{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:40:58Z","timestamp":1793724058847,"version":"4.6.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T00:00:00Z","timestamp":1644364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.ymthe.2022.02.011","type":"journal-article","created":{"date-parts":[[2022,2,10]],"date-time":"2022-02-10T02:18:24Z","timestamp":1644459504000},"page":"1913-1925","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform"],"prefix":"10.1016","volume":"30","author":[{"given":"Christopher","family":"Chevillard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Amen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Besson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalil","family":"Hannani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Dettling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Gout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe J.","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlyse","family":"Buisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Gallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphna","family":"Fenel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Vassal-Stermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Schoehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Poignard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Claire","family":"Dagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Fender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2022.02.011_bib1","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.immuni.2021.07.017","article-title":"Accelerated COVID-19 vaccine development: milestones, lessons, and prospects","volume":"54","author":"Bok","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.ymthe.2022.02.011_bib2","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41541-021-00330-7","article-title":"Protein-based antigen presentation platforms for nanoparticle vaccines","volume":"6","author":"Nguyen","year":"2021","journal-title":"NPJ Vaccin."},{"key":"10.1016\/j.ymthe.2022.02.011_bib3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nbt0197-52","article-title":"Adenovirus dodecahedron, a new vector for human gene transfer","volume":"15","author":"Fender","year":"1997","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib4","doi-asserted-by":"crossref","first-page":"718","DOI":"10.3390\/v12070718","article-title":"The adenovirus dodecahedron: beyond the platonic story","volume":"12","author":"Besson","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.ymthe.2022.02.011_bib5","doi-asserted-by":"crossref","first-page":"eaaw2853","DOI":"10.1126\/sciadv.aaw2853","article-title":"Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display","volume":"5","author":"Vragniau","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2022.02.011_bib6","doi-asserted-by":"crossref","first-page":"E690","DOI":"10.1073\/pnas.1115485109","article-title":"Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin","volume":"109","author":"Zakeri","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ymthe.2022.02.011_bib7","doi-asserted-by":"crossref","first-page":"19234","DOI":"10.1038\/srep19234","article-title":"Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization","volume":"6","author":"Brune","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2022.02.011_bib8","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jmb.2013.10.021","article-title":"Structural analysis and optimization of the covalent association between SpyCatcher and a peptide tag","volume":"426","author":"Li","year":"2014","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib9","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1039\/D0SC01878C","article-title":"Power to the protein: enhancing and combining activities using the Spy toolbox","volume":"11","author":"Keeble","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ymthe.2022.02.011_bib10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib11","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/s41591-021-01377-8","article-title":"Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection","volume":"27","author":"Khoury","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.ymthe.2022.02.011_bib12","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41586-020-03041-6","article-title":"Correlates of protection against SARS-CoV-2 in rhesus macaques","volume":"590","author":"McMahan","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib13","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2022.02.011_bib14","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMoa2022483","article-title":"An mRNA vaccine against SARS-CoV-2 \u2014 preliminary report","volume":"383","author":"Jackson","year":"2020","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2022.02.011_bib15","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1056\/NEJMoa2107659","article-title":"Safety and efficacy of NVX-CoV2373 covid-19 vaccine","volume":"385","author":"Heath","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2022.02.011_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41586-020-2179-y","article-title":"Structural basis of receptor recognition by SARS-CoV-2","volume":"581","author":"Shang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib17","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2","volume":"367","author":"Yan","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.02.011_bib18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib19","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.cell.2020.08.012","article-title":"Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding","volume":"182","author":"Starr","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2022.02.011_bib20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.cell.2020.09.037","article-title":"Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology","volume":"183","author":"Piccoli","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2022.02.011_bib21","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.cell.2020.06.025","article-title":"Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies","volume":"182","author":"Barnes","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2022.02.011_bib22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-020-2456-9","article-title":"Convergent antibody responses to SARS-CoV-2 in convalescent individuals","volume":"584","author":"Robbiani","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.abc5902","article-title":"Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability","volume":"369","author":"Brouwer","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.02.011_bib24","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s41586-020-2852-1","article-title":"SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies","volume":"588","author":"Barnes","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.2000583","article-title":"A potently neutralizing antibody protects mice against SARS-CoV-2 infection","volume":"205","author":"Alsoussi","year":"2020","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41586-020-2548-6","article-title":"Potently neutralizing and protective human antibodies against SARS-CoV-2","volume":"584","author":"Zost","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib27","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1056\/NEJMoa2109682","article-title":"Subcutaneous REGEN-COV antibody combination to prevent covid-19","volume":"385","author":"O\u2019Brien","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2022.02.011_bib28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jmb.2005.11.048","article-title":"Structure of the dodecahedral penton particle from human adenovirus type 3","volume":"356","author":"Fuschiotti","year":"2006","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib29","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/s41467-020-16048-4","article-title":"Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig","volume":"11","author":"Lei","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2022.02.011_bib30","article-title":"Persistence at one year of neutralizing antibodies after SARS-CoV-2 infection: influence of initial severity and steroid use","author":"Epaulard","year":"2021","journal-title":"J.