{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:10:33Z","timestamp":1791483033981,"version":"4.3.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Molecular Therapy"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.ymthe.2023.05.011","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T01:02:47Z","timestamp":1684285367000},"page":"2206-2219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tracking human neurologic disease status in mouse brain\/plasma using reporter-tagged, EV-associated biomarkers"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-7328","authenticated-orcid":false,"given":"Katia E.","family":"Maalouf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine A.","family":"Vaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Frederick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Yoshinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Obuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Mahjoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Al Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Cristopher","family":"Bragg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6036-0399","authenticated-orcid":false,"given":"Xandra O.","family":"Breakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0713-2407","authenticated-orcid":false,"given":"Koen","family":"Breyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ymthe.2023.05.011_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1474-4422(02)00100-X","article-title":"Mouse models for neurological disease","volume":"1","author":"Hafezparast","year":"2002","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib2","doi-asserted-by":"crossref","first-page":"eabo0924","DOI":"10.1126\/science.abo0924","article-title":"Connectomic comparison of mouse and human cortex","volume":"377","author":"Loomba","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.ymthe.2023.05.011_bib3","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1517\/17460441.2015.1041913","article-title":"Rodent models for Alzheimer\u2019s disease drug discovery","volume":"10","author":"Puzzo","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.ymthe.2023.05.011_bib4","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1056\/NEJMra1704286","article-title":"Circulating extracellular vesicles in human disease","volume":"379","author":"Shah","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.ymthe.2023.05.011_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41467-017-02261-1","article-title":"Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles","volume":"9","author":"Re\u00e1tegui","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ymthe.2023.05.011_bib6","doi-asserted-by":"crossref","first-page":"121366","DOI":"10.1016\/j.biomaterials.2022.121366","article-title":"Using genetically modified extracellular vesicles as a non-invasive strategy to evaluate brain-specific cargo","volume":"281","author":"Rufino-Ramos","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.ymthe.2023.05.011_bib7","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00005792-199105000-00002","article-title":"The phenotype of the X-linked dystonia-parkinsonism syndrome. An assessment of 42 cases in the Philippines","volume":"70","author":"Lee","year":"1991","journal-title":"Medicine"},{"key":"10.1016\/j.ymthe.2023.05.011_bib8","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2018.02.011","article-title":"Dissecting the causal mechanism of X-linked dystonia-parkinsonism by integrating genome and transcriptome assembly","volume":"172","author":"Aneichyk","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.ymthe.2023.05.011_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1086\/512129","article-title":"Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism","volume":"80","author":"Makino","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.ymthe.2023.05.011_bib10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/mds.28305","article-title":"TAF1 transcripts and neurofilament light chain as biomarkers for X-linked dystonia-parkinsonism","volume":"36","author":"Al Ali","year":"2021","journal-title":"Mov. Disord."},{"key":"10.1016\/j.ymthe.2023.05.011_bib11","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tibtech.2017.12.005","article-title":"Personalized cancer medicine: an organoid approach","volume":"36","author":"Aboulkheyr Es","year":"2018","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib12","doi-asserted-by":"crossref","first-page":"e101654","DOI":"10.15252\/embj.2019101654","article-title":"Xenograft and organoid model systems in cancer research","volume":"38","author":"Bleijs","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.ymthe.2023.05.011_bib13","doi-asserted-by":"crossref","DOI":"10.3791\/56023","article-title":"Tumor engraftment in a xenograft mouse model of human mantle cell lymphoma","author":"Vijaya Kumar","year":"2018","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.ymthe.2023.05.011_bib14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuron.2017.03.042","article-title":"iPSC-derived human microglia-like cells to study neurological diseases","volume":"94","author":"Abud","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.ymthe.2023.05.011_bib15","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1038\/s41380-020-00910-4","article-title":"Human