{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:21:59Z","timestamp":1790882519124,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T00:00:00Z","timestamp":1680739200000},"content-version":"vor","delay-in-days":370,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001641","name":"Glaucoma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001641","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-20-036-01"],"award-info":[{"award-number":["RSG-20-036-01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["R01EY032159"],"award-info":[{"award-number":["R01EY032159"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ3742"],"award-info":[{"award-number":["2018JJ3742"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["CX001298"],"award-info":[{"award-number":["CX001298"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["R01EY025295"],"award-info":[{"award-number":["R01EY025295"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY028106"],"award-info":[{"award-number":["EY028106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY023295"],"award-info":[{"award-number":["EY023295"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY024932"],"award-info":[{"award-number":["EY024932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY031063"],"award-info":[{"award-number":["EY031063"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY026877"],"award-info":[{"award-number":["P30 EY026877"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015521","name":"Stanford Maternal and Child Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015521","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.ymthe.2022.01.035","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T11:56:42Z","timestamp":1643630202000},"page":"1421-1431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function"],"prefix":"10.1016","volume":"30","author":[{"given":"Fang","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-3956","authenticated-orcid":false,"given":"Haoliang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haowen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7980-1649","authenticated-orcid":false,"given":"Yang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2022.01.035_bib1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.ymthe.2022.01.035_bib2","first-page":"774","article-title":"Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis","volume":"36","author":"Quigley","year":"1995","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1371\/journal.pgen.0010004","article-title":"Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage","volume":"1","author":"Libby","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.ymthe.2022.01.035_bib4","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.200706181","article-title":"Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma","volume":"179","author":"Howell","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib5","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.neuro.051508.135728","article-title":"Under pressure: cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy","volume":"35","author":"Nickells","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib6","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2022.01.035_bib7","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1038\/nrdp.2016.67","article-title":"Primary open-angle glaucoma","volume":"2","author":"Weinreb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.ymthe.2022.01.035_bib8","doi-asserted-by":"crossref","first-page":"100953","DOI":"10.1016\/j.preteyeres.2021.100953","article-title":"Adaptive responses to neurodegenerative stress in glaucoma","author":"Calkins","year":"2021","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/ICU.0000000000000644","article-title":"Toward a new definition of glaucomatous optic neuropathy for clinical research","volume":"31","author":"Iyer","year":"2020","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/09286580500180572","article-title":"Primary open-angle glaucoma presentation at a tertiary unit in Africa: intraocular pressure levels and visual status","volume":"12","author":"Mafwiri","year":"2005","journal-title":"Ophthalmic Epidemiol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.exer.2010.09.005","article-title":"A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma","volume":"93","author":"Burgoyne","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exer.2017.02.005","article-title":"Biomechanical aspects of axonal damage in glaucoma: a brief review","volume":"157","author":"Stowell","year":"2017","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib13","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib14","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(14)62111-5","article-title":"Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial","volume":"385","author":"Garway-Heath","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ymthe.2022.01.035_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00055735-200304000-00006","article-title":"Collaborative normal tension glaucoma study","volume":"14","author":"Anderson","year":"2003","journal-title":"Curr. Opin. Ophthalmol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41433-019-0687-5","article-title":"Systematic reviews and randomised controlled trials on open angle glaucoma","volume":"34","author":"Wormald","year":"2020","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.ymthe.2022.01.035_bib17","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.expneurol.2012.01.014","article-title":"Intrinsic axonal degeneration pathways are critical for glaucomatous