\u00a0Infect."},{"key":"10.1016\/j.ymthe.2022.02.011_bib31","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41467-020-20654-7","article-title":"A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses","volume":"12","author":"Tan","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2022.02.011_bib32","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature12202","article-title":"Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies","volume":"499","author":"Kanekiyo","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib33","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.cell.2015.07.043","article-title":"Rational design of an epstein-barr virus vaccine targeting the receptor-binding site","volume":"162","author":"Kanekiyo","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2022.02.011_bib34","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.immunol.15.1.235","article-title":"Neutralizing antiviral B cell responses","volume":"15","author":"Bachmann","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1126\/science.abb9983","article-title":"Site-specific glycan analysis of the SARS-CoV-2 spike","volume":"369","author":"Watanabe","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.02.011_bib36","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1056\/NEJMoa2107659","article-title":"Efficacy of NVX-CoV2373 covid-19 vaccine against the B.1.351 variant","volume":"385","author":"Shinde","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2022.02.011_bib37","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.abf6840","article-title":"Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice","volume":"371","author":"Cohen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2022.02.011_bib38","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.cell.2020.10.043","article-title":"Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2","volume":"183","author":"Walls","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2022.02.011_bib39","doi-asserted-by":"crossref","first-page":"eabf1591","DOI":"10.1126\/sciadv.abf1591","article-title":"Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates","volume":"7","author":"He","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ymthe.2022.02.011_bib40","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/1873-3468.14171","article-title":"Single-dose immunisation with a multimerised SARS-CoV-2 receptor binding domain (RBD) induces an enhanced and protective response in mice","volume":"595","author":"Salzer","year":"2021","journal-title":"FEBS Lett."},{"key":"10.1016\/j.ymthe.2022.02.011_bib41","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-021-03594-0","article-title":"Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses","volume":"594","author":"Saunders","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.ymthe.2022.02.011_bib42","doi-asserted-by":"crossref","first-page":"8263","DOI":"10.1128\/JVI.77.15.8263-8271.2003","article-title":"Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: efficient human cell infection and bypass of preexisting adenovirus immunity","volume":"77","author":"Vogels","year":"2003","journal-title":"JVI"},{"key":"10.1016\/j.ymthe.2022.02.011_bib43","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.tips.2012.04.005","article-title":"Adenovirus receptors: implications for targeting of viral vectors","volume":"33","author":"Arnberg","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.ymthe.2022.02.011_bib44","doi-asserted-by":"crossref","first-page":"e0194516","DOI":"10.1371\/journal.pone.0194516","article-title":"Worldwide increased prevalence of human adenovirus type 3 (HAdV-3) respiratory infections is well correlated with heterogeneous hypervariable regions (HVRs) of hexon","volume":"13","author":"Haque","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ymthe.2022.02.011_bib45","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.vaccine.2010.12.025","article-title":"Anti-adenovirus humoral responses influence on the efficacy of vaccines based on epitope display on adenovirus capsid","volume":"29","author":"Lanzi","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.ymthe.2022.02.011_bib46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fimmu.2018.00124","article-title":"Humoral responses elicited by adenovirus displaying epitopes are induced independently of the infection process and shaped by the toll-like receptor\/MyD88 pathway","volume":"9","author":"Anchim","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib47","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-2478(03)00078-6","article-title":"Feedback regulation by IgG antibodies","volume":"88","author":"Heyman","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.ymthe.2022.02.011_bib48","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41565-020-0719-0","article-title":"Role of nanoscale antigen organization on B-cell activation probed using DNA origami","volume":"15","author":"Veneziano","year":"2020","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib49","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-1-62703-679-5_4","article-title":"Use of dodecahedron \u201cVLPs\u201d as an alternative to the whole adenovirus","volume":"1089","author":"Fender","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2022.02.011_bib50","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nmeth.4193","article-title":"MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy","volume":"14","author":"Zheng","year":"2017","journal-title":"Nat. Methods"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001622000946?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001622000946?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:02:46Z","timestamp":1761501766000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001622000946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S1525001622000946"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2022.02.011","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.13.460076","asserted-by":"object"}]},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization with a versatile adenovirus-inspired multimerization platform","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2022.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}]}}