cerebral organoids establish subcortical projections in the mouse brain after transplantation","volume":"26","author":"Dong","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.ymthe.2023.05.011_bib16","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.1038\/emm.2016.163","article-title":"In\u00a0vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns","volume":"49","author":"Kim","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.ymthe.2023.05.011_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0165-3806(94)00162-S","article-title":"Nestin mRNA expression correlates with the central nervous system progenitor cell state in many, but not all, regions of developing central nervous system","volume":"84","author":"Dahlstrand","year":"1995","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.ymthe.2023.05.011_bib18","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1002\/glia.21201","article-title":"Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells in\u00a0vitro","volume":"59","author":"G\u00f3mez-L\u00f3pez","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.ymthe.2023.05.011_bib19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.acthis.2016.05.002","article-title":"Ki67, PCNA, and MCM proteins: markers of proliferation in the diagnosis of breast cancer","volume":"118","author":"Jur\u00edkov\u00e1","year":"2016","journal-title":"Acta Histochem."},{"key":"10.1016\/j.ymthe.2023.05.011_bib20","first-page":"451","article-title":"Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells","volume":"9","author":"Ito","year":"2016","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.ymthe.2023.05.011_bib21","first-page":"3325","article-title":"Comparison of the EF-1 alpha and the CMV promoter for engineering stable tumor cell lines using recombinant adeno-associated virus","volume":"22","author":"Teschendorf","year":"2002","journal-title":"Anticancer Res."},{"key":"10.1016\/j.ymthe.2023.05.011_bib22","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1021\/acsnano.6b06131","article-title":"Exodisc for rapid, size-selective, and efficient isolation and analysis of nanoscale extracellular vesicles from biological samples","volume":"11","author":"Woo","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.ymthe.2023.05.011_bib23","doi-asserted-by":"crossref","first-page":"e0236439","DOI":"10.1371\/journal.pone.0236439","article-title":"Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo-Implications for biomarker discovery","volume":"15","author":"Palviainen","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ymthe.2023.05.011_bib24","doi-asserted-by":"crossref","first-page":"7929","DOI":"10.1080\/21655979.2021.1982320","article-title":"Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems","volume":"12","author":"Xu","year":"2021","journal-title":"Bioengineered"},{"key":"10.1016\/j.ymthe.2023.05.011_bib25","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ccell.2016.10.009","article-title":"Extracellular vesicles in cancer: cell-to-cell mediators of metastasis","volume":"30","author":"Becker","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ymthe.2023.05.011_bib26","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jhep.2020.07.014","article-title":"Extracellular vesicles as biomarkers in liver diseases: a clinician\u2019s point of view","volume":"73","author":"Thietart","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib27","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrcardio.2017.7","article-title":"Extracellular vesicles in coronary artery disease","volume":"14","author":"Boulanger","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13041-019-0448-1","article-title":"Blood-based molecular biomarkers for Alzheimer\u2019s disease","volume":"12","author":"Zetterberg","year":"2019","journal-title":"Mol. Brain"},{"key":"10.1016\/j.ymthe.2023.05.011_bib29","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.14336\/AD.2021.0516","article-title":"Extracellular vesicles for the diagnosis and treatment of Parkinson\u2019s disease","volume":"12","author":"Upadhya","year":"2021","journal-title":"Aging Dis."},{"key":"10.1016\/j.ymthe.2023.05.011_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41416-019-0603-6","article-title":"Circulating biomarkers in patients with glioblastoma","volume":"122","author":"M\u00fcller Bark","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.ymthe.2023.05.011_bib31","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1080\/14737159.2017.1374854","article-title":"Liquid biopsy for brain tumors","volume":"17","author":"Shankar","year":"2017","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.ymthe.2023.05.011_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s00018-022-04494-w","article-title":"NPC transplantation rescues sci-driven cAMP\/EPAC2 alterations, leading to neuroprotection and microglial modulation","volume":"79","author":"Mart\u00ednez-Rojas","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ymthe.2023.05.011_bib33","doi-asserted-by":"crossref","first-page":"E10","DOI":"10.3171\/2018.12.FOCUS18602","article-title":"Stem cell therapies for acute spinal cord injury in humans: a review","volume":"46","author":"Jin","year":"2019","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.ymthe.2023.05.011_bib34","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.neuint.2006.09.005","article-title":"Targeted stem cell transplantation strategies in ALS","volume":"50","author":"Lepore","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.ymthe.2023.05.011_bib35","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fneur.2018.00428","article-title":"Transplantation of neural precursor cells attenuates chronic immune environment in cervical spinal cord injury","volume":"9","author":"Riemann","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib36","doi-asserted-by":"crossref","first-page":"101429","DOI":"10.1016\/j.scr.2019.101429","article-title":"The in\u00a0vivo timeline of differentiation of engrafted human neural progenitor cells","volume":"37","author":"Vogel","year":"2019","journal-title":"Stem Cel Res."