damage","volume":"246","author":"Howell","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.conb.2020.02.012","article-title":"The SARM1 axon degeneration pathway: control of the NAD(+) metabolome regulates axon survival in health and disease","volume":"63","author":"Figley","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.conb.2021.05.004","article-title":"SARM1 signaling mechanisms in the injured nervous system","volume":"69","author":"Sambashivan","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41583-020-0269-3","article-title":"Programmed axon degeneration: from mouse to mechanism to medicine","volume":"21","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1083\/jcb.200504028","article-title":"A local mechanism mediates NAD-dependent protection of axon degeneration","volume":"170","author":"Wang","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib22","doi-asserted-by":"crossref","first-page":"10093","DOI":"10.1073\/pnas.1508337112","article-title":"Local axonal protection by WldS as revealed by conditional regulation of protein stability","volume":"112","author":"Wang","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.ymthe.2022.01.035_bib23","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1126\/science.1258366","article-title":"SARM1 activation triggers axon degeneration locally via NAD(+) destruction","volume":"348","author":"Gerdts","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.01.035_bib24","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nn770","article-title":"Wallerian degeneration of injured axons and synapses is delayed by a Ube4b\/Nmnat chimeric gene","volume":"4","author":"Mack","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib25","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1523\/JNEUROSCI.1429-09.2009","article-title":"Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in\u00a0vivo","volume":"29","author":"Sasaki","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib26","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1460-9568.2008.06426.x","article-title":"The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model","volume":"28","author":"Beirowski","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fnins.2017.00232","article-title":"Nicotinamide and WLD(S) act together to prevent neurodegeneration in glaucoma","volume":"11","author":"Williams","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13024-021-00459-y","article-title":"Neuroprotection by Wld(S) depends on retinal ganglion cell type and age in glaucoma","volume":"16","author":"Risner","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.ymthe.2022.01.035_bib29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.01.035_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1167\/iovs.12-10861","article-title":"Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1","volume":"54","author":"Zhu","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib31","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M508660200","article-title":"Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms","volume":"280","author":"Berger","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.ymthe.2022.01.035_bib32","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4178-07.2008","article-title":"A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function","volume":"28","author":"Cahoy","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib33","doi-asserted-by":"crossref","first-page":"e1000300","DOI":"10.1371\/journal.pbio.1000300","article-title":"Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons","volume":"8","author":"Gilley","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib34","doi-asserted-by":"crossref","first-page":"13410","DOI":"10.1523\/JNEUROSCI.1534-13.2013","article-title":"Rescue of peripheral and CNS axon defects in mice lacking NMNAT2","volume":"33","author":"Gilley","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib35","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1002\/jnr.22498","article-title":"Overexpression of Wld(S) or Nmnat2 in mauthner cells by single-cell electroporation delays axon degeneration in live zebrafish","volume":"88","author":"Feng","year":"2010","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neuint.2009.09.007","article-title":"Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity","volume":"56","author":"Yan","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ymthe.2022.01.035_bib37","doi-asserted-by":"crossref","first-page":"e1002472","DOI":"10.1371\/journal.pbio.1002472","article-title":"NMNAT2:HSP90 complex mediates proteostasis in proteinopathies","volume":"14","author":"Ali","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib38","doi-asserted-by":"crossref","first-page":"e45881","DOI":"10.7554\/eLife.45881","article-title":"Silicone oil-induced ocular hypertension and glaucomatous neurodegeneration in mouse","volume":"8","author":"Zhang","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.ymthe.2022.01.035_bib39","article-title":"A reversible silicon oil-induced ocular hypertension model in mice","volume":"153","author":"Zhang","year":"2019","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.ymthe.2022.01.035_bib40","doi-asserted-by":"crossref","first-page":"9052","DOI":"10.1038\/s41598-021-88690-x","article-title":"Chronic mild and acute severe glaucomatous neurodegeneration derived from silicone oil-induced ocular hypertension","volume":"11","author":"Fang","year":"2021","journal-title":"Scientific Rep."