007_bib18","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.2337\/db07-1781","article-title":"Mitochondrial networking protects beta-cells from nutrient-induced apoptosis","volume":"58","author":"Molina","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.ymthe.2021.06.007_bib19","doi-asserted-by":"crossref","first-page":"eaat5185","DOI":"10.1126\/scisignal.aat5185","article-title":"Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence","volume":"11","author":"Nishimura","year":"2018","journal-title":"Sci. Signal."},{"key":"10.1016\/j.ymthe.2021.06.007_bib20","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.bbrc.2017.12.012","article-title":"Calmodulin-dependent protein kinase II (CaMKII) mediates radiation-induced mitochondrial fission by regulating the phosphorylation of dynamin-related protein 1 (Drp1) at serine 616","volume":"495","author":"Bo","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ymthe.2021.06.007_bib21","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1073\/pnas.95.9.4882","article-title":"Protein-bound acrolein: potential markers for oxidative stress","volume":"95","author":"Uchida","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ymthe.2021.06.007_bib22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1056\/NEJMra0910283","article-title":"Hypoxia and inflammation","volume":"364","author":"Eltzschig","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2021.06.007_bib23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/ana.10176","article-title":"Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome","volume":"51","author":"Schlame","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib24","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1194\/jlr.M600551-JLR200","article-title":"Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure","volume":"48","author":"Sparagna","year":"2007","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ymthe.2021.06.007_bib25","doi-asserted-by":"crossref","first-page":"4493","DOI":"10.1128\/MCB.01092-12","article-title":"Ablation of ALCAT1 mitigates hypertrophic cardiomyopathy through effects on oxidative stress and mitophagy","volume":"32","author":"Liu","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib26","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/hep.27420","article-title":"ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis","volume":"61","author":"Wang","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.ymthe.2021.06.007_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/ajmg.a.20660","article-title":"X-linked cardioskeletal myopathy and neutropenia (Barth syndrome): an update","volume":"126A","author":"Barth","year":"2004","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.ymthe.2021.06.007_bib28","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0022-2275(20)32186-6","article-title":"Docosahexaenoic acid accumulates in cardiolipin and enhances HT-29 cell oxidant production","volume":"39","author":"Watkins","year":"1998","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.ymthe.2021.06.007_bib29","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/carcin\/bgi163","article-title":"The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes","volume":"26","author":"Ng","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.ymthe.2021.06.007_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-511X-5-2","article-title":"Selective remodeling of cardiolipin fatty acids in the aged rat heart","volume":"5","author":"Lee","year":"2006","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.ymthe.2021.06.007_bib31","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.freeradbiomed.2010.02.020","article-title":"Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging","volume":"48","author":"Paradies","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.ymthe.2021.06.007_bib32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.ceca.2009.03.012","article-title":"Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease","volume":"45","author":"Paradies","year":"2009","journal-title":"Cell Calcium"},{"key":"10.1016\/j.ymthe.2021.06.007_bib33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2021.06.007_bib34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.immuni.2013.08.001","article-title":"Mitochondrial cardiolipin is required for Nlrp3 inflammasome activation","volume":"39","author":"Iyer","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2021.06.007_bib35","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cmet.2005.05.003","article-title":"Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation","volume":"1","author":"Mansfield","year":"2005","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2021.06.007_bib36","doi-asserted-by":"crossref","first-page":"e000461","DOI":"10.1161\/JAHA.113.000461","article-title":"Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction","volume":"2","author":"Disatnik","year":"2013","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.ymthe.2021.06.007_bib37","doi-asserted-by":"crossref","first-page":"13189","DOI":"10.1038\/ncomms13189","article-title":"CaMKII induces permeability transition through Drp1 phosphorylation during chronic \u03b2-AR stimulation","volume":"7","author":"Xu","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2021.06.007_bib38","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","article-title":"Epidemiology and aetiology of heart failure","volume":"13","author":"Ziaeian","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ymthe.2021.06.007_bib39","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1001\/jama.2019.12843","article-title":"Effect of Sacubitril-Valsartan vs Enalapril on Aortic Stiffness in Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial","volume":"322","author":"Desai","year":"2019","journal-title":"JAMA"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001621003130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001621003130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:02:20Z","timestamp":1761501740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001621003130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S1525001621003130"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.06.007","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiolipin remodeling by ALCAT1 links hypoxia to coronary artery disease by promoting mitochondrial dysfunction","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2021.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}