},{"key":"10.1016\/j.ymthe.2023.05.011_bib37","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/glia.22862","article-title":"Modeling cognition and disease using human glial chimeric mice","volume":"63","author":"Goldman","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.ymthe.2023.05.011_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00335-019-09807-2","article-title":"Uses for humanised mouse models in precision medicine for neurodegenerative disease","volume":"30","author":"Nair","year":"2019","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.ymthe.2023.05.011_bib39","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1634\/stemcells.21-6-647","article-title":"Stable expression of hrGFP by mouse embryonic stem cells: promoter activity in the undifferentiated state and during dopaminergic neural differentiation","volume":"21","author":"Zeng","year":"2003","journal-title":"Stem Cells"},{"key":"10.1016\/j.ymthe.2023.05.011_bib40","doi-asserted-by":"crossref","first-page":"1800222","DOI":"10.1080\/20013078.2020.1800222","article-title":"Quantification of extracellular vesicles in\u00a0vitro and in\u00a0vivo using sensitive bioluminescence imaging","volume":"9","author":"Gupta","year":"2020","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2023.05.011_bib41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/978-1-0716-2209-4_25","article-title":"Quantitative measurement of extracellular vesicle content delivery within acceptor cells","volume":"2473","author":"Bonsergent","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib42","doi-asserted-by":"crossref","first-page":"1663043","DOI":"10.1080\/20013078.2019.1663043","article-title":"Systematic characterization of extracellular vesicle sorting domains and quantification at the single molecule - single vesicle level by fluorescence correlation spectroscopy and single particle imaging","volume":"8","author":"Corso","year":"2019","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2023.05.011_bib43","doi-asserted-by":"crossref","first-page":"17387","DOI":"10.1038\/s41598-019-53554-y","article-title":"Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles","volume":"9","author":"Zaborowski","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ymthe.2023.05.011_bib44","first-page":"R668","article-title":"Simple and inexpensive delivery of halogenated inhalation anesthetics to rodents","volume":"257","author":"Henry","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib45","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1440-1681.2007.04601.x","article-title":"Optimizing dosage of ketamine and xylazine in murine echocardiography","volume":"34","author":"Xu","year":"2007","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.ymthe.2023.05.011_bib46","doi-asserted-by":"crossref","first-page":"1348885","DOI":"10.1080\/20013078.2017.1348885","article-title":"A rigorous method to enrich for exosomes from brain tissue","volume":"6","author":"Vella","year":"2017","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2023.05.011_bib47","doi-asserted-by":"crossref","first-page":"e12089","DOI":"10.1002\/jev2.12089","article-title":"Characterization of brain-derived extracellular vesicle lipids in Alzheimer\u2019s disease","volume":"10","author":"Su","year":"2021","journal-title":"J.\u00a0Extracell. Vesicles"},{"key":"10.1016\/j.ymthe.2023.05.011_bib48","doi-asserted-by":"crossref","first-page":"1785746","DOI":"10.1080\/20013078.2020.1785746","article-title":"Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles","volume":"9","author":"Huang","year":"2020","journal-title":"J.\u00a0Extracell. Vesicles"}],"container-title":["Molecular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001623002678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525001623002678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:08:32Z","timestamp":1761502112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525001623002678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1525001623002678"],"URL":"https:\/\/doi.org\/10.1016\/j.ymthe.2023.05.011","relation":{},"ISSN":["1525-0016"],"issn-type":[{"value":"1525-0016","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tracking human neurologic disease status in mouse brain\/plasma using reporter-tagged, EV-associated biomarkers","name":"articletitle","label":"Article Title"},{"value":"Molecular Therapy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ymthe.2023.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s).","name":"copyright","label":"Copyright"}]}}