},{"key":"10.1016\/j.ymthe.2022.01.035_bib41","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1523\/JNEUROSCI.0102-20.2020","article-title":"Mouse gamma-synuclein promoter-mediated gene expression and editing in mammalian retinal ganglion cells","volume":"40","author":"Wang","year":"2020","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib42","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.ymthe.2022.01.035_bib43","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.aac4854","article-title":"NAD(+) in aging, metabolism, and neurodegeneration","volume":"350","author":"Verdin","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.01.035_bib44","doi-asserted-by":"crossref","first-page":"e1001539","DOI":"10.1371\/journal.pbio.1001539","article-title":"Subcellular localization determines the stability and axon protective capacity of axon survival factor Nmnat2","volume":"11","author":"Milde","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib45","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.celrep.2013.04.013","article-title":"The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction","volume":"3","author":"Babetto","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2022.01.035_bib46","doi-asserted-by":"crossref","first-page":"e1001440","DOI":"10.1371\/journal.pbio.1001440","article-title":"The Highwire ubiquitin ligase promotes axonal degeneration by tuning levels of Nmnat protein","volume":"10","author":"Xiong","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib47","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.celrep.2016.09.043","article-title":"An atypical SCF-like ubiquitin ligase complex promotes Wallerian degeneration through regulation of axonal Nmnat2","volume":"17","author":"Yamagishi","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2022.01.035_bib48","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1038\/srep02567","article-title":"Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in\u00a0vivo","volume":"3","author":"Milde","year":"2013","journal-title":"Scientific Rep."},{"key":"10.1016\/j.ymthe.2022.01.035_bib49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.exer.2015.05.008","article-title":"Electrophysiological assessment of retinal ganglion cell function","volume":"141","author":"Porciatti","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib50","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1167\/iovs.14-13943","article-title":"Robust mouse pattern electroretinograms derived simultaneously from each eye using a common snout electrode","volume":"55","author":"Chou","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib51","doi-asserted-by":"crossref","first-page":"4611","DOI":"10.1167\/iovs.04-0541","article-title":"Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system","volume":"45","author":"Prusky","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib52","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1017\/S0952523805225166","article-title":"Independent visual threshold measurements in the two eyes of freely moving rats and mice using a virtual-reality optokinetic system","volume":"22","author":"Douglas","year":"2005","journal-title":"Vis. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib53","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1016\/j.visres.2006.02.025","article-title":"Perception of visual motion coherence by rats and mice","volume":"46","author":"Douglas","year":"2006","journal-title":"Vis. Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib54","doi-asserted-by":"crossref","first-page":"754651","DOI":"10.3389\/fncel.2021.754651","article-title":"Neuronal NMNAT2 overexpression does not achieve significant neuroprotection in experimental autoimmune encephalomyelitis\/optic neuritis","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib55","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neurobiolaging.2014.09.018","article-title":"Axonal transport declines with age in two distinct phases separated by a period of relative stability","volume":"36","author":"Milde","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.ymthe.2022.01.035_bib56","doi-asserted-by":"crossref","first-page":"112958","DOI":"10.1016\/j.expneurol.2019.112958","article-title":"Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia","volume":"320","author":"Huppke","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib57","doi-asserted-by":"crossref","first-page":"112961","DOI":"10.1016\/j.expneurol.2019.112961","article-title":"Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence","volume":"320","author":"Lukacs","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib58","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.celrep.2015.02.060","article-title":"Absence of SARM1 rescues development and survival of NMNAT2-deficient axons","volume":"10","author":"Gilley","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2022.01.035_bib59","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/ng.2361","article-title":"NMNAT1 mutations cause Leber congenital amaurosis","volume":"44","author":"Falk","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2022.01.035_bib60","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/ng.2357","article-title":"Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy","volume":"44","author":"Perrault","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2022.01.035_bib61","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ng.2356","article-title":"Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration","volume":"44","author":"Koenekoop","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2022.01.035_bib62","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/ng.2370","article-title":"Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis","volume":"44","author":"Chiang","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.ymthe.2022.01.035_bib63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1051\/medsci\/2013291008","article-title":"[Mutations in NMNAT1 cause Leber congenital amaurosis with severe macular and optic atrophy]","volume":"29","author":"Kaplan","year":"2013","journal-title":"Med. Sci. (Paris)"},{"key":"10.1016\/j.ymthe.2022.01.035_bib64","doi-asserted-by":"crossref","first-page":"e62027","DOI":"10.7554\/eLife.62027","article-title":"SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration","volume":"9","author":"Sasaki","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.ymthe.2022.01.035_bib65","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exer.2018.04.010","article-title":"NMNAT1 E257K variant, associated with Leber Congenital Amaurosis (LCA9), causes a mild retinal degeneration phenotype","volume":"173","author":"Eblimit","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib66","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neuron.2017.02.022","article-title":"The SARM1 toll\/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration","volume":"93","author":"Essuman","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2022.01.035_bib67","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1223899","article-title":"dSarm\/Sarm1 is required for activation of an injury-induced axon death pathway","volume":"337","author":"Osterloh","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.01.035_bib68","doi-asserted-by":"crossref","first-page":"13569","DOI":"10.1523\/JNEUROSCI.1197-13.2013","article-title":"Sarm1-mediated axon degeneration requires both SAM and TIR interactions","volume":"33","author":"Gerdts","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib69","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exer.2018.03.007","article-title":"Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury","volume":"171","author":"Fernandes","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib70","doi-asserted-by":"crossref","first-page":"e201912047","DOI":"10.1083\/jcb.201912047","article-title":"SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration","volume":"219","author":"Ko","year":"2020","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.ymthe.2022.01.035_bib71","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","article-title":"NAD(+) in brain aging and neurodegenerative disorders","volume":"30","author":"Lautrup","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.ymthe.2022.01.035_bib72","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.celrep.2016.08.073","article-title":"NAMPT-mediated NAD(+) biosynthesis is essential for vision in mice","volume":"17","author":"Lin","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.ymthe.2022.01.035_bib73","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.preteyeres.2018.06.002","article-title":"NAD(+) and sirtuins in retinal degenerative diseases: a look at future therapies","volume":"67","author":"Lin","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.ymthe.2022.01.035_bib74","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1523\/JNEUROSCI.3709-15.2016","article-title":"Rescue of glaucomatous neurodegeneration by differentially modulating neuronal endoplasmic reticulum stress molecules","volume":"36","author":"Yang","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib75","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/ncomms6416","article-title":"The mTORC1 effectors S6K1 and 4E-BP play different roles in\u00a0CNS axon regeneration","volume":"5","author":"Yang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2022.01.035_bib76","doi-asserted-by":"crossref","first-page":"e14908","DOI":"10.7554\/eLife.14908","article-title":"mTORC1 is necessary but mTORC2 and GSK3beta are inhibitory for AKT3-induced axon regeneration in the central nervous system","volume":"5","author":"Miao","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.ymthe.2022.01.035_bib77","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3389\/fncel.2020.00109","article-title":"Longitudinal morphological and functional assessment of RGC neurodegeneration after optic nerve crush in mouse","volume":"14","author":"Li","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ymthe.2022.01.035_bib78","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41419-018-1289-z","article-title":"AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration","volume":"10","author":"Huang","year":"2019","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2022.01.035_bib79","doi-asserted-by":"crossref","first-page":"e2936","DOI":"10.1038\/cddis.2017.329","article-title":"Neuroprotection by eIF2alpha-CHOP inhibition and XBP-1 activation in EAE\/optic neuritiss","volume":"8","author":"Huang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ymthe.2022.01.035_bib80","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41419-020-2303-9","article-title":"Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001622000740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001622000740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:02:27Z","timestamp":1761501747000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001622000740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":80,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["S1525001622000740"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2022.01.035","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NMNAT2 is downregulated in glaucomatous RGCs, and RGC-specific gene therapy rescues neurodegeneration and visual function","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2022.01.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The American Society of Gene and Cell Therapy.","name":"copyright","label":"Copyright